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Louis J Vaickus, MD, PhD

Title(s)
Associate Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Medical Director of Pathology Informatics

Department(s)
Pathology and Laboratory Medicine

Education
BA, Hamilton College, Clinton NY, 2001-2005
MD, Boston University School of Medicine, Boston MA, 2005-2012
PhD, Boston University School of Medicine, Boston MA, 2005-2012
Anatomic Pathology Residency, Massachusetts General Hospital, Boston MA, 2012-2016
Cytopathology Fellowship, Massachusetts General Hospital, Boston MA, 2014-2015

Contact Information

1 Medical Center Drive
Lebanon NH 03766

Office: Borwell 4
Phone: 53844
Email: Louis.J.Vaickus@Dartmouth.edu


Professional Interests

Informatics
Deep learning
Medical image analysis
Automation
Programming

Grant Information

SYNERGY Clinical Research Fellow, 2018-2019


Selected Publications

 

An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer.
Rao VR, Sadanandappa MK, Black CC, Palisoul SM, Workman AA, MacKenzie TA, Liu X, Chamberlin MD, Vaickus LJ, Zanazzi GJ, Sukhadia SS
Am J Pathol. 2026 Aug 7; pii: S0002-9440(26)00229-4. doi: 10.1016/j.ajpath.2026.07.007. Epub 2026 Aug 7.
PMID: 42567444

Metastasis-associated DNA methylation alterations persist after accounting for immune and stromal cell heterogeneity in primary colorectal tumors.
Diallo AB, Hart SD, Zavras JP, Palisoul SM, Kolling FW, Vaickus LJ, Sun JE, Salas LA, Christensen BC, Levy JJ
Res Sq. 2026 Jul 14; pii: rs.3.rs-9657747. doi: 10.21203/rs.3.rs-9657747/v1. Epub 2026 Jul 14.
PMID: 42523546

Adapting transformer-based encoder models for automated billing code assignment of current procedural terminology from pathology reports in multi-institutional settings.
Renner E, Patel O, McOsker S, Le MK, Lu Y, Vaickus LJ, Berg A, Yao K, Levy J
J Pathol Inform. 2026 Aug;22:100687. doi: 10.1016/j.jpi.2026.100687. Epub 2026 Jun 14.
PMID: 42436742

Accurate focal-plane selection is crucial for artificial intelligence assessment of three-dimensional urine cytology specimens for bladder cancer screening and surveillance.
Sayegh Y, McNutt B, Le MK, Liao IC, Yao K, Ng C, Kohsar A, Shou D, Yu M, Jin Y, Vaickus LJ, Liu X, VandenBussche CJ, Harvey SE, Levy JJ
Cancer Cytopathol. 2026 Jul;134(7):e70117. doi: 10.1002/cncy.70117.
PMID: 42363782

Interpreting and Validating a Deep Learning Model Predictive of Spatial Morphologic-Molecular Patterns in Lung Adenocarcinoma, Using Ground Truth Immunohistochemistry Images.
Rao VR, Workman AA, Palisoul SM, Limoge CJ, Vaickus LJ, Zanazzi GJ, Lu L, Liu X, Sukhadia SS
bioRxiv. 2026 Apr 23; pii: 2026.04.20.719723. doi: 10.64898/2026.04.20.719723. Epub 2026 Apr 23.
PMID: 42079136

X-SPATIO: An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer.
Rao VR, Sadanandappa MK, Black CC, Palisoul SM, Workman AA, MacKenzie TA, Liu X, Chamberlin MD, Vaickus LJ, Zanazzi GJ, Sukhadia SS
bioRxiv. 2026 Feb 11; pii: 2026.02.09.704587. doi: 10.64898/2026.02.09.704587. Epub 2026 Feb 11.
PMID: 41726881

Seven-year retrospective review of medical microbiologist consultations on cytology specimens at an academic medical center.
Marotti JD, Gutmann EJ, Loeven NA, Liu X, Kerr DA, Vaickus LJ, Martin IW
Am J Clin Pathol. 2025 Nov 19;164(5):752-758. doi: 10.1093/ajcp/aqaf100.
PMID: 40994162

Association of deep learning-derived histologic features of placental chorionic villi with maternal and infant characteristics in the New Hampshire birth cohort study.
Anderson EC, Srinivasan G, Howe CG, Zhang E, Jeon C, Gupta Paruchuri GS, Zhang L, Hwang L, Sengar A, Reddy N, Karan A, Chen A, Shen J, Owo O, Caraballo-Bobea Z, Khatchikian C, Palys TJ, Vaickus LJ, Yao K, Medeiros F, Nguyen H, Madan JC, Karagas MR, Bentz JL, Levy JJ
Placenta. 2025 Oct;170:87-96. doi: 10.1016/j.placenta.2025.07.084. Epub 2025 Jul 23.
PMID: 40902262

Association of Deep Learning-Derived Histologic Features of Placental Chorionic Villi with Maternal and Infant Characteristics in the New Hampshire Birth Cohort Study.
Anderson EC, Srinivasan G, Howe CG, Zhang E, Jeon C, Paruchuri GSG, Zhang L, Hwang L, Sengar A, Reddy N, Karan A, Chen A, Shen J, Owo O, Caraballo-Bobea Z, Khatchikian C, Palys TJ, Vaickus LJ, Madan JC, Karagas MR, Bentz JL, Levy JJ
medRxiv. 2025 Apr 23; pii: 2025.04.22.25325465. doi: 10.1101/2025.04.22.25325465. Epub 2025 Apr 23.
PMID: 40313259

An initial game-theoretic assessment of enhanced tissue preparation and imaging protocols for improved deep learning inference of spatial transcriptomics from tissue morphology.
Fatemi MY, Lu Y, Diallo AB, Srinivasan G, Azher ZL, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW 4th, Vaickus LJ, Levy JJ
Brief Bioinform. 2024 Sep 23;25(6) doi: 10.1093/bib/bbae476.
PMID: 39367648

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