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Louis J Vaickus, MD, PhD

Assistant Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations:
Medical Director of Pathology Informatics

Pathology and Laboratory Medicine

BA, Hamilton College, Clinton NY, 2001-2005
MD, Boston University School of Medicine, Boston MA, 2005-2012
PhD, Boston University School of Medicine, Boston MA, 2005-2012
Anatomic Pathology Residency, Massachusetts General Hospital, Boston MA, 2012-2016
Cytopathology Fellowship, Massachusetts General Hospital, Boston MA, 2014-2015

Contact Information:

1 Medical Center Drive
Lebanon NH 03766

Office: Borwell 4
Phone: 53844

Professional Interests:

Deep learning
Medical image analysis

Grant Information:

SYNERGY Clinical Research Fellow, 2018-2019

Selected Publications:


Using molecular testing to improve the management of thyroid nodules with indeterminate cytology: an institutional experience with review of molecular alterations.
Glass RE, Marotti JD, Kerr DA, Levy JJ, Vaickus LJ, Gutmann EJ, Tafe LJ, Motanagh SA, Sorensen MJ, Davies L, Liu X
J Am Soc Cytopathol. 2021 Aug 21; pii: S2213-2945(21)00218-0. doi: 10.1016/j.jasc.2021.08.004. Epub 2021 Aug 21.
PMID: 34627720

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.
Levy JJ, Chen Y, Azizgolshani N, Petersen CL, Titus AJ, Moen EL, Vaickus LJ, Salas LA, Christensen BC
NPJ Syst Biol Appl. 2021 Aug 20;7(1):33. doi: 10.1038/s41540-021-00193-7. Epub 2021 Aug 20.
PMID: 34417465

Atypia of undetermined significance in thyroid cytology: Nuclear atypia and architectural atypia are associated with different molecular alterations and risks of malignancy.
Glass RE, Levy JJ, Motanagh SA, Vaickus LJ, Liu X
Cancer Cytopathol. 2021 Aug 16; doi: 10.1002/cncy.22495. Epub 2021 Aug 16.
PMID: 34399035

A large-scale internal validation study of unsupervised virtual trichrome staining technologies on nonalcoholic steatohepatitis liver biopsies.
Levy JJ, Azizgolshani N, Andersen MJ Jr, Suriawinata A, Liu X, Lisovsky M, Ren B, Bobak CA, Christensen BC, Vaickus LJ
Mod Pathol. 2021 Apr;34(4):808-822. doi: 10.1038/s41379-020-00718-1. Epub 2020 Dec 9.
PMID: 33299110

Fine needle aspiration of an intranodal follicular dendritic cell sarcoma: A case report with molecular analysis and review of the literature.
Andersen MJ Jr, Kerr DA, Lisovsky M, Vaickus LJ, Linos K
Diagn Cytopathol. 2021 Feb;49(2):E65-E70. doi: 10.1002/dc.24584. Epub 2020 Aug 20.
PMID: 32816379

Evaluation of a Deep Neural Network for Automated Classification of Colorectal Polyps on Histopathologic Slides.
Wei JW, Suriawinata AA, Vaickus LJ, Ren B, Liu X, Lisovsky M, Tomita N, Abdollahi B, Kim AS, Snover DC, Baron JA, Barry EL, Hassanpour S
JAMA Netw Open. 2020 Apr 1;3(4):e203398. doi: 10.1001/jamanetworkopen.2020.3398. Epub 2020 Apr 1.
PMID: 32324237

A machine learning algorithm for simulating immunohistochemistry: development of SOX10 virtual IHC and evaluation on primarily melanocytic neoplasms.
Jackson CR, Sriharan A, Vaickus LJ
Mod Pathol. 2020 Sep;33(9):1638-1648. doi: 10.1038/s41379-020-0526-z. Epub 2020 Apr 1.
PMID: 32238879

PathFlowAI: A High-Throughput Workflow for Preprocessing, Deep Learning and Interpretation in Digital Pathology.
Levy JJ, Salas LA, Christensen BC, Sriharan A, Vaickus LJ
Pac Symp Biocomput. 2020;25:403-414.
PMID: 31797614

Pathologist-level classification of histologic patterns on resected lung adenocarcinoma slides with deep neural networks.
Wei JW, Tafe LJ, Linnik YA, Vaickus LJ, Tomita N, Hassanpour S
Sci Rep. 2019 Mar 4;9(1):3358. doi: 10.1038/s41598-019-40041-7. Epub 2019 Mar 4.
PMID: 30833650

Automating the Paris System for urine cytopathology-A hybrid deep-learning and morphometric approach.
Vaickus LJ, Suriawinata AA, Wei JW, Liu X
Cancer Cytopathol. 2019 Feb;127(2):98-115. doi: 10.1002/cncy.22099. Epub 2019 Jan 31.
PMID: 30702803

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