Louis J Vaickus, MD, PhD

Selected Publications

Interpreting and Validating a Deep Learning Model Predictive of Spatial Morphologic-Molecular Patterns in Lung Adenocarcinoma, Using Ground Truth Immunohistochemistry Images.
Rao VR, Workman AA, Palisoul SM, Limoge CJ, Vaickus LJ, Zanazzi GJ, Lu L, Liu X, Sukhadia SS
bioRxiv. 2026 Apr 23; pii: 2026.04.20.719723. doi: 10.64898/2026.04.20.719723. Epub 2026 Apr 23.
PMID: 42079136

X-SPATIO: An Explanatory Deep Learning Pipeline for the Prediction and Visualization of Spatially Resolved Biomarker Expression in Triple-Negative Breast Cancer.
Rao VR, Sadanandappa MK, Black CC, Palisoul SM, Workman AA, MacKenzie TA, Liu X, Chamberlin MD, Vaickus LJ, Zanazzi GJ, Sukhadia SS
bioRxiv. 2026 Feb 11; pii: 2026.02.09.704587. doi: 10.64898/2026.02.09.704587. Epub 2026 Feb 11.
PMID: 41726881

Seven-year retrospective review of medical microbiologist consultations on cytology specimens at an academic medical center.
Marotti JD, Gutmann EJ, Loeven NA, Liu X, Kerr DA, Vaickus LJ, Martin IW
Am J Clin Pathol. 2025 Nov 19;164(5):752-758. doi: 10.1093/ajcp/aqaf100.
PMID: 40994162

Association of deep learning-derived histologic features of placental chorionic villi with maternal and infant characteristics in the New Hampshire birth cohort study.
Anderson EC, Srinivasan G, Howe CG, Zhang E, Jeon C, Gupta Paruchuri GS, Zhang L, Hwang L, Sengar A, Reddy N, Karan A, Chen A, Shen J, Owo O, Caraballo-Bobea Z, Khatchikian C, Palys TJ, Vaickus LJ, Yao K, Medeiros F, Nguyen H, Madan JC, Karagas MR, Bentz JL, Levy JJ
Placenta. 2025 Oct;170:87-96. doi: 10.1016/j.placenta.2025.07.084. Epub 2025 Jul 23.
PMID: 40902262

Association of Deep Learning-Derived Histologic Features of Placental Chorionic Villi with Maternal and Infant Characteristics in the New Hampshire Birth Cohort Study.
Anderson EC, Srinivasan G, Howe CG, Zhang E, Jeon C, Paruchuri GSG, Zhang L, Hwang L, Sengar A, Reddy N, Karan A, Chen A, Shen J, Owo O, Caraballo-Bobea Z, Khatchikian C, Palys TJ, Vaickus LJ, Madan JC, Karagas MR, Bentz JL, Levy JJ
medRxiv. 2025 Apr 23; pii: 2025.04.22.25325465. doi: 10.1101/2025.04.22.25325465. Epub 2025 Apr 23.
PMID: 40313259

An initial game-theoretic assessment of enhanced tissue preparation and imaging protocols for improved deep learning inference of spatial transcriptomics from tissue morphology.
Fatemi MY, Lu Y, Diallo AB, Srinivasan G, Azher ZL, Christensen BC, Salas LA, Tsongalis GJ, Palisoul SM, Perreard L, Kolling FW 4th, Vaickus LJ, Levy JJ
Brief Bioinform. 2024 Sep 23;25(6) doi: 10.1093/bib/bbae476.
PMID: 39367648

Artificial Intelligence Applications in Cytopathology: Current State of the Art.
Vaickus LJ, Kerr DA, Velez Torres JM, Levy J
Surg Pathol Clin. 2024 Sep;17(3):521-531. doi: 10.1016/j.path.2024.04.011. Epub 2024 May 30.
PMID: 39129146

Thyroid Fine-Needle Aspiration: The Current and Future Landscape of Cytopathology.
Velez Torres JM, Vaickus LJ, Kerr DA
Surg Pathol Clin. 2024 Sep;17(3):371-381. doi: 10.1016/j.path.2024.04.005. Epub 2024 May 19.
PMID: 39129137

Intraoperative margin assessment for basal cell carcinoma with deep learning and histologic tumor mapping to surgical site.
Levy JJ, Davis MJ, Chacko RS, Davis MJ, Fu LJ, Goel T, Pamal A, Nafi I, Angirekula A, Suvarna A, Vempati R, Christensen BC, Hayden MS, Vaickus LJ, LeBoeuf MR
NPJ Precis Oncol. 2024 Jan 3;8(1):2. doi: 10.1038/s41698-023-00477-7. Epub 2024 Jan 3.
PMID: 38172524

Correction: A2B Adenosine Receptor Expression by Myeloid Cells is Proinflammatory in Murine Allergic-Airway Inflammation.
Belikoff BG, Vaickus LJ, Sitkovsky M, Remick DG
J Immunol. 2024 Feb 15;212(4):748. doi: 10.4049/jimmunol.2300855.
PMID: 38169328

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