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Hildreth R Frost, PhD

Title(s):
Assistant Professor of Biomedical Data Science

Department(s):
Biomedical Data Science

Contact Information:


Selected Publications:

 

The tumor microenvironment of colorectal cancer metastases: opportunities in cancer immunotherapy.
Kamal Y, Schmit SL, Frost HR, Amos CI
Immunotherapy. 2020 Oct;12(14):1083-1100. doi: 10.2217/imt-2020-0026. Epub 2020 Aug 13.
PMID: 32787587

Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring.
Frost HR
Nucleic Acids Res. 2020 Sep 18;48(16):e94. doi: 10.1093/nar/gkaa582.
PMID: 32633778

Updated emm-typing protocol for Streptococcus pyogenes.
Frost HR, Davies MR, Velusamy S, Delforge V, Erhart A, Darboe S, Steer A, Walker MJ, Beall B, Botteaux A, Smeesters PR
Clin Microbiol Infect. 2020 Jul;26(7):946.e5-946.e8. doi: 10.1016/j.cmi.2020.02.026. Epub 2020 Feb 28.
PMID: 32120034

Comparison of pathway and gene-level models for cancer prognosis prediction.
Zheng X, Amos CI, Frost HR
BMC Bioinformatics. 2020 Feb 28;21(1):76. doi: 10.1186/s12859-020-3423-z. Epub 2020 Feb 28.
PMID: 32111152

Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins.
Frost HR, Davies MR, Delforge V, Lakhloufi D, Sanderson-Smith M, Srinivasan V, Steer AC, Walker MJ, Beall B, Botteaux A, Smeesters PR
mSphere. 2020 Jan 8;5(1) pii: e00806-19. doi: 10.1128/mSphere.00806-19. Epub 2020 Jan 8.
PMID: 31915226

Author Correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.
Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchene S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ
Nat Genet. 2019 Aug;51(8):1295. doi: 10.1038/s41588-019-0482-z.
PMID: 31324894

Transcriptomic Differences between Primary Colorectal Adenocarcinomas and Distant Metastases Reveal Metastatic Colorectal Cancer Subtypes.
Kamal Y, Schmit SL, Hoehn HJ, Amos CI, Frost HR
Cancer Res. 2019 Aug 15;79(16):4227-4241. doi: 10.1158/0008-5472.CAN-18-3945. Epub 2019 Jun 25.
PMID: 31239274

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.
Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchene S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ
Nat Genet. 2019 Jun;51(6):1035-1043. doi: 10.1038/s41588-019-0417-8. Epub 2019 May 27.
PMID: 31133745

Predictors of disease aggressiveness influence outcome from immunotherapy treatment in renal clear cell carcinoma.
Kamal Y, Cheng C, Frost HR, Amos CI
Oncoimmunology. 2019;8(1):e1500106. doi: 10.1080/2162402X.2018.1500106. Epub 2018 Oct 16.
PMID: 30546942

A multi-omics approach for identifying important pathways and genes in human cancer.
Frost HR, Amos CI
BMC Bioinformatics. 2018 Dec 12;19(1):479. doi: 10.1186/s12859-018-2476-8. Epub 2018 Dec 12.
PMID: 30541428

View more publications on PubMed