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Hildreth R Frost, PhD

Assistant Professor of Biomedical Data Science

Biomedical Data Science

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Selected Publications:


Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse.
Kamal Y, Dwan D, Hoehn HJ, Sanz-Pamplona R, Alonso MH, Moreno V, Cheng C, Schell MJ, Kim Y, Felder SI, Rennert HS, Melas M, Lazaris C, Bonner JD, Siegel EM, Shibata D, Rennert G, Gruber SB, Frost HR, Amos CI, Schmit SL
Oncoimmunology. 2021 Mar 9;10(1):1862529. doi: 10.1080/2162402X.2020.1862529. Epub 2021 Mar 9.
PMID: 33763292

Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models.
Zheng X, Amos CI, Frost HR
BMC Bioinformatics. 2020 Oct 20;21(1):467. doi: 10.1186/s12859-020-03791-0. Epub 2020 Oct 20.
PMID: 33081688

Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity.
Sun Y, Preiss NK, Valenteros KB, Kamal Y, Usherwood YK, Frost HR, Usherwood EJ
J Immunol. 2020 Nov 15;205(10):2649-2666. doi: 10.4049/jimmunol.2000459. Epub 2020 Sep 30.
PMID: 32998985

The tumor microenvironment of colorectal cancer metastases: opportunities in cancer immunotherapy.
Kamal Y, Schmit SL, Frost HR, Amos CI
Immunotherapy. 2020 Oct;12(14):1083-1100. doi: 10.2217/imt-2020-0026. Epub 2020 Aug 13.
PMID: 32787587

Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring.
Frost HR
Nucleic Acids Res. 2020 Sep 18;48(16):e94. doi: 10.1093/nar/gkaa582.
PMID: 32633778

Updated emm-typing protocol for Streptococcus pyogenes.
Frost HR, Davies MR, Velusamy S, Delforge V, Erhart A, Darboe S, Steer A, Walker MJ, Beall B, Botteaux A, Smeesters PR
Clin Microbiol Infect. 2020 Jul;26(7):946.e5-946.e8. doi: 10.1016/j.cmi.2020.02.026. Epub 2020 Feb 28.
PMID: 32120034

Comparison of pathway and gene-level models for cancer prognosis prediction.
Zheng X, Amos CI, Frost HR
BMC Bioinformatics. 2020 Feb 28;21(1):76. doi: 10.1186/s12859-020-3423-z. Epub 2020 Feb 28.
PMID: 32111152

Analysis of Global Collection of Group A Streptococcus Genomes Reveals that the Majority Encode a Trio of M and M-Like Proteins.
Frost HR, Davies MR, Delforge V, Lakhloufi D, Sanderson-Smith M, Srinivasan V, Steer AC, Walker MJ, Beall B, Botteaux A, Smeesters PR
mSphere. 2020 Jan 8;5(1) pii: e00806-19. doi: 10.1128/mSphere.00806-19. Epub 2020 Jan 8.
PMID: 31915226

Author Correction: Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics.
Davies MR, McIntyre L, Mutreja A, Lacey JA, Lees JA, Towers RJ, Duchene S, Smeesters PR, Frost HR, Price DJ, Holden MTG, David S, Giffard PM, Worthing KA, Seale AC, Berkley JA, Harris SR, Rivera-Hernandez T, Berking O, Cork AJ, Torres RSLA, Lithgow T, Strugnell RA, Bergmann R, Nitsche-Schmitz P, Chhatwal GS, Bentley SD, Fraser JD, Moreland NJ, Carapetis JR, Steer AC, Parkhill J, Saul A, Williamson DA, Currie BJ, Tong SYC, Dougan G, Walker MJ
Nat Genet. 2019 Aug;51(8):1295. doi: 10.1038/s41588-019-0482-z.
PMID: 31324894

Transcriptomic Differences between Primary Colorectal Adenocarcinomas and Distant Metastases Reveal Metastatic Colorectal Cancer Subtypes.
Kamal Y, Schmit SL, Hoehn HJ, Amos CI, Frost HR
Cancer Res. 2019 Aug 15;79(16):4227-4241. doi: 10.1158/0008-5472.CAN-18-3945. Epub 2019 Jun 25.
PMID: 31239274

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