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Hildreth R Frost, PhD

Assistant Professor of Biomedical Data Science

Biomedical Data Science

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Selected Publications:


Pan-cancer evaluation of gene expression and somatic alteration data for cancer prognosis prediction.
Zheng X, Amos CI, Frost HR
BMC Cancer. 2021 Sep 25;21(1):1053. doi: 10.1186/s12885-021-08796-3. Epub 2021 Sep 25.
PMID: 34563154

Associations between the gut microbiome and metabolome in early life.
Nguyen QP, Karagas MR, Madan JC, Dade E, Palys TJ, Morrison HG, Pathmasiri WW, McRitche S, Sumner SJ, Frost HR, Hoen AG
BMC Microbiol. 2021 Aug 28;21(1):238. doi: 10.1186/s12866-021-02282-3. Epub 2021 Aug 28.
PMID: 34454437

Analyzing cancer gene expression data through the lens of normal tissue-specificity.
Frost HR
PLoS Comput Biol. 2021 Jun;17(6):e1009085. doi: 10.1371/journal.pcbi.1009085. Epub 2021 Jun 18.
PMID: 34143767

An emm-type specific qPCR to track bacterial load during experimental human Streptococcus pyogenes pharyngitis.
Fabri LV, Azzopardi KI, Osowicki J, Frost HR, Smeesters PR, Steer AC
BMC Infect Dis. 2021 May 21;21(1):463. doi: 10.1186/s12879-021-06173-w. Epub 2021 May 21.
PMID: 34020607

Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse.
Kamal Y, Dwan D, Hoehn HJ, Sanz-Pamplona R, Alonso MH, Moreno V, Cheng C, Schell MJ, Kim Y, Felder SI, Rennert HS, Melas M, Lazaris C, Bonner JD, Siegel EM, Shibata D, Rennert G, Gruber SB, Frost HR, Amos CI, Schmit SL
Oncoimmunology. 2021 Mar 9;10(1):1862529. doi: 10.1080/2162402X.2020.1862529. Epub 2021 Mar 9.
PMID: 33763292

Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models.
Zheng X, Amos CI, Frost HR
BMC Bioinformatics. 2020 Oct 20;21(1):467. doi: 10.1186/s12859-020-03791-0. Epub 2020 Oct 20.
PMID: 33081688

Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity.
Sun Y, Preiss NK, Valenteros KB, Kamal Y, Usherwood YK, Frost HR, Usherwood EJ
J Immunol. 2020 Nov 15;205(10):2649-2666. doi: 10.4049/jimmunol.2000459. Epub 2020 Sep 30.
PMID: 32998985

The tumor microenvironment of colorectal cancer metastases: opportunities in cancer immunotherapy.
Kamal Y, Schmit SL, Frost HR, Amos CI
Immunotherapy. 2020 Oct;12(14):1083-1100. doi: 10.2217/imt-2020-0026. Epub 2020 Aug 13.
PMID: 32787587

Variance-adjusted Mahalanobis (VAM): a fast and accurate method for cell-specific gene set scoring.
Frost HR
Nucleic Acids Res. 2020 Sep 18;48(16):e94. doi: 10.1093/nar/gkaa582.
PMID: 32633778

Updated emm-typing protocol for Streptococcus pyogenes.
Frost HR, Davies MR, Velusamy S, Delforge V, Erhart A, Darboe S, Steer A, Walker MJ, Beall B, Botteaux A, Smeesters PR
Clin Microbiol Infect. 2020 Jul;26(7):946.e5-946.e8. doi: 10.1016/j.cmi.2020.02.026. Epub 2020 Feb 28.
PMID: 32120034

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