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Hildreth R Frost, PhD

Assistant Professor of Biomedical Data Science

Biomedical Data Science

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Selected Publications


CBEA: Competitive balances for taxonomic enrichment analysis.
Nguyen QP, Hoen AG, Frost HR
PLoS Comput Biol. 2022 May 18;18(5):e1010091. doi: 10.1371/journal.pcbi.1010091. Epub 2022 May 18.
PMID: 35584140

A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study.
Osowicki J, Azzopardi KI, Fabri L, Frost HR, Rivera-Hernandez T, Neeland MR, Whitcombe AL, Grobler A, Gutman SJ, Baker C, Wong JMF, Lickliter JD, Waddington CS, Pandey M, Schuster T, Cheng AC, Pollard AJ, McCarthy JS, Good MF, Dale JB, Batzloff M, Moreland NJ, Walker MJ, Carapetis JR, Smeesters PR, Steer AC
Lancet Microbe. 2021 Jul;2(7):e291-e299. doi: 10.1016/S2666-5247(20)30240-8. Epub 2021 Apr 15.
PMID: 35544165

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial.
Anderson J, Imran S, Frost HR, Azzopardi KI, Jalali S, Novakovic B, Osowicki J, Steer AC, Licciardi PV, Pellicci DG
Nat Commun. 2022 Feb 9;13(1):769. doi: 10.1038/s41467-022-28335-3. Epub 2022 Feb 9.
PMID: 35140232

CAMML: Multi-Label Immune Cell-Typing and Stemness Analysis for Single-Cell RNA-sequencing.
Schiebout C, Frost HR
Pac Symp Biocomput. 2022;27:199-210.
PMID: 34890149

Pan-cancer evaluation of gene expression and somatic alteration data for cancer prognosis prediction.
Zheng X, Amos CI, Frost HR
BMC Cancer. 2021 Sep 25;21(1):1053. doi: 10.1186/s12885-021-08796-3. Epub 2021 Sep 25.
PMID: 34563154

Associations between the gut microbiome and metabolome in early life.
Nguyen QP, Karagas MR, Madan JC, Dade E, Palys TJ, Morrison HG, Pathmasiri WW, McRitche S, Sumner SJ, Frost HR, Hoen AG
BMC Microbiol. 2021 Aug 28;21(1):238. doi: 10.1186/s12866-021-02282-3. Epub 2021 Aug 28.
PMID: 34454437

Analyzing cancer gene expression data through the lens of normal tissue-specificity.
Frost HR
PLoS Comput Biol. 2021 Jun;17(6):e1009085. doi: 10.1371/journal.pcbi.1009085. Epub 2021 Jun 18.
PMID: 34143767

An emm-type specific qPCR to track bacterial load during experimental human Streptococcus pyogenes pharyngitis.
Fabri LV, Azzopardi KI, Osowicki J, Frost HR, Smeesters PR, Steer AC
BMC Infect Dis. 2021 May 21;21(1):463. doi: 10.1186/s12879-021-06173-w. Epub 2021 May 21.
PMID: 34020607

Tumor immune infiltration estimated from gene expression profiles predicts colorectal cancer relapse.
Kamal Y, Dwan D, Hoehn HJ, Sanz-Pamplona R, Alonso MH, Moreno V, Cheng C, Schell MJ, Kim Y, Felder SI, Rennert HS, Melas M, Lazaris C, Bonner JD, Siegel EM, Shibata D, Rennert G, Gruber SB, Frost HR, Amos CI, Schmit SL
Oncoimmunology. 2021 Mar 9;10(1):1862529. doi: 10.1080/2162402X.2020.1862529. Epub 2021 Mar 9.
PMID: 33763292

Cancer prognosis prediction using somatic point mutation and copy number variation data: a comparison of gene-level and pathway-based models.
Zheng X, Amos CI, Frost HR
BMC Bioinformatics. 2020 Oct 20;21(1):467. doi: 10.1186/s12859-020-03791-0. Epub 2020 Oct 20.
PMID: 33081688

View more publications on PubMed