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Hildreth R Frost, PhD

Assistant Professor of Biomedical Data Science

Biomedical Data Science

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Selected Publications


Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors.
Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH
Cancer Immunol Res. 2022 Aug 3;10(8):962-977. doi: 10.1158/2326-6066.CIR-21-0536.
PMID: 35696724

Eigenvectors from Eigenvalues Sparse Principal Component Analysis (EESPCA).
Frost HR
J Comput Graph Stat. 2022;31(2):486-501. doi: 10.1080/10618600.2021.1987254. Epub 2021 Nov 12.
PMID: 35693984

Internal oligo(dT) priming introduces systematic bias in bulk and single-cell RNA sequencing count data.
Svoboda M, Frost HR, Bosco G
NAR Genom Bioinform. 2022 Jun;4(2):lqac035. doi: 10.1093/nargab/lqac035. Epub 2022 May 25.
PMID: 35651651

CBEA: Competitive balances for taxonomic enrichment analysis.
Nguyen QP, Hoen AG, Frost HR
PLoS Comput Biol. 2022 May;18(5):e1010091. doi: 10.1371/journal.pcbi.1010091. Epub 2022 May 18.
PMID: 35584140

A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study.
Osowicki J, Azzopardi KI, Fabri L, Frost HR, Rivera-Hernandez T, Neeland MR, Whitcombe AL, Grobler A, Gutman SJ, Baker C, Wong JMF, Lickliter JD, Waddington CS, Pandey M, Schuster T, Cheng AC, Pollard AJ, McCarthy JS, Good MF, Dale JB, Batzloff M, Moreland NJ, Walker MJ, Carapetis JR, Smeesters PR, Steer AC
Lancet Microbe. 2021 Jul;2(7):e291-e299. doi: 10.1016/S2666-5247(20)30240-8. Epub 2021 Apr 15.
PMID: 35544165

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial.
Anderson J, Imran S, Frost HR, Azzopardi KI, Jalali S, Novakovic B, Osowicki J, Steer AC, Licciardi PV, Pellicci DG
Nat Commun. 2022 Feb 9;13(1):769. doi: 10.1038/s41467-022-28335-3. Epub 2022 Feb 9.
PMID: 35140232

CAMML: Multi-Label Immune Cell-Typing and Stemness Analysis for Single-Cell RNA-sequencing.
Schiebout C, Frost HR
Pac Symp Biocomput. 2022;27:199-210.
PMID: 34890149

Pan-cancer evaluation of gene expression and somatic alteration data for cancer prognosis prediction.
Zheng X, Amos CI, Frost HR
BMC Cancer. 2021 Sep 25;21(1):1053. doi: 10.1186/s12885-021-08796-3. Epub 2021 Sep 25.
PMID: 34563154

Associations between the gut microbiome and metabolome in early life.
Nguyen QP, Karagas MR, Madan JC, Dade E, Palys TJ, Morrison HG, Pathmasiri WW, McRitche S, Sumner SJ, Frost HR, Hoen AG
BMC Microbiol. 2021 Aug 28;21(1):238. doi: 10.1186/s12866-021-02282-3. Epub 2021 Aug 28.
PMID: 34454437

Analyzing cancer gene expression data through the lens of normal tissue-specificity.
Frost HR
PLoS Comput Biol. 2021 Jun;17(6):e1009085. doi: 10.1371/journal.pcbi.1009085. Epub 2021 Jun 18.
PMID: 34143767

View more publications on PubMed