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H Robert Frost, PhD

Associate Professor of Biomedical Data Science
Associate Professor of Molecular and Systems Biology

Additional Titles/Positions/Affiliations
Associate Director of Quantitative Biomedical Sciences Graduate Program

Biomedical Data Science
Molecular and Systems Biology

Dartmouth College, Ph.D., 2014
Stanford University, MS, 1995
Stanford University, BS, 1993

Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences


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Contact Information

HB 7936
Hanover NH 03755

Office: Rubin 704
Email: Hildreth.R.Frost@Dartmouth.edu

Professional Interests

My research focuses on the development of bioinformatics and biostatistics methods for analyzing high-dimensional genomic data. Areas of statistical interest include dimensionality reduction (e.g., PCA), hypothesis aggregation (e.g., gene set testing), and penalized estimation (e.g., LASSO penalized regression). Areas of biological interest include cell signaling, tissue-specific gene activity, tumor immunology, and cancer prognosis prediction.

Grant Information

NIH grants R35GM146586 and R21CA253408

Courses Taught

QBS 120: Foundations of Biostatistics I, Statistical Theory for the Quantitative Biomedical Sciences

Selected Publications


CAraCAl: CAMML with the integration of chromatin accessibility.
Schiebout C, Frost HR
BMC Bioinformatics. 2024 Jun 13;25(1):212. doi: 10.1186/s12859-024-05833-3. Epub 2024 Jun 13.
PMID: 38872103

A highly sensitive 3baseā„¢ assay for detecting Streptococcus pyogenes in saliva during controlled human pharyngitis.
Indraratna AD, Mytton S, Ricafrente A, Millar D, Gorman J, Azzopardi KI, Frost HR, Osowicki J, Steer AC, Skropeta D, Sanderson-Smith ML
Talanta. 2024 Aug 15;276:126221. doi: 10.1016/j.talanta.2024.126221. Epub 2024 May 6.
PMID: 38776768

A generalized eigenvector centrality for multilayer networks with inter-layer constraints on adjacent node importance.
Frost HR
Appl Netw Sci. 2024;9(1):14. doi: 10.1007/s41109-024-00620-8. Epub 2024 Apr 30.
PMID: 38699246

Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors.
Lee MK, Azizgolshani N, Shapiro JA, Nguyen LN, Kolling FW, Zanazzi GJ, Frost HR, Christensen BC
Nat Commun. 2024 Apr 30;15(1):3634. doi: 10.1038/s41467-024-47712-8. Epub 2024 Apr 30.
PMID: 38688897

Reconstruction Set Test (RESET): A computationally efficient method for single sample gene set testing based on randomized reduced rank reconstruction error.
Frost HR
PLoS Comput Biol. 2024 Apr;20(4):e1012084. doi: 10.1371/journal.pcbi.1012084. Epub 2024 Apr 29.
PMID: 38683883

Tissue-adjusted pathway analysis of cancer (TPAC): A novel approach for quantifying tumor-specific gene set dysregulation relative to normal tissue.
Frost HR
PLoS Comput Biol. 2024 Jan;20(1):e1011717. doi: 10.1371/journal.pcbi.1011717. Epub 2024 Jan 11.
PMID: 38206988

Molecular characterization of the interaction between human IgG and the M-related proteins from Streptococcus pyogenes.
Proctor EJ, Frost HR, Satapathy S, Botquin G, Urbaniec J, Gorman J, De Oliveira DMP, McArthur J, Davies MR, Botteaux A, Smeesters P, Sanderson-Smith M
J Biol Chem. 2024 Feb;300(2):105623. doi: 10.1016/j.jbc.2023.105623. Epub 2024 Jan 3.
PMID: 38176650

Cell type-specific interaction analysis using doublets in scRNA-seq.
Schiebout C, Lust H, Huang Y, Frost HR
Bioinform Adv. 2023;3(1):vbad120. doi: 10.1093/bioadv/vbad120. Epub 2023 Sep 6.
PMID: 37745004

STREAK: A supervised cell surface receptor abundance estimation strategy for single cell RNA-sequencing data using feature selection and thresholded gene set scoring.
Javaid A, Frost HR
PLoS Comput Biol. 2023 Aug;19(8):e1011413. doi: 10.1371/journal.pcbi.1011413. Epub 2023 Aug 21.
PMID: 37603589

Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20.
Preiss NK, Kamal Y, Wilkins OM, Li C, Kolling FW 4th, Trask HW, Usherwood YK, Cheng C, Frost HR, Usherwood EJ
Life Sci Alliance. 2023 Sep;6(9) doi: 10.26508/lsa.202201683. Epub 2023 Jul 6.
PMID: 37414528

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