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H Robert Frost, PhD

Assistant Professor of Biomedical Data Science

Additional Titles/Positions/Affiliations
Associate Director of Quantitative Biomedical Sciences Graduate Program

Biomedical Data Science

Dartmouth College, Ph.D., 2014
Stanford University, MS, 1995
Stanford University, BS, 1993

Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Contact Information

HB 7936
Hanover NH 03755

Office: Rubin 704
Email: Hildreth.R.Frost@Dartmouth.edu

Professional Interests

My research focuses on the development of bioinformatics and biostatistics methods for analyzing high-dimensional genomic data. Areas of statistical interest include dimensionality reduction (e.g., PCA), hypothesis aggregation (e.g., gene set testing), and penalized estimation (e.g., LASSO penalized regression). Areas of biological interest include cell signaling, tissue-specific gene activity, tumor immunology, and cancer prognosis prediction.

Grant Information

NIH grants R35GM146586 and R21CA253408

Courses Taught

QBS 120: Foundations of Biostatistics I, Statistical Theory for the Quantitative Biomedical Sciences

Selected Publications


Intraoperative plasma proteomic changes in cardiac surgery: In search of biomarkers of post-operative delirium.
Wiredu K, O'Connor S, Naseem H, Brauer BL, Kettenbach AN, Frost HR, Shaefi S, Gerber SA
Proteomics Clin Appl. 2022 Dec 25;:e2200066. doi: 10.1002/prca.202200066. Epub 2022 Dec 25.
PMID: 36567636

CAMML with the Integration of Marker Proteins (ChIMP).
Schiebout C, Frost HR
Bioinformatics. 2022 Nov 30;38(23):5206-5213. doi: 10.1093/bioinformatics/btac674.
PMID: 36214642

Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors.
Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH
Cancer Immunol Res. 2022 Aug 3;10(8):962-977. doi: 10.1158/2326-6066.CIR-21-0536.
PMID: 35696724

Eigenvectors from Eigenvalues Sparse Principal Component Analysis (EESPCA).
Frost HR
J Comput Graph Stat. 2022;31(2):486-501. doi: 10.1080/10618600.2021.1987254. Epub 2021 Nov 12.
PMID: 35693984

Internal oligo(dT) priming introduces systematic bias in bulk and single-cell RNA sequencing count data.
Svoboda M, Frost HR, Bosco G
NAR Genom Bioinform. 2022 Jun;4(2):lqac035. doi: 10.1093/nargab/lqac035. Epub 2022 May 25.
PMID: 35651651

CBEA: Competitive balances for taxonomic enrichment analysis.
Nguyen QP, Hoen AG, Frost HR
PLoS Comput Biol. 2022 May;18(5):e1010091. doi: 10.1371/journal.pcbi.1010091. Epub 2022 May 18.
PMID: 35584140

A controlled human infection model of Streptococcus pyogenes pharyngitis (CHIVAS-M75): an observational, dose-finding study.
Osowicki J, Azzopardi KI, Fabri L, Frost HR, Rivera-Hernandez T, Neeland MR, Whitcombe AL, Grobler A, Gutman SJ, Baker C, Wong JMF, Lickliter JD, Waddington CS, Pandey M, Schuster T, Cheng AC, Pollard AJ, McCarthy JS, Good MF, Dale JB, Batzloff M, Moreland NJ, Walker MJ, Carapetis JR, Smeesters PR, Steer AC
Lancet Microbe. 2021 Jul;2(7):e291-e299. doi: 10.1016/S2666-5247(20)30240-8. Epub 2021 Apr 15.
PMID: 35544165

Immune signature of acute pharyngitis in a Streptococcus pyogenes human challenge trial.
Anderson J, Imran S, Frost HR, Azzopardi KI, Jalali S, Novakovic B, Osowicki J, Steer AC, Licciardi PV, Pellicci DG
Nat Commun. 2022 Feb 9;13(1):769. doi: 10.1038/s41467-022-28335-3. Epub 2022 Feb 9.
PMID: 35140232

CAMML: Multi-Label Immune Cell-Typing and Stemness Analysis for Single-Cell RNA-sequencing.
Schiebout C, Frost HR
Pac Symp Biocomput. 2022;27:199-210.
PMID: 34890149

Pan-cancer evaluation of gene expression and somatic alteration data for cancer prognosis prediction.
Zheng X, Amos CI, Frost HR
BMC Cancer. 2021 Sep 25;21(1):1053. doi: 10.1186/s12885-021-08796-3. Epub 2021 Sep 25.
PMID: 34563154

View more publications on PubMed