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H Robert Frost, PhD

Title(s)
Associate Professor of Biomedical Data Science
Associate Professor of Molecular and Systems Biology

Additional Titles/Positions/Affiliations
Associate Director of Quantitative Biomedical Sciences Graduate Program

Department(s)
Biomedical Data Science
Molecular and Systems Biology

Education
Dartmouth College, Ph.D., 2014
Stanford University, MS, 1995
Stanford University, BS, 1993

Programs
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences

Websites
https://sites.dartmouth.edu/frost

Contact Information

HB 7936
Hanover NH 03755

Office: Rubin 704
Email: Hildreth.R.Frost@Dartmouth.edu


Professional Interests

My research focuses on the development of bioinformatics and biostatistics methods for analyzing high-dimensional genomic data. Areas of statistical interest include dimensionality reduction (e.g., PCA), hypothesis aggregation (e.g., gene set testing), and penalized estimation (e.g., LASSO penalized regression). Areas of biological interest include cell signaling, tissue-specific gene activity, tumor immunology, and cancer prognosis prediction.

Grant Information

NIH grants R35GM146586 and R21CA253408

Courses Taught

QBS 120: Foundations of Biostatistics I, Statistical Theory for the Quantitative Biomedical Sciences


Selected Publications

 

Randomized Spatial PCA (RASP): a computationally efficient method for dimensionality reduction of high-resolution spatial transcriptomics data.
Gingerich IK, Goods BA, Frost HR
bioRxiv. 2024 Dec 24; pii: 2024.12.20.629785. doi: 10.1101/2024.12.20.629785. Epub 2024 Dec 24.
PMID: 39763720

Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections.
Osowicki J, Frost HR, Azzopardi KI, Whitcombe AL, McGregor R, Carlton LH, Baker C, Fabri L, Pandey M, Good MF, Carapetis JR, Walker MJ, Smeesters PR, Licciardi PV, Moreland NJ, Hill DL, Steer AC
Nat Commun. 2024 Dec 3;15(1):10506. doi: 10.1038/s41467-024-54665-5. Epub 2024 Dec 3.
PMID: 39627204

Leveraging cell type-specificity for gene set analysis of single cell transcriptomics.
Frost HR
bioRxiv. 2024 Sep 27; pii: 2024.09.25.615040. doi: 10.1101/2024.09.25.615040. Epub 2024 Sep 27.
PMID: 39386631

CAraCAl: CAMML with the integration of chromatin accessibility.
Schiebout C, Frost HR
BMC Bioinformatics. 2024 Jun 13;25(1):212. doi: 10.1186/s12859-024-05833-3. Epub 2024 Jun 13.
PMID: 38872103

A highly sensitive 3base™ assay for detecting Streptococcus pyogenes in saliva during controlled human pharyngitis.
Indraratna AD, Mytton S, Ricafrente A, Millar D, Gorman J, Azzopardi KI, Frost HR, Osowicki J, Steer AC, Skropeta D, Sanderson-Smith ML
Talanta. 2024 Aug 15;276:126221. doi: 10.1016/j.talanta.2024.126221. Epub 2024 May 6.
PMID: 38776768

A generalized eigenvector centrality for multilayer networks with inter-layer constraints on adjacent node importance.
Frost HR
Appl Netw Sci. 2024;9(1):14. doi: 10.1007/s41109-024-00620-8. Epub 2024 Apr 30.
PMID: 38699246

Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors.
Lee MK, Azizgolshani N, Shapiro JA, Nguyen LN, Kolling FW, Zanazzi GJ, Frost HR, Christensen BC
Nat Commun. 2024 Apr 30;15(1):3634. doi: 10.1038/s41467-024-47712-8. Epub 2024 Apr 30.
PMID: 38688897

Reconstruction Set Test (RESET): A computationally efficient method for single sample gene set testing based on randomized reduced rank reconstruction error.
Frost HR
PLoS Comput Biol. 2024 Apr;20(4):e1012084. doi: 10.1371/journal.pcbi.1012084. Epub 2024 Apr 29.
PMID: 38683883

Tissue-adjusted pathway analysis of cancer (TPAC): A novel approach for quantifying tumor-specific gene set dysregulation relative to normal tissue.
Frost HR
PLoS Comput Biol. 2024 Jan;20(1):e1011717. doi: 10.1371/journal.pcbi.1011717. Epub 2024 Jan 11.
PMID: 38206988

Molecular characterization of the interaction between human IgG and the M-related proteins from Streptococcus pyogenes.
Proctor EJ, Frost HR, Satapathy S, Botquin G, Urbaniec J, Gorman J, De Oliveira DMP, McArthur J, Davies MR, Botteaux A, Smeesters P, Sanderson-Smith M
J Biol Chem. 2024 Feb;300(2):105623. doi: 10.1016/j.jbc.2023.105623. Epub 2024 Jan 3.
PMID: 38176650

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