H Robert Frost, PhD
Title(s)
Associate Professor of Biomedical Data Science
Associate Professor of Molecular and Systems Biology
Additional Titles/Positions/Affiliations
Associate Director of Quantitative Biomedical Sciences Graduate Program
Department(s)
Biomedical Data Science
Molecular and Systems Biology
Education
Dartmouth College, Ph.D., 2014
Stanford University, MS, 1995
Stanford University, BS, 1993
Programs
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences
Websites
https:
Contact Information
HB 7936
Hanover NH 03755
Office: Rubin 704
Email: Hildreth.R.Frost@Dartmouth.edu
Professional Interests
My research focuses on the development of bioinformatics and biostatistics methods for analyzing high-dimensional genomic data. Areas of statistical interest include dimensionality reduction (e.g., PCA), hypothesis aggregation (e.g., gene set testing), and penalized estimation (e.g., LASSO penalized regression). Areas of biological interest include cell signaling, tissue-specific gene activity, tumor immunology, and cancer prognosis prediction.
Grant Information
NIH grants R35GM146586 and R21CA253408
Courses Taught
QBS 120: Foundations of Biostatistics I, Statistical Theory for the Quantitative Biomedical Sciences
Antibody responses against bacterial glycans affinity mature and diversify in germinal centers. Fibrinogen-binding M-related proteins facilitate the recruitment of plasminogen by Streptococcus pyogenes. Randomized Spatial PCA (RASP): a computationally efficient method for dimensionality reduction of high-resolution spatial transcriptomics data. Randomized Spatial PCA (RASP): a computationally efficient method for dimensionality reduction of high-resolution spatial transcriptomics data. Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections. Leveraging cell type-specificity for gene set analysis of single cell transcriptomics. CAraCAl: CAMML with the integration of chromatin accessibility. A highly sensitive 3base™ assay for detecting Streptococcus pyogenes in saliva during controlled human pharyngitis. A generalized eigenvector centrality for multilayer networks with inter-layer constraints on adjacent node importance. Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors. |
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