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Rahul Sarpeshkar, PhD

Professor of Microbiology and Immunology
Professor of Molecular and Systems Biology

Additional Titles/Positions/Affiliations:
Thomas E. Kurtz Professor
Professor of Engineering
Professor of Physics

Microbiology and Immunology
Molecular and Systems Biology

BS, Electrical Engineering and Physics, MIT
PhD, Computation and Neural Systems, California Institute of Technology

Molecular and Cellular Biology Graduate Programs

Thayer Profile:

TEDx Talk:

Contact Information:

Professional Interests:

Synthetic analog and digital biological circuits in electri-cigenic and other microbes. Applications of synthetic and systems biology to immunology, infectious disease, and cancer.


ONR Young Investigator Award
Packard Fellow Award
Junior Bose Teaching Award, MIT
Fellow, National Academy of Inventors
Fellow, IEEE

Selected Publications:


Measuring and modeling energy and power consumption in living microbial cells with a synthetic ATP reporter.
Deng Y, Beahm DR, Ionov S, Sarpeshkar R
BMC Biol. 2021 May 17;19(1):101. doi: 10.1186/s12915-021-01023-2. Epub 2021 May 17.
PMID: 34001118

The Merging of Biological and Electronic Circuits.
Teo JJY, Sarpeshkar R
iScience. 2020 Nov 20;23(11):101688. doi: 10.1016/j.isci.2020.101688. Epub 2020 Oct 15.
PMID: 33163942

A compiler for biological networks on silicon chips.
Medley JK, Teo J, Woo SS, Hellerstein J, Sarpeshkar R, Sauro HM
PLoS Comput Biol. 2020 Sep;16(9):e1008063. doi: 10.1371/journal.pcbi.1008063. Epub 2020 Sep 23.
PMID: 32966274

Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?
Kleinfeld D, Luan L, Mitra PP, Robinson JT, Sarpeshkar R, Shepard K, Xie C, Harris TD
Neuron. 2019 Sep 25;103(6):1005-1015. doi: 10.1016/j.neuron.2019.08.011. Epub 2019 Sep 5.
PMID: 31495645

A Novel Bioelectronic Reporter System in Living Cells Tested with a Synthetic Biological Comparator.
Zeng J, Banerjee A, Kim J, Deng Y, Chapman TW, Daniel R, Sarpeshkar R
Sci Rep. 2019 May 13;9(1):7275. doi: 10.1038/s41598-019-43771-w. Epub 2019 May 13.
PMID: 31086248

An Artificial Tissue Homeostasis Circuit Designed via Analog Circuit Techniques.
Teo JJY, Weiss R, Sarpeshkar R
IEEE Trans Biomed Circuits Syst. 2019 Jun;13(3):540-553. doi: 10.1109/TBCAS.2019.2907074. Epub 2019 Mar 25.
PMID: 30908238

A Synthetic Microbial Operational Amplifier.
Zeng J, Teo J, Banerjee A, Chapman TW, Kim J, Sarpeshkar R
ACS Synth Biol. 2018 Sep 21;7(9):2007-2013. doi: 10.1021/acssynbio.8b00138. Epub 2018 Aug 30.
PMID: 30152993

Fast and Precise Emulation of Stochastic Biochemical Reaction Networks With Amplified Thermal Noise in Silicon Chips.
Kim J, Woo SS, Sarpeshkar R
IEEE Trans Biomed Circuits Syst. 2018 Apr;12(2):379-389. doi: 10.1109/TBCAS.2017.2786306.
PMID: 29570064

A Digitally Programmable Cytomorphic Chip for Simulation of Arbitrary Biochemical Reaction Networks.
Woo SS, Kim J, Sarpeshkar R
IEEE Trans Biomed Circuits Syst. 2018 Apr;12(2):360-378. doi: 10.1109/TBCAS.2017.2781253.
PMID: 29570063

Bioelectronic measurement and feedback control of molecules in living cells.
Banerjee A, Weaver I, Thorsen T, Sarpeshkar R
Sci Rep. 2017 Oct 2;7(1):12511. doi: 10.1038/s41598-017-12655-2. Epub 2017 Oct 2.
PMID: 28970494

View more publications on PubMed