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Rahul Sarpeshkar, PhD

Professor of Microbiology and Immunology
Professor of Molecular and Systems Biology

Additional Titles/Positions/Affiliations
Thomas E. Kurtz Professor
Professor of Engineering
Professor of Physics

Microbiology and Immunology
Molecular and Systems Biology

BS, Electrical Engineering and Physics, MIT
PhD, Computation and Neural Systems, California Institute of Technology

Molecular and Cellular Biology Graduate Programs

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Professional Interests

Synthetic analog and digital biological circuits in electri-cigenic and other microbes. Applications of synthetic and systems biology to immunology, infectious disease, and cancer.


ONR Young Investigator Award
Packard Fellow Award
Junior Bose Teaching Award, MIT
Fellow, National Academy of Inventors
Fellow, IEEE

Selected Publications


Drug Cocktail Formulation via Circuit Design.
Beahm DR, Deng Y, DeAngelo TM, Sarpeshkar R
IEEE Trans Mol Biol Multiscale Commun. 2023 Mar;9(1):28-48. doi: 10.1109/tmbmc.2023.3246928. Epub 2023 Feb 22.
PMID: 37397625

Rapid modeling of experimental molecular kinetics with simple electronic circuits instead of with complex differential equations.
Deng Y, Beahm DR, Ran X, Riley TG, Sarpeshkar R
Front Bioeng Biotechnol. 2022;10:947508. doi: 10.3389/fbioe.2022.947508. Epub 2022 Sep 28.
PMID: 36246369

Cytomorphic Electronic Systems: A review and perspective.
Beahm DR, Deng Y, Riley TG, Sarpeshkar R
IEEE Nanotechnol Mag. 2021 Dec;15(6):41-53. doi: 10.1109/mnano.2021.3113192. Epub 2021 Oct 4.
PMID: 35242267

Formulation and Emulation of Quantum-Inspired Dynamical Systems With Classical Analog Circuits.
Cressman AJ, Wattanapanitch W, Chuang I, Sarpeshkar R
Neural Comput. 2022 Mar 23;34(4):856-890. doi: 10.1162/neco_a_01481.
PMID: 35231932

Measuring and modeling energy and power consumption in living microbial cells with a synthetic ATP reporter.
Deng Y, Beahm DR, Ionov S, Sarpeshkar R
BMC Biol. 2021 May 17;19(1):101. doi: 10.1186/s12915-021-01023-2. Epub 2021 May 17.
PMID: 34001118

The Merging of Biological and Electronic Circuits.
Teo JJY, Sarpeshkar R
iScience. 2020 Nov 20;23(11):101688. doi: 10.1016/j.isci.2020.101688. Epub 2020 Oct 15.
PMID: 33163942

A compiler for biological networks on silicon chips.
Medley JK, Teo J, Woo SS, Hellerstein J, Sarpeshkar R, Sauro HM
PLoS Comput Biol. 2020 Sep;16(9):e1008063. doi: 10.1371/journal.pcbi.1008063. Epub 2020 Sep 23.
PMID: 32966274

Can One Concurrently Record Electrical Spikes from Every Neuron in a Mammalian Brain?
Kleinfeld D, Luan L, Mitra PP, Robinson JT, Sarpeshkar R, Shepard K, Xie C, Harris TD
Neuron. 2019 Sep 25;103(6):1005-1015. doi: 10.1016/j.neuron.2019.08.011. Epub 2019 Sep 5.
PMID: 31495645

A Novel Bioelectronic Reporter System in Living Cells Tested with a Synthetic Biological Comparator.
Zeng J, Banerjee A, Kim J, Deng Y, Chapman TW, Daniel R, Sarpeshkar R
Sci Rep. 2019 May 13;9(1):7275. doi: 10.1038/s41598-019-43771-w. Epub 2019 May 13.
PMID: 31086248

An Artificial Tissue Homeostasis Circuit Designed via Analog Circuit Techniques.
Teo JJY, Weiss R, Sarpeshkar R
IEEE Trans Biomed Circuits Syst. 2019 Jun;13(3):540-553. doi: 10.1109/TBCAS.2019.2907074. Epub 2019 Mar 25.
PMID: 30908238

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