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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Claire Weaver
Asst. Phone: 603-653-9022
Asst. Email: Claire.Weaver@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: The HOME Study.
Romano ME, Eliot MN, Zoeller RT, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Chen A, Lanphear BP, Braun JM
Int J Hyg Environ Health. 2018 Mar 23; pii: S1438-4639(17)30823-4. doi: 10.1016/j.ijheh.2018.03.010. Epub 2018 Mar 23.
PMID: 29606598

Risk of basal cell carcinoma in a randomized clinical trial of aspirin and folic acid for the prevention of colorectal adenomas.
Passarelli MN, Barry EL, Zhang D, Gangar P, Rees JR, Bresalier RS, McKeown-Eyssen G, Karagas MR, Baron JA
Br J Dermatol. 2018 Mar 23; doi: 10.1111/bjd.16571. Epub 2018 Mar 23.
PMID: 29570772

RE: Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic.
Koutros S, Lenz P, Hewitt SM, Kida M, Jones M, Schned AR, Baris D, Pfeiffer R, Schwenn M, Johnson A, Karagas MR, Garcia-Closas M, Rothman N, Moore LE, Silverman DT
J Natl Cancer Inst. 2018 Mar 14; doi: 10.1093/jnci/djy045. Epub 2018 Mar 14.
PMID: 29548022

Author Correction: Distinct arsenic metabolites following seaweed consumption in humans.
Taylor VF, Li Z, Sayarath V, Palys TJ, Morse KR, Scholz-Bright RA, Karagas MR
Sci Rep. 2018 Mar 2;8(1):4145. doi: 10.1038/s41598-018-22625-x. Epub 2018 Mar 2.
PMID: 29500413

Epigenetics as a mechanism linking developmental exposures to long-term toxicity.
Barouki R, Melen E, Herceg Z, Beckers J, Chen J, Karagas M, Puga A, Xia Y, Chadwick L, Yan W, Audouze K, Slama R, Heindel J, Grandjean P, Kawamoto T, Nohara K
Environ Int. 2018 May;114:77-86. doi: 10.1016/j.envint.2018.02.014. Epub 2018 Feb 27.
PMID: 29499450

Better Diet Quality during Pregnancy Is Associated with a Reduced Likelihood of an Infant Born Small for Gestational Age: An Analysis of the Prospective New Hampshire Birth Cohort Study.
Emond JA, Karagas MR, Baker ER, Gilbert-Diamond D
J Nutr. 2018 Jan 1;148(1):22-30. doi: 10.1093/jn/nxx005.
PMID: 29378041

Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts.
Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ
Environ Health Perspect. 2018 Jan 22;126(1):017010. doi: 10.1289/EHP2192. Epub 2018 Jan 22.
PMID: 29373860

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study.
Farzan SF, Howe CG, Zens MS, Palys T, Channon JY, Li Z, Chen Y, Karagas MR
Environ Health Perspect. 2017 Dec 15;125(12):127002. doi: 10.1289/EHP2062. Epub 2017 Dec 15.
PMID: 29373859

Associations of early life urinary triclosan concentrations with maternal, neonatal, and child thyroid hormone levels.
Braun JM, Chen A, Hoofnagle A, Papandonatos GD, Jackson-Browne M, Hauser R, Romano ME, Karagas MR, Yolton K, Thomas Zoeller R, Lanphear BP
Horm Behav. 2017 Dec 4; pii: S0018-506X(17)30362-8. doi: 10.1016/j.yhbeh.2017.11.009. Epub 2017 Dec 4.
PMID: 29154791

Penalized estimation of sparse concentration matrices based on prior knowledge with applications to placenta elemental data.
Lee JW, Punshon T, Moen EL, Karagas MR, Gui J
Comput Biol Chem. 2017 Dec;71:219-223. doi: 10.1016/j.compbiolchem.2017.10.012. Epub 2017 Nov 4.
PMID: 29153892