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Margaret Rita Karagas, PhD

Title(s)
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s)
Epidemiology
Community and Family Medicine

Education
University of Washington, PhD 1990

Programs
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
https://cancer.dartmouth.edu/scientists-researchers/cancer-population-sciences
http://www.dartmouth.edu/~toxmetal/index.html
http://iqbs.org

Contact Information

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Evan Vickers
Asst. Phone: 603-650-1918
Asst. Email: Evan.G.Vickers@dartmouth.edu


Professional Interests

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers over the lifecourse, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications

 

Inter-method reliability of silicone exposome wristbands and urinary biomarker assays in a pregnancy cohort.
Romano ME, Gallagher L, Doherty BT, Yeum D, Lee S, Takazawa M, Anderson KA, Kannan K, Karagas MR, program collaborators for Environmental Influences on Child Health Outcomes.
Environ Res. 2022 Aug 8;:113981. doi: 10.1016/j.envres.2022.113981. Epub 2022 Aug 8.
PMID: 35952739

Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.
Signes-Pastor AJ, Romano ME, Jackson B, Braun JM, Yolton K, Chen A, Lanphear B, Karagas MR
Int J Hyg Environ Health. 2022 Aug 7;245:114009. doi: 10.1016/j.ijheh.2022.114009. Epub 2022 Aug 7.
PMID: 35947921

Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth.
Tehrani JM, Kennedy E, Tung PW, Burt A, Hermetz K, Punshon T, Jackson BP, Hao K, Chen J, Karagas MR, Koestler DC, Lester B, Marsit CJ
Pediatr Res. 2022 Jul 29; doi: 10.1038/s41390-022-02201-w. Epub 2022 Jul 29.
PMID: 35906307

Metagenomic analysis reveals associations between salivary microbiota and body composition in early childhood.
Coker MO, Lebeaux RM, Hoen AG, Moroishi Y, Gilbert-Diamond D, Dade EF, Palys TJ, Madan JC, Karagas MR
Sci Rep. 2022 Jul 29;12(1):13075. doi: 10.1038/s41598-022-14668-y. Epub 2022 Jul 29.
PMID: 35906254

Sociodemographic Variation in Children's Health Behaviors During the COVID-19 Pandemic.
Bekelman TA, Knapp EA, Dong Y, Dabelea D, Bastain TM, Breton CV, Carroll KN, Camargo CA, Davis AM, Dunlop AL, Elliott AJ, Ferrara A, Fry RC, Ganiban JM, Gilbert-Diamond D, Gilliland FD, Hedderson MM, Hipwell AE, Hockett CW, Huddleston KC, Karagas MR, Kelly N, Lai JS, Lester BM, Lucchini M, Melough MM, Mihalopoulos NL, O'Shea TM, Rundle AG, Stanford JB, VanBronkhorst S, Wright RJ, Zhao Q, Sauder KA, program collaborators for Environmental influences on Child Health Outcomes (ECHO).
Child Obes. 2022 Jul 19; doi: 10.1089/chi.2022.0085. Epub 2022 Jul 19.
PMID: 35856858

The relationship between the gut microbiome and the risk of respiratory infections among newborns.
Moroishi Y, Gui J, Hoen AG, Morrison HG, Baker ER, Nadeau KC, Li H, Li Z, Madan JC, Karagas MR
Commun Med (Lond). 2022;2:87. doi: 10.1038/s43856-022-00152-1. Epub 2022 Jul 14.
PMID: 35847562

Estimating cumulative spatial risk over time with low-rank kriging multiple membership models.
Boyle J, Ward MH, Koutros S, Karagas MR, Schwenn M, Silverman D, Wheeler DC
Stat Med. 2022 Jul 11; doi: 10.1002/sim.9527. Epub 2022 Jul 11.
PMID: 35816955

Changes in BMI During the COVID-19 Pandemic.
Knapp EA, Dong Y, Dunlop AL, Aschner JL, Stanford JB, Hartert T, Teitelbaum SL, Hudak ML, Carroll K, O'Connor TG, McEvoy CT, O'Shea TM, Carnell S, Karagas MR, Herbstman JB, Dabelea D, Ganiban JM, Ferrara A, Hedderson M, Bekelman TA, Rundle AG, Alshawabkeh A, Gilbert-Diamond D, Fry RC, Chen Z, Gilliland FD, Wright RJ, Camargo CA Jr, Jacobson L, Lester BM, Hockett CW, Hodges ML, Chandran A
Pediatrics. 2022 Jun 30; doi: 10.1542/peds.2022-056552. Epub 2022 Jun 30.
PMID: 35768891

Diet quality, common genetic polymorphisms, and bladder cancer risk in a New England population-based study.
Leeming RC, Koutros S, Karagas MR, Baris D, Schwenn M, Johnson A, Zens MS, Schned AR, Rothman N, Silverman DT, Passarelli MN
Eur J Nutr. 2022 Jun 27; doi: 10.1007/s00394-022-02932-w. Epub 2022 Jun 27.
PMID: 35759030

MarZIC: A Marginal Mediation Model for Zero-Inflated Compositional Mediators with Applications to Microbiome Data.
Wu Q, O'Malley J, Datta S, Gharaibeh RZ, Jobin C, Karagas MR, Coker MO, Hoen AG, Christensen BC, Madan JC, Li Z
Genes (Basel). 2022 Jun 11;13(6) pii: 1049. doi: 10.3390/genes13061049. Epub 2022 Jun 11.
PMID: 35741811

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