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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
https://cancer.dartmouth.edu/scientists-researchers/cancer-population-sciences
http://www.dartmouth.edu/~toxmetal/index.html
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Evan Vickers
Asst. Phone: 603-650-1918
Asst. Email: Evan.G.Vickers@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers over the lifecourse, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

The infant gut resistome is associated with E. coli and early-life exposures.
Lebeaux RM, Coker MO, Dade EF, Palys TJ, Morrison HG, Ross BD, Baker ER, Karagas MR, Madan JC, Hoen AG
BMC Microbiol. 2021 Jul 2;21(1):201. doi: 10.1186/s12866-021-02129-x. Epub 2021 Jul 2.
PMID: 34215179

Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES.
Signes-Pastor AJ, Desai G, Garcia-Villarino M, Karagas MR, Kordas K
Expo Health. 2021 Jun;13(2):173-184. doi: 10.1007/s12403-020-00371-8. Epub 2020 Jul 13.
PMID: 34151044

Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures.
Movassagh H, Halchenko Y, Sampath V, Nygaard UC, Jackson B, Robbins D, Li Z, Nadeau KC, Karagas MR
Environ Res. 2021 Jun 12;201:111385. doi: 10.1016/j.envres.2021.111385. Epub 2021 Jun 12.
PMID: 34129869

Prenatal exposure to arsenic and lung function in children from the New Hampshire Birth Cohort Study.
Signes-Pastor AJ, Martinez-Camblor P, Baker E, Madan J, Guill MF, Karagas MR
Environ Int. 2021 Oct;155:106673. doi: 10.1016/j.envint.2021.106673. Epub 2021 Jun 3.
PMID: 34091160

Unexplained multi-sensory neuropathy syndrome in young Tanzanian adults.
Massawe ER, Moshi N, Ren J, Rieke CC, Magohe AK, Fellows AM, Arega EA, Niemczak CE, Jackson BP, Karagas MR, Buckey JC
J Glob Health Rep. 2021;5 pii: e2021013. doi: 10.29392/001c.21360. Epub 2021 Mar 30.
PMID: 34084947

Fat-enlarged axillary lymph nodes are associated with node-positive breast cancer in obese patients.
diFlorio-Alexander RM, Song Q, Dwan D, Austin-Strohbehn JA, Muller KE, Kinlaw WB, MacKenzie TA, Karagas MR, Hassanpour S
Breast Cancer Res Treat. 2021 Aug;189(1):257-267. doi: 10.1007/s10549-021-06262-z. Epub 2021 Jun 3.
PMID: 34081259

Erratum: "Rare, protein-altering variants in AS3MT and arsenic metabolism efficiency: a multi-population association study".
Delgado DA, Chernoff M, Huang L, Tong L, Chen L, Jasmine F, Shinkle J, Cole SA, Haack K, Kent J, Umans J, Best LG, Nelson H, Vander Griend D, Graziano J, Kibriya MG, Navas-Acien A, Karagas MR, Ahsan H, Pierce BL
Environ Health Perspect. 2021 May;129(5):59003. doi: 10.1289/EHP9488. Epub 2021 May 26.
PMID: 34038222

US Childhood Asthma Incidence Rate Patterns From the ECHO Consortium to Identify High-Risk Groups for Primary Prevention.
Johnson CC, Chandran A, Havstad S, Li X, McEvoy CT, Ownby DR, Litonjua AA, Karagas MR, Camargo CA Jr, Gern JE, Gilliland F, Togias A, Environmental Influences on Child Health Outcomes (ECHO) collaborators.
JAMA Pediatr. 2021 May 17;:e210667. doi: 10.1001/jamapediatrics.2021.0667. Epub 2021 May 17.
PMID: 33999100

Charting the life course: Emerging opportunities to advance scientific approaches using life course research.
Hanson HA, Leiser CL, Bandoli G, Pollock BH, Karagas MR, Armstrong D, Dozier A, Weiskopf NG, Monaghan M, Davis AM, Eckstrom E, Weng C, Tobin JN, Kaskel F, Schleiss MR, Szilagyi P, Dykes C, Cooper D, Barkin SL
J Clin Transl Sci. 2020 Jun 15;5(1):e9. doi: 10.1017/cts.2020.492. Epub 2020 Jun 15.
PMID: 33948236

Infant Feeding Alters the Longitudinal Impact of Birth Mode on the Development of the Gut Microbiota in the First Year of Life.
Coker MO, Laue HE, Hoen AG, Hilliard M, Dade E, Li Z, Palys T, Morrison HG, Baker E, Karagas MR, Madan JC
Front Microbiol. 2021;12:642197. doi: 10.3389/fmicb.2021.642197. Epub 2021 Apr 7.
PMID: 33897650

View more publications on PubMed