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Margaret Rita Karagas, PhD

Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Community and Family Medicine

University of Washington, PhD 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences


Contact Information

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093

Assistant: Evan Vickers
Asst. Phone: 603-650-1918
Asst. Email:

Professional Interests

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers over the lifecourse, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.

Selected Publications


Placental microRNAs relate to early childhood growth trajectories.
Kennedy EM, Hermetz K, Burt A, Pei D, Koestler DC, Hao K, Chen J, Gilbert-Diamond D, Ramakrishnan U, Karagas MR, Marsit CJ
Pediatr Res. 2022 Nov 15; doi: 10.1038/s41390-022-02386-0. Epub 2022 Nov 15.
PMID: 36380070

The association between early life antibiotic exposure and the gut resistome of young children: a systematic review.
Lebeaux RM, Karalis DB, Lee J, Whitehouse HC, Madan JC, Karagas MR, Hoen AG
Gut Microbes. 2022 Jan-Dec;14(1):2120743. doi: 10.1080/19490976.2022.2120743.
PMID: 36289062

Adaptive-mixture-categorization (AMC)-based g-computation and its application to trace element mixtures and bladder cancer risk.
Li S, Karagas MR, Jackson BP, Passarelli MN, Gui J
Sci Rep. 2022 Oct 25;12(1):17841. doi: 10.1038/s41598-022-21747-7. Epub 2022 Oct 25.
PMID: 36284198

Bladder cancer prognosis using deep neural networks and histopathology images.
Barrios W, Abdollahi B, Goyal M, Song Q, Suriawinata M, Richards R, Ren B, Schned A, Seigne J, Karagas M, Hassanpour S
J Pathol Inform. 2022;13:100135. doi: 10.1016/j.jpi.2022.100135. Epub 2022 Aug 28.
PMID: 36268091

Dietary Exposure to Toxic Elements and the Health of Young Children: Methodological Considerations and Data Needs.
Kordas K, Cantoral A, Desai G, Halabicky O, Signes-Pastor AJ, Tellez-Rojo MM, Peterson KE, Karagas MR
J Nutr. 2022 Oct 4; pii: nxac185. doi: 10.1093/jn/nxac185. Epub 2022 Oct 4.
PMID: 36196005

Impact of the COVID-19 pandemic on children's sleep habits: an ECHO study.
Lucchini M, Bekelman TA, Li M, Knapp EA, Dong Y, Ballard S, Deoni S, Dunlop AL, Elliott AJ, Ferrara A, Friedman C, Galarce M, Gilbert-Diamond D, Glueck D, Hedderson M, Hockett CW, Karagas MR, LeBourgeois MK, Margolis A, McDonald J, Ngai P, Pellerite M, Sauder K, Ma T, Dabelea D, Environmental influences on Child Health Outcomes
Pediatr Res. 2022 Oct 4;:1-9. doi: 10.1038/s41390-022-02309-z. Epub 2022 Oct 4.
PMID: 36195633

Gestational per- and polyfluoroalkyl substances exposure and infant body mass index trajectory in the New Hampshire Birth Cohort Study.
Romano ME, Heggeseth BC, Gallagher LG, Botelho JC, Calafat AM, Gilbert-Diamond D, Karagas MR
Environ Res. 2022 Dec;215(Pt 3):114418. doi: 10.1016/j.envres.2022.114418. Epub 2022 Sep 23.
PMID: 36162478

Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population.
Tung PW, Kennedy EM, Burt A, Hermetz K, Karagas M, Marsit CJ
Epigenetics. 2022 Dec;17(13):2404-2420. doi: 10.1080/15592294.2022.2126087. Epub 2022 Sep 23.
PMID: 36148884

Arsenic exposure and respiratory outcomes during childhood in the INMA study.
Signes-Pastor AJ, Diaz-Coto S, Martinez-Camblor P, Carey M, Soler-Blasco R, Garcia-Villarino M, Fernandez-Somoano A, Julvez J, Carrasco P, Lertxundi A, Santa Marina L, Casas M, Meharg AA, Karagas MR, Vioque-Lopez J
PLoS One. 2022;17(9):e0274215. doi: 10.1371/journal.pone.0274215. Epub 2022 Sep 9.
PMID: 36083997

Exposure to melamine and its derivatives and aromatic amines among pregnant women in the United States: The ECHO Program.
Choi G, Kuiper JR, Bennett DH, Barrett ES, Bastain TM, Breton CV, Chinthakindi S, Dunlop AL, Farzan SF, Herbstman JB, Karagas MR, Marsit CJ, Meeker JD, Morello-Frosch R, O'Connor TG, Pellizzari ED, Romano ME, Sathyanarayana S, Schantz S, Schmidt RJ, Watkins DJ, Zhu H, Kannan K, Buckley JP, Woodruff TJ, program collaborators for Environmental influences on Child Health Outcomes
Chemosphere. 2022 Nov;307(Pt 2):135599. doi: 10.1016/j.chemosphere.2022.135599. Epub 2022 Aug 30.
PMID: 36055588

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