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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Claire Weaver
Asst. Phone: 603-653-9022
Asst. Email: Claire.Weaver@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Dietary B Vitamin Intake Is Associated with Lower Urinary Monomethyl Arsenic and Oxidative Stress Marker 15-F<sub>2t</sub>-Isoprostane among New Hampshire Adults.
Howe CG, Li Z, Zens MS, Palys T, Chen Y, Channon JY, Karagas MR, Farzan SF
J Nutr. 2017 Oct 25; pii: jn253419. doi: 10.3945/jn.117.253419. Epub 2017 Oct 25.
PMID: 29070711

A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease.
Moon KA, Oberoi S, Barchowsky A, Chen Y, Guallar E, Nachman KE, Rahman M, Sohel N, D'Ippoliti D, Wade TJ, James KA, Farzan SF, Karagas MR, Ahsan H, Navas-Acien A
Int J Epidemiol. 2017 Sep 23; doi: 10.1093/ije/dyx202. Epub 2017 Sep 23.
PMID: 29040626

Identification and replication of the interplay of four genetic high risk variants for urinary bladder cancer.
Selinski S, Blaszkewicz M, Ickstadt K, Gerullis H, Otto T, Roth E, Volkert F, Ovsiannikov D, Moormann O, Banfi G, Nyirady P, Vermeulen SH, Garcia-Closas M, Figueroa JD, Johnson A, Karagas MR, Kogevinas M, Malats N, Schwenn M, Silverman DT, Koutros S, Rothman N, Kiemeney LA, Hengstler JG, Golka K
Carcinogenesis. 2017 Sep 27; doi: 10.1093/carcin/bgx102. Epub 2017 Sep 27.
PMID: 29028944

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium.
Felix JF, Joubert BR, Baccarelli AA, Sharp GC, Almqvist C, Annesi-Maesano I, Arshad H, Baiz N, Bakermans-Kranenburg MJ, Bakulski KM, Binder EB, Bouchard L, Breton CV, Brunekreef B, Brunst KJ, Burchard EG, Bustamante M, Chatzi L, Cheng Munthe-Kaas M, Corpeleijn E, Czamara D, Dabelea D, Davey Smith G, De Boever P, Duijts L, Dwyer T, Eng C, Eskenazi B, Everson TM, Falahi F, Fallin MD, Farchi S, Fernandez MF, Gao L, Gaunt TR, Ghantous A, Gillman MW, Gonseth S, Grote V, Gruzieva O, Haberg SE, Herceg Z, Hivert MF, Holland N, Holloway JW, Hoyo C, Hu D, Huang RC, Huen K, Jarvelin MR, Jima DD, Just AC, Karagas MR, Karlsson R, Karmaus W, Kechris KJ, Kere J, Kogevinas M, Koletzko B, Koppelman GH, Kupers LK, Ladd-Acosta C, Lahti J, Lambrechts N, Langie SAS, Lie RT, Liu AH, Magnus MC, Magnus P, Maguire RL, Marsit CJ, McArdle W, Melen E, Melton P, Murphy SK, Nawrot TS, Nistico L, Nohr EA, Nordlund B, Nystad W, Oh SS, Oken E, Page CM, Perron P, Pershagen G, Pizzi C, Plusquin M, Raikkonen K, Reese SE, Reischl E, Richiardi L, Ring S, Roy RP, Rzehak P, Schoeters G, Schwartz DA, Sebert S, Snieder H, Sorensen TIA, Starling AP, Sunyer J, Taylor JA, Tiemeier H, Ullemar V, Vafeiadi M, Van Ijzendoorn MH, Vonk JM, Vriens A, Vrijheid M, Wang P, Wiemels JL, Wilcox AJ, Wright RJ, Xu CJ, Xu Z, Yang IV, Yousefi P, Zhang H, Zhang W, Zhao S, Agha G, Relton CL, Jaddoe VWV, London SJ
Int J Epidemiol. 2017 Sep 13; doi: 10.1093/ije/dyx190. Epub 2017 Sep 13.
PMID: 29025028

Maternal BMI at the start of pregnancy and offspring epigenome-wide DNA methylation: findings from the pregnancy and childhood epigenetics (PACE) consortium.
Sharp GC, Salas LA, Monnereau C, Allard C, Yousefi P, Everson TM, Bohlin J, Xu Z, Huang RC, Reese SE, Xu CJ, Baiz N, Hoyo C, Agha G, Roy R, Holloway JW, Ghantous A, Merid SK, Bakulski KM, Kupers LK, Zhang H, Richmond RC, Page CM, Duijts L, Lie RT, Melton PE, Vonk JM, Nohr EA, Williams-DeVane C, Huen K, Rifas-Shiman SL, Ruiz-Arenas C, Gonseth S, Rezwan FI, Herceg Z, Ekstrom S, Croen L, Falahi F, Perron P, Karagas MR, Quraishi BM, Suderman M, Magnus MC, Jaddoe VWV, Taylor JA, Anderson D, Zhao S, Smit HA, Josey MJ, Bradman A, Baccarelli AA, Bustamante M, Haberg SE, Pershagen G, Hertz-Picciotto I, Newschaffer C, Corpeleijn E, Bouchard L, Lawlor DA, Maguire RL, Barcellos LF, Davey Smith G, Eskenazi B, Karmaus W, Marsit CJ, Hivert MF, Snieder H, Fallin MD, Melen E, Munthe-Kaas MC, Arshad H, Wiemels JL, Annesi-Maesano I, Vrijheid M, Oken E, Holland N, Murphy SK, Sorensen TIA, Koppelman GH, Newnham JP, Wilcox AJ, Nystad W, London SJ, Felix JF, Relton CL
Hum Mol Genet. 2017 Oct 15;26(20):4067-4085. doi: 10.1093/hmg/ddx290.
PMID: 29016858

Rice Consumption and Squamous Cell Carcinoma of the Skin in a United States Population.
Gossai A, Zens MS, Punshon T, Jackson BP, Perry AE, Karagas MR
Environ Health Perspect. 2017 Sep 7;125(9):097005. doi: 10.1289/EHP1065. Epub 2017 Sep 7.
PMID: 28934722

Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire.
Bommarito PA, Martin E, Smeester L, Palys T, Baker ER, Karagas MR, Fry RC
Reprod Toxicol. 2017 Oct;73:184-195. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.
PMID: 28793237

Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation.
Kuklinski LF, Li S, Karagas MR, Weng WK, Kwong BY
J Am Acad Dermatol. 2017 Oct;77(4):706-712. doi: 10.1016/j.jaad.2017.06.032. Epub 2017 Aug 2.
PMID: 28780363

Concentrations of urinary arsenic species in relation to rice and seafood consumption among children living in Spain.
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, Garcia de la Hera M, Sunyer J, Casas M, Riaño-Galan I, Tardon A, Llop S, Amoros R, Amiano P, Bilbao JR, Karagas MR, Meharg AA
Environ Res. 2017 Nov;159:69-75. doi: 10.1016/j.envres.2017.07.046. Epub 2017 Aug 1.
PMID: 28772151

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies.
Patel CJ, Kerr J, Thomas DC, Mukherjee B, Ritz B, Chatterjee N, Jankowska M, Madan J, Karagas MR, McAllister KA, Mechanic LE, Fallin MD, Ladd-Acosta C, Blair IA, Teitelbaum SL, Amos CI
Cancer Epidemiol Biomarkers Prev. 2017 Sep;26(9):1370-1380. doi: 10.1158/1055-9965.EPI-17-0459. Epub 2017 Jul 14.
PMID: 28710076