Margaret Rita Karagas, PhD
Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor
Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology
Department(s):
Epidemiology
Community and Family Medicine
Education:
University of Washington, PhD 1990
Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences
Websites:
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Contact Information:
Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756
Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu
Assistant: Evan Vickers
Asst. Phone: 603-650-1918
Asst. Email: Evan.G.Vickers@dartmouth.edu
Professional Interests:
Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers over the lifecourse, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.
Selected Publications: |
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Ranitidine and risk of bladder and kidney cancer: a population based cohort study. The Role of Childhood Asthma in Obesity Development: A Nationwide U.S. Multi-cohort Study. Disparities in Risks of Inadequate and Excessive Intake of Micronutrients during Pregnancy. Regional and sociodemographic differences in average BMI among US children in the ECHO program. Association between placental toxic metal exposure and NICU Network Neurobehavioral Scales (NNNS) profiles in the Rhode Island Child Health Study (RICHS). Associations between the gut microbiome and metabolome in early life. Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. The infant gut resistome is associated with E. coli and early-life exposures. Exposure to a mixture of metals and growth indicators in 6-11-year-old children from the 2013-16 NHANES. Maternal gestational mercury exposure in relation to cord blood T cell alterations and placental gene expression signatures. |
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