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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Kara Caputo
Asst. Phone: 603-653-9022
Asst. Email: Kara.L.Caputo@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Ingested nitrate and nitrite and bladder cancer in Northern New England.
Barry KH, Jones RR, Cantor KP, Freeman LEB, Wheeler DC, Baris D, Johnson AT, Hosain GMM, Schwenn M, Zhang H, Sinha R, Koutros S, Karagas MR, Silverman DT, Ward MH
Epidemiology. 2019 Sep 30; doi: 10.1097/EDE.0000000000001112. Epub 2019 Sep 30.
PMID: 31577632

Maternal urinary cadmium, glucose intolerance and gestational diabetes in the New Hampshire Birth Cohort Study.
Romano ME, Gallagher LG, Jackson BP, Baker E, Karagas MR
Environ Res. 2019 Sep 7;179(Pt A):108733. doi: 10.1016/j.envres.2019.108733. Epub 2019 Sep 7.
PMID: 31561054

An Integrated Gaussian Graphical Model to evaluate the impact of exposures on metabolic networks.
Lee JW, Moen EL, Punshon T, Hoen AG, Stewart D, Li H, Karagas MR, Gui J
Comput Biol Med. 2019 Aug 31;114:103417. doi: 10.1016/j.compbiomed.2019.103417. Epub 2019 Aug 31.
PMID: 31521894

Copper associates with differential methylation in placentae from two US birth cohorts.
Kennedy E, Everson TM, Punshon T, Jackson BP, Hao K, Lambertini L, Chen J, Karagas MR, Marsit CJ
Epigenetics. 2019 Sep 4;:1-16. doi: 10.1080/15592294.2019.1661211. Epub 2019 Sep 4.
PMID: 31462129

Validity of retrospective occupational exposure estimates of lead and manganese in a case-control study.
Sauve JF, Ramsay JM, Locke SJ, Dopart PJ, Josse PR, Zaebst DD, Albert PS, Cantor KP, Baris D, Jackson BP, Karagas MR, Hosain GM, Schwenn M, Johnson A, Purdue MP, Koutros S, Silverman DT, Friesen MC
Occup Environ Med. 2019 Sep;76(9):680-687. doi: 10.1136/oemed-2019-105744. Epub 2019 Jul 15.
PMID: 31308155

Residential wood stove use and indoor exposure to PM2.5 and its components in Northern New England.
Fleisch AF, Rokoff LB, Garshick E, Grady ST, Chipman JW, Baker ER, Koutrakis P, Karagas MR
J Expo Sci Environ Epidemiol. 2019 Jun 28; doi: 10.1038/s41370-019-0151-4. Epub 2019 Jun 28.
PMID: 31253828

Altered Stool Microbiota of Infants with Cystic Fibrosis Shows a Reduction in Genera Associated with Immune Programming from Birth.
Antosca KM, Chernikova DA, Price CE, Ruoff KL, Li K, Guill MF, Sontag NR, Morrison HG, Hao S, Drumm ML, MacKenzie TA, Dorman DB, Feenan LM, Williams MA, Dessaint J, Yuan IH, Aldrich BJ, Moulton LA, Ting L, Martinez-Del Campo A, Stewart EJ, Karagas MR, O'Toole GA, Madan JC
J Bacteriol. 2019 Aug 15;201(16) pii: e00274-19. doi: 10.1128/JB.00274-19. Epub 2019 Jul 24.
PMID: 31209076

Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated with Placental Cadmium Concentrations and Birth Size.
Everson TM, Marable C, Deyssenroth MA, Punshon T, Jackson BP, Lambertini L, Karagas MR, Chen J, Marsit CJ
Environ Health Perspect. 2019 May;127(5):57005. doi: 10.1289/EHP4264.
PMID: 31082282

Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain.
Signes-Pastor AJ, Vioque J, Navarrete-Muñoz EM, Carey M, Garcia-Villarino M, Fernandez-Somoano A, Tardon A, Santa-Marina L, Irizar A, Casas M, Guxens M, Llop S, Soler-Blasco R, Garcia-de-la-Hera M, Karagas MR, Meharg AA
Environ Res. 2019 Jul;174:135-142. doi: 10.1016/j.envres.2019.04.028. Epub 2019 Apr 29.
PMID: 31075694

Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight.
Kupers LK, Monnereau C, Sharp GC, Yousefi P, Salas LA, Ghantous A, Page CM, Reese SE, Wilcox AJ, Czamara D, Starling AP, Novoloaca A, Lent S, Roy R, Hoyo C, Breton CV, Allard C, Just AC, Bakulski KM, Holloway JW, Everson TM, Xu CJ, Huang RC, van der Plaat DA, Wielscher M, Merid SK, Ullemar V, Rezwan FI, Lahti J, van Dongen J, Langie SAS, Richardson TG, Magnus MC, Nohr EA, Xu Z, Duijts L, Zhao S, Zhang W, Plusquin M, DeMeo DL, Solomon O, Heimovaara JH, Jima DD, Gao L, Bustamante M, Perron P, Wright RO, Hertz-Picciotto I, Zhang H, Karagas MR, Gehring U, Marsit CJ, Beilin LJ, Vonk JM, Jarvelin MR, Bergstrom A, Örtqvist AK, Ewart S, Villa PM, Moore SE, Willemsen G, Standaert ARL, Haberg SE, Sorensen TIA, Taylor JA, Raikkonen K, Yang IV, Kechris K, Nawrot TS, Silver MJ, Gong YY, Richiardi L, Kogevinas M, Litonjua AA, Eskenazi B, Huen K, Mbarek H, Maguire RL, Dwyer T, Vrijheid M, Bouchard L, Baccarelli AA, Croen LA, Karmaus W, Anderson D, de Vries M, Sebert S, Kere J, Karlsson R, Arshad SH, Hamalainen E, Routledge MN, Boomsma DI, Feinberg AP, Newschaffer CJ, Govarts E, Moisse M, Fallin MD, Melen E, Prentice AM, Kajantie E, Almqvist C, Oken E, Dabelea D, Boezen HM, Melton PE, Wright RJ, Koppelman GH, Trevisi L, Hivert MF, Sunyer J, Munthe-Kaas MC, Murphy SK, Corpeleijn E, Wiemels J, Holland N, Herceg Z, Binder EB, Davey Smith G, Jaddoe VWV, Lie RT, Nystad W, London SJ, Lawlor DA, Relton CL, Snieder H, Felix JF
Nat Commun. 2019 Apr 23;10(1):1893. doi: 10.1038/s41467-019-09671-3. Epub 2019 Apr 23.
PMID: 31015461

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