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Margaret Rita Karagas, PhD

Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations
Director, Center for Biomedical Research Excellence, Center for Molecular Epidemiology
Director, Children's Environmental Health and Disease Prevention Research Center

Community and Family Medicine

University of Washington, PhD 1990

Dartmouth Cancer Center
Quantitative Biomedical Sciences

Websites Margaret Karagas - Epidemiology Faculty Profile
Children's Environmental Health and Disease Prevention Research Center
Center for Molecular Epidemiology
Cancer Epidemiology
Dartmouth Toxic Metals Superfund Research Program
Graduate Program in Quantitative Biomedical Sciences
The Dartmouth Institute
Dartmouth SYNERGY
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Contact Information

Department of Epidemiology
1 Medical Center Drive
Williamson Building, 7th floor
Lebanon NH 03756

Office: 760 Williamson Bldg Lebanon, NH
Email: Margaret.Karagas@dartmouth.edu

Asst. Phone:

Professional Interests

Professor Karagas is the inaugural chair of the Department of Epidemiology at the Geisel School of Medicine and director of the Centers for Molecular Epidemiology and Children’s Environmental Health and Disease Prevention Research at Dartmouth College. As part of her deep commitment to interdisciplinary training, Professor Karagas collaboratively established an innovative, cross-disciplinary postdoctoral and graduate program in the quantitative biomedical sciences (QBS) that integrates epidemiology, bioinformatics, and biostatistics and mentors diverse investigators at all stages of their career. Her research interests encompass interdisciplinary studies that seek to illuminate the causes of human disease by investigating emerging environmental exposures, host factors, and mechanisms -- that impact health from infancy to adult life. Her studies focus on under-studied, rural populations while contributing to large multi-center efforts such as the NIH-funded Environmental Influences on Child Health Outcomes (ECHO) Study, which includes over 90,000 participants across the USA. Her work incorporates high-dimensional analytic tools along with biomarkers and sensors of the exposome, genetic susceptibility and biologic response. These efforts have helped to uncovered adverse cardiometabolic, neurodevelopmental and immune-related pregnancy-child health outcomes as well as carcinogenic effects of drinking water contaminants, food-borne toxicants including in infant first foods, and exposures from woodstoves along with other environmental threats and have led to practice and policy changes. She has served on international consensus panels and committees for the United Nations, World Health Organization, International Agency for Research on Cancer, European Food Safety Authority, US National Institute of Health and National Academies of Science, and Engineering and Medicine among others.

Selected Publications


Time-varying associations of gestational and childhood triclosan with pubertal and adrenarchal outcomes in early adolescence.
Laue HE, Lanphear BP, Calafat AM, Cecil KM, Chen A, Xu Y, Kalkwarf HJ, Madan JC, Karagas MR, Yolton K, Fleisch AF, Braun JM
Environ Epidemiol. 2024 Apr;8(2):e305. doi: 10.1097/EE9.0000000000000305. Epub 2024 Mar 28.
PMID: 38617430

Erratum: "Associations of Organophosphate Ester Flame Retardant Exposures during Pregnancy with Gestational Duration and Fetal Growth: The Environmental influences on Child Health Outcomes (ECHO) Program".
Oh J, Buckley JP, Li X, Gachigi KK, Kannan K, Lyu W, Ames JL, Barrett ES, Bastain TM, Breton CV, Buss C, Croen LA, Dunlop AL, Ferrara A, Ghassabian A, Herbstman JB, Hernandez-Castro I, Hertz-Picciotto I, Kahn LG, Karagas MR, Kuiper JR, McEvoy CT, Meeker JD, Morello-Frosch R, Padula AM, Romano ME, Sathyanarayana S, Schantz S, Schmidt RJ, Simhan H, Starling AP, Tylavsky FA, Volk HE, Woodruff TJ, Zhu Y, Bennett DH, and program collaborators for Environmental influences on Child Health Outcomes
Environ Health Perspect. 2024 Apr;132(4):49003. doi: 10.1289/EHP14968. Epub 2024 Apr 10.
PMID: 38598327

Measuring Greenspace in Rural Areas for Studies of Birth Outcomes: A Comparison of Street View Data and Satellite Data.
Shi X, Zhang F, Chipman JW, Li M, Khatchikian C, Karagas MR
Geohealth. 2024 Apr;8(4):e2024GH001012. doi: 10.1029/2024GH001012. Epub 2024 Mar 28.
PMID: 38560559

Plasma per- and polyfluoroalkyl substance mixtures during pregnancy and duration of breastfeeding in the New Hampshire birth cohort study.
Romano ME, Gallagher LG, Price G, Crawford KA, Criswell R, Baker E, Botelho JC, Calafat AM, Karagas MR
Int J Hyg Environ Health. 2024 May;258:114359. doi: 10.1016/j.ijheh.2024.114359. Epub 2024 Mar 22.
PMID: 38521049

Patterns of infant fecal metabolite concentrations and social behavioral development in toddlers.
Laue HE, Bauer JA, Pathmasiri W, Sumner SCJ, McRitchie S, Palys TJ, Hoen AG, Madan JC, Karagas MR
Pediatr Res. 2024 Mar 20; doi: 10.1038/s41390-024-03129-z. Epub 2024 Mar 20.
PMID: 38509226

Urinary mutagenicity and bladder cancer risk in northern New England.
Wong JYY, Fischer AH, Baris D, Beane Freeman LE, Karagas MR, Schwenn M, Johnson A, Matthews PP, Swank AE, Hosain GM, Koutros S, Silverman DT, DeMarini DM, Rothman N
Environ Mol Mutagen. 2024 Jan-Feb;65(1-2):47-54. doi: 10.1002/em.22588. Epub 2024 Mar 11.
PMID: 38465801

In utero arsenic exposure and early childhood motor development in the New Hampshire Birth Cohort Study.
Butler EE, Karagas MR, Demidenko E, Bellinger DC, Korrick SA
Front Epidemiol. 2023;3:1139337. doi: 10.3389/fepid.2023.1139337. Epub 2023 May 9.
PMID: 38455900

Birth outcomes in relation to neighborhood food access and individual food insecurity during pregnancy in the Environmental Influences on Child Health Outcomes (ECHO)-wide cohort study.
Aris IM, Lin PD, Wu AJ, Dabelea D, Lester BM, Wright RJ, Karagas MR, Kerver JM, Dunlop AL, Joseph CL, Camargo CA Jr, Ganiban JM, Schmidt RJ, Strakovsky RS, McEvoy CT, Hipwell AE, O'Shea TM, McCormack LA, Maldonado LE, Niu Z, Ferrara A, Zhu Y, Chehab RF, Kinsey EW, Bush NR, Nguyen RHN, Carroll KN, Barrett ES, Lyall K, Sims-Taylor LM, Trasande L, Biagini JM, Breton CV, Patti MA, Coull B, Amutah-Onukagha N, Hacker MR, James-Todd T, Oken E, program collaborators for Environmental Influences on Child Health Outcomes, ECHO components—Coordinating Center, Data Analysis Center, Person-Reported Outcomes Core, ECHO Awardees and Cohorts
Am J Clin Nutr. 2024 Mar 1; pii: S0002-9165(24)00168-0. doi: 10.1016/j.ajcnut.2024.02.022. Epub 2024 Mar 1.
PMID: 38431121

Demographic and health characteristics associated with fish and n-3 fatty acid supplement intake during pregnancy: results from pregnancy cohorts in the ECHO programme.
Oken E, Musci RJ, Westlake M, Gachigi K, Aschner JL, Barnes KL, Bastain TM, Buss C, Camargo CA Jr, Cordero JF, Dabelea D, Dunlop AL, Ghassabian A, Hipwell AE, Hockett CW, Karagas MR, Lugo-Candelas C, Margolis AE, O'Connor TG, Shuster CL, Straughen JK, Lyall K, program collaborators for Environmental influences on Child Health Outcomes
Public Health Nutr. 2024 Feb 27;27(1):e94. doi: 10.1017/S136898002400051X. Epub 2024 Feb 27.
PMID: 38410088

Seasonal patterns in trace elements assessed in toenails.
Wojcik KM, Holle AV, O'Brien KM, White AJ, Karagas MR, Levine KE, Jackson BP, Weinberg CR
Environ Adv. 2024 Apr;15 pii: 100496. doi: 10.1016/j.envadv.2024.100496. Epub 2024 Feb 2.
PMID: 38405619

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