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Margaret Rita Karagas, PhD

Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Community and Family Medicine

University of Washington, PhD 1990

Norris Cotton Cancer Center
Quantitative Biomedical Sciences


Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Kara Caputo
Asst. Phone: 603-653-9022
Asst. Email: Kara.L.Caputo@dartmouth.edu

Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.

Selected Publications:


Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program.
Buckley JP, Barrett ES, Beamer PI, Bennett DH, Bloom MS, Fennell TR, Fry RC, Funk WE, Hamra GB, Hecht SS, Kannan K, Iyer R, Karagas MR, Lyall K, Parsons PJ, Pellizzari ED, Signes-Pastor AJ, Starling AP, Wang A, Watkins DJ, Zhang M, Woodruff TJ, program collaborators for ECHO.
J Expo Sci Environ Epidemiol. 2020 Feb 17; doi: 10.1038/s41370-020-0211-9. Epub 2020 Feb 17.
PMID: 32066883

Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts.
Tian FY, Everson TM, Lester B, Punshon T, Jackson BP, Hao K, Lesseur C, Chen J, Karagas MR, Marsit CJ
Environ Int. 2020 Jan 30;137:105508. doi: 10.1016/j.envint.2020.105508. Epub 2020 Jan 30.
PMID: 32007686

Prediagnostic breast milk DNA methylation alterations in women who develop breast cancer.
Salas LA, Lundgren SN, Browne EP, Punska EC, Anderton DL, Karagas MR, Arcaro KF, Christensen BC
Hum Mol Genet. 2020 Jan 16; pii: ddz301. doi: 10.1093/hmg/ddz301. Epub 2020 Jan 16.
PMID: 31943067

Microbial Communities in Human Milk Relate to Measures of Maternal Weight.
Lundgren SN, Madan JC, Karagas MR, Morrison HG, Hoen AG, Christensen BC
Front Microbiol. 2019;10:2886. doi: 10.3389/fmicb.2019.02886. Epub 2019 Dec 20.
PMID: 31921063

Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes.
Koutros S, Kogevinas M, Friesen MC, Stewart PA, Baris D, Karagas MR, Schwenn M, Johnson A, Monawar Hosain GM, Serra C, Tardon A, Carrato A, Garcia-Closas R, Moore LE, Nickerson ML, Hewitt SM, Lenz P, Schned AR, Lloreta J, Allory Y, Zhang H, Chatterjee N, Garcia-Closas M, Rothman N, Malats N, Silverman DT
Environ Int. 2020 Feb;135:105346. doi: 10.1016/j.envint.2019.105346. Epub 2019 Dec 18.
PMID: 31864026

Prenatal exposure to metal mixture and sex-specific birth outcomes in the New Hampshire Birth Cohort Study.
Signes-Pastor AJ, Doherty BT, Romano ME, Gleason KM, Gui J, Baker E, Karagas MR
Environ Epidemiol. 2019 Oct;3(5) pii: e068. doi: 10.1097/EE9.0000000000000068.
PMID: 31844832

Pelvic inflammatory disease and risk of cancer: A nationwide cohort study.
Sogaard KK, Leisner MZ, Laugesen K, Farkas DK, Karagas MR, Sorensen HT
Int J Gynaecol Obstet. 2019 Nov 25; doi: 10.1002/ijgo.13066. Epub 2019 Nov 25.
PMID: 31765001

Rice Intake and Emerging Concerns on Arsenic in Rice: a Review of the Human Evidence and Methodologic Challenges.
Karagas MR, Punshon T, Davis M, Bulka CM, Slaughter F, Karalis D, Argos M, Ahsan H
Curr Environ Health Rep. 2019 Dec;6(4):361-372. doi: 10.1007/s40572-019-00249-1.
PMID: 31760590

Transcriptome-wide analysis of changes in the fetal placenta associated with prenatal arsenic exposure in the New Hampshire Birth Cohort Study.
Winterbottom EF, Ban Y, Sun X, Capobianco AJ, Marsit CJ, Chen X, Wang L, Karagas MR, Robbins DJ
Environ Health. 2019 Nov 21;18(1):100. doi: 10.1186/s12940-019-0535-x. Epub 2019 Nov 21.
PMID: 31752878

Exposures to chemical mixtures during pregnancy and neonatal outcomes: The HOME study.
Kalloo G, Wellenius GA, McCandless L, Calafat AM, Sjodin A, Romano ME, Karagas MR, Chen A, Yolton K, Lanphear BP, Braun JM
Environ Int. 2020 Jan;134:105219. doi: 10.1016/j.envint.2019.105219. Epub 2019 Nov 12.
PMID: 31726361

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