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Margaret Rita Karagas, PhD

Title(s)
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations
Director, Center for Biomedical Research Excellence, Center for Molecular Epidemiology
Director, Children's Environmental Health and Disease Prevention Research Center

Department(s)
Epidemiology
Community and Family Medicine

Education
University of Washington, PhD 1990

Programs
Dartmouth Cancer Center
Quantitative Biomedical Sciences
SYNERGY

Websites Margaret Karagas - Epidemiology Faculty Profile
Children's Environmental Health and Disease Prevention Research Center
Center for Molecular Epidemiology
Cancer Epidemiology
Dartmouth Toxic Metals Superfund Research Program
Graduate Program in Quantitative Biomedical Sciences
The Dartmouth Institute
Dartmouth SYNERGY
View Publications

Contact Information

Department of Epidemiology
1 Medical Center Drive
Williamson Building, 7th floor
Lebanon NH 03756

Office: 760 Williamson Bldg Lebanon, NH
Email: Margaret.Karagas@dartmouth.edu

Assistant:
Asst. Phone:


Professional Interests

Professor Karagas is the inaugural chair of the Department of Epidemiology at the Geisel School of Medicine and director of the Centers for Molecular Epidemiology and Children’s Environmental Health and Disease Prevention Research at Dartmouth College. As part of her deep commitment to interdisciplinary training, Professor Karagas collaboratively established an innovative, cross-disciplinary postdoctoral and graduate program in the quantitative biomedical sciences (QBS) that integrates epidemiology, bioinformatics, and biostatistics and mentors diverse investigators at all stages of their career. Her research interests encompass interdisciplinary studies that seek to illuminate the causes of human disease by investigating emerging environmental exposures, host factors, and mechanisms -- that impact health from infancy to adult life. Her studies focus on under-studied, rural populations while contributing to large multi-center efforts such as the NIH-funded Environmental Influences on Child Health Outcomes (ECHO) Study, which includes over 90,000 participants across the USA. Her work incorporates high-dimensional analytic tools along with biomarkers and sensors of the exposome, genetic susceptibility and biologic response. These efforts have helped to uncovered adverse cardiometabolic, neurodevelopmental and immune-related pregnancy-child health outcomes as well as carcinogenic effects of drinking water contaminants, food-borne toxicants including in infant first foods, and exposures from woodstoves along with other environmental threats and have led to practice and policy changes. She collaborates globally and has served on international consensus panels and committees for the United Nations, World Health Organization, International Agency for Research on Cancer, European Food Safety Authority, US National Institute of Health and National Academies of Science, and Engineering and Medicine among others.


Selected Publications

 

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort.
Sherris AR, Dearborn LC, Goin DE, Loftus CT, Szpiro AA, Casey JA, Ilango SD, Angal J, Bennett DH, Buxton MA, Camargo CA Jr, Carroll KN, Childs ML, Cioffi C, Croen LA, Dabelea D, Eick SM, Farzan SF, Ferrara A, Garcia E, Gemmill A, Gilliland F, Habre R, Hertz-Picciotto I, Hipwell AE, Hirtz D, Karagas MR, Koinis-Mitchell D, Kress AM, Leve LD, Liang D, Lyall K, McCormack LA, McEvoy CT, Mirzakhani H, Morello-Frosch R, Niu Z, O'Connor TG, Peterson AK, Schmidt RJ, Karr CJ, Padula AM
Environ Epidemiol. 2026 Oct;10(5):e526. doi: 10.1097/EE9.0000000000000526. Epub 2026 Sep 9.
PMID: 42725203

Associations between a mixture of trace elements and bladder cancer occurrence: A study of possible reverse causation.
Kamenetsky ME, Koutros S, Spaur M, Kim SD, Karagas MR, Johnson A, Baris D, Le XC, Silverman DT, Keil AP
Environ Epidemiol. 2026 Oct;10(5):e525. doi: 10.1097/EE9.0000000000000525. Epub 2026 Sep 9.
PMID: 42725121

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk.
Prokunina-Olsson L, Florez-Vargas O, Levin MG, Dutta D, Breeze CE, Hurwitz LM, Yan W, Lamy P, Papenberg BW, Wang K, Lee CH, Milne RL, Gu J, Um CY, Joseph V, Furberg H, Le Calvez-Kelm F, Lori A, Choudhury PP, Afshar N, Kogevinas M, Offit K, Vermeulen SH, Lopez de Maturana E, Albanes D, Purdue MP, Cortessis VK, Karagas MR, Kooperberg C, Bjurlin M, Tadesse DA, Moore SC, Huang WY, Haiman CA, Stern MC, Eliassen AH, Mucci LA, Aben KK, Galesloot TE, UROMOL Consortium, Verma A, Yoshino S, Hikino K, Terao C, Rafnar T, Matsuda K, Shuin T, Garcia-Closas M, Real FX, Kiemeney LA, Chanock SJ, Malats N, Silverman DT, Dyrskjot L, Rothman N, Damrauer SM, Koutros S, Damrauer JS
Nat Commun. 2026 Aug 8;17(1) doi: 10.1038/s41467-026-76157-4. Epub 2026 Aug 8.
PMID: 42706231

Prenatal Organophosphate Exposure and Autism-Related Traits in Children.
Cavalier HM, Volk HE, Kivumbi A, Liu M, Lyall K, Afanasyeva Y, Chen Y, Wang Y, Kannan K, Li Z, Sherris AR, Croen LA, Schmidt RJ, Bennett DH, Ames JL, Breton CV, Bakian AV, Bastain TM, Alkhouri NB, Eick SM, Goodrich JM, Schantz SL, O'Connor TG, Karagas MR, Herbstman JB, Trasande L, Ghassabian A, ECHO Cohort Consortium
JAMA Pediatr. 2026 Aug 24; doi: 10.1001/jamapediatrics.2026.3785. Epub 2026 Aug 24.
PMID: 42636007

Impact of sample mass on the reliability of toenail fluoride for exposure assessment.
Tamayo-Cabeza G, Zenni M, Castiblanco-Rubio GA, Lippert F, Flora DB, Peacock JL, Till C, Goodman CV, Lanphear BP, Korrick SA, Karagas MR, Martinez-Mier EA
Toxicol Environ Health Sci. 2026;18(3):431-438. doi: 10.1007/s13530-026-00321-y. Epub 2026 Apr 27.
PMID: 42601994

Prenatal exposure to fluoride in public water and child cognition in the US ECHO cohort, 2006-2019.
Simon KR, Bloomquist T, Rajeev T, Hernandez A, Kulali S, Burjak M, Kress AM, Palmore M, Akbaryan A, Sanchez TR, Van Horne YO, Shin HM, Goin DE, Tamayo-Ortiz M, Patel G, Shuffrey LC, Ghassabian A, Karagas MR, Leventhal B, Fry RC, Miller R, Herbstman J, Morales S, Margolis AE, Nigra AE, Consortium FTECHOC
Am J Epidemiol. 2026 Aug 14; pii: kwag186. doi: 10.1093/aje/kwag186. Epub 2026 Aug 14.
PMID: 42596505

Corrigendum to '2020-2025 Dietary Guidelines for Americans in Pregnancy: Adherence Shortfalls and Associations with Gestational Weight Gain' [J. Nutr. 2026; 156: 101198].
Notario-Barandiaran L, Signes-Pastor AJ, Himes KP, Karagas MR
J Nutr. 2026 Sep;156(9):101770. doi: 10.1016/j.tjnut.2026.101770. Epub 2026 Aug 12.
PMID: 42586516

Exposure to Organophosphate Ester Flame Retardants and Plasticizers during Pregnancy and Autism-Related Outcomes in the ECHO Cohort.
Ames JL, Ferrara A, Feng J, Alexeeff S, Avalos LA, Barrett ES, Bastain TM, Bennett DH, Buckley JP, Carignan CC, Cintora P, Ghassabian A, Hedderson MM, Hernandez-Castro I, Kannan K, Karagas MR, Karr CJ, Kuiper JR, Liang D, Lyall K, McEvoy CT, Morello-Frosch R, O'Connor TG, Oh J, Peterson AK, Quiros-Alcala L, Sathyanarayana S, Schantz S, Schmidt RJ, Starling AP, Woodruff TJ, Volk HE, Zhu Y, Croen LA, ECHO Cohort Consortium
Environ Health Perspect. 2026 Aug 4;134(4):423-437. doi: 10.1021/EHP.6c00247. Epub 2026 May 7.
PMID: 42564610

Evaluation of the United States' Permitless Concealed Carry Laws and Child Health in the ECHO Cohort.
ChurchilL ML, Knapp EA, Mccourt AD, Somayaji N, Blackwell CK, Avalos LA, Hirko KA, Lewinn KZ, Lewis J, Zhu Y, Hipwell AE, Karagas MR, Lyall K, Ganiban JM, Paneth N, O'shea TM, Johnson CC, Camargo CA Jr, Crifasi CK, Chandran A, Echo Cohort Consortium
Health Hum Rights. 2026 Jun;28(1):23-40.
PMID: 42441048

Prenatal Air Pollution Exposure and Autism Spectrum Disorder in the ECHO Consortium.
Ghassabian A, Dickerson AS, Wang Y, Braun JM, Bennett DH, Croen LA, LeWinn KZ, Burris HH, Habre R, Lyall K, Frazier JA, Glass HC, Hooper SR, Joseph RM, Karr CJ, Schmidt RJ, Friedman C, Karagas MR, Stroustrup A, Straughen JK, Dunlop AL, Ganiban JM, Leve LD, Wright RJ, McEvoy CT, Hipwell AE, Giardino AP, Santos HP Jr, Krause H, Oken E, Camargo CA Jr, Oh J, Loftus C, O'Shea TM, O'Connor TG, Szpiro A, Volk HE
Environ Health Perspect. 2026 Jul 7;134(3):324-334. doi: 10.1021/EHP.6c00106. Epub 2026 Apr 22.
PMID: 42428257

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