Margaret Rita Karagas, PhD
Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology
Department(s):
Epidemiology
Community and Family Medicine
Education:
University of Washington, PhD 1990
Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences
Websites:
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Contact Information:
Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756
Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu
Assistant: Kara Caputo
Asst. Phone: 603-653-9022
Asst. Email: Kara.L.Caputo@dartmouth.edu
Professional Interests:
Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.
Selected Publications: |
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Ingested nitrate and nitrite and bladder cancer in Northern New England. Maternal urinary cadmium, glucose intolerance and gestational diabetes in the New Hampshire Birth Cohort Study. An Integrated Gaussian Graphical Model to evaluate the impact of exposures on metabolic networks. Copper associates with differential methylation in placentae from two US birth cohorts. Validity of retrospective occupational exposure estimates of lead and manganese in a case-control study. Residential wood stove use and indoor exposure to PM2.5 and its components in Northern New England. Altered Stool Microbiota of Infants with Cystic Fibrosis Shows a Reduction in Genera Associated with Immune Programming from Birth. Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated with Placental Cadmium Concentrations and Birth Size. Inorganic arsenic exposure and neuropsychological development of children of 4-5 years of age living in Spain. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight. |
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