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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
http://cancer.dartmouth.edu/res/cancer_epi_chemo.html
http://www.dartmouth.edu/~toxmetal/index.html
http://synergy.dartmouth.edu
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Claire Weaver
Asst. Phone: 603-653-9022
Asst. Email: Claire.Weaver@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Potential effect modifiers of the arsenic-bladder cancer risk relationship.
Koutros S, Baris D, Waddell R, Freeman LEB, Colt JS, Schwenn M, Johnson A, Ward MH, Monawar Hosain GM, Moore LE, Stolzenberg-Solomon R, Rothman N, Karagas MR, Silverman DT
Int J Cancer. 2018 Jul 7; doi: 10.1002/ijc.31720. Epub 2018 Jul 7.
PMID: 29981168

Maternal diet during pregnancy is related with the infant stool microbiome in a delivery mode-dependent manner.
Lundgren SN, Madan JC, Emond JA, Morrison HG, Christensen BC, Karagas MR, Hoen AG
Microbiome. 2018 Jul 5;6(1):109. doi: 10.1186/s40168-018-0490-8. Epub 2018 Jul 5.
PMID: 29973274

Urine and toenail cadmium levels in pregnant women: A reliability study.
White AJ, O'Brien KM, Jackson BP, Karagas MR
Environ Int. 2018 Sep;118:86-91. doi: 10.1016/j.envint.2018.05.030. Epub 2018 May 29.
PMID: 29857281

The premature infant gut microbiome during the first 6 weeks of life differs based on gestational maturity at birth.
Chernikova DA, Madan JC, Housman ML, Zain-Ul-Abideen M, Lundgren SN, Morrison HG, Sogin ML, Williams SM, Moore JH, Karagas MR, Hoen AG
Pediatr Res. 2018 May 23; doi: 10.1038/s41390-018-0022-z. Epub 2018 May 23.
PMID: 29795209

Infants' dietary arsenic exposure during transition to solid food.
Signes-Pastor AJ, Cottingham KL, Carey M, Sayarath V, Palys T, Meharg AA, Folt CL, Karagas MR
Sci Rep. 2018 May 8;8(1):7114. doi: 10.1038/s41598-018-25372-1. Epub 2018 May 8.
PMID: 29739998

A dose-response meta-analysis of chronic arsenic exposure and incident cardiovascular disease.
Moon KA, Oberoi S, Barchowsky A, Chen Y, Guallar E, Nachman KE, Rahman M, Sohel N, D'Ippoliti D, Wade TJ, James KA, Farzan SF, Karagas MR, Ahsan H, Navas-Acien A
Int J Epidemiol. 2018 Apr 25; doi: 10.1093/ije/dyy073. Epub 2018 Apr 25.
PMID: 29697784

Maternal urinary phthalate metabolites during pregnancy and thyroid hormone concentrations in maternal and cord sera: The HOME Study.
Romano ME, Eliot MN, Zoeller RT, Hoofnagle AN, Calafat AM, Karagas MR, Yolton K, Chen A, Lanphear BP, Braun JM
Int J Hyg Environ Health. 2018 May;221(4):623-631. doi: 10.1016/j.ijheh.2018.03.010. Epub 2018 Mar 23.
PMID: 29606598

Risk of basal cell carcinoma in a randomized clinical trial of aspirin and folic acid for the prevention of colorectal adenomas.
Passarelli MN, Barry EL, Zhang D, Gangar P, Rees JR, Bresalier RS, McKeown-Eyssen G, Karagas MR, Baron JA
Br J Dermatol. 2018 Mar 23; doi: 10.1111/bjd.16571. Epub 2018 Mar 23.
PMID: 29570772

RE: Elevated Bladder Cancer in Northern New England: The Role of Drinking Water and Arsenic.
Koutros S, Lenz P, Hewitt SM, Kida M, Jones M, Schned AR, Baris D, Pfeiffer R, Schwenn M, Johnson A, Karagas MR, Garcia-Closas M, Rothman N, Moore LE, Silverman DT
J Natl Cancer Inst. 2018 Mar 14; doi: 10.1093/jnci/djy045. Epub 2018 Mar 14.
PMID: 29548022

Author Correction: Distinct arsenic metabolites following seaweed consumption in humans.
Taylor VF, Li Z, Sayarath V, Palys TJ, Morse KR, Scholz-Bright RA, Karagas MR
Sci Rep. 2018 Mar 2;8(1):4145. doi: 10.1038/s41598-018-22625-x. Epub 2018 Mar 2.
PMID: 29500413