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Margaret Rita Karagas, PhD

Title(s):
Chair and Professor of Epidemiology
Professor of Community and Family Medicine
James W. Squires Professor

Additional Titles/Positions/Affiliations:
Director, Children's Environmental Health and Disease Prevention Research Center and Center for Molecular Epidemiology

Department(s):
Epidemiology
Community and Family Medicine

Education:
University of Washington, PhD 1990

Programs:
Norris Cotton Cancer Center
Quantitative Biomedical Sciences

Websites:
http://epidemiology.dartmouth.edu/faculty/karagasm.html
http://www.dartmouth.edu/~childrenshealth/
http://sites.dartmouth.edu/molecepi/
https://cancer.dartmouth.edu/scientists-researchers/cancer-population-sciences
http://www.dartmouth.edu/~toxmetal/index.html
http://iqbs.org

Contact Information:

Department of Epidemiology
1 Medical Center Drive
7927 Rubin Building
Lebanon NH 03756

Office: 863 Rubin Bldg Lebanon, NH
Phone: 603-653-9010
Fax: 603-653-9093
Email: Margaret.Karagas@dartmouth.edu

Assistant: Evan Vickers
Asst. Phone: 603-650-1918
Asst. Email: Evan.G.Vickers@dartmouth.edu


Professional Interests:

Professor Karagas' research encompasses several epidemiological studies focusing on the etiology and prevention of human cancers over the lifecourse, as well as adverse pregnancy and children's health outcomes. These include investigations to determine incidence rates of basal cell and squamous cell skin cancer for a geographically defined US population, and to assess the extent of any increase over the past 20 years. Another aspect of this research is a case-control study of these malignancies to identify risks associated with emerging exposures such as indoor tanning, ingestion of arsenic-containing drinking water and foods, immunosuppressive therapies and other factors. This research has been extended to bladder cancer. One of her current initiatives involves establishing a cohort of pregnant women in New Hampshire to assess the potential impact of arsenic and other exposures on risk of maternal and child health. Her ongoing work further includes studies of melanoma in women and collaborative investigations of exposure biomarkers, individual susceptibility, and biological response to environmental agents. Professor Karagas is one of the Principal Investigators of a NCI-funded cross-disciplinary postdoctoral training grant, serves as a mentor for early career investigators and participates in a variety of courses at the undergraduate and graduate level.


Selected Publications:

 

Rare, Protein-Altering Variants in AS3MT and Arsenic Metabolism Efficiency: A Multi-Population Association Study.
Delgado DA, Chernoff M, Huang L, Tong L, Chen L, Jasmine F, Shinkle J, Cole SA, Haack K, Kent J, Umans J, Best LG, Nelson H, Griend DV, Graziano J, Kibriya MG, Navas-Acien A, Karagas MR, Ahsan H, Pierce BL
Environ Health Perspect. 2021 Apr;129(4):47007. doi: 10.1289/EHP8152. Epub 2021 Apr 7.
PMID: 33826413

Chemical mixture exposures during pregnancy and cognitive abilities in school-aged children.
Kalloo G, Wellenius GA, McCandless L, Calafat AM, Sjodin A, Sullivan AJ, Romano ME, Karagas MR, Chen A, Yolton K, Lanphear BP, Braun JM
Environ Res. 2021 Mar 18;197:111027. doi: 10.1016/j.envres.2021.111027. Epub 2021 Mar 18.
PMID: 33744271

Information enhanced model selection for Gaussian graphical model with application to metabolomic data.
Zhou J, Hoen AG, Mcritchie S, Pathmasiri W, Viles WD, Nguyen QP, Madan JC, Dade E, Karagas MR, Gui J
Biostatistics. 2021 Mar 15; pii: kxab006. doi: 10.1093/biostatistics/kxab006. Epub 2021 Mar 15.
PMID: 33720330

Bladder cancer risk associated with family history of cancer.
Koutros S, Decker KL, Baris D, Pardo LA, Johnson A, Hosain GMM, Rothman N, Karagas MR, Schwenn MR, Silverman DT
Int J Cancer. 2021 Jan 27; doi: 10.1002/ijc.33486. Epub 2021 Jan 27.
PMID: 33506540

Racial and geographic variation in effects of maternal education and neighborhood-level measures of socioeconomic status on gestational age at birth: Findings from the ECHO cohorts.
Dunlop AL, Essalmi AG, Alvalos L, Breton C, Camargo CA, Cowell WJ, Dabelea D, Dager SR, Duarte C, Elliott A, Fichorova R, Gern J, Hedderson MM, Thepaksorn EH, Huddleston K, Karagas MR, Kleinman K, Leve L, Li X, Li Y, Litonjua A, Ludena-Rodriguez Y, Madan JC, Nino JM, McEvoy C, O'Connor TG, Padula AM, Paneth N, Perera F, Sathyanarayana S, Schmidt RJ, Schultz RT, Snowden J, Stanford JB, Trasande L, Volk HE, Wheaton W, Wright RJ, McGrath M, program collaborators for Environmental Influences on Child Health Outcomes.
PLoS One. 2021;16(1):e0245064. doi: 10.1371/journal.pone.0245064. Epub 2021 Jan 8.
PMID: 33418560

Prediction of an outcome using NETwork Clusters (NET-C).
Lee JW, Zhou J, Moen EL, Punshon T, Hoen AG, Romano ME, Karagas MR, Gui J
Comput Biol Chem. 2021 Feb;90:107425. doi: 10.1016/j.compbiolchem.2020.107425. Epub 2020 Dec 8.
PMID: 33360198

Arsenic exposure in relation to apple consumption among infants in the New Hampshire Birth Cohort Study.
Signes-Pastor AJ, Punshon T, Cottingham KL, Jackson BP, Sayarath V, Gilbert-Diamond D, Korrick S, Karagas MR
Expo Health. 2020 Dec;12(4):561-567. doi: 10.1007/s12403-020-00356-7. Epub 2020 Apr 8.
PMID: 33195875

Periconceptional and prenatal exposure to metal mixtures in relation to behavioral development at 3 years of age.
Doherty BT, Romano ME, Gui J, Punshon T, Jackson BP, Karagas MR, Korrick SA
Environ Epidemiol. 2020 Aug;4(4):e0106. doi: 10.1097/EE9.0000000000000106. Epub 2020 Jul 6.
PMID: 33154986

Prenatal and postnatal mercury exposure and blood pressure in childhood.
Farzan SF, Howe CG, Chen Y, Gilbert-Diamond D, Korrick S, Jackson BP, Weinstein AR, Karagas MR
Environ Int. 2021 Jan;146:106201. doi: 10.1016/j.envint.2020.106201. Epub 2020 Oct 28.
PMID: 33129000

Assessment of Multipollutant Exposures During Pregnancy Using Silicone Wristbands.
Doherty BT, Pearce JL, Anderson KA, Karagas MR, Romano ME
Front Public Health. 2020;8:547239. doi: 10.3389/fpubh.2020.547239. Epub 2020 Sep 29.
PMID: 33117768

View more publications on PubMed