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Francesca Gilli, MS, PhD

Associate Professor of Neurology
Associate Professor of Microbiology and Immunology

Microbiology and Immunology

2000 MS (Medical Biotechnology), Università degli Studi di Torino (Italy)
2005 PhD (Human Biology), Università degli Studi di Torino (Italy)
2008-2011 Clinical Chemistry and Laboratory Medicine Fellowship, Università degli Studi di Torino (Italy)

Neuroscience Center at Dartmouth


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Contact Information

DHMC, HB 7999
1 Medical Center Drive
554W Borwell
Lebanon NH 03756

Office: (603)650-2633
Phone: (603) 650-5433 (Lab)
Email: Francesca.Gilli@dartmouth.edu

Professional Interests

Dr. Gilli’s principal research interest is understanding the cellular and molecular pathways that contribute to neuroinflammation and central nervous system (CNS)-related tissue damage in Multiple Sclerosis (MS). The goal of Dr. Gilli’s current research is to elucidate how inflammation contributes to neurodegeneration and disability progression. The overall intention of this work is to identify new therapeutic targets or strategies that will improve our ability to manage progressive MS as well as other neurodegenerative diseases.

Grant Information

Genzyme-Sanofi: 2019-2020 -(PI) Antiviral effects of Teriflunomide.
Italian MS Society 2018/R/6: 2019-2020 -(PI) Sex effects on intrathecal humoral inflammation and disease progression in multiple sclerosis.
Hitchcock Foundation Scholar Award: 2017-2019 – (PI) lntrathecal B-cell response pattern for improved diagnosis and management of progressive Multiple Sclerosis.
Hitchcock Foundation Pilot Award: 2016-2017 – (PI) Plasmalemma vesicle associated protein (PV1) as a novel target in neuroinflammation.
Biogen Idec Research Grant: 2014-2016 – (PI) Interaction of PEG-IFNβ with Antibodies to Native IFNβ
Hitchcock Foundation Pilot Award: 2014-2015 – (PI) Toward reliable biomarkers in MS: Microarray analysis of spinal cord gene expression in animal models of Multiple Sclerosis.

Courses Taught

Lecturer - Scientific basis of diseases 1 (PEMM 101)
Lecturer - Ethical and Responsible Conduct of Research (PEMM 124)
Lecturer - Neurobiology of Diseases (PEMM 211)
Lecturer - Neuroscience II -Neuroimmunology module (PEMM 212)
Lecturer - Advanced Biomedical Sciences (PEMM 271)


Born in Italy, Dr. Gilli earned a M.S. in Medical Biotechnology and a Ph.D. in Human Biology from the Università degli Studi di Torino (Italy). She then completed her postdoctoral research in neuroimmunology at Università degli Studi di Torino (Italy), and University of Basel (Switzerland). Her postdoctoral research focused on the immunogenicity and biological action of IFNβ therapy in patients with MS, and, later, on the molecular mechanisms behind the adaptive immune response in pregnancy in MS. She also completed a Clinical Chemistry and Laboratory Medicine Fellowship at the Università degli Studi di Torino (Italy) in 2011. In 2014, Dr. Gilli joined the faculty in the Neurology Department of the Geisel School of Medicine as an Assistant Professor, where she works as a basic scientist affiliated with the Multiple Sclerosis Center at Dartmouth.

Selected Publications


Effects of a similar amount of regular non-structured or competitive physical activity across late adulthood: a cross-sectional study.
Palumbo M, Modena R, Bortolan L, Skafidas S, Callovini A, Savoldelli A, Gilli F, Fornasiero A, Schena F, Pellegrini B, Zoppirolli C
Front Sports Act Living. 2024;6:1416080. doi: 10.3389/fspor.2024.1416080. Epub 2024 May 30.
PMID: 38873229

CXCL10/IgG1 Axis in Multiple Sclerosis as a Potential Predictive Biomarker of Disease Activity.
Welsh N, Disano K, Linzey M, Pike SC, Smith AD 3rd, Pachner AR, Gilli F
Neurol Neuroimmunol Neuroinflamm. 2024 Mar;11(2):e200200. doi: 10.1212/NXI.0000000000200200. Epub 2024 Feb 12.
PMID: 38346270

Immunological shifts during early-stage Parkinson's disease identified with DNA methylation data on longitudinally collected blood samples.
Pike SC, Havrda M, Gilli F, Zhang Z, Salas LA
NPJ Parkinsons Dis. 2024 Jan 11;10(1):21. doi: 10.1038/s41531-023-00626-6. Epub 2024 Jan 11.
PMID: 38212355

High throughput method for detecting murine brain atrophy using a clinical 3T MRI.
Linzey M, DiSano K, Welsh N, Ford JC, Gilli F, Wishart H, Pachner A
BMC Med Imaging. 2023 Nov 13;23(1):183. doi: 10.1186/s12880-023-01124-0. Epub 2023 Nov 13.
PMID: 37957588

Clinical outcomes of aspergillosis among paediatric and adult inpatients: A multicentre study in a Brazilian metropolitan area.
Martins AC, Psaltikidis EM, Cristiano de Lima T, Fagnani R, Gomide HCAC, Gilli FH, Schreiber AZ, de Oliveira Conterno L, Matsuzawa T, Watanabe A, Kamei K, Brandalise SR, Trabasso P, Resende MR, Moretti ML
J Mycol Med. 2023 Nov;33(4):101435. doi: 10.1016/j.mycmed.2023.101435. Epub 2023 Sep 5.
PMID: 37708696

The CXCL13 Index as a Predictive Biomarker for Activity in Clinically Isolated Syndrome.
Pike SC, Gilli F, Pachner AR
Int J Mol Sci. 2023 Jul 4;24(13) doi: 10.3390/ijms241311050. Epub 2023 Jul 4.
PMID: 37446228

Magnetic resonance imaging approaches for studying mouse models of multiple sclerosis: A mini review.
Gilli F, Ceccarelli A
J Neurosci Res. 2023 Aug;101(8):1259-1274. doi: 10.1002/jnr.25193. Epub 2023 Mar 31.
PMID: 37001997

Theiler's virus-induced demyelinating disease as an infectious model of progressive multiple sclerosis.
Pike SC, Welsh N, Linzey M, Gilli F
Front Mol Neurosci. 2022;15:1019799. doi: 10.3389/fnmol.2022.1019799. Epub 2022 Oct 13.
PMID: 36311024

Divergent complement system activation in two clinically distinct murine models of multiple sclerosis.
Linzey M, DiSano K, Welsh N, Pachner A, Gilli F
Front Immunol. 2022;13:924734. doi: 10.3389/fimmu.2022.924734. Epub 2022 Jul 26.
PMID: 35958570

SARS-CoV-2 in children with cancer or after haematopoietic stem cell transplant: An analysis of 131 patients.
Haeusler GM, Ammann RA, Carlesse F, Groll AH, Averbuch D, Castagnola E, Agyeman PKA, Phillips B, Gilli F, Solopova G, Attarbaschi A, Wegehaupt O, Speckmann C, Sung L, Lehrnbecher T
Eur J Cancer. 2021 Dec;159:78-86. doi: 10.1016/j.ejca.2021.09.027. Epub 2021 Oct 9.
PMID: 34736044

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