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Yina H. Huang, PhD

Associate Professor of Microbiology and Immunology
Associate Professor of Pathology and Laboratory Medicine

Microbiology and Immunology
Pathology and Laboratory Medicine

Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center


Contact Information:

Professional Interests:

We investigate how T cells traffic and respond to infections. In particular, we study the signals that regulate T cell migration and activation to ensure protective immunity while preventing autoimmunity and immunodeficiency disease.

Selected Publications:


Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019.
PMID: 34525340

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway.
Valenca-Pereira F, Fang Q, Marie IJ, Giddings EL, Fortner KA, Yang R, Villarino AV, Huang YH, Frank DA, Wen H, Levy DE, Rincon M
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37) pii: e2103444118. doi: 10.1073/pnas.2103444118.
PMID: 34507993

Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells.
Vella JL, Molodtsov A, Angeles CV, Branchini BR, Turk MJ, Huang YH
Life Sci Alliance. 2021 Oct;4(10) pii: e202101056. doi: 10.26508/lsa.202101056. Epub 2021 Aug 6.
PMID: 34362825

Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.
Butler SE, Brog RA, Chang CH, Sentman CL, Huang YH, Ackerman ME
Cancer Immunol Immunother. 2021 May 27; doi: 10.1007/s00262-021-02971-y. Epub 2021 May 27.
PMID: 34046711

Diverse Roles of Akt in T cells.
Abdullah L, Hills LB, Winter EB, Huang YH
Immunometabolism. 2021;3(1) pii: e210007. doi: 10.20900/immunometab20210007. Epub 2021 Jan 28.
PMID: 33604081

Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival.
Hills LB, Abdullah L, Lust HE, Degefu H, Huang YH
J Immunol. 2021 Jan 1;206(1):89-100. doi: 10.4049/jimmunol.2000216. Epub 2020 Nov 23.
PMID: 33229443

Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.
Preiss NK, Kang T, Usherwood YK, Huang YH, Branchini BR, Usherwood EJ
J Immunol. 2020 Dec 15;205(12):3372-3382. doi: 10.4049/jimmunol.2000734. Epub 2020 Nov 13.
PMID: 33188072

AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.
Hampsch RA, Wells JD, Traphagen NA, McCleery CF, Fields JL, Shee K, Dillon LM, Pooler DB, Lewis LD, Demidenko E, Huang YH, Marotti JD, Goen AE, Kinlaw WB, Miller TW
Clin Cancer Res. 2020 Jul 15;26(14):3707-3719. doi: 10.1158/1078-0432.CCR-20-0269. Epub 2020 Apr 22.
PMID: 32321715

Author Correction: Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L
Sci Rep. 2018 Mar 1;8(1):4054. doi: 10.1038/s41598-018-22151-w. Epub 2018 Mar 1.
PMID: 29497089

IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C, Huang YH, Hamilton TA, Su B, Li X
J Immunol. 2017 Dec 1;199(11):3849-3857. doi: 10.4049/jimmunol.1601540. Epub 2017 Oct 25.
PMID: 29070673

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