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Yina H. Huang, PhD

Professor of Microbiology and Immunology
Professor of Pathology and Laboratory Medicine

Microbiology and Immunology
Pathology and Laboratory Medicine

Immunology Program
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center


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Professional Interests

We investigate how T cells traffic and respond to infections. In particular, we study the signals that regulate T cell migration and activation to ensure protective immunity while preventing autoimmunity and immunodeficiency disease.

Selected Publications


Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect.
Tavakkoli AD, Clark MA, Kheirollah A, Sloop AM, Soderholm HE, Daniel NJ, Petusseau AF, Huang YH, Thomas CR, Jarvis LA, Zhang R, Pogue BW, Gladstone DJ, Hoopes PJ
bioRxiv. 2023 Nov 5; pii: 2023.11.04.565626. doi: 10.1101/2023.11.04.565626. Epub 2023 Nov 5.
PMID: 37961549

In the right place at the right time: tissue-resident memory T cells in immunity to cancer.
Ramirez DE, Mohamed A, Huang YH, Turk MJ
Curr Opin Immunol. 2023 Aug;83:102338. doi: 10.1016/j.coi.2023.102338. Epub 2023 May 23.
PMID: 37229984

Toward high-throughput engineering techniques for improving CAR intracellular signaling domains.
Butler SE, Hartman CJ, Huang YH, Ackerman ME
Front Bioeng Biotechnol. 2023;11:1101122. doi: 10.3389/fbioe.2023.1101122. Epub 2023 Mar 27.
PMID: 37051270

Cell type-specific Interaction Analysis using Doublets in scRNA-seq (CIcADA).
Schiebout C, Lust HE, Huang YH, Frost HR
bioRxiv. 2023 Feb 15; pii: 2023.02.13.528326. doi: 10.1101/2023.02.13.528326. Epub 2023 Feb 15.
PMID: 36824707

Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors.
Brog RA, Ferry SL, Schiebout CT, Messier CM, Cook WJ, Abdullah L, Zou J, Kumar P, Sentman CL, Frost HR, Huang YH
Cancer Immunol Res. 2022 Aug 3;10(8):962-977. doi: 10.1158/2326-6066.CIR-21-0536.
PMID: 35696724

Life support for transitory exhausted CTLs.
Mohamed A, Huang YH
Trends Immunol. 2021 Dec;42(12):1057-1059. doi: 10.1016/j.it.2021.10.012. Epub 2021 Nov 9.
PMID: 34772619

Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019.
PMID: 34525340

IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca(2+) through the noncanonical STAT3 pathway.
Valenca-Pereira F, Fang Q, Marie IJ, Giddings EL, Fortner KA, Yang R, Villarino AV, Huang YH, Frank DA, Wen H, Levy DE, Rincon M
Proc Natl Acad Sci U S A. 2021 Sep 14;118(37) doi: 10.1073/pnas.2103444118.
PMID: 34507993

Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells.
Vella JL, Molodtsov A, Angeles CV, Branchini BR, Turk MJ, Huang YH
Life Sci Alliance. 2021 Oct;4(10) doi: 10.26508/lsa.202101056. Epub 2021 Aug 6.
PMID: 34362825

Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30.
Butler SE, Brog RA, Chang CH, Sentman CL, Huang YH, Ackerman ME
Cancer Immunol Immunother. 2022 Jan;71(1):165-176. doi: 10.1007/s00262-021-02971-y. Epub 2021 May 27.
PMID: 34046711

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