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Yina H. Huang, PhD

Title(s):
Associate Professor of Microbiology and Immunology
Associate Professor of Pathology & Laboratory Medicine

Department(s):
Microbiology and Immunology
Pathology & Laboratory Medicine

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites:
http://geiselmed.dartmouth.edu/huang/

Contact Information:


Professional Interests:

We investigate how T cells traffic and respond to infections. In particular, we study the signals that regulate T cell migration and activation to ensure protective immunity while preventing autoimmunity and immunodeficiency disease.


Selected Publications:

 

Author Correction: Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L
Sci Rep. 2018 Mar 1;8(1):4054. doi: 10.1038/s41598-018-22151-w. Epub 2018 Mar 1.
PMID: 29497089

IL-17A-Induced PLET1 Expression Contributes to Tissue Repair and Colon Tumorigenesis.
Zepp JA, Zhao J, Liu C, Bulek K, Wu L, Chen X, Hao Y, Wang Z, Wang X, Ouyang W, Kalady MF, Carman J, Yang WP, Zhu J, Blackburn C, Huang YH, Hamilton TA, Su B, Li X
J Immunol. 2017 Dec 1;199(11):3849-3857. doi: 10.4049/jimmunol.1601540. Epub 2017 Oct 25.
PMID: 29070673

Resident memory T cells in the skin mediate durable immunity to melanoma.
Malik BT, Byrne KT, Vella JL, Zhang P, Shabaneh TB, Steinberg SM, Molodtsov AK, Bowers JS, Angeles CV, Paulos CM, Huang YH, Turk MJ
Sci Immunol. 2017 Apr 14;2(10) pii: eaam6346. doi: 10.1126/sciimmunol.aam6346.
PMID: 28738020

Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis.
Li N, Xu W, Yuan Y, Ayithan N, Imai Y, Wu X, Miller H, Olson M, Feng Y, Huang YH, Jo Turk M, Hwang ST, Malarkannan S, Wang L
Sci Rep. 2017 May 3;7(1):1485. doi: 10.1038/s41598-017-01411-1. Epub 2017 May 3.
PMID: 28469254

Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer.
Hampsch RA, Shee K, Bates D, Lewis LD, Desire L, Leblond B, Demidenko E, Stefan K, Huang YH, Miller TW
Oncotarget. 2017 Mar 28;8(13):21806-21817. doi: 10.18632/oncotarget.15586.
PMID: 28423521

Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.
Xu X, Wang X, Todd EM, Jaeger ER, Vella JL, Mooren OL, Feng Y, Hu J, Cooper JA, Morley SC, Huang YH
J Immunol. 2016 Sep 1;197(5):1683-91. doi: 10.4049/jimmunol.1600874. Epub 2016 Jul 27.
PMID: 27465533

Melanoma Induces, and Adenosine Suppresses, CXCR3-Cognate Chemokine Production and T-cell Infiltration of Lungs Bearing Metastatic-like Disease.
Clancy-Thompson E, Perekslis TJ, Croteau W, Alexander MP, Chabanet TB, Turk MJ, Huang YH, Mullins DW
Cancer Immunol Res. 2015 Aug;3(8):956-67. doi: 10.1158/2326-6066.CIR-15-0015. Epub 2015 Jun 5.
PMID: 26048575

Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses.
Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller HE, Guleria I, Barth RJ, Huang YH, Wang L
Proc Natl Acad Sci U S A. 2015 May 26;112(21):6682-7. doi: 10.1073/pnas.1420370112. Epub 2015 May 11.
PMID: 25964334

Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.
Xu X, Jaeger ER, Wang X, Lagler-Ferrez E, Batalov S, Mathis NL, Wiltshire T, Walker JR, Cooke MP, Sauer K, Huang YH
PLoS One. 2014;9(8):e105561. doi: 10.1371/journal.pone.0105561. Epub 2014 Aug 18.
PMID: 25133611

Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Wang X, Boyken SE, Hu J, Xu X, Rimer RP, Shea MA, Shaw AS, Andreotti AH, Huang YH
Sci Signal. 2014 Aug 5;7(337):ra74. doi: 10.1126/scisignal.2005147. Epub 2014 Aug 5.
PMID: 25097034

View more publications on PubMed