Yina H. Huang, PhD
Title(s)
Associate Professor of Microbiology and Immunology
Associate Professor of Pathology and Laboratory Medicine
Department(s)
Microbiology and Immunology
Pathology and Laboratory Medicine
Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Websites
http:
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Contact Information
Email: Yina.H.Huang@Dartmouth.edu
Professional Interests
We investigate how T cells traffic and respond to infections. In particular, we study the signals that regulate T cell migration and activation to ensure protective immunity while preventing autoimmunity and immunodeficiency disease.
In the right place at the right time: tissue-resident memory T cells in immunity to cancer. Toward high-throughput engineering techniques for improving CAR intracellular signaling domains. Cell type-specific Interaction Analysis using Doublets in scRNA-seq (CIcADA). Superkine IL-2 and IL-33 Armored CAR T Cells Reshape the Tumor Microenvironment and Reduce Growth of Multiple Solid Tumors. Life support for transitory exhausted CTLs. Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma. IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca(2+) through the noncanonical STAT3 pathway. Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells. Engineering a natural ligand-based CAR: directed evolution of the stress-receptor NKp30. Diverse Roles of Akt in T cells. |
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