Yina H. Huang, PhD
Title(s)
Professor of Microbiology and Immunology
Professor of Pathology and Laboratory Medicine
Department(s)
Microbiology and Immunology
Pathology and Laboratory Medicine
Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Contact Information
Email: Yina.H.Huang@Dartmouth.edu
Professional Interests
We investigate how T cells traffic and respond to infections. In particular, we study the signals that regulate T cell migration and activation to ensure protective immunity while preventing autoimmunity and immunodeficiency disease.
The endogenous antigen-specific CD8(+) T cell repertoire is composed of unbiased and biased clonotypes with differential fate commitments. KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection. CD4 T cell depletion increases memory differentiation of endogenous and CAR T cells and enhances the efficacy of Super2 and IL-33-armored CAR T cells against solid tumors. Depletion of conventional CD4(+) T cells is required for robust priming and dissemination of tumor antigen-specific CD8(+) T cells in the setting of anti-CD4 therapy. Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect. Hierarchal single-cell lineage tracing reveals differential fate commitment of CD8 T-cell clones in response to acute infection. Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect. In the right place at the right time: tissue-resident memory T cells in immunity to cancer. Toward high-throughput engineering techniques for improving CAR intracellular signaling domains. Cell type-specific Interaction Analysis using Doublets in scRNA-seq (CIcADA). |
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