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James O'Malley, MS, PhD

Professor of The Dartmouth Institute
Professor of Biomedical Data Science

Additional Titles/Positions/Affiliations
Adjunct Professor of Computer Science
Adjunct Professor of Mathematics

The Dartmouth Institute
Biomedical Data Science

1994 B.Sc. (Hons) in Statistics: University of Canterbury, New Zealand
1999 M.S. in Applied Statistics: Purdue University, West Lafayette, Indiana
1999 Ph.D. in Statistics: University of Canterbury, New Zealand
2001 Postdoctoral-fellowship in Biostatistics: Harvard Medical School, Boston, Massachusetts

Norris Cotton Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice

Curriculum Vitae

NIH Biosketch


Contact Information

The Dartmouth Institute
Williamson Translational Research Building
1 Medical Center Drive
Lebanon NH 03756

Office: 544
Phone: 603-646-5653
Fax: 603-653-0896

Assistant: Kathryn Hutchins
Asst. Email:

Professional Interests

My research interests span both statistical methodology and various areas of medicine and health care. My prior and ongoing contributions to statistical methodology involve statistical inference for social networks, multivariate hierarchical models, comparative effectiveness research including causal inference for both randomized and observational studies, and Bayesian analysis. Specific research projects are typically motivated by problems encountered in my collaborative work with physicians, sociologists, health economists, health services researchers, epidemiologists and others. Application areas of focus include evaluating the relationship between health and social networks, evaluation/estimation of variations in health quality and outcomes, vascular surgery and cardiology, and evaluation of medical devices.

Rotations and Thesis Projects

Statistical Methods:
- Analysis of Social Network Data
- Multivariate-Multilevel Models
- Comparative Effectiveness Research (Causal Inference)
- Bayesian Analysis
- Design and Analysis of Medical Device Clinical Trials

Collaborative Work:
- Social networks and health
- The measurement and reporting of health care quality
- Diffusion of medical technology
- Tracking health systems
- Comparative effectiveness in vascular surgery
- Comparative effectiveness in cardiology
- Comparative effectiveness in mental health

Grant Information

Projects currently leading or in a leading role:

NIH/NIA P01AG019783 (Skinner PI) 07/01/2001-11/30/2023
Causes and Consequences of Healthcare Efficiency
PI: Statistical and Network Analysis Core

AHRQ U19HS024075 (Fisher PI) 09/01/2015-08/31/2021
Accelerating the Use of Evidence-Based Innovations in Healthcare Systems
PI: Data Core

NIH P20GM130454 (Whitfield PI)
8/1/2019 - 7/30/2024
Center for Quantitative Biology: A focus on "omics", from organisms to single cells (COBRE)
PI: Data Core

IHS-2018C2-12902-IC (Leyenaar PI)
7/1/2019 - 6/30/2023
Comparative Effectiveness of Direct Admission & Admission through Emergency Departments for Children
PI: Sub-contract

NIH RO1 HS025408 (Landon PI)
9/30/2017 - 7/31/2021
Identifying Predictors of Hospital Admission from the ED Among the Elderly
PI: Sub-contract

PCS-2017C2-7724-IC (Pratt PI)
2/15/2019 - 2/14/2024
Integrated Physical and Mental Health Self¬-management Compared to Chronic Disease Self-¬management
PI: Sub-contract

Notable completed projects:

PCORI ME-1503-28261 (O’Malley PI)
Advancing Patient-Centered Outcomes Research in Survival Data with Unmeasured Confounding to Improve Patient Risk Communication

NIH 1U01 AG046830 (Skinner PI)
Diffusion of Medical Technology and Effects on Outcomes and Expenditures
Project Leader: Methods for Modeling the Diffusion of Implantable Cardiac Defibrillators

NIH 1R01HL109263-01A1 (O’Malley, Subramanian PIs) 04/01/2012-03/31/2015
Proximity to Food Establishments and BMI in the Framingham Heart Study

NIH 1RC4MH092717-01 (O’Malley PI)
Accounting for confounding bias and heterogeneity in comparative effectiveness

NIH/NIA P01 AG0309301 (Christakis PI),
Networks and Neighborhoods
Project Leader: Methods for the Analysis of Longitudinal Social Network Data

Courses Taught

2018- Biostatistics III: Statistical Analysis of Complex Data (QBS 122)
2014-2018 The Practice of Statistics in Medicine (ECS.245.1-TFA13)
2013-2014 Advanced Statistical Methods (ECS.245.1-TFA13)


In 2011 I received the Mid-career Excellence award from the Health Policy Section of the ASA and in 2012 became an elected fellow of the ASA. In 2019 I was the recipient of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Award for Excellence in Methodology in Health Economics and Outcomes Research.

I was chair of the Health Policy Statistics Section of the America Statistical Association (ASA) in 2008, co-chair of the 2011 International Conference on Health Policy Statistics, and am an Associate Editor at Statistics in Medicine.

I was one of the organizers of the Dartmouth Interdisciplinary Network Research (DINR) seminar series (

Mentoring Information

Post-doctoral fellows
2007-2009 Brian Neelon, Postdoctoral Fellow, Harvard Medical School
2010-2012 Sudeshna Paul, Postdoctoral Fellow, Harvard Medical School
2011-2014 Jaeun Choi, Postdoctoral Fellow, Harvard Medical School
2015-2018 Erika Moen, R25 Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2015-2017 Weston Viles, R25 Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2016-2018 Pablo Martinez-Camblor, Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2018-2020 Seho Park, Postdoctoral Fellow, Geisel School of Medicine at Dartmouth

PhD Students
2017- Guanqing Chen, Ph.D. Candidate, Program in Quantitative Biomedical Science
2017- Carly Bobak (Co-advisor), Program in Quantitative Biomedical Science
2017 - Chuankai An (Co-advisor), Computer Science
2018- Xin Ran, Program in Quantitative Biomedical Science

PhD Committees
2014-2017 Elizabeth Nichols, Program in Health Policy and Clinical Practice
2018-2020 Helen Newton, Program in Health Policy and Clinical Practice
2019- Renata West Yen, Program in Health Policy and Clinical Practice
2020- Reed Bratches, Program in Health Policy and Clinical Practice
2020- Catherine Pollack, Program in Quantitative Biomedical Science
2020- Joshua Levy, Program in Quantitative Biomedical Science
2020- Devin Parker, Program in Health Policy and Clinical Practice

Selected Publications


Sacubitril/Valsartan vs. ACEi/ARB at Hospital Discharge and 5-Year Survival in Older Patients with Heart Failure with Reduced Ejection Fraction: A Decision Analysis Approach.
Gilstrap L, Zipkin RJ, Barnes JA, King A, O'Malley AJ, Gaziano TA, Tosteson ANA
Am Heart J. 2022 May 4; pii: S0002-8703(22)00082-5. doi: 10.1016/j.ahj.2022.04.007. Epub 2022 May 4.
PMID: 35525261

Prevalence of Children With Medical Complexity and Associations With Health Care Utilization and In-Hospital Mortality.
Leyenaar JK, Schaefer AP, Freyleue SD, Austin AM, Simon TD, Van Cleave J, Moen EL, O'Malley AJ, Goodman DC
JAMA Pediatr. 2022 Apr 18;:e220687. doi: 10.1001/jamapediatrics.2022.0687. Epub 2022 Apr 18.
PMID: 35435932

Perceptions of the impact of COVID-19 on healthcare communication in a nationally representative cross-sectional survey of family caregivers.
Bratches RWR, Freundlich NZ, Dionne-Odom JN, O'Malley AJ, Barr PJ
BMJ Open. 2022 Apr 13;12(4):e051154. doi: 10.1136/bmjopen-2021-051154. Epub 2022 Apr 13.
PMID: 35418422

Innovations in Care Delivery for Patients With Serious Mental Illness Among Accountable Care Organizations.
Newton H, Busch SH, Brunette MF, Maust DT, O'Malley AJ, Meara E
Psychiatr Serv. 2022 Apr 5;:appips202000484. doi: 10.1176/ Epub 2022 Apr 5.
PMID: 35378992

Estimating population-averaged hazard ratios in the presence of unmeasured confounding.
Martinez-Camblor P, MacKenzie TA, O'Malley AJ
Int J Biostat. 2022 Mar 23; doi: 10.1515/ijb-2021-0096. Epub 2022 Mar 23.
PMID: 35320637

A national evaluation of geographic accessibility and provider availability of obesity medicine diplomates in the United States between 2011 and 2019.
Pollack CC, Onega T, Emond JA, Vosoughi S, O'Malley AJ, McClure AC, Rothstein RI, Gilbert-Diamond D
Int J Obes (Lond). 2022 Mar;46(3):669-675. doi: 10.1038/s41366-021-01024-9. Epub 2022 Jan 7.
PMID: 34992242

A measure of local uniqueness to identify linchpins in a social network with node attributes.
Nemesure MD, Schwedhelm TM, Sacerdote S, O'Malley AJ, Rozema LR, Moen EL
Appl Netw Sci. 2021;6 pii: 56. doi: 10.1007/s41109-021-00400-8. Epub 2021 Jul 17.
PMID: 34938853

Analysis of Consistency in Emergency Department Physician Variation in Propensity for Admission Across Patient Sociodemographic Groups.
Khidir H, McWilliams JM, O'Malley AJ, Zaborski L, Landon BE, Smulowitz PB
JAMA Netw Open. 2021 Sep 1;4(9):e2125193. doi: 10.1001/jamanetworkopen.2021.25193. Epub 2021 Sep 1.
PMID: 34546373

National Trends In ED Visits, Hospital Admissions, And Mortality For Medicare Patients During The COVID-19 Pandemic.
Smulowitz PB, O'Malley AJ, Khidir H, Zaborski L, McWilliams JM, Landon BE
Health Aff (Millwood). 2021 Sep;40(9):1457-1464. doi: 10.1377/hlthaff.2021.00561.
PMID: 34495730

Treatment intensity and mortality among COVID-19 patients with dementia: A retrospective observational study.
Barnato AE, Birkmeyer JD, Skinner JS, O'Malley AJ, Birkmeyer NJO
J Am Geriatr Soc. 2022 Jan;70(1):40-48. doi: 10.1111/jgs.17463. Epub 2021 Oct 2.
PMID: 34480354

View more publications on PubMed