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James O'Malley, MS, PhD

Professor of The Dartmouth Institute
Professor of Biomedical Data Science

Additional Titles/Positions/Affiliations
Adjunct Professor of Computer Science
Adjunct Professor of Mathematics

The Dartmouth Institute
Biomedical Data Science

1994 B.Sc. (Hons) in Statistics: University of Canterbury, New Zealand
1999 M.S. in Applied Statistics: Purdue University, West Lafayette, Indiana
1999 Ph.D. in Statistics: University of Canterbury, New Zealand
2001 Postdoctoral-fellowship in Biostatistics: Harvard Medical School, Boston, Massachusetts

Norris Cotton Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice

Curriculum Vitae

NIH Biosketch


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Contact Information

The Dartmouth Institute
Williamson Translational Research Building
1 Medical Center Drive
Lebanon NH 03756

Office: 546
Phone: 603-646-5653
Fax: 603-653-0896
Email: James.OMalley@Dartmouth.edu

Assistant: Kathy Stroffolino
Asst. Email: Kathy.M.Stroffolino@dartmouth.edu

Professional Interests

My research interests span both statistical methodology and various areas of medicine and health care. My prior and ongoing contributions to statistical methodology involve statistical inference for social networks, multivariate hierarchical models, comparative effectiveness research including causal inference for both randomized and observational studies, and Bayesian analysis. Specific research projects are typically motivated by problems encountered in my collaborative work with physicians, sociologists, health economists, health services researchers, epidemiologists and others. Application areas of focus include evaluating the relationship between health and social networks, evaluation/estimation of variations in health quality and outcomes, vascular surgery and cardiology, and evaluation of medical devices.

Rotations and Thesis Projects

Statistical Methods:
- Analysis of Social Network Data
- Multivariate-Multilevel Models
- Comparative Effectiveness Research (Causal Inference)
- Bayesian Analysis
- Design and Analysis of Medical Device Clinical Trials

Collaborative Work:
- Social networks and health
- The measurement and reporting of health care quality
- Diffusion of medical technology
- Tracking health systems
- Comparative effectiveness in vascular surgery
- Comparative effectiveness in cardiology
- Comparative effectiveness in mental health

Grant Information

Projects currently leading or in a leading role:

NIH/NIA P01AG019783 (Skinner PI) 07/01/2001-11/30/2023
Causes and Consequences of Healthcare Efficiency
PI: Statistical and Network Analysis Core

AHRQ U19HS024075 (Fisher PI) 09/01/2015-08/31/2021
Accelerating the Use of Evidence-Based Innovations in Healthcare Systems
PI: Data Core

NIH P20GM130454 (Whitfield PI)
8/1/2019 - 7/30/2024
Center for Quantitative Biology: A focus on "omics", from organisms to single cells (COBRE)
PI: Data Core

IHS-2018C2-12902-IC (Leyenaar PI)
7/1/2019 - 6/30/2023
Comparative Effectiveness of Direct Admission & Admission through Emergency Departments for Children
PI: Sub-contract

NIH RO1 HS025408 (Landon PI)
9/30/2017 - 7/31/2021
Identifying Predictors of Hospital Admission from the ED Among the Elderly
PI: Sub-contract

PCS-2017C2-7724-IC (Pratt PI)
2/15/2019 - 2/14/2024
Integrated Physical and Mental Health Self¬-management Compared to Chronic Disease Self-¬management
PI: Sub-contract

Notable completed projects:

PCORI ME-1503-28261 (O’Malley PI)
Advancing Patient-Centered Outcomes Research in Survival Data with Unmeasured Confounding to Improve Patient Risk Communication

NIH 1U01 AG046830 (Skinner PI)
Diffusion of Medical Technology and Effects on Outcomes and Expenditures
Project Leader: Methods for Modeling the Diffusion of Implantable Cardiac Defibrillators

NIH 1R01HL109263-01A1 (O’Malley, Subramanian PIs) 04/01/2012-03/31/2015
Proximity to Food Establishments and BMI in the Framingham Heart Study

NIH 1RC4MH092717-01 (O’Malley PI)
Accounting for confounding bias and heterogeneity in comparative effectiveness

NIH/NIA P01 AG0309301 (Christakis PI),
Networks and Neighborhoods
Project Leader: Methods for the Analysis of Longitudinal Social Network Data

Courses Taught

2018- Biostatistics III: Statistical Analysis of Complex Data (QBS 122)
2014-2018 The Practice of Statistics in Medicine (ECS.245.1-TFA13)
2013-2014 Advanced Statistical Methods (ECS.245.1-TFA13)

Mentoring Information

Post-doctoral fellows
2007-2009 Brian Neelon, Postdoctoral Fellow, Harvard Medical School
2010-2012 Sudeshna Paul, Postdoctoral Fellow, Harvard Medical School
2011-2014 Jaeun Choi, Postdoctoral Fellow, Harvard Medical School
2015-2018 Erika Moen, R25 Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2015-2017 Weston Viles, R25 Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2016-2018 Pablo Martinez-Camblor, Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2018-2020 Seho Park, Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2021-2022 Carly Bobak, Postdoctoral Fellow, Geisel School of Medicine at Dartmouth

PhD Students
2017-2021 Guanqing Chen, Ph.D. Candidate, Program in Quantitative Biomedical Science
2017-2021 Carly Bobak (Co-advisor), Program in Quantitative Biomedical Science
2017-2019 Chuankai An (Co-advisor), Computer Science
2018- Xin Ran, Program in Quantitative Biomedical Science
2022- Bo Qin, Program in Quantitative Biomedical Science
2022- Haobin (Tony) Chen, Program in Quantitative Biomedical Science

PhD Committees
2014-2017 Elizabeth Nichols, Program in Health Policy and Clinical Practice
2018-2020 Helen Newton, Program in Health Policy and Clinical Practice
2019- Renata West Yen, Program in Health Policy and Clinical Practice
2020-2022 Reed Bratches, Program in Health Policy and Clinical Practice
2020-2022 Catherine Pollack, Program in Quantitative Biomedical Science
2020-2021 Joshua Levy, Program in Quantitative Biomedical Science
2022- Sarah Cornelius, Program in Quantitative Biomedical Science
2022- Bruno Scodari, Program in Quantitative Biomedical Science


In 2011 I received the Mid-career Excellence award from the Health Policy Section of the ASA and in 2012 became an elected fellow of the ASA. In 2019 I was the recipient of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Award for Excellence in Methodology in Health Economics and Outcomes Research. In 2021 I received the Peggy Y. Thomson Professorship in the Evaluative Clinical Sciences

I was chair of the Health Policy Statistics Section of the America Statistical Association (ASA) in 2008, co-chair of the 2011 International Conference on Health Policy Statistics, and am an Associate Editor at Statistics in Medicine.

I was one of the organizers of the Dartmouth Interdisciplinary Network Research (DINR) seminar series (http://www.dartmouth.edu/~dinr/).

Selected Publications


Association of neurocognitive disorders with morbidity and mortality in older adults undergoing major surgery in the USA: a retrospective, population-based, cohort study.
Abess AT, Deiner SG, Briggs A, Whitlock EL, Charette KE, Chow VW, Shaefi S, Martinez-Camblor P, O'Malley AJ, Boone MD
Lancet Healthy Longev. 2023 Nov;4(11):e608-e617. doi: 10.1016/S2666-7568(23)00194-0.
PMID: 37924842

Constructing within and between hospital physician social networks for modeling physician research participation.
Bobak CA, Mohan D, Murphy MA, Barnato AE, O'Malley AJ
BMC Med Res Methodol. 2023 Oct 28;23(1):253. doi: 10.1186/s12874-023-02069-2. Epub 2023 Oct 28.
PMID: 37898745

Racial differences in low value care among older adult Medicare patients in US health systems: retrospective cohort study.
Ganguli I, Mackwood MB, Yang CW, Crawford M, Mulligan KL, O'Malley AJ, Fisher ES, Morden NE
BMJ. 2023 Oct 25;383:e074908. doi: 10.1136/bmj-2023-074908. Epub 2023 Oct 25.
PMID: 37879735

The role of comorbidities, medications, and social determinants of health in understanding urban-rural outcome differences among patients with heart failure.
Zeitler EP, Joly J, Leggett CG, Wong SL, O'Malley AJ, Kraft SA, Mackwood MB, Jones ST, Skinner JS
J Rural Health. 2023 Oct 22; doi: 10.1111/jrh.12803. Epub 2023 Oct 22.
PMID: 37867249

Clinically informed machine learning elucidates the shape of hospice racial disparities within hospitals.
Khayal IS, O'Malley AJ, Barnato AE
NPJ Digit Med. 2023 Oct 12;6(1):190. doi: 10.1038/s41746-023-00925-5. Epub 2023 Oct 12.
PMID: 37828119

Adoption and Diffusion of Transcarotid Artery Revascularization in Contemporary Practice.
Columbo JA, Stone DH, Martinez-Camblor P, Goodney PP, O'Malley AJ
Circ Cardiovasc Interv. 2023 Sep;16(9):e012805. doi: 10.1161/CIRCINTERVENTIONS.122.012805. Epub 2023 Sep 19.
PMID: 37725675

Association between a network-based physician linchpin score and cancer patient mortality: A SEER-Medicare analysis.
Moen EL, Schmidt RO, Onega T, Brooks GA, O'Malley AJ
J Natl Cancer Inst. 2023 Sep 7; pii: djad180. doi: 10.1093/jnci/djad180. Epub 2023 Sep 7.
PMID: 37676831

Pediatric Hospitalizations at Rural and Urban Teaching and Nonteaching Hospitals in the US, 2009-2019.
Leyenaar JK, Freyleue SD, Arakelyan M, Goodman DC, O'Malley AJ
JAMA Netw Open. 2023 Sep 5;6(9):e2331807. doi: 10.1001/jamanetworkopen.2023.31807. Epub 2023 Sep 5.
PMID: 37656457

Who's Accountable? Low-Value Care Received By Medicare Beneficiaries Outside Of Their Attributed Health Systems.
Ganguli I, Crawford ML, Usadi B, Mulligan KL, O'Malley AJ, Yang CW, Fisher ES, Morden NE
Health Aff (Millwood). 2023 Aug;42(8):1128-1139. doi: 10.1377/hlthaff.2022.01319.
PMID: 37549329

Response by Zeitler et al to Letter Regarding Article, "Comparative Effectiveness of Left Atrial Appendage Occlusion Versus Oral Anticoagulation by Sex".
Zeitler EP, Kearing S, Coylewright M, Nair D, Hsu JC, Darden D, O'Malley AJ, Russo AM, Al-Khatib SM
Circulation. 2023 Aug 8;148(6):510-511. doi: 10.1161/CIRCULATIONAHA.123.065359. Epub 2023 Aug 7.
PMID: 37549206

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