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James O'Malley, MS, PhD

Professor of The Dartmouth Institute
Professor of Biomedical Data Science

Additional Titles/Positions/Affiliations:
Adjunct Professor of Computer Science
Adjunct Professor of Mathematics

The Dartmouth Institute
Biomedical Data Science

1994 B.Sc. (Hons) in Statistics: University of Canterbury, New Zealand
1999 M.S. in Applied Statistics: Purdue University, West Lafayette, Indiana
1999 Ph.D. in Statistics: University of Canterbury, New Zealand
2001 Postdoctoral-fellowship in Biostatistics: Harvard Medical School, Boston, Massachusetts

Norris Cotton Cancer Center
Quantitative Biomedical Sciences
The Dartmouth Institute for Health Policy and Clinical Practice

Curriculum Vitae:

NIH Biosketch:


Contact Information:

The Dartmouth Institute
Williamson Translational Research Building
1 Medical Center Drive
Lebanon NH 03756

Office: 544
Phone: 603-653-0854
Fax: 603-653-0896

Assistant: Kathryn Hutchins
Asst. Phone: 603-653-0835
Asst. Email:

Professional Interests:

My research interests span both statistical methodology and various areas of medicine and health care. My prior and ongoing contributions to statistical methodology involve statistical inference for social networks, multivariate hierarchical models, comparative effectiveness research including causal inference for both randomized and observational studies, and Bayesian analysis. Specific research projects are typically motivated by problems encountered in my collaborative work with physicians, sociologists, health economists, health services researchers, epidemiologists and others. Application areas of focus include evaluating the relationship between health and social networks, evaluation/estimation of variations in health quality and outcomes, vascular surgery and cardiology, and evaluation of medical devices.

Rotations and Thesis Projects:

Statistical Methods:
- Analysis of Social Network Data
- Multivariate-Multilevel Models
- Comparative Effectiveness Research (Causal Inference)
- Bayesian Analysis
- Design and Analysis of Medical Device Clinical Trials

Collaborative Work:
- Social networks and health
- The measurement and reporting of health care quality
- Diffusion of medical technology
- Tracking health systems
- Comparative effectiveness in vascular surgery
- Comparative effectiveness in cardiology
- Comparative effectiveness in mental health

Grant Information:

Projects currently leading or in a leading role:

NIH/NIA P01AG019783 (Skinner PI) 07/01/2001-11/30/2023
Causes and Consequences of Healthcare Efficiency
PI: Statistical and Network Analysis Core

AHRQ U19HS024075 (Fisher PI) 09/01/2015-08/31/2021
Accelerating the Use of Evidence-Based Innovations in Healthcare Systems
PI: Data Core

NIH P20GM130454 (Whitfield PI)
8/1/2019 - 7/30/2024
Center for Quantitative Biology: A focus on "omics", from organisms to single cells (COBRE)
PI: Data Core

IHS-2018C2-12902-IC (Leyenaar PI)
7/1/2019 - 6/30/2023
Comparative Effectiveness of Direct Admission & Admission through Emergency Departments for Children
PI: Sub-contract

NIH RO1 HS025408 (Landon PI)
9/30/2017 - 7/31/2021
Identifying Predictors of Hospital Admission from the ED Among the Elderly
PI: Sub-contract

PCS-2017C2-7724-IC (Pratt PI)
2/15/2019 - 2/14/2024
Integrated Physical and Mental Health Self¬-management Compared to Chronic Disease Self-¬management
PI: Sub-contract

Notable completed projects:

PCORI ME-1503-28261 (O’Malley PI)
Advancing Patient-Centered Outcomes Research in Survival Data with Unmeasured Confounding to Improve Patient Risk Communication

NIH 1U01 AG046830 (Skinner PI)
Diffusion of Medical Technology and Effects on Outcomes and Expenditures
Project Leader: Methods for Modeling the Diffusion of Implantable Cardiac Defibrillators

NIH 1R01HL109263-01A1 (O’Malley, Subramanian PIs) 04/01/2012-03/31/2015
Proximity to Food Establishments and BMI in the Framingham Heart Study

NIH 1RC4MH092717-01 (O’Malley PI)
Accounting for confounding bias and heterogeneity in comparative effectiveness

NIH/NIA P01 AG0309301 (Christakis PI),
Networks and Neighborhoods
Project Leader: Methods for the Analysis of Longitudinal Social Network Data

Courses Taught:

2018- Biostatistics III: Statistical Analysis of Complex Data (QBS 122)
2014-2018 The Practice of Statistics in Medicine (ECS.245.1-TFA13)
2013-2014 Advanced Statistical Methods (ECS.245.1-TFA13)


In 2011 I received the Mid-career Excellence award from the Health Policy Section of the ASA and in 2012 became an elected fellow of the ASA. In 2019 I was the recipient of the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) Award for Excellence in Methodology in Health Economics and Outcomes Research.

I was chair of the Health Policy Statistics Section of the America Statistical Association (ASA) in 2008, co-chair of the 2011 International Conference on Health Policy Statistics, and am an Associate Editor at Statistics in Medicine.

I was one of the organizers of the Dartmouth Interdisciplinary Network Research (DINR) seminar series (

Mentoring Information:

Post-doctoral fellows
2015-2018 Erika Moen, R25 Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2015-2017 Weston Viles, R25 Postdoctoral Fellow, Geisel School of Medicine at Dartmouth
2016-2018 Pablo Martinez-Camblor, Postdoctoral Fellow, Geisel School of Medicine at Dartmouth

PhD Students
2017- Guanqing Chen, Ph.D. Candidate, Program in Quantitative Biomedical Science
2017- Carly Bobak (Co-advisor), Program in Quantitative Biomedical Science
2017 - Chuankai An (Co-advisor), Computer Science
2018- Xin Ran, Program in Quantitative Biomedical Science

PhD Committees
2014-2017 Elizabeth Nichols, Program in Health Policy and Clinical Practice
2018-2020 Helen Newton, Program in Health Policy and Clinical Practice
2019- Renata West Yen, Program in Health Policy and Clinical Practice
2020- Reed Bratches, Program in Health Policy and Clinical Practice
2020- Catherine Pollack, Program in Quantitative Biomedical Science
2020- Joshua Levy, Program in Quantitative Biomedical Science
2020- Devin Parker, Program in Health Policy and Clinical Practice

Selected Publications:


Social connections and the healthfulness of food choices in an employee population.
Levy DE, Pachucki MC, O'Malley AJ, Porneala B, Yaqubi A, Thorndike AN
Nat Hum Behav. 2021 Apr 22; doi: 10.1038/s41562-021-01103-x. Epub 2021 Apr 22.
PMID: 33888881

Infant Mortality Associated With Prenatal Opioid Exposure.
Leyenaar JK, Schaefer AP, Wasserman JR, Moen EL, O'Malley AJ, Goodman DC
JAMA Pediatr. 2021 Apr 12; doi: 10.1001/jamapediatrics.2020.6364. Epub 2021 Apr 12.
PMID: 33843963

Videogame intervention to increase advance care planning conversations by hospitalists with older adults: study protocol for a stepped-wedge clinical trial.
Mohan D, O'Malley AJ, Chelen J, MacMartin M, Murphy M, Rudolph M, Barnato A
BMJ Open. 2021 Mar 22;11(3):e045084. doi: 10.1136/bmjopen-2020-045084. Epub 2021 Mar 22.
PMID: 33753443

Time dependent hazard ratio estimation using instrumental variables without conditioning on an omitted covariate.
MacKenzie TA, Martinez-Camblor P, O'Malley AJ
BMC Med Res Methodol. 2021 Mar 20;21(1):56. doi: 10.1186/s12874-021-01245-6. Epub 2021 Mar 20.
PMID: 33743583

Estimating Heterogeneous Effects of a Policy Intervention across Organizations when Organization Affiliation is Missing for the Control Group: Application to the Evaluation of Accountable Care Organizations.
Chen G, Lewis VA, Gottlieb D, O'Malley AJ
Health Serv Outcomes Res Methodol. 2021 Mar;21(1):54-68. doi: 10.1007/s10742-020-00230-8. Epub 2021 Jan 4.
PMID: 33658885

Association of Adoption of Transcarotid Artery Revascularization With Center-Level Perioperative Outcomes.
Columbo JA, Martinez-Camblor P, O'Malley AJ, Stone DH, Kashyap VS, Powell RJ, Schermerhorn ML, Malas M, Nolan BW, Goodney PP
JAMA Netw Open. 2021 Feb 1;4(2):e2037885. doi: 10.1001/jamanetworkopen.2020.37885. Epub 2021 Feb 1.
PMID: 33616666

A Novel Cluster Sampling Design that Couples Multiple Surveys to Support Multiple Inferential Objectives.
O'Malley AJ, Park S
Health Serv Outcomes Res Methodol. 2020 Sep;20(2-3):85-110. doi: 10.1007/s10742-020-00210-y. Epub 2020 Jun 9.
PMID: 33613088

Variation In Emergency Department Admission Rates Among Medicare Patients: Does The Physician Matter?
Smulowitz PB, O'Malley AJ, Zaborski L, McWilliams JM, Landon BE
Health Aff (Millwood). 2021 Feb;40(2):251-257. doi: 10.1377/hlthaff.2020.00670.
PMID: 33523749

Assessment of Racial Disparities in Primary Care Physician Specialty Referrals.
Landon BE, Onnela JP, Meneades L, O'Malley AJ, Keating NL
JAMA Netw Open. 2021 Jan 4;4(1):e2029238. doi: 10.1001/jamanetworkopen.2020.29238. Epub 2021 Jan 4.
PMID: 33492373

Hospital-based health systems 20 years later: A taxonomy for policy research and analysis.
Shortell SM, Gottlieb DJ, Martinez Camblor P, O'Malley AJ
Health Serv Res. 2021 Jan 11; doi: 10.1111/1475-6773.13621. Epub 2021 Jan 11.
PMID: 33429460

View more publications on PubMed