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Periannan Kuppusamy, PhD

Title(s):
Professor of Radiology
Professor of Medicine

Department(s):
Radiology
Medicine

Education:
1987-90 Cardiovascular Fellowship - Johns Hopkins University
1986-87 Fogarty Fellow, National Institutes of Health
1980-85 PhD - Indian Institute of Technology (Chennai)
1975-77 MSc - University of Madras
1972-75 BSc - University of Madras

Programs:
Program in Experimental and Molecular Medicine

Contact Information:

601 Rubin Building
One Medical Center Dr
Lebanon NH 03756

Office: 601 Rubin Bldg
Phone: 603-653-3577
Email: kuppu@dartmouth.edu


Professional Interests:

Oxygen/ROS pathobiology
Electron paramagnetic resonance
Probes and methods for oxygen measurement
Molecular therapeutics for cancer
Myocardial infarction and protection

Rotations and Thesis Projects:

Triple Negative Breast Cancer - Biology & Therapeutics using PDX model
Pancreatic cancer - Molecular Therapeutics (STAT3 inhibitor)
Oxygen signalling in cancer progression and treatment
EPR oximetry (OxyChip - technology development)
Clinical oximetry (for cancer)

Grant Information:

R01 NIBIB (2004-2019) - "Probes and methods for clinical oximetry" (PI)
P01 NCI (2015-2020) - Project 2: "Direct & repeated pO2 measurements for cancer using EPR oximetry with OxyChip" (PI)
R21 NIBIB (2012-2016) - "Hand-held scanner for EPR oximetry" (PI)
R21 NIH (2013-2016) - "Real-time monitoring of cerebral tissue oxygen in ischemic stroke" (PI)
R21 NIBIB (2016-2019) - "Miniature EPR system for on-site oximetry" (PI)
R01 NCI (2014-2019) - "Dissecting the role of STAT3 and targeting in ovarian cancer" (Co-I)
R01 NHLBI (2013-2018) - "Mechanisms of Coronary Vasomotor Control" (Co-I)
R21 AG052722 (2017-2019) "Caveolae as capacitors for oxygen" (Co-I)

Biography:

Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry).
He has published over 350 peer-reviewed scientific papers, reviews, and book chapters. As of 06/2015, he has 15,808 citations of my research publications including 6,720 in the last 5 years. The h-index of his publications is 62.
Dr. Kuppusamy has received continuous funding from the National Institutes of Health (NIH) and the American Heart Association.
Dr. Kuppusamy has received the Silver Medal for Biology and Medicine from the International EPR Society in 2006; honorary title of “Doctor Honoris Causa” from the University of Pécs, in Pécs, Hungary in 2008; recipient of the 2014 Piette Award by the EPR Society; and 2015 Distinguished Alumni Award from Indian Institute of Technology (IIT) Chennai.
Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2). Development of a clinical version of this technology is in progress.

Mentoring Information:

Active:
Jesse Mast (PhD candidate, PEMM)

Past:
K Awardees: Valery Khramtsov (K01); Elaine Fisher (K01); Hiranmoy Das (K01); Mahmood Khan (SDG/AHA); Rajan Gogna (K99)

Post-Doctoral Fellows: Ravi A. Shankar, MD; Haiquan Li, MD; G. Ilangovan, PhD; R. Pandian, PhD; S. P. Evalappan, MD; Anna Bratasz, PhD ; Ashish Sharma, MD ; Vijay Kumar Kutala, PhD; Simi M. Chacko, PhD; Mahmood Khan, PhD; Joe Z. Sostaric, PhD; Rizwan Ahmad, PhD; K. Selvendiran, PhD; Iyappu K Mohan, PhD; Sheik Wisel, PhD; Yazhini Ravi, MBBS; Balazs Bognar, PhD; Guru Meenakshisundaram, PhD; Masaki Nagane, DVM PhD; Esha Madan, PhD; Rajan Gogna, PhD

Graduate (PhD) students: Rizwan Ahmad, Deepti S. Vikram, Aditi C. Kulkarni, Simi M. Chacko, Jonathan Pillai, Guruguhan Meenakshisundaram, Lucas Citro



Selected Publications:

 

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction.
Prabhat AM, Kuppusamy ML, Naidu SK, Meduru S, Reddy PT, Dominic A, Khan M, Rivera BK, Kuppusamy P
Front Cardiovasc Med. 2018;5:114. doi: 10.3389/fcvm.2018.00114. Epub 2018 Aug 28.
PMID: 30211171

Electron-Spin-Resonance Dipstick.
Zgadzai O, Twig Y, Wolfson H, Ahmad R, Kuppusamy P, Blank A
Anal Chem. 2018 Jul 3;90(13):7830-7836. doi: 10.1021/acs.analchem.8b00917. Epub 2018 Jun 13.
PMID: 29856211

Pre-clinical evaluation of OxyChip for long-term EPR oximetry.
Hou H, Khan N, Gohain S, Kuppusamy ML, Kuppusamy P
Biomed Microdevices. 2018 Mar 16;20(2):29. doi: 10.1007/s10544-018-0272-x. Epub 2018 Mar 16.
PMID: 29549438

Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.
Nagane M, Kuppusamy ML, An J, Mast JM, Gogna R, Yasui H, Yamamori T, Inanami O, Kuppusamy P
Radiat Res. 2018 May;189(5):519-528. doi: 10.1667/RR14781.1. Epub 2018 Feb 23.
PMID: 29474156

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
Madan E, Parker TM, Bauer MR, Dhiman A, Pelham CJ, Nagane M, Kuppusamy ML, Holmes M, Holmes TR, Shaik K, Shee K, Kiparoidze S, Smith SD, Park YA, Gomm JJ, Jones LJ, Tomas AR, Cunha AC, Selvendiran K, Hansen LA, Fersht AR, Hideg K, Gogna R, Kuppusamy P
J Biol Chem. 2018 Mar 23;293(12):4262-4276. doi: 10.1074/jbc.RA117.000950. Epub 2018 Jan 30.
PMID: 29382728

Development of the Implantable Resonator System for Clinical EPR Oximetry.
Caston RM, Schreiber W, Hou H, Williams BB, Chen EY, Schaner PE, Jarvis LA, Flood AB, Petryakov SV, Kmiec MM, Kuppusamy P, Swartz HM
Cell Biochem Biophys. 2017 Dec;75(3-4):275-283. doi: 10.1007/s12013-017-0809-2. Epub 2017 Jul 7.
PMID: 28687906

Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents.
Bognar B, Kuppusamy ML, Madan E, Kalai T, Balog M, Jeko J, Kuppusamy P, Hideg K
Med Chem. 2017;13(8):761-772. doi: 10.2174/1871520617666170522124712.
PMID: 28530545

Dynamic EPR Oximetry of Changes in Intracerebral Oxygen Tension During Induced Thromboembolism.
Hou H, Khan N, Gohain S, Eskey CJ, Moodie KL, Maurer KJ, Swartz HM, Kuppusamy P
Cell Biochem Biophys. 2017 Dec;75(3-4):285-294. doi: 10.1007/s12013-017-0798-1. Epub 2017 Apr 22.
PMID: 28434138

Anticancer potential of diarylidenyl piperidone derivatives, HO-4200 and H-4318, in cisplatin resistant primary ovarian cancer.
ElNaggar AC, Saini U, Naidu S, Wanner R, Sudhakar M, Fowler J, Nagane M, Kuppusamy P, Cohn DE, Selvendiran K
Cancer Biol Ther. 2016 Oct 2;17(10):1107-1115.
PMID: 27415751

Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer's disease Mouse Brain.
Fang D, Zhang Z, Li H, Yu Q, Douglas JT, Bratasz A, Kuppusamy P, Yan SS
J Alzheimers Dis. 2016;51(2):571-80. doi: 10.3233/JAD-150917.
PMID: 26890765