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Periannan Kuppusamy, PhD

Professor of Radiology
Professor of Medicine


1987-90 Cardiovascular Fellowship - Johns Hopkins University
1986-87 Fogarty Fellow, National Institutes of Health
1980-85 PhD - Indian Institute of Technology (Chennai)
1975-77 MSc - University of Madras
1972-75 BSc - University of Madras

Program in Experimental and Molecular Medicine

Contact Information:

601 Rubin Building
One Medical Center Dr
Lebanon NH 03756

Office: 601 Rubin Bldg
Phone: 603-653-3577
Fax: 603-643-0304
Email: kuppu@dartmouth.edu

Assistant: Jennifer Thody
Asst. Phone: 603-650-1952
Asst. Email: Jennfer.Thody@Dartmouth.edu

Professional Interests:

Oxygen/ROS pathobiology
Electron paramagnetic resonance
Probes and methods for oxygen measurement
Molecular therapeutics for cancer
Myocardial infarction and protection

Rotations and Thesis Projects:

Triple Negative Breast Cancer - Biology & Therapeutics using PDX model
Pancreatic cancer - Molecular Therapeutics (STAT3 inhibitor)
Oxygen signalling in cancer progression and treatment
EPR oximetry (OxyChip - technology development)
Clinical oximetry (for cancer)

Grant Information:

R01 NIBIB (2004-2018) - "Probes and methods for clinical oximetry" (PI)
P01 NCI (2015-2020) - Project 1: "Direct & repeated pO2 measurements for cancer using EPR oximetry with carbon particulates" (PI)
P01 NCI (2015-2020) - Project 2: "Direct & repeated pO2 measurements for cancer using EPR oximetry with OxyChip" (PI)
R21 NIBIB (2012-2016) - "Hand-held scanner for EPR oximetry" (PI)
R21 NIH (2013-2016) - "Real-time monitoring of cerebral tissue oxygen in ischemic stroke" (PI)
R21 NIBIB (2016-2018) - "Miniature EPR system for on-site oximetry" (PI)
R01 NCI (2014-2019) - "Dissecting the role of STAT3 and targeting in ovarian cancer" (Co-I)
R01 NHLBI (2013-2017) - "Mechanisms of Coronary Vasomotor Control" (Co-I)


Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry).
He has published over 350 peer-reviewed scientific papers, reviews, and book chapters. As of 06/2015, he has 15,808 citations of my research publications including 6,720 in the last 5 years. The h-index of his publications is 62.
Dr. Kuppusamy has received continuous funding from the National Institutes of Health (NIH) and the American Heart Association.
Dr. Kuppusamy has received the Silver Medal for Biology and Medicine from the International EPR Society in 2006; honorary title of “Doctor Honoris Causa” from the University of Pécs, in Pécs, Hungary in 2008; recipient of the 2014 Piette Award by the EPR Society; and 2015 Distinguished Alumni Award from Indian Institute of Technology (IIT) Chennai.
Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2). Development of a clinical version of this technology is in progress.

Mentoring Information:

Jesse Mast (PhD candidate, PEMM)

K Awardees: Valery Khramtsov (K01); Elaine Fisher (K01); Hiranmoy Das (K01); Mahmood Khan (SDG/AHA); Rajan Gogna (K99)

Post-Doctoral Fellows: Ravi A. Shankar, MD; Haiquan Li, MD; G. Ilangovan, PhD; R. Pandian, PhD; S. P. Evalappan, MD; Anna Bratasz, PhD ; Ashish Sharma, MD ; Vijay Kumar Kutala, PhD; Simi M. Chacko, PhD; Mahmood Khan, PhD; Joe Z. Sostaric, PhD; Rizwan Ahmad, PhD; K. Selvendiran, PhD; Iyappu K Mohan, PhD; Sheik Wisel, PhD; Yazhini Ravi, MBBS; Balazs Bognar, PhD; Guru Meenakshisundaram, PhD; Masaki Nagane, DVM PhD; Esha Madan, PhD; Rajan Gogna, PhD

Graduate (PhD) students: Rizwan Ahmad, Deepti S. Vikram, Aditi C. Kulkarni, Simi M. Chacko, Jonathan Pillai, Guruguhan Meenakshisundaram, Lucas Citro

Selected Publications:


  • Gogna, R. Madan, E. Khan, M. Pati, U. Kuppusamy, P. p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation. EMBO Mol Med (2013) 5, 1662-1683. (view details on MedLine)

  • Ravi Y, Selvendiran K, Naidu SK, Meduru S, Citro LA, Bognar B, Khan M, Kalai T, Hideg K, Kuppusamy P, Sai-Sudhakar CB, Pulmonary hypertension secondary to left-heart failure involves peroxynitrite-induced downregulation of PTEN in the lung. Hypertension (2013) 61, 593-601. (view details on MedLine)

  • Ravi Y, Selvendiran K, Meduru S, Citro L, Naidu S, Khan M, Rivera BK, Sai-Sudhakar CB, and Kuppusamy P, Dysregulation of PTEN in cardiopulmonary vascular remodeling induced by pulmonary hypertension. Cell Biochem Biophys (2013) 67, 363-372. (view details on MedLine)

  • Fisher EM, Khan M, Salisbury R, and Kuppusamy P Noninvasive monitoring of small intestinal oxygen in a rat model of chronic mesenteric ischemia. Cell Biochem Biophys (2013) 67, 451-459. (view details on MedLine)

  • Khan M, Brauner ME, Plewa MC, Kutala VK, Angelos M, and Kuppusamy P Effect of pulmonary-generated reactive oxygen species on left-ventricular dysfunction associated with cardio-pulmonary ischemia-reperfusion injury. . Cell Biochem Biophys (2013) 67, 275-280. (view details on MedLine)

  • Madan E, Gogna R, Kuppusamy P, Bhatt M, Mahdi AA, and Pati U SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex. Mol Cell Biol (2013) 33, 1285-1302 (view details on MedLine)

  • Reddy CA, Somepalli V, Golakoti T, Kanugula AK, Karnewar S, Rajendiran K, Vasagiri N, Prabhakar S, Kuppusamy P, Kotamraju S, and Kutala VK, Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin. PLoS One (2014) 9, e89351 (view details on MedLine)

  • Rath KS, Naidu SK, Lata P, Bid HK, Rivera BK, McCann GA, Tierney BJ, Elnaggar AC, Bravo V, Leone G, Houghton P, Hideg K, Kuppusamy P, Cohn DE, and Selvendiran K HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res (2014) 74, 2316-2327 (view details on MedLine)

  • McCann GA, Naidu S, Rath KS, Bid HK, Tierney BJ, Suarez A, Varadharaj S, Zhang J, Hideg K, Houghton P, Kuppusamy P, Cohn DE, and Selvendiran K Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor. Oncoscience (2014) 1, 216-228. (view details on MedLine)

  • Khan N, Hou H, Eskey CJ, Moodie K, Gohain S, Du G, Hodge S, Culp WC, Kuppusamy P, and Swartz HM Deep-tissue oxygen monitoring in the brain of rabbits for stroke research. Stroke (2015) 46, e62-66. (view details on MedLine)