Periannan Kuppusamy, PhD
Professor of Radiology
Professor of Medicine
1987-90 Cardiovascular Fellowship - Johns Hopkins University
1986-87 Fogarty Fellow, National Institutes of Health
1980-85 PhD - Indian Institute of Technology (Chennai)
1975-77 MSc - University of Madras
1972-75 BSc - University of Madras
Program in Experimental and Molecular Medicine
601 Rubin Building
One Medical Center Dr
Lebanon NH 03756
Office: 601 Rubin Bldg
Electron paramagnetic resonance
Probes and methods for oxygen measurement
Molecular therapeutics for cancer
Myocardial infarction and protection
Rotations and Thesis Projects:
Triple Negative Breast Cancer - Biology & Therapeutics using PDX model
Pancreatic cancer - Molecular Therapeutics (STAT3 inhibitor)
Oxygen signalling in cancer progression and treatment
EPR oximetry (OxyChip - technology development)
Clinical oximetry (for cancer)
R01 NIBIB (2004-2019) - "Probes and methods for clinical oximetry" (PI)
P01 NCI (2015-2020) - Project 2: "Direct & repeated pO2 measurements for cancer using EPR oximetry with OxyChip" (PI)
R21 NIBIB (2012-2016) - "Hand-held scanner for EPR oximetry" (PI)
R21 NIH (2013-2016) - "Real-time monitoring of cerebral tissue oxygen in ischemic stroke" (PI)
R21 NIBIB (2016-2019) - "Miniature EPR system for on-site oximetry" (PI)
R01 NCI (2014-2019) - "Dissecting the role of STAT3 and targeting in ovarian cancer" (Co-I)
R01 NHLBI (2013-2018) - "Mechanisms of Coronary Vasomotor Control" (Co-I)
R21 AG052722 (2017-2019) "Caveolae as capacitors for oxygen" (Co-I)
Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry).
He has published over 350 peer-reviewed scientific papers, reviews, and book chapters. As of 06/2015, he has 15,808 citations of my research publications including 6,720 in the last 5 years. The h-index of his publications is 62.
Dr. Kuppusamy has received continuous funding from the National Institutes of Health (NIH) and the American Heart Association.
Dr. Kuppusamy has received the Silver Medal for Biology and Medicine from the International EPR Society in 2006; honorary title of “Doctor Honoris Causa” from the University of Pécs, in Pécs, Hungary in 2008; recipient of the 2014 Piette Award by the EPR Society; and 2015 Distinguished Alumni Award from Indian Institute of Technology (IIT) Chennai.
Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2). Development of a clinical version of this technology is in progress.
Jesse Mast (PhD candidate, PEMM)
K Awardees: Valery Khramtsov (K01); Elaine Fisher (K01); Hiranmoy Das (K01); Mahmood Khan (SDG/AHA); Rajan Gogna (K99)
Post-Doctoral Fellows: Ravi A. Shankar, MD; Haiquan Li, MD; G. Ilangovan, PhD; R. Pandian, PhD; S. P. Evalappan, MD; Anna Bratasz, PhD ; Ashish Sharma, MD ; Vijay Kumar Kutala, PhD; Simi M. Chacko, PhD; Mahmood Khan, PhD; Joe Z. Sostaric, PhD; Rizwan Ahmad, PhD; K. Selvendiran, PhD; Iyappu K Mohan, PhD; Sheik Wisel, PhD; Yazhini Ravi, MBBS; Balazs Bognar, PhD; Guru Meenakshisundaram, PhD; Masaki Nagane, DVM PhD; Esha Madan, PhD; Rajan Gogna, PhD
Graduate (PhD) students: Rizwan Ahmad, Deepti S. Vikram, Aditi C. Kulkarni, Simi M. Chacko, Jonathan Pillai, Guruguhan Meenakshisundaram, Lucas Citro
Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction.
Pre-clinical evaluation of OxyChip for long-term EPR oximetry.
Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.
The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.
Development of the Implantable Resonator System for Clinical EPR Oximetry.
Synthesis and Biological Evaluation of Curcumin-Nitroxide-Based Molecular Hybrids as Antioxidant and Anti-Proliferative Agents.
Dynamic EPR Oximetry of Changes in Intracerebral Oxygen Tension During Induced Thromboembolism.
Anticancer potential of diarylidenyl piperidone derivatives, HO-4200 and H-4318, in cisplatin resistant primary ovarian cancer.
Increased Electron Paramagnetic Resonance Signal Correlates with Mitochondrial Dysfunction and Oxidative Stress in an Alzheimer's disease Mouse Brain.