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Periannan (Kupps) Kuppusamy, MSc, PhD

Title(s)
Professor of Radiology
Professor of Medicine

Additional Titles/Positions/Affiliations
Adjunct Professor, Radiation Oncology
Adjunct Professor, Thayer School of Engineering
Adjunct Professor of Chemistry

Department(s)
Radiology
Medicine

Education
1987-90 Cardiovascular Fellowship - Johns Hopkins University (Post-doctoral)
1986-87 Fogarty Fellow, National Institutes of Health (Post-doctoral)
1980-85 PhD - Indian Institute of Technology (Chennai) - Alumni Award (2015)
1975-77 MSc - University of Madras (1st Rank/Gold medal)
1972-75 BSc - University of Madras (4th rank)

Programs
Program in Experimental and Molecular Medicine

Curriculum Vitae
Kuppusamy_P_CV_2021-11-08.pdf

NIH Biosketch
Kuppusamy_P_BIO_2021-11-08.pdf

Contact Information

601 Rubin Building
One Medical Center Dr
Lebanon NH 03756

Office: 601 Rubin Bldg
Phone: 603-653-3577
Email: kuppu@dartmouth.edu


Professional Interests

Oxygen/ROS pathobiology
Electron paramagnetic resonance
Probes and methods for oxygen measurement
Molecular therapeutics for cancer
Myocardial infarction and protection

Rotations and Thesis Projects

Triple Negative Breast Cancer - Biology & Therapeutics
Pancreatic cancer - Molecular Therapeutics
Oxygen in cancer progression and treatment
EPR oximetry (OxyChip, SPOT chip - technology development)
Oxygen measurement in cancer patients (clinical trial)
Portable, bed-side scanners for clinical oximetry

Grant Information

> Active
R01 EB004031 (2004–2026) - Probes and Methods for Clinical Oximetry" (PI)
P01 CA190193 (2015–2022) - "Direct and Repeated Clinical Measurement of pO2 for Enhancing Cancer Therapy" (PI/PD)
P01 CA190193 (2015–2022) - Project 2: "Direct & repeated pO2 measurements for cancer using EPR oximetry with OxyChip" (PI)
P01 CA190193 (2015-2022) - Core 1: Administrative Core - "Direct and Repeated Clinical Measurement of pO2 for Enhancing Cancer Therapy" (PI)

> Completed
R21 NIBIB (2016-2020) - "Miniature EPR system for on-site oximetry" (PI)
R01 NCI (2014-2019) - "Dissecting the role of STAT3 and targeting in ovarian cancer" (Co-I)
R21 AG052722 (2017-2019) "Caveolae as capacitors for oxygen" (Co-I)
R01 HL135024 (2017-2018, Co-I) - “The critical role of the coronary microcirculation in heart failure”
R01 HL115114 (2013-2017, Co-I) - "Mechanisms of Coronary Vasomotor Control"
R21 EB016189 (2012-2016, PI) - “Hand-held scanner for EPR oximetry”
R21 NS022247 (2015-2016, PI) - “Real-time monitoring of cerebral tissue oxygen in ischemic stroke”
US-Israel BSF (2010-2014, PI) - “Oxygen sensing in live systems at micro-scale ESR”
U19 U19AI091173 - Pilot (2013-2016, PI) “Intensity Standard for L-band EPR Tooth Dosimetry”
R01 EB004031 (2004-2013, PI) - “Development of spin probes for cell-tagging and oximetry”
R01 EB007373 (2008-2013, PI) - “Novel trityl probes for determination of superoxide”
US-Israel BSF (2006-2010, PI) - “Biophysical and medical applications of ESR microscopy”
R21 HL0955066 (2009 – 2011, PI) - “PTENuating Restenosis: an innovative PTEN promoter for cardioprotection”
R21 EB008836 (2009-2911, Co-I) - “Sparse multispectral processing for accelerated EPR oximetry in three dimensions”
R01 EB006153 (2007-2011, PI) - “Oxygenation in stem cell therapy for myocardial infarction”
R01 CA102264 (2004-2009, PI) - “In vivo EPR imaging of redox status and thiols in tumor”
R01 EB005004 (2005-2009, PI) - “Novel methods for in vivo imaging of tissue oxygenation”
BRTT Node 1.3 (2003-2005, PI) - “Noninvasive measurement of myocardial oxygenation during cell therapy”
R01 HL038324 (2004-2009, Co-I) - “Measurement of free radical generation in the heart”
R01 EB004658 (2004-2009, Co-I) - “Development of proton-electron double resonance imaging”
BRTT, State of OH (2004-2007, PI) - “Development of a noninvasive method for imaging thiols in ovarian tumor s”
R01 GM58582 (1999-2005, Co-I) - “In vivo EPR imaging of free radicals at 300 MHz”
R01 CA78886 (1998-2006, PI) - “EPR imaging of tumor heterogeneity and oxygenation”
R01 RR12190 (1998-2004, Co-I) - “Center for biomedical EPR spectroscopy and imaging”
R01 HL63744 (2000-2005, Co-I) - “Oxygen radicals and nitric oxide in post-ischemic injury”
P01 HL656608 (2000-2005, Co-I) - “Oxidants and nitric oxide in post-ischemic heart injury”
R01 EB000890 (2002-2006, Co-I) - “MRI/EPRI – Co-imaging of biological samples”
R01 HL057027 (2002-2005, Co-I) - “Reperfusion-induced endothelial cell dysfunction”
P20 EB000591 (2002-2007, Co-I) - “Development and processing of high-resolution cardiac MRI”
Established Investigator Award AHA 96003210 (1996-2001, PI) - -“Measurement of oxygen concentration in the heart”
Grant-in-Aid Award - AHA 96003210 (1995-1998, PI) - “Measurement of oxygen in the heart using EPR imaging”

Courses Taught

No formal courses offered.

Biography

Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry).
He has published over 400 peer-reviewed scientific papers, reviews, and book chapters. As of 10/2021, he has 26,080 citations of his research publications including 7,451 in the last 5 years. The h-index of his publications is 78.
Dr. Kuppusamy has received continuous funding from the National Institutes of Health (NIH) and the American Heart Association from 1995.
He was an Established Investigator Awardee of the American Heart Association (1996-2001).
Dr. Kuppusamy was the inaugural endowed chair holder of "William D. and Jacquelyn L. Wells Chair in Imaging Research" from 2005-2013 at the Davis Heart & Lung Research Institute, Wexner Medical Center, The Ohio State University.
Dr. Kuppusamy has received the following recognition/awards:
2006 - Silver Medal for Biology and Medicine from the International EPR Society
2008 - Award of “Doctor Honoris Causa” (MD) for cardiovascular medicine by University of Pécs, Hungary
2014 - Recipient of the Piette Award for the development of in vivo EPR spectroscopy/imaging
2015 - Distinguished Alumni Award from his alma mater Indian Institute of Technology (IIT) Madras (Chennai)
Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2). Development of a clinical version of this technology including an NCI-funded clinical study is in progress.

Mentoring Information

Active
>Graduate Students | Publications
Jesse Mast (PhD/PEMM/Dartmouth) | 6

> Undergraduate Students | Publications
Anjali M Prabhat (BS 2020/Dartmouth) | 4
Thomas M Drews (BS/UMass) | 2

Past
> Faculties | Publications
Govindasamy Ilangovan PhD | 24
Associate (tenured) Professor, Internal Medicine, OSU
K. Selvendiran PhD | 31
Associate (tenured) Professor, OBGYN, OSU
Mahmood Khan PhD | 51
Associate Professor, Emergency Medicine, OSU
Hiranmoy Das PhD | 2
Professor, Cell Biology & Biochemistry, Texas Tech U.
Rizwan Ahmad PhD | 23
Assistant Professor, Biomedical Engineering, OSU

> K Awardees | Publications
Valery Khramtsov (K01) | 2
Elaine Fisher (K01) | 2
Hiranmoy Das (K01) | 2
Mahmood Khan (SDG/AHA) | 51
Rajan Gogna (K99) | 14

>Post-Doctoral Fellows | Publications
Ravi A Shankar, MD | 5
Haiquan Li, MD | 9
Govindasamy Ilangovan, PhD | 24
Ramasamy P Pandian, PhD | 28
Sathesh P Evalappan, MBBS | 1
Anna Bratasz, PhD | 29
Ashish Sharma, MBBS | 1
Vijay Kumar Kutala, PhD | 41
Simi M Chacko, PhD, MPH | 9
Mahmood Khan, PhD | 51
Joe Z Sostaric, PhD | 4
Rizwan Ahmad, PhD | 24
Karuppaiyah Selvendiran, PhD | 31
Iyappu K Mohan, PhD | 11
Sheik Wisel, PhD | 7
Yazhini Ravi, MBBS | 4
Balazs Bognar, PhD | 5
Guruguhan Meenakshisundaram, PhD | 7
Masaki Nagane, DVM PhD | 7
Esha Madan, PhD | 13
Rajan Gogna, PhD | 14

> Graduate (MS/PhD) students | Publications
Haihong Li, MS | 3
Rizwan Ahmad, PhD | 24
Deepti S Vikram, PhD | 16
Aditi C Kulkarni, PhD | 6
Simi M Chacko, PhD | 9
Jonathan Pillai, PhD | 0
Guruguhan Meenakshisundaram, PhD | 7
Lucas A Citro PhD | 5

> Undergraduate students | Publications
Nathan M Weir, MD PhD | 5
Rajarsi Mandal, MD | 5
Jayachandran Swaminathan, PhD | 2
Alexander Dayton, MD PhD | 13
Mia F Tazi, PhD | 3
Praneeth T Reddy, MD | 1
Vandana Potaraju, MD| 1
Shilpa Viswanath, MS | 1
Vinh Dang, MS | 5
Abhisai Dominic, MS | 1

> Collaborators | Publications
Active (with funding)
Jay C Buckey Jr , MD (Geisel, Dartmouth) | 2
Philip E Schaner, MD PhD (Dartmouth-Hitchcock) | 7
Eunice Y Chen, MD PhD (Dartmouth-Hitchcock) | 10
Lesley A Jarvis, MD PhD (Dartmouth-Hitchcock) | 8
Peter A Kaufman, MD (Dartmouth-Hitchcock) | 1
Eugene Demidenko, PhD (Geisel, Dartmouth) | 2
Aharon Blank, PhD (Technion U., Israel) | 13
Rizwan Ahmad , PhD (OSU) | 23
Karuppaiyah Selvendiran, PhD (OSU) | 31
Mahmood Khan, PhD (OSU) | 51
William M Chilian (NEOMED) | 1
Hemal Patel, PhD (UCSD) | 0
Tamas Kalai , PhD (University of Pecs) | 17
Kalman Hideg, PhD (University of Pecs) | 27

Past
*Not listed*

> Mentors
Periakaruppan T Manoharan, PhD | 17
Joseph M Rifkind, PhD | 1
Jay L Zweier, MD | 163


Selected Publications

 

Aberrant expression of TMEM205 signaling promotes platinum resistance in ovarian cancer: An implication for the antitumor potential of DAP compound.
Calo CA, Smith BQ, Dorayappan KDP, Saini U, Lightfoot M, Wagner V, Kalaiyarasan D, Cosgrove C, Wang QE, Maxwell GL, Kalai T, Kuppusamy P, Cohn DE, Selvendiran K
Gynecol Oncol. 2022 Jan;164(1):136-145. doi: 10.1016/j.ygyno.2021.10.076. Epub 2021 Oct 30.
PMID: 34756749

Evaluation of a Refined Implantable Resonator for Deep-Tissue EPR Oximetry in the Clinic.
Chen EY, Tse D, Hou H, Schreiber WA, Schaner PE, Kmiec MM, Hebert KA, Kuppusamy P, Swartz HM, Williams BB
Appl Magn Reson. 2021 Oct;52(10):1321-1342. doi: 10.1007/s00723-021-01376-5. Epub 2021 Jul 9.
PMID: 34744319

OxyChip embedded with radio-opaque gold nanoparticles for anatomic registration and oximetry in tissues.
Kmiec MM, Hebert KA, Tse D, Hodge S, Williams BB, Schaner PE, Kuppusamy P
Magn Reson Med. 2022 Mar;87(3):1621-1637. doi: 10.1002/mrm.29039. Epub 2021 Oct 31.
PMID: 34719047

First-In-Human Study in Cancer Patients Establishing the Feasibility of Oxygen Measurements in Tumors Using Electron Paramagnetic Resonance With the OxyChip.
Schaner PE, Williams BB, Chen EY, Pettus JR, Schreiber WA, Kmiec MM, Jarvis LA, Pastel DA, Zuurbier RA, DiFlorio-Alexander RM, Paydarfar JA, Gosselin BJ, Barth RJ, Rosenkranz KM, Petryakov SV, Hou H, Tse D, Pletnev A, Flood AB, Wood VA, Hebert KA, Mosher RE, Demidenko E, Swartz HM, Kuppusamy P
Front Oncol. 2021;11:743256. doi: 10.3389/fonc.2021.743256. Epub 2021 Oct 1.
PMID: 34660306

PTEN as a Therapeutic Target in Pulmonary Hypertension Secondary to Left-heart Failure: Effect of HO-3867 and Supplemental Oxygenation.
Ravi Y, Sai-Sudhakar CB, Kuppusamy P
Cell Biochem Biophys. 2021 Sep;79(3):593-607. doi: 10.1007/s12013-021-01010-y. Epub 2021 Jun 16.
PMID: 34133009

Oxygen-Sensing Paramagnetic Probes for Clinical Oximetry.
Kmiec MM, Tse D, Kuppusamy P
Adv Exp Med Biol. 2021;1269:259-263. doi: 10.1007/978-3-030-48238-1_41.
PMID: 33966227

Estimation of pO2 distribution in EPR oximetry.
Demidenko E, Kmiec MM, Kuppusamy P
J Magn Reson. 2021 Jul;328:106992. doi: 10.1016/j.jmr.2021.106992. Epub 2021 Apr 28.
PMID: 33965648

DNA damage response in vascular endothelial senescence: Implication for radiation-induced cardiovascular diseases.
Nagane M, Yasui H, Kuppusamy P, Yamashita T, Inanami O
J Radiat Res. 2021 Jul 10;62(4):564-573. doi: 10.1093/jrr/rrab032.
PMID: 33912932

The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography.
Schaner PE, Tran LB, Zaki BI, Swartz HM, Demidenko E, Williams BB, Siegel A, Kuppusamy P, Flood AB, Gallez B
Sci Rep. 2021 Feb 24;11(1):4422. doi: 10.1038/s41598-021-82754-8. Epub 2021 Feb 24.
PMID: 33627688

Sense and Sensibility of Oxygen in Pathophysiology Using EPR Oximetry
Kuppusamy P, Berliner LJ, Parinandi NL
. 2020;
PMID: 33411441

View more publications on PubMed