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Periannan (Kupps) Kuppusamy, PhD

Title(s):
Professor of Radiology
Professor of Medicine

Additional Titles/Positions/Affiliations:
None

Department(s):
Radiology
Medicine

Education:
1987-90 Cardiovascular Fellowship - Johns Hopkins University (Post-doctoral)
1986-87 Fogarty Fellow, National Institutes of Health (Post-doctoral)
1980-85 PhD - Indian Institute of Technology (Chennai) - Alumni Award (2015)
1975-77 MSc - University of Madras (1st Rank/Gold medal)
1972-75 BSc - University of Madras (4th rank)

Programs:
Program in Experimental and Molecular Medicine

Contact Information:

601 Rubin Building
One Medical Center Dr
Lebanon NH 03756

Office: 601 Rubin Bldg
Phone: 603-653-3577
Email: kuppu@dartmouth.edu


Professional Interests:

Oxygen/ROS pathobiology
Electron paramagnetic resonance
Probes and methods for oxygen measurement
Molecular therapeutics for cancer
Myocardial infarction and protection

Rotations and Thesis Projects:

Triple Negative Breast Cancer - Biology & Therapeutics
Pancreatic cancer - Molecular Therapeutics
Oxygen in cancer progression and treatment
EPR oximetry (OxyChip, SPOT chip - technology development)
Oxygen measurement in cancer patients (clinical trial)
Portable, bed-side scanners for clinical oximetry

Grant Information:

> Active
R01 NIBIB (2004-2020) - "Probes and methods for clinical oximetry" (PI)
P01 NCI (2015-2020) - Project 2: "Direct & repeated pO2 measurements for cancer using EPR oximetry with OxyChip" (PI)
R21 NIBIB (2016-2020) - "Miniature EPR system for on-site oximetry" (PI)
R01 NCI (2014-2019) - "Dissecting the role of STAT3 and targeting in ovarian cancer" (Co-I)
R21 AG052722 (2017-2020) "Caveolae as capacitors for oxygen" (Co-I)

> Completed
R01 HL135024 (2017-2018, Co-I) - “The critical role of the coronary microcirculation in heart failure”
R01 HL115114 (2013-2017, Co-I) - "Mechanisms of Coronary Vasomotor Control"
R21 EB016189 (2012-2016, PI) - “Hand-held scanner for EPR oximetry”
R21 NS022247 (2015-2016, PI) - “Real-time monitoring of cerebral tissue oxygen in ischemic stroke”
US-Israel BSF (2010-2014, PI) - “Oxygen sensing in live systems at micro-scale ESR”
U19 U19AI091173 - Pilot (2013-2016, PI) “Intensity Standard for L-band EPR Tooth Dosimetry”
R01 EB004031 (2004-2013, PI) - “Development of spin probes for cell-tagging and oximetry”
R01 EB007373 (2008-2013, PI) - “Novel trityl probes for determination of superoxide”
US-Israel BSF (2006-2010, PI) - “Biophysical and medical applications of ESR microscopy”
R21 HL0955066 (2009 – 2011, PI) - “PTENuating Restenosis: an innovative PTEN promoter for cardioprotection”
R21 EB008836 (2009-2911, Co-I) - “Sparse multispectral processing for accelerated EPR oximetry in three dimensions”
R01 EB006153 (2007-2011, PI) - “Oxygenation in stem cell therapy for myocardial infarction”
R01 CA102264 (2004-2009, PI) - “In vivo EPR imaging of redox status and thiols in tumor”
R01 EB005004 (2005-2009, PI) - “Novel methods for in vivo imaging of tissue oxygenation”
BRTT Node 1.3 (2003-2005, PI) - “Noninvasive measurement of myocardial oxygenation during cell therapy”
R01 HL038324 (2004-2009, Co-I) - “Measurement of free radical generation in the heart”
R01 EB004658 (2004-2009, Co-I) - “Development of proton-electron double resonance imaging”
BRTT, State of OH (2004-2007, PI) - “Development of a noninvasive method for imaging thiols in ovarian tumor s”
R01 GM58582 (1999-2005, Co-I) - “In vivo EPR imaging of free radicals at 300 MHz”
R01 CA78886 (1998-2006, PI) - “EPR imaging of tumor heterogeneity and oxygenation”
R01 RR12190 (1998-2004, Co-I) - “Center for biomedical EPR spectroscopy and imaging”
R01 HL63744 (2000-2005, Co-I) - “Oxygen radicals and nitric oxide in post-ischemic injury”
P01 HL656608 (2000-2005, Co-I) - “Oxidants and nitric oxide in post-ischemic heart injury”
R01 EB000890 (2002-2006, Co-I) - “MRI/EPRI – Co-imaging of biological samples”
R01 HL057027 (2002-2005, Co-I) - “Reperfusion-induced endothelial cell dysfunction”
P20 EB000591 (2002-2007, Co-I) - “Development and processing of high-resolution cardiac MRI”
Established Investigator Award AHA 96003210 (1996-2001, PI) - -“Measurement of oxygen concentration in the heart”
Grant-in-Aid Award - AHA 96003210 (1995-1998, PI) - “Measurement of oxygen in the heart using EPR imaging”

Courses Taught:

No formal courses offered.

Biography:

Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry).
He has published over 375 peer-reviewed scientific papers, reviews, and book chapters. As of 12/2018, he has 21,586 citations of his research publications including 7,730 in the last 5 years. The h-index of his publications is 73.
Dr. Kuppusamy has received continuous funding from the National Institutes of Health (NIH) and the American Heart Association from 1995.
He was an Established Investigator Awardee of the American Heart Association (1996-2001).
Dr. Kuppusamy was the inaugural endowed chair holder of "William D. and Jacquelyn L. Wells Chair in Imaging Research" from 2005-2013 at the Davis Heart & Lung Research Institute, Wexner Medical Center, Ohio State University.
Dr. Kuppusamy has received the following recognition/awards:
2006 - Silver Medal for Biology and Medicine from the International EPR Society
2008 - Award of “Doctor Honoris Causa” (MD) for cardiovascular medicine by University of Pécs, Hungary
2014 - Recipient of the Piette Award for the development of in vivo EPR spectroscopy/imaging
2015 - Distinguished Alumni Award from his alma mater Indian Institute of Technology (IIT) Madras
Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2). Development of a clinical version of this technology including an NCI-funded clinical trial is in progress.

Mentoring Information:

Active
>Graduate Students | Publications
Jesse Mast (PhD/PEMM/Dartmouth) | 4

> Undergraduate Students | Publications
Anjali M Prabhat (BS 2020/Dartmouth) | 4
Thomas M Drews (BS/UMass) | 2

Past
> Faculties | Publications
Govindasamy Ilangovan PhD | 24
Associate (tenured) Professor, Internal Medicine, OSU
K. Selvendiran PhD | 31
Associate (tenured) Professor, OBGYN, OSU
Mahmood Khan PhD | 51
Associate Professor, Emergency Medicine, OSU
Hiranmoy Das PhD | 2
Professor, Cell Biology & Biochemistry, Texas Tech U.
Rizwan Ahmad PhD | 21
Assistant Professor, Biomedical Engineering, OSU

> K Awardees | Publications
Valery Khramtsov (K01) | 2
Elaine Fisher (K01) | 2
Hiranmoy Das (K01) | 2
Mahmood Khan (SDG/AHA) | 51
Rajan Gogna (K99) | 12

>Post-Doctoral Fellows | Publications
Ravi A Shankar, MD | 5
Haiquan Li, MD | 9
Govindasamy Ilangovan, PhD | 24
Ramasamy P Pandian, PhD | 28
Sathesh P Evalappan, MBBS | 1
Anna Bratasz, PhD | 29
Ashish Sharma, MBBS | 1
Vijay Kumar Kutala, PhD | 41
Simi M Chacko, PhD, MPH | 9
Mahmood Khan, PhD | 51
Joe Z Sostaric, PhD | 4
Rizwan Ahmad, PhD | 22
Karuppaiyah Selvendiran, PhD | 31
Iyappu K Mohan, PhD | 11
Sheik Wisel, PhD | 7
Yazhini Ravi, MBBS | 4
Balazs Bognar, PhD | 5
Guruguhan Meenakshisundaram, PhD | 7
Masaki Nagane, DVM PhD | 5
Esha Madan, PhD | 11
Rajan Gogna, PhD | 12

> Graduate (MS/PhD) students | Publications
Haihong Li, MS | 3
Rizwan Ahmad, PhD | 22
Deepti S Vikram, PhD | 16
Aditi C Kulkarni, PhD | 6
Simi M Chacko, PhD | 9
Jonathan Pillai, PhD | 0
Guruguhan Meenakshisundaram, PhD | 7
Lucas A Citro PhD | 5

> Undergraduate students | Publications
Nathan M Weir, MD PhD | 5
Rajarsi Mandal, MD | 5
Jayachandran Swaminathan, PhD | 2
Alexander Dayton, MD PhD | 13
Mia F Tazi, PhD | 3
Praneeth T Reddy, MD | 1
Vandana Potaraju, MD| 1
Shilpa Viswanath, MS | 1
Vinh Dang, MS | 5
Abhisai Dominic, MS | 1

> Collaborators | Publications
Active (with funding)
Jay C Buckey Jr , MD (Geisel, Dartmouth) | 2
Philip E Schaner, MD PhD (Dartmouth-Hitchcock) | 7
Eunice Y Chen, MD PhD (Dartmouth-Hitchcock) | 10
Lesley A Jarvis, MD PhD (Dartmouth-Hitchcock) | 8
Peter A Kaufman, MD (Dartmouth-Hitchcock) | 1
Eugene Demidenko, PhD (Geisel, Dartmouth) | 2
Aharon Blank, PhD (Technion U., Israel) | 11
Rizwan Ahmad , PhD (OSU) | 21
Karuppaiyah Selvendiran, PhD (OSU) | 31
Mahmood Khan, PhD (OSU) | 51
William M Chilian (NEOMED) | 1
Hemal Patel, PhD (UCSD) | 0
Tamas Kalai , PhD (University of Pecs) | 15
Kalman Hideg, PhD (University of Pecs) | 27

Past
*Not listed*

> Mentors
Periakaruppan T Manoharan, PhD | 17
Joseph M Rifkind, PhD | 1
Jay L Zweier, MD | 163


Selected Publications:

 

Flower isoforms promote competitive growth in cancer.
Madan E, Pelham CJ, Nagane M, Parker TM, Canas-Marques R, Fazio K, Shaik K, Yuan Y, Henriques V, Galzerano A, Yamashita T, Pinto MAF, Palma AM, Camacho D, Vieira A, Soldini D, Nakshatri H, Post SR, Rhiner C, Yamashita H, Accardi D, Hansen LA, Carvalho C, Beltran AL, Kuppusamy P, Gogna R, Moreno E
Nature. 2019 Aug;572(7768):260-264. doi: 10.1038/s41586-019-1429-3. Epub 2019 Jul 24.
PMID: 31341286

Implantable microchip containing oxygen-sensing paramagnetic crystals for long-term, repeated, and multisite in vivo oximetry.
Kmiec MM, Tse D, Mast JM, Ahmad R, Kuppusamy P
Biomed Microdevices. 2019 Jul 8;21(3):71. doi: 10.1007/s10544-019-0421-x. Epub 2019 Jul 8.
PMID: 31286244

Diarylidenylpiperidones, H-4073 and HO-3867, Induce G2/M Cell-Cycle Arrest, Apoptosis and Inhibit STAT3 Phosphorylation in Human Pancreatic Cancer Cells.
Mast JM, Tse D, Shee K, Lakshmi Kuppusamy M, Kmiec MM, Kalai T, Kuppusamy P
Cell Biochem Biophys. 2019 Jun;77(2):109-119. doi: 10.1007/s12013-019-00873-6. Epub 2019 May 14.
PMID: 31089934

Measuring Flap Oxygen Using Electron Paramagnetic Resonance Oximetry.
Polacco MA, Hou H, Kuppusamy P, Chen EY
Laryngoscope. 2019 Apr 29; doi: 10.1002/lary.28043. Epub 2019 Apr 29.
PMID: 31034638

Application of SPOT chip for transcutaneous oximetry.
Kmiec MM, Hou H, Kuppusamy ML, Drews TM, Prabhat AM, Petryakov SV, Demidenko E, Schaner PE, Buckey JC, Blank A, Kuppusamy P
Magn Reson Med. 2019 May;81(5):2837-2840. doi: 10.1002/mrm.27667. Epub 2019 Feb 13.
PMID: 30761605

Advanced surface resonators for electron spin resonance of single microcrystals.
Dayan N, Ishay Y, Artzi Y, Cristea D, Reijerse E, Kuppusamy P, Blank A
Rev Sci Instrum. 2018 Dec;89(12):124707. doi: 10.1063/1.5063367.
PMID: 30599630

Antiproliferative Effect of a Novel 4,4'-Disulfonyldiarylidenyl Piperidone in Human Colon Cancer Cells.
Prabhat AM, Kuppusamy ML, Bognar B, Kalai T, Hideg K, Kuppusamy P
Cell Biochem Biophys. 2019 Mar;77(1):61-67. doi: 10.1007/s12013-018-0862-5. Epub 2018 Dec 14.
PMID: 30552554

Hyperoxygenation as a Therapeutic Supplement for Treatment of Triple Negative Breast Cancer.
Mast JM, Kuppusamy P
Front Oncol. 2018;8:527. doi: 10.3389/fonc.2018.00527. Epub 2018 Nov 20.
PMID: 30524959

Transcutaneous oxygen measurement in humans using a paramagnetic skin adhesive film.
Kmiec MM, Hou H, Lakshmi Kuppusamy M, Drews TM, Prabhat AM, Petryakov SV, Demidenko E, Schaner PE, Buckey JC, Blank A, Kuppusamy P
Magn Reson Med. 2019 Feb;81(2):781-794. doi: 10.1002/mrm.27445. Epub 2018 Sep 11.
PMID: 30277275

Supplemental Oxygen Protects Heart Against Acute Myocardial Infarction.
Prabhat AM, Kuppusamy ML, Naidu SK, Meduru S, Reddy PT, Dominic A, Khan M, Rivera BK, Kuppusamy P
Front Cardiovasc Med. 2018;5:114. doi: 10.3389/fcvm.2018.00114. Epub 2018 Aug 28.
PMID: 30211171

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