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Periannan (Kupps) Kuppusamy, MSc, PhD

Professor of Radiology
Professor of Medicine

Additional Titles/Positions/Affiliations:
Adjunct Professor, Thayer School of Engineering
Adjunct Professor of Chemistry


1987-90 Cardiovascular Fellowship - Johns Hopkins University (Post-doctoral)
1986-87 Fogarty Fellow, National Institutes of Health (Post-doctoral)
1980-85 PhD - Indian Institute of Technology (Chennai) - Alumni Award (2015)
1975-77 MSc - University of Madras (1st Rank/Gold medal)
1972-75 BSc - University of Madras (4th rank)

Program in Experimental and Molecular Medicine

Contact Information:

601 Rubin Building
One Medical Center Dr
Lebanon NH 03756

Office: 601 Rubin Bldg
Phone: 603-653-3577

Professional Interests:

Oxygen/ROS pathobiology
Electron paramagnetic resonance
Probes and methods for oxygen measurement
Molecular therapeutics for cancer
Myocardial infarction and protection

Rotations and Thesis Projects:

Triple Negative Breast Cancer - Biology & Therapeutics
Pancreatic cancer - Molecular Therapeutics
Oxygen in cancer progression and treatment
EPR oximetry (OxyChip, SPOT chip - technology development)
Oxygen measurement in cancer patients (clinical trial)
Portable, bed-side scanners for clinical oximetry

Grant Information:

> Active
P01 CA190193 (2015–2021) - "Direct and Repeated Clinical Measurement of pO2 for Enhancing Cancer Therapy" (PI/PD)
P01 CA190193 (2015–2021) - Project 2: "Direct & repeated pO2 measurements for cancer using EPR oximetry with OxyChip" (PI)
P01 CA190193 (2015-2021) - Core 1: Administrative Core - "Direct and Repeated Clinical Measurement of pO2 for Enhancing Cancer Therapy" (PI)
R01 EB004031 (2004–2020) - Probes and Methods for Clinical Oximetry" (PI)
R21 NIBIB (2016-2020) - "Miniature EPR system for on-site oximetry" (PI)
R01 NCI (2014-2019) - "Dissecting the role of STAT3 and targeting in ovarian cancer" (Co-I)
R21 AG052722 (2017-2019) "Caveolae as capacitors for oxygen" (Co-I)

> Completed
R01 HL135024 (2017-2018, Co-I) - “The critical role of the coronary microcirculation in heart failure”
R01 HL115114 (2013-2017, Co-I) - "Mechanisms of Coronary Vasomotor Control"
R21 EB016189 (2012-2016, PI) - “Hand-held scanner for EPR oximetry”
R21 NS022247 (2015-2016, PI) - “Real-time monitoring of cerebral tissue oxygen in ischemic stroke”
US-Israel BSF (2010-2014, PI) - “Oxygen sensing in live systems at micro-scale ESR”
U19 U19AI091173 - Pilot (2013-2016, PI) “Intensity Standard for L-band EPR Tooth Dosimetry”
R01 EB004031 (2004-2013, PI) - “Development of spin probes for cell-tagging and oximetry”
R01 EB007373 (2008-2013, PI) - “Novel trityl probes for determination of superoxide”
US-Israel BSF (2006-2010, PI) - “Biophysical and medical applications of ESR microscopy”
R21 HL0955066 (2009 – 2011, PI) - “PTENuating Restenosis: an innovative PTEN promoter for cardioprotection”
R21 EB008836 (2009-2911, Co-I) - “Sparse multispectral processing for accelerated EPR oximetry in three dimensions”
R01 EB006153 (2007-2011, PI) - “Oxygenation in stem cell therapy for myocardial infarction”
R01 CA102264 (2004-2009, PI) - “In vivo EPR imaging of redox status and thiols in tumor”
R01 EB005004 (2005-2009, PI) - “Novel methods for in vivo imaging of tissue oxygenation”
BRTT Node 1.3 (2003-2005, PI) - “Noninvasive measurement of myocardial oxygenation during cell therapy”
R01 HL038324 (2004-2009, Co-I) - “Measurement of free radical generation in the heart”
R01 EB004658 (2004-2009, Co-I) - “Development of proton-electron double resonance imaging”
BRTT, State of OH (2004-2007, PI) - “Development of a noninvasive method for imaging thiols in ovarian tumor s”
R01 GM58582 (1999-2005, Co-I) - “In vivo EPR imaging of free radicals at 300 MHz”
R01 CA78886 (1998-2006, PI) - “EPR imaging of tumor heterogeneity and oxygenation”
R01 RR12190 (1998-2004, Co-I) - “Center for biomedical EPR spectroscopy and imaging”
R01 HL63744 (2000-2005, Co-I) - “Oxygen radicals and nitric oxide in post-ischemic injury”
P01 HL656608 (2000-2005, Co-I) - “Oxidants and nitric oxide in post-ischemic heart injury”
R01 EB000890 (2002-2006, Co-I) - “MRI/EPRI – Co-imaging of biological samples”
R01 HL057027 (2002-2005, Co-I) - “Reperfusion-induced endothelial cell dysfunction”
P20 EB000591 (2002-2007, Co-I) - “Development and processing of high-resolution cardiac MRI”
Established Investigator Award AHA 96003210 (1996-2001, PI) - -“Measurement of oxygen concentration in the heart”
Grant-in-Aid Award - AHA 96003210 (1995-1998, PI) - “Measurement of oxygen in the heart using EPR imaging”

Courses Taught:

No formal courses offered.


Dr. Kuppusamy’s research expertise includes detection and imaging of oxygen free radicals; myocardial ischemia-reperfusion injury; stem-cell therapy for cardiac repair; ROS pathophysiology in vascular remodeling; tumor physiology, oxygenation, and drug-resistance; small-molecule therapeutics for heart disease and cancer; technology development for noninvasive measurement of tissue oxygen levels (oximetry).
He has published over 375 peer-reviewed scientific papers, reviews, and book chapters. As of 12/2018, he has 21,586 citations of his research publications including 7,730 in the last 5 years. The h-index of his publications is 73.
Dr. Kuppusamy has received continuous funding from the National Institutes of Health (NIH) and the American Heart Association from 1995.
He was an Established Investigator Awardee of the American Heart Association (1996-2001).
Dr. Kuppusamy was the inaugural endowed chair holder of "William D. and Jacquelyn L. Wells Chair in Imaging Research" from 2005-2013 at the Davis Heart & Lung Research Institute, Wexner Medical Center, Ohio State University.
Dr. Kuppusamy has received the following recognition/awards:
2006 - Silver Medal for Biology and Medicine from the International EPR Society
2008 - Award of “Doctor Honoris Causa” (MD) for cardiovascular medicine by University of Pécs, Hungary
2014 - Recipient of the Piette Award for the development of in vivo EPR spectroscopy/imaging
2015 - Distinguished Alumni Award from his alma mater Indian Institute of Technology (IIT) Madras
Dr. Kuppusamy’s laboratory has developed oxygen-sensing magnetic chips for tissue oximetry. The patented technology is capable of noninvasive and repeated measurement of oxygen concentration (pO2). Development of a clinical version of this technology including an NCI-funded clinical trial is in progress.

Mentoring Information:

>Graduate Students | Publications
Jesse Mast (PhD/PEMM/Dartmouth) | 6

> Undergraduate Students | Publications
Anjali M Prabhat (BS 2020/Dartmouth) | 4
Thomas M Drews (BS/UMass) | 2

> Faculties | Publications
Govindasamy Ilangovan PhD | 24
Associate (tenured) Professor, Internal Medicine, OSU
K. Selvendiran PhD | 31
Associate (tenured) Professor, OBGYN, OSU
Mahmood Khan PhD | 51
Associate Professor, Emergency Medicine, OSU
Hiranmoy Das PhD | 2
Professor, Cell Biology & Biochemistry, Texas Tech U.
Rizwan Ahmad PhD | 23
Assistant Professor, Biomedical Engineering, OSU

> K Awardees | Publications
Valery Khramtsov (K01) | 2
Elaine Fisher (K01) | 2
Hiranmoy Das (K01) | 2
Mahmood Khan (SDG/AHA) | 51
Rajan Gogna (K99) | 14

>Post-Doctoral Fellows | Publications
Ravi A Shankar, MD | 5
Haiquan Li, MD | 9
Govindasamy Ilangovan, PhD | 24
Ramasamy P Pandian, PhD | 28
Sathesh P Evalappan, MBBS | 1
Anna Bratasz, PhD | 29
Ashish Sharma, MBBS | 1
Vijay Kumar Kutala, PhD | 41
Simi M Chacko, PhD, MPH | 9
Mahmood Khan, PhD | 51
Joe Z Sostaric, PhD | 4
Rizwan Ahmad, PhD | 24
Karuppaiyah Selvendiran, PhD | 31
Iyappu K Mohan, PhD | 11
Sheik Wisel, PhD | 7
Yazhini Ravi, MBBS | 4
Balazs Bognar, PhD | 5
Guruguhan Meenakshisundaram, PhD | 7
Masaki Nagane, DVM PhD | 7
Esha Madan, PhD | 13
Rajan Gogna, PhD | 14

> Graduate (MS/PhD) students | Publications
Haihong Li, MS | 3
Rizwan Ahmad, PhD | 24
Deepti S Vikram, PhD | 16
Aditi C Kulkarni, PhD | 6
Simi M Chacko, PhD | 9
Jonathan Pillai, PhD | 0
Guruguhan Meenakshisundaram, PhD | 7
Lucas A Citro PhD | 5

> Undergraduate students | Publications
Nathan M Weir, MD PhD | 5
Rajarsi Mandal, MD | 5
Jayachandran Swaminathan, PhD | 2
Alexander Dayton, MD PhD | 13
Mia F Tazi, PhD | 3
Praneeth T Reddy, MD | 1
Vandana Potaraju, MD| 1
Shilpa Viswanath, MS | 1
Vinh Dang, MS | 5
Abhisai Dominic, MS | 1

> Collaborators | Publications
Active (with funding)
Jay C Buckey Jr , MD (Geisel, Dartmouth) | 2
Philip E Schaner, MD PhD (Dartmouth-Hitchcock) | 7
Eunice Y Chen, MD PhD (Dartmouth-Hitchcock) | 10
Lesley A Jarvis, MD PhD (Dartmouth-Hitchcock) | 8
Peter A Kaufman, MD (Dartmouth-Hitchcock) | 1
Eugene Demidenko, PhD (Geisel, Dartmouth) | 2
Aharon Blank, PhD (Technion U., Israel) | 13
Rizwan Ahmad , PhD (OSU) | 23
Karuppaiyah Selvendiran, PhD (OSU) | 31
Mahmood Khan, PhD (OSU) | 51
William M Chilian (NEOMED) | 1
Hemal Patel, PhD (UCSD) | 0
Tamas Kalai , PhD (University of Pecs) | 17
Kalman Hideg, PhD (University of Pecs) | 27

*Not listed*

> Mentors
Periakaruppan T Manoharan, PhD | 17
Joseph M Rifkind, PhD | 1
Jay L Zweier, MD | 163

Selected Publications:


The impact of particulate electron paramagnetic resonance oxygen sensors on fluorodeoxyglucose imaging characteristics detected via positron emission tomography.
Schaner PE, Tran LB, Zaki BI, Swartz HM, Demidenko E, Williams BB, Siegel A, Kuppusamy P, Flood AB, Gallez B
Sci Rep. 2021 Feb 24;11(1):4422. doi: 10.1038/s41598-021-82754-8. Epub 2021 Feb 24.
PMID: 33627688

Sense and Sensibility of Oxygen in Pathophysiology Using EPR Oximetry
Kuppusamy P, Berliner LJ, Parinandi NL
. 2020;
PMID: 33411441

NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion.
Ochocinska MJ, Spitalnik SL, Abuhamad A, Bennett-Guerrero E, Carlo WA, Cherukuri M, Doctor A, Dzik W, Evans CL, Forzani E, Kuppusamy P, Moan NL, Li L, Luban N, Mohandas N, Patel RM, Roback J, Swartz H, Textor S, Vinogradov S, Wang LV, Wisniewski N, Glynn S
Transfus Med Rev. 2021 Jan;35(1):46-55. doi: 10.1016/j.tmrv.2020.12.003. Epub 2020 Dec 6.
PMID: 33353783

Compact electron spin resonance skin oximeter: Properties and initial clinical results.
Cristea D, Wolfson H, Ahmad R, Twig Y, Kuppusamy P, Blank A
Magn Reson Med. 2021 May;85(5):2915-2925. doi: 10.1002/mrm.28595. Epub 2020 Nov 18.
PMID: 33210362

OxyChip Implantation and Subsequent Electron Paramagnetic Resonance Oximetry in Human Tumors Is Safe and Feasible: First Experience in 24 Patients.
Schaner PE, Pettus JR, Flood AB, Williams BB, Jarvis LA, Chen EY, Pastel DA, Zuurbier RA, diFlorio-Alexander RM, Swartz HM, Kuppusamy P
Front Oncol. 2020;10:572060. doi: 10.3389/fonc.2020.572060. Epub 2020 Oct 27.
PMID: 33194670

Selective Induction of Cellular Toxicity and Anti-tumor Efficacy by N-Methylpiperazinyl Diarylidenylpiperidone and its Pro-nitroxide Conjugate through ROS-mediated Mitochondrial Dysfunction and G2/M Cell-cycle Arrest in Human Pancreatic Cancer.
Mast JM, Hinds JW, Tse D, Axelrod K, Kuppusamy ML, Kmiec MM, Bognar B, Kalai T, Kuppusamy P
Cell Biochem Biophys. 2020 Jun;78(2):191-202. doi: 10.1007/s12013-020-00919-0. Epub 2020 May 24.
PMID: 32449075

Estimation of pO2 histogram from a composite EPR Spectrum of multiple random implants.
Kuppusamy P, Kmiec MM, Tse D, Mast JM, Ahmad R
Biomed Microdevices. 2019 Dec 3;22(1):3. doi: 10.1007/s10544-019-0451-4. Epub 2019 Dec 3.
PMID: 31797058

HIF-transcribed p53 chaperones HIF-1α.
Madan E, Parker TM, Pelham CJ, Palma AM, Peixoto ML, Nagane M, Chandaria A, Tomas AR, Canas-Marques R, Henriques V, Galzerano A, Cabral-Teixeira J, Selvendiran K, Kuppusamy P, Carvalho C, Beltran A, Moreno E, Pati UK, Gogna R
Nucleic Acids Res. 2019 Nov 4;47(19):10212-10234. doi: 10.1093/nar/gkz766.
PMID: 31538203

Biocompatibility of Oxygen-Sensing Paramagnetic Implants.
Tse D, Kuppusamy P
Cell Biochem Biophys. 2019 Sep;77(3):197-202. doi: 10.1007/s12013-019-00881-6. Epub 2019 Aug 23.
PMID: 31444784

Flower isoforms promote competitive growth in cancer.
Madan E, Pelham CJ, Nagane M, Parker TM, Canas-Marques R, Fazio K, Shaik K, Yuan Y, Henriques V, Galzerano A, Yamashita T, Pinto MAF, Palma AM, Camacho D, Vieira A, Soldini D, Nakshatri H, Post SR, Rhiner C, Yamashita H, Accardi D, Hansen LA, Carvalho C, Beltran AL, Kuppusamy P, Gogna R, Moreno E
Nature. 2019 Aug;572(7768):260-264. doi: 10.1038/s41586-019-1429-3. Epub 2019 Jul 24.
PMID: 31341286

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