Todd W Miller, PhD
Associate Professor of Molecular and Systems Biology
Director, PhD Program in Experimental & Molecular Medicine
Co-Director, Cancer Biology & Therapeutics Research Program, Norris Cotton Cancer Center
Scientific Director, Comprehensive Breast Program, Norris Cotton Cancer Center
Co-Director, Molecular Tumor Board, Norris Cotton Cancer Center
Molecular and Systems Biology
University of Connecticut (Storrs, CT), B.S., Physiology & Neurobiology, 1998
University at Albany (Albany, NY), Ph.D. in Biomedical Sciences, 2004
Vanderbilt University (Nashville, TN), Post-doctoral Fellowship in Breast Cancer, 2004-2009
Program in Experimental and Molecular Medicine
1 Medical Center Drive
Rubin Bldg, HB 7936
Lebanon NH 03756
Office: Rubin 604
Breast cancer, targeted therapeutics, signaling pathways, drug resistance, biomarker development
R01 CA200994 (PI: Miller) 04/01/2017 – 03/31/2022
A precision medicine basis for estrogen therapy for advanced breast cancer.
R01 CA211869 (PI: Miller)
09/04/2017 – 08/31/2022
A precision medicine basis for Pl3K inhibition in ER+ breast cancer.
Pilot Project Grant (PI: Miller) 08/01/2014 – no end
Norris Cotton Cancer Center Early-Phase Trials Program
Alternating estradiol and anti-estrogen therapies to prevent disease progression in advanced ER+/HER2- breast cancer.
Investigator-initiated Phase I clinical study (PI: Schwartz)
Takeda Pharmaceuticals 10/01/2015 – no end
Phase 1 study of combination of MLN9708 and Fulvestrant in patients with advanced ER+ breast cancer.
PEMM 102- Scientific Basis of Disease II
PEMM 126- Cancer Biology
PEMM 132- Clinical Management of Cancer
Dr. Miller received his B.S. in Physiology and Neurobiology at the University of Connecticut in 1998, and his Ph.D. in Biomedical Sciences at the State University of New York at Albany in 2004 (thesis: Immunization and single-chain Fv intrabody gene therapies for Huntington’s Disease). He did his postdoctoral training at Vanderbilt University (2004-2009), and served as a Research Faculty member 2009-2012. Dr. Miller joined the Geisel School of Medicine at Dartmouth in 2012.
2012-2014 Lloye Dillon, Ph.D., Postdoctoral Fellow (Current Position: Senior Scientist, Research & Development, OncoTAb, Inc., Charlotte, NC)
2012-2018 Wei Yang, M.S., PhD Student (Current position: Postdoctoral Fellow at Memorial Sloan Kettering Cancer Center)
2013-2018 Sarah Hosford, PhD Student (Current position: Scientist in In Vivo Pharmacology at Cobalt Biomedicine)
2014-2018 Kevin Shee, MD/PhD student (Current position: medical student at Geisel)
2015-present Riley Hampsch, PhD student
2016-present Nicole Traphagen, PhD student
2017-present Jason Wells, PhD student
2017-present Bianca Romo, PhD student
2018-present Jackie Griffin, PhD, Postdoctoral Fellow
High estrogen receptor alpha activation confers resistance to estrogen deprivation and is required for therapeutic response to estrogen in breast cancer.
Pan-Cancer Transcriptional Models Predicting Chemosensitivity in Human Tumors.
Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer.
Identification of Let-7f-5p as a novel biomarker of recurrence in non-muscle invasive bladder cancer.
Molecular matching and treatment strategies for advanced stage lung cancer at Dartmouth-Hitchcock Medical Center: A three-year review of a Molecular Tumor Board.
Plasma DNA as a "liquid biopsy" incompletely complements tumor biopsy for identification of mutations in a case series of four patients with oligometastatic breast cancer.
AMPK Activation by Metformin Promotes Survival of Dormant ER+ Breast Cancer Cells.
Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells.
Statistical determination of synergy based on Bliss definition of drugs independence.
Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy.