Edit Entry | Edit CV

David W Mullins, PhD

Title(s)
Associate Professor of Medical Education
Associate Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations
Associate Dean for Basic Science Integration
Chair, Geisel Academy of Master Educators

Department(s)
Medical Education
Microbiology and Immunology

Education
BS, Biology (Microbiology), Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
BS, Biochemistry,Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Ph.D., Microbiology and Immunology, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA
Postdoctoral, Cancer Immunology and Immunotherapy, Carter Immunology Center, University of Virginia, Charlottesville, VA

Programs
Academy of Master Faculty Educators
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

Websites
https://www.linkedin.com/in/david-mullins-1981785a Twitter: @dmullinsdms

Academic Analytics
View Profile

Contact Information

Remsen 232
HB7100
Hanover NH 03755

Office: Remsen 232
Phone: 603-650-1208
Email: David.W.Mullins@Dartmouth.edu


Professional Interests

Cancer Immunology and Immunotherapy, including 1) Lymphocyte Trafficking and Infiltration of Tumors, 2) Biological Therapies for Cancer, and 3) Innate Immunity in Anti-cancer Therapy.

Undergraduate Medical Education.

Rotations and Thesis Projects

Lab Alumni:
- Matthew P. Alexander, Ph.D. (Ph.D., November 2017). PA Student, Mass College of Pharmacy and Health Sciences)
- Amanda Costa, M.S. (Grad Student, 2014-2017).
- Kiah Sanders, Ph.D. (PostDoc 2015-2016). Research Scientist, Merck Research Laboratories, Palo Alto, CA
- Kristen Vondrak '16 (Undergraduate Research Scholar, 2015-2016).
- Meagan Dechen, M.S. (Geisel Medical Student Scholar, 2014-15). MD Candidate, Geisel School of Medicine at Dartmouth.
- Molly Harris-Jenkins, Ph.D. (PostDoc, 2012-2015). Research Scientist, Minerva Biotechnologies, Waltham, MA
- Eleanor Clancy-Thompson, Ph.D. (Ph.D., December 2014). Postdoctoral Fellow, Dana-Farber Cancer Institute, Boston, MA
- Tom Perekslis (technician, 2012-14). Jackson Labs, Bar Harbor, ME
Undergrad Research Students:
- Sasha Alcon '15 (Junior/Senior Science Scholar, 2013-15). MD Student, Hofstra Northwell School of Medicine
- Julia Bratic '15 (Presidential Science Scholar, 2013-15). MD/MPH student, UT Southwestern, Dallas, TX
- Julianne Ivy '15 (Presidential Science Scholar, 2013-15).

Grant Information

Melanoma Research Alliance, Young Investigator Award, 2008
USPHS R01 CA134799, Role of CD8 T cell CXCR3 in the Regulation of Cancer, 2009-2014
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Eleanor Clancy-Thompson, 2012-13
Joanna M. Nicolay Melanoma Research Scholar Fellowship to Matthew P. Alexander, 2013-14
Harry J. Lloyd Charitable Trust, Research Grant 2014-15
USPHS R03 CA188418, Combinatorial therapy of melanoma using T cells and site-specific Immunomodulators, 2015-2017.
USPHS R03 CA216016, Beta-adrenergic mediated suppression of T cell chemotaxis by cancers, 2017-2019.

Courses Taught

Course Director:
- Medical Immunology and Virology (MICR111)
- Basic Science of Microbial Disease (MICR112)
- Cancer Immunology and Immunotherapy (Geisel Enrichment Elective)

Participating Faculty:
- Cellular and Molecular Basis of Immunity (MICR144), Tumor Immunology and Transplantation
- Biochemistry and Genetic Basis of Medicine (BIOC110)


Selected Publications

 

The IL-20RB receptor and the IL-20 signaling pathway in regulating host defense in oral mucosal candidiasis.
Beute JE, Kim AY, Park JJ, Yang A, Torres-Shafer K, Mullins DW, Sundstrom P
Front Cell Infect Microbiol. 2022;12:979701. doi: 10.3389/fcimb.2022.979701. Epub 2022 Sep 26.
PMID: 36225230

Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses.
Lo JA, Kawakubo M, Juneja VR, Su MY, Erlich TH, LaFleur MW, Kemeny LV, Rashid M, Malehmir M, Rabi SA, Raghavan R, Allouche J, Kasumova G, Frederick DT, Pauken KE, Weng QY, Pereira da Silva M, Xu Y, van der Sande AAJ, Silkworth W, Roider E, Browne EP, Lieb DJ, Wang B, Garraway LA, Wu CJ, Flaherty KT, Brinckerhoff CE, Mullins DW, Adams DJ, Hacohen N, Hoang MP, Boland GM, Freeman GJ, Sharpe AH, Manstein D, Fisher DE
Sci Transl Med. 2021 Feb 17;13(581) doi: 10.1126/scitranslmed.abd8636.
PMID: 33597266

Distinct inactivated bacterial-based immune modulators vary in their therapeutic efficacies for treating disease based on the organ site of pathology.
Kalyan S, Bazett M, Sham HP, Bosiljcic M, Luk B, Dhanji S, Costa AM, Wong SWY, Netea MG, Mullins DW, Gunn H
Sci Rep. 2020 Apr 3;10(1):5901. doi: 10.1038/s41598-020-62735-z. Epub 2020 Apr 3.
PMID: 32246043

A TLR7 agonist strengthens T and NK cell function during BRAF-targeted therapy in a preclinical melanoma model.
Bellmann L, Cappellano G, Schachtl-Riess JF, Prokopi A, Seretis A, Ortner D, Tripp CH, Brinckerhoff CE, Mullins DW, Stoitzner P
Int J Cancer. 2020 Mar 1;146(5):1409-1420. doi: 10.1002/ijc.32777. Epub 2019 Dec 4.
PMID: 31702822

Novel Microbial-Based Immunotherapy Approach for Crohn's Disease.
Sutcliffe S, Kalyan S, Pankovich J, Chen JMH, Gluck R, Thompson D, Bosiljcic M, Bazett M, Fedorak RN, Panaccione R, Axler J, Marshall JK, Mullins DW, Kabakchiev B, McGovern DPB, Jang J, Coldman A, Vandermeirsch G, Bressler B, Gunn H
Front Med (Lausanne). 2019;6:170. doi: 10.3389/fmed.2019.00170. Epub 2019 Jul 19.
PMID: 31380382

LNK suppresses interferon signaling in melanoma.
Ding LW, Sun QY, Edwards JJ, Fernandez LT, Ran XB, Zhou SQ, Scolyer RA, Wilmott JS, Thompson JF, Doan N, Said JW, Venkatachalam N, Xiao JF, Loh XY, Pein M, Xu L, Mullins DW, Yang H, Lin DC, Koeffler HP
Nat Commun. 2019 May 20;10(1):2230. doi: 10.1038/s41467-019-09711-y. Epub 2019 May 20.
PMID: 31110180

Beta-glucan-induced inflammatory monocytes mediate antitumor efficacy in the murine lung.
Alexander MP, Fiering SN, Ostroff GR, Cramer RA, Mullins DW
Cancer Immunol Immunother. 2018 Nov;67(11):1731-1742. doi: 10.1007/s00262-018-2234-9. Epub 2018 Aug 23.
PMID: 30167860

Harnessing innate lung anti-cancer effector functions with a novel bacterial-derived immunotherapy.
Bazett M, Costa AM, Bosiljcic M, Anderson RM, Alexander MP, Wong SWY, Dhanji S, Chen JM, Pankovich J, Lam S, Sutcliffe S, Gunn H, Kalyan S, Mullins DW
Oncoimmunology. 2018;7(3):e1398875. doi: 10.1080/2162402X.2017.1398875. Epub 2017 Nov 27.
PMID: 29399400

CXCR3(+) monocytes/macrophages are required for establishment of pulmonary metastases.
Butler KL, Clancy-Thompson E, Mullins DW
Sci Rep. 2017 Mar 30;7:45593. doi: 10.1038/srep45593. Epub 2017 Mar 30.
PMID: 28358049

Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment.
Varn FS, Wang Y, Mullins DW, Fiering S, Cheng C
Cancer Res. 2017 Mar 15;77(6):1271-1282. doi: 10.1158/0008-5472.CAN-16-2490. Epub 2017 Jan 26.
PMID: 28126714

View more publications on PubMed