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Brock C Christensen, PhD

Professor of Epidemiology
Professor of Community and Family Medicine
Professor of Molecular and Systems Biology

Community and Family Medicine
Molecular and Systems Biology

Harvard University, Ph.D. 2008
University of Wisconsin - Madison, B.S. 2002

Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences


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Contact Information

Geisel School of Medicine at Dartmouth
660 Williamson Translation Research Building
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Office: 660 Williamson
Phone: 603-650-1827
Fax: 603-650-1129
Email: Brock.Christensen@Dartmouth.edu

Professional Interests

Dr. Christensen's research is focused on combining advances in molecular biology, genomics and bioinformatics with the powerful techniques of modern epidemiology and statistics to characterize epigenetic states in human health and disease. His interests include understanding relationships between epigenetic states and exposures in the context of disease susceptibility, occurrence, and progression. By investigating complex interactions between the environment and somatic epigenetic alterations in target tissues, as well as epigenetic susceptibility traits in surrogate tissues, he hopes to develop their potential translational utility for diagnostic, prognostic, and/or treatment purposes.

Courses Taught

PEMM103 Introductory Applied Biostatistics with R (Course director)


Dr. Christensen received his B.S. from the University of Wisconsin Madison in Medical Microbiology & Immunology and French in 2002, and his Ph.D. from the Program in Biological Sciences in Public Health at Harvard University in 2008. He trained as a postdoctoral research associate in molecular epidemiology of cancer at Brown University in the Department of Pathology and Laboratory Medicine. Dr. Christensen joined the faculty at Dartmouth in 2011 as an Assistant Professor in the Departments of Community and Family Medicine in the Section of Biostatistics and Epidemiology, and Pharmacology and Toxicology.

Selected Publications


Genome-Scale Methylation Analysis Identifies Immune Profiles and Age Acceleration Associations with Bladder Cancer Outcomes.
Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BC
Cancer Epidemiol Biomarkers Prev. 2023 Oct 2;32(10):1328-1337. doi: 10.1158/1055-9965.EPI-23-0331.
PMID: 37527159

Alteration of DNMT1/DNMT3A by eribulin elicits global DNA methylation changes with potential therapeutic implications for triple-negative breast cancer.
Bagheri M, Lee MK, Muller KE, Miller TW, Pattabiraman DR, Christensen BC
bioRxiv. 2023 Jun 10; pii: 2023.06.09.544426. doi: 10.1101/2023.06.09.544426. Epub 2023 Jun 10.
PMID: 37333096

Hydroxymethylation alterations in progenitor-like cell types of pediatric central nervous system tumors are associated with cell type-specific transcriptional changes.
Lee MK, Azizgolshani N, Zhang Z, Perreard L, Kolling FW, Nguyen LN, Zanazzi GJ, Salas LA, Christensen BC
Res Sq. 2023 Feb 28; pii: rs.3.rs-2517758. doi: 10.21203/rs.3.rs-2517758/v1. Epub 2023 Feb 28.
PMID: 36909536

Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seq.
Lee MK, Azizgolshani N, Shapiro JA, Nguyen LN, Kolling FW, Zanazzi GJ, Frost HR, Christensen BC
Res Sq. 2023 Feb 23; pii: rs.3.rs-2517703. doi: 10.21203/rs.3.rs-2517703/v1. Epub 2023 Feb 23.
PMID: 36865335

Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer-Risk Factors.
Muse ME, Carroll CD, Salas LA, Karagas MR, Christensen BC
Cancer Epidemiol Biomarkers Prev. 2023 Apr 3;32(4):550-560. doi: 10.1158/1055-9965.EPI-22-0405.
PMID: 36780234

Distinct cytosine modification profiles define epithelial-to-mesenchymal cell-state transitions.
Lee MK, Brown MS, Wilkins OM, Pattabiraman DR, Christensen BC
Epigenomics. 2022 May;14(9):519-535. doi: 10.2217/epi-2022-0023. Epub 2022 Apr 6.
PMID: 35382559

Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling.
Salas LA, Zhang Z, Koestler DC, Butler RA, Hansen HM, Molinaro AM, Wiencke JK, Kelsey KT, Christensen BC
Nat Commun. 2022 Feb 9;13(1):761. doi: 10.1038/s41467-021-27864-7. Epub 2022 Feb 9.
PMID: 35140201

Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes.
Chen JQ, Salas LA, Wiencke JK, Koestler DC, Molinaro AM, Andrew AS, Seigne JD, Karagas MR, Kelsey KT, Christensen BC
Clin Epigenetics. 2022 Jan 21;14(1):14. doi: 10.1186/s13148-022-01234-6. Epub 2022 Jan 21.
PMID: 35063012

DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker.
Azizgolshani N, Petersen CL, Chen Y, Levy JJ, Salas LA, Perreard L, Nguyen LN, Christensen BC
Clin Epigenetics. 2021 Sep 19;13(1):176. doi: 10.1186/s13148-021-01156-9. Epub 2021 Sep 19.
PMID: 34538273

MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.
Levy JJ, Chen Y, Azizgolshani N, Petersen CL, Titus AJ, Moen EL, Vaickus LJ, Salas LA, Christensen BC
NPJ Syst Biol Appl. 2021 Aug 20;7(1):33. doi: 10.1038/s41540-021-00193-7. Epub 2021 Aug 20.
PMID: 34417465

View more publications on PubMed