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Brock C Christensen, PhD

Title(s):
Associate Professor of Epidemiology
Associate Professor of Community and Family Medicine
Associate Professor of Molecular and Systems Biology

Department(s):
Epidemiology
Community and Family Medicine
Molecular and Systems Biology

Education:
Harvard University, Ph.D. 2008
University of Wisconsin - Madison, B.S. 2002

Programs:
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences

Websites:
http://Christensen-lab.com

Contact Information:

Geisel School of Medicine at Dartmouth
660 Williamson Translation Research Building
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Office: 660 Williamson
Phone: 603-650-1827
Fax: 603-650-1129
Email: Brock.Christensen@Dartmouth.edu


Professional Interests:

Dr. Christensen's research is focused on combining advances in molecular biology, genomics and bioinformatics with the powerful techniques of modern epidemiology and statistics to characterize epigenetic states in human health and disease. His interests include understanding relationships between epigenetic states and exposures in the context of disease susceptibility, occurrence, and progression. By investigating complex interactions between the environment and somatic epigenetic alterations in target tissues, as well as epigenetic susceptibility traits in surrogate tissues, he hopes to develop their potential translational utility for diagnostic, prognostic, and/or treatment purposes.

Courses Taught:

PEMM103 Introductory Applied Biostatistics with R (Course director)

Biography:

Dr. Christensen received his B.S. from the University of Wisconsin Madison in Medical Microbiology & Immunology and French in 2002, and his Ph.D. from the Program in Biological Sciences in Public Health at Harvard University in 2008. He trained as a postdoctoral research associate in molecular epidemiology of cancer at Brown University in the Department of Pathology and Laboratory Medicine. Dr. Christensen joined the faculty at Dartmouth in 2011 as an Assistant Professor in the Departments of Community and Family Medicine in the Section of Biostatistics and Epidemiology, and Pharmacology and Toxicology.


Selected Publications:

 

PyMethylProcess - convenient high-throughput preprocessing workflow for DNA methylation data.
Levy JJ, Titus AJ, Salas LA, Christensen BC
Bioinformatics. 2019 Aug 1; pii: btz594. doi: 10.1093/bioinformatics/btz594. Epub 2019 Aug 1.
PMID: 31368477

Molecular and epigenetic profiles of BRCA1-like hormone-receptor-positive breast tumors identified with development and application of a copy-number-based classifier.
Chen Y, Wang Y, Salas LA, Miller TW, Mark K, Marotti JD, Kettenbach AN, Cheng C, Christensen BC
Breast Cancer Res. 2019 Jan 25;21(1):14. doi: 10.1186/s13058-018-1090-z. Epub 2019 Jan 25.
PMID: 30683142

MicroRNA-Related Genetic Variants Associated with Survival of Head and Neck Squamous Cell Carcinoma.
Wilkins OM, Titus AJ, Salas LA, Gui J, Eliot M, Butler RA, Sturgis EM, Li G, Kelsey KT, Christensen BC
Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):127-136. doi: 10.1158/1055-9965.EPI-18-0002. Epub 2018 Jun 7.
PMID: 29880533

An optimized library for reference-based deconvolution of whole-blood biospecimens assayed using the Illumina HumanMethylationEPIC BeadArray.
Salas LA, Koestler DC, Butler RA, Hansen HM, Wiencke JK, Kelsey KT, Christensen BC
Genome Biol. 2018 May 29;19(1):64. doi: 10.1186/s13059-018-1448-7. Epub 2018 May 29.
PMID: 29843789

Cell-type deconvolution from DNA methylation: a review of recent applications.
Titus AJ, Gallimore RM, Salas LA, Christensen BC
Hum Mol Genet. 2017 Oct 1;26(R2):R216-R224. doi: 10.1093/hmg/ddx275.
PMID: 28977446

Deconvolution of DNA methylation identifies differentially methylated gene regions on 1p36 across breast cancer subtypes.
Titus AJ, Way GP, Johnson KC, Christensen BC
Sci Rep. 2017 Sep 14;7(1):11594. doi: 10.1038/s41598-017-10199-z. Epub 2017 Sep 14.
PMID: 28912426

Concordance of DNA methylation profiles between breast core biopsy and surgical excision specimens containing ductal carcinoma in situ (DCIS).
Chen Y, Marotti JD, Jenson EG, Onega TL, Johnson KC, Christensen BC
Exp Mol Pathol. 2017 Aug;103(1):78-83. doi: 10.1016/j.yexmp.2017.07.001. Epub 2017 Jul 12.
PMID: 28711544

Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age.
Johnson KC, Houseman EA, King JE, Christensen BC
Breast Cancer Res. 2017 Jul 10;19(1):81. doi: 10.1186/s13058-017-0873-y. Epub 2017 Jul 10.
PMID: 28693600

Genome-scale identification of microRNA-related SNPs associated with risk of head and neck squamous cell carcinoma.
Wilkins OM, Titus AJ, Gui J, Eliot M, Butler RA, Sturgis EM, Li G, Kelsey KT, Christensen BC
Carcinogenesis. 2017 Oct 1;38(10):986-993. doi: 10.1093/carcin/bgx056.
PMID: 28582492

Integrative epigenetic and genetic pan-cancer somatic alteration portraits.
Salas LA, Johnson KC, Koestler DC, O'Sullivan DE, Christensen BC
Epigenetics. 2017 Jul 3;12(7):561-574. doi: 10.1080/15592294.2017.1319043. Epub 2017 Apr 20.
PMID: 28426276

View more publications on PubMed