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Laura J. Tafe, MD

Title(s)
Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Assistant Director, Laboratory for Clinical Genomics and Advanced Technology (CGAT), Dartmouth-Hitchcock Medical Center

Department(s)
Pathology and Laboratory Medicine

Education
Medical School:
MD, Wayne State University School of Medicine, Detroit, MI, 2004

Residency:
Dartmouth-Hitchcock Medical Center, Lebanon, NH, Anatomic and Clinical Pathology, 2004-08

Fellowship:
Memorial Sloan-Kettering Cancer Center, New York, NY, Oncologic Pathology, 2008-09

Fellowship:
Memorial Sloan-Kettering Cancer Center, New York, NY, Diagnostic Molecular Pathology, 2009-10

Board Certification:
Anatomic and Clinical Pathology, 2008
Molecular Genetic Pathology, 2011

Websites
http://cancer.dartmouth.edu/lung_thoracic/teamprofile/56703/Laura_J_Tafe_MD

Contact Information

Department of Pathology
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756


Selected Publications

 

Perineuronal net degradation in aggressive glioblastomas with KANK1::NTRK2 fusions.
Sadanandappa MK, Karbhari N, Knowles B, Palisoul SM, Hughes EG, Tafe LJ, Zanazzi GJ, Lin CC, Hong J
Neurooncol Adv. 2026 Jan-Dec;8(1):vdag219. doi: 10.1093/noajnl/vdag219. Epub 2026 Aug 20.
PMID: 42713184

Limited Availability of Short Tandem Repeat Genotype Testing in the United States for Diagnosis of Partial Hydatidiform Mole: A Dilemma for Practicing Precision Medicine.
Warren L, Tafe LJ, Devine WP, Rabban JT
Am J Surg Pathol. 2026 Aug 1;50(8):917-923. doi: 10.1097/PAS.0000000000002558. Epub 2026 Apr 30.
PMID: 42424170

Optical genome mapping uncovers disease-defining variants in an adult T-lymphoblastic leukemia and impacts prognosis.
Maxfield AM, Bickford MA, Tonseth KA, Bao J, Murad F, Wilson DN, Wainman LM, Hill JM, Donnelly LL, Kaur P, Tafe LJ, Karrs JX, Khan WA
Mol Cytogenet. 2026 May 24;19(1) doi: 10.1186/s13039-026-00770-7. Epub 2026 May 24.
PMID: 42178565

Lung adenocarcinoma with malignant serous effusions: A comprehensive clinicopathologic, molecular, and outcome analysis.
Ma W, Li J, Ould Ismail AA, Li T, Kerr DA, Tafe LJ, Liu X
Cancer Cytopathol. 2026 Jun;134(6):e70108. doi: 10.1002/cncy.70108.
PMID: 42145151

The Utility of Comprehensive Sampling in Cervical Lymph Node Dissection for Head and Neck Squamous Cell Carcinoma: Is More Better?
Ould Ismail AA, Pettus JR, Tafe LJ, Black CC, Schutz SN, Pastel DA, Paydarfar JA, Kerr DA
Head Neck. 2026 Apr 23; doi: 10.1002/hed.70288. Epub 2026 Apr 23.
PMID: 42025582

Spindle Cell Rhabdomyosarcoma of Oral Cavity With TCF12::VGLL3 Fusion, Expanding on a Recently Described Entity With Digital Spatial Profiling and Long-Term Follow Up.
Dashti NK, Chakraborty D, Sadanandappa MK, Dehner CA, Zhang PJ, Paydarfar JA, Tafe LJ
Genes Chromosomes Cancer. 2026 Apr;65(4):e70126. doi: 10.1002/gcc.70126.
PMID: 41983910

Optical Genome Mapping Enhances Structural Variant Detection and Refines Risk Stratification in Chronic Lymphocytic Leukemia.
Chakraborty SR, Bickford MA, Smuliac NA, Tonseth KA, Bao J, Murad F, Dominguez Vigil IG, Steinmetz HB, Wainman LM, Shah P, Bengtson EM, PonnamReddy S, Harmon GA, Donnelly LL, Tafe LJ, Karrs JX, Kaur P, Khan WA
Genes (Basel). 2026 Jan 19;17(1) doi: 10.3390/genes17010106. Epub 2026 Jan 19.
PMID: 41595525

Predicting targeted therapy resistance in non-small cell lung cancer using multimodal machine learning.
Hua P, Olofson A, Farhadi F, Hondelink L, Tsongalis G, Dragnev K, Hoegemann Savellano D, Suriawinata A, Tafe L, Hassanpour S
J Thorac Dis. 2025 Oct 31;17(10):8700-8714. doi: 10.21037/jtd-2025-1012. Epub 2025 Oct 29.
PMID: 41229771

Clinical Implementation of Expanded Solid Tumor Fusion Detection With Whole-Transcriptome Sequencing at an Academic Cancer Center.
Hughes EG, Bergman DT, Green DC, Sukhadia SS, Lefferts JA, Karrs JX, Vyas RS, Cieslak Z, Barbuto JN, Ognjenovic NB, Palisoul BE, Tsongalis GJ, Tafe LJ, Shah PS
JCO Precis Oncol. 2025 May;9:e2400830. doi: 10.1200/PO-24-00830. Epub 2025 May 29.
PMID: 40440583

Clinicopathological and molecular characterization of non-small cell lung cancer with pericardial effusions.
Ma W, Rodrigues Simoes NJ, Seery PP, Li T, Tafe LJ, Kerr DA, Liu X
Cancer Cytopathol. 2025 May;133(5):e70015. doi: 10.1002/cncy.70015.
PMID: 40227522

View more publications on PubMed