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Matthew C. Havrda, PhD

Title(s):
Assistant Professor of Molecular and Systems Biology

Department(s):
Molecular and Systems Biology

Education:
University of Maine: Graduate School of Biomedical Sciences and Engineering, Ph.D.

Programs:
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

Contact Information:


Professional Interests:

Glial Cell Biology
Neuroinflammation
Neurodegenerative Diseases
Brain Cancer

Rotations and Thesis Projects:

Glioblastoma
Parkinson's disease

Grant Information:

NIH-NIEHS 1R01ES024745
NIH-NIA 3R01ES024745-04S1
Target Validation Award: The Michael J. Fox Foundation
Dartmouth SYNERGY Scholars Award
The Hitchcock Foundation
NIH/NINDS 1F32NS059126-01A1

Courses Taught:

Scientific Basis of Disease I and II (PEMM)
Neurobiology of Disease (PEMM)
Neurosciences II (PEMM)
Cancer Biology (PEMM)
Brain Tumors Elective (GSOM)

Biography:

Dr. Havrda is a molecular biologist interested in characterizing neoplastic and neurodegenerative disorders of the central nervous system. He received his Ph.D. in 2006 from the Graduate School of Biomedical Science and Engineering and is an Assistant Professor of Molecular and Systems Biology at the Geisel School of Medicine at Dartmouth. Throughout his career, Dr. Havrda and his team have published numerous research reports, reviews, and book chapters in the contexts of glioblastoma and Parkinson’s disease. Ongoing work in Dr. Havrda’s laboratory is focused on two main themes: The study of how the neuronal microenvironment contributes to the development of gliomas in adults and children, and the characterization of pyroptotic processes as they impact the progression of Parkinson's disease. Studies are supported by the National Institute for Environmental Health Sciences, The National Institute on Aging, The Michael J. Fox Foundation, and the Jordan and Kyra Memorial Foundation.

Mentoring Information:

Sponsor, NIEHS F31, Faith Anderson (PEMM)
Sponsor, NINDS F31, Katharine von Herrmann (PEMM)
Co-Sponsor, NINDS F31, Adrianna Delatorre (PEMM)
Sponsor, NINDS F31, Eileen Martinez (PEMM)
Thesis Advisor, Katharina Horn, (Dartmouth 20)
Thesis Advisor, Myung Chang Lee, (Dartmouth 18)


Selected Publications:

 

Characterizing the heterogeneity in 5-aminolevulinic acid-induced fluorescence in glioblastoma.
Almiron Bonnin DA, Havrda MC, Lee MC, Evans L, Ran C, Qian DC, Harrington LX, Valdes PA, Cheng C, Amos CI, Harris BT, Paulsen KD, Roberts DW, Israel MA
J Neurosurg. 2019 May 24;:1-9. doi: 10.3171/2019.2.JNS183128. Epub 2019 May 24.
PMID: 31125970

Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target.
Almiron Bonnin DA, Havrda MC, Israel MA
Cancer Res. 2018 Nov 1;78(21):6031-6039. doi: 10.1158/0008-5472.CAN-18-0345. Epub 2018 Oct 17.
PMID: 30333116

Inflammasomes: An Emerging Mechanism Translating Environmental Toxicant Exposure Into Neuroinflammation in Parkinson's Disease.
Anderson FL, Coffey MM, Berwin BL, Havrda MC
Toxicol Sci. 2018 Nov 1;166(1):3-15. doi: 10.1093/toxsci/kfy219.
PMID: 30203060

NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease.
von Herrmann KM, Salas LA, Martinez EM, Young AL, Howard JM, Feldman MS, Christensen BC, Wilkins OM, Lee SL, Hickey WF, Havrda MC
NPJ Parkinsons Dis. 2018;4:24. doi: 10.1038/s41531-018-0061-5. Epub 2018 Aug 15.
PMID: 30131971

Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia.
Almiron Bonnin DA, Havrda MC, Lee MC, Liu H, Zhang Z, Nguyen LN, Harrington LX, Hassanpour S, Cheng C, Israel MA
Oncogene. 2018 Feb 22;37(8):1107-1118. doi: 10.1038/onc.2017.404. Epub 2017 Nov 20.
PMID: 29155422

Editor's Highlight: Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice.
Martinez EM, Young AL, Patankar YR, Berwin BL, Wang L, von Herrmann KM, Weier JM, Havrda MC
Toxicol Sci. 2017 Sep 1;159(1):64-75. doi: 10.1093/toxsci/kfx117.
PMID: 28903492

ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function.
Zhang Z, Rahme GJ, Chatterjee PD, Havrda MC, Israel MA
Cell Death Dis. 2017 Feb 16;8(2):e2615. doi: 10.1038/cddis.2017.14. Epub 2017 Feb 16.
PMID: 28206987

Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas.
Almiron Bonnin DA, Ran C, Havrda MC, Liu H, Hitoshi Y, Zhang Z, Cheng C, Ung M, Israel MA
Mol Cancer Ther. 2017 Apr;16(4):705-716. doi: 10.1158/1535-7163.MCT-16-0616. Epub 2017 Jan 30.
PMID: 28138037

Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells.
Sullivan JM, Havrda MC, Kettenbach AN, Paolella BR, Zhang Z, Gerber SA, Israel MA
Stem Cells. 2016 May;34(5):1321-31. doi: 10.1002/stem.2291. Epub 2016 Feb 1.
PMID: 26756672

Inhibitor of differentiation 4 (ID4): From development to cancer.
Patel D, Morton DJ, Carey J, Havrda MC, Chaudhary J
Biochim Biophys Acta. 2015 Jan;1855(1):92-103. doi: 10.1016/j.bbcan.2014.12.002. Epub 2014 Dec 12.
PMID: 25512197

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