Matthew C. Havrda, PhD
Title(s)
Associate Professor of Molecular and Systems Biology
Department(s)
Molecular and Systems Biology
Education
University of Maine: Graduate School of Biomedical Sciences and Engineering, Ph.D.
Programs
Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Contact Information
Professional Interests
Glial Cell Biology
Neuroinflammation
Neurodegenerative Diseases
Brain Cancer
Rotations and Thesis Projects
Parkinson's disease
Glioblastoma
Grant Information
NIH-NIEHS 1R01ES024745
NIH-NIA 3R01ES024745-04S1
Target Validation Award: The Michael J. Fox Foundation
Dartmouth SYNERGY Scholars Award
The Hitchcock Foundation
NIH/NINDS 1F32NS059126-01A1
Courses Taught
Scientific Basis of Disease I and II (PEMM)
Neurobiology of Disease (PEMM)
Neurosciences II (PEMM)
Cancer Biology (PEMM)
Brain Tumors Elective (GSOM)
Mentoring Information
Sponsor, NIEHS F31, Faith Anderson (PEMM)
Sponsor, NINDS F31, Katharine von Herrmann (PEMM)
Co-Sponsor, NINDS F31, Adrianna Delatorre (PEMM)
Sponsor, NINDS F31, Eileen Martinez (PEMM)
Thesis Advisor, Katharina Horn, (Dartmouth 20)
Thesis Advisor, Myung Chang Lee, (Dartmouth 18)
Biography
Dr. Havrda is a molecular biologist interested in characterizing neoplastic and neurodegenerative disorders of the central nervous system. He received his Ph.D. in 2006 from the Graduate School of Biomedical Science and Engineering and is an Assistant Professor of Molecular and Systems Biology at the Geisel School of Medicine at Dartmouth. Throughout his career, Dr. Havrda and his team have published numerous research reports, reviews, and book chapters in the contexts of glioblastoma and Parkinson’s disease. Ongoing work in Dr. Havrda’s laboratory is focused on two main themes: The study of how the neuronal microenvironment contributes to the development of gliomas in adults and children, and the characterization of pyroptotic processes as they impact the progression of Parkinson's disease. Studies are supported by the National Institute for Environmental Health Sciences, The National Institute on Aging, The Michael J. Fox Foundation, and the Jordan and Kyra Memorial Foundation.
Inhibiting the cholesterol storage enzyme ACAT1/SOAT1 in aging Apolipoprotein E4 mice alter their brains inflammatory profiles. Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1. NLRP3 inflammasome in neurodegenerative disease. Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture. Lifestyle Factors and Parkinson's Disease Risk in a Rural New England Case-Control Study. Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos. The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate. Plasma-borne indicators of inflammasome activity in Parkinson's disease patients. The effect of botulinum toxin on ureteral inflammation. Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice. |
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