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Matthew C. Havrda, PhD

Title(s):
Assistant Professor of Molecular and Systems Biology

Department(s):
Molecular and Systems Biology

Education:
University of Maine: Graduate School of Biomedical Sciences and Engineering, Ph.D.

Programs:
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine

Contact Information:


Professional Interests:

Glial Cell Biology
Neuroinflammation
Neurodegenerative Diseases
Brain Cancer

Rotations and Thesis Projects:

Glioblastoma
Parkinson's disease

Grant Information:

NIH-NIEHS 1R01ES024745
NIH-NIA 3R01ES024745-04S1
Target Validation Award: The Michael J. Fox Foundation
Dartmouth SYNERGY Scholars Award
The Hitchcock Foundation
NIH/NINDS 1F32NS059126-01A1

Courses Taught:

Scientific Basis of Disease I and II (PEMM)
Neurobiology of Disease (PEMM)
Neurosciences II (PEMM)
Cancer Biology (PEMM)
Brain Tumors Elective (GSOM)

Biography:

Dr. Havrda is a molecular biologist interested in characterizing neoplastic and neurodegenerative disorders of the central nervous system. He received his Ph.D. in 2006 from the Graduate School of Biomedical Science and Engineering and is an Assistant Professor of Molecular and Systems Biology at the Geisel School of Medicine at Dartmouth. Throughout his career, Dr. Havrda and his team have published numerous research reports, reviews, and book chapters in the contexts of glioblastoma and Parkinson’s disease. Ongoing work in Dr. Havrda’s laboratory is focused on two main themes: The study of how the neuronal microenvironment contributes to the development of gliomas in adults and children, and the characterization of pyroptotic processes as they impact the progression of Parkinson's disease. Studies are supported by the National Institute for Environmental Health Sciences, The National Institute on Aging, The Michael J. Fox Foundation, and the Jordan and Kyra Memorial Foundation.

Mentoring Information:

Sponsor, NIEHS F31, Faith Anderson (PEMM)
Sponsor, NINDS F31, Katharine von Herrmann (PEMM)
Co-Sponsor, NINDS F31, Adrianna Delatorre (PEMM)
Sponsor, NINDS F31, Eileen Martinez (PEMM)
Thesis Advisor, Katharina Horn, (Dartmouth 20)
Thesis Advisor, Myung Chang Lee, (Dartmouth 18)


Selected Publications:

 

Lifestyle Factors and Parkinson's Disease Risk in a Rural New England Case-Control Study.
Andrew AS, Anderson FL, Lee SL, Von Herrmann KM, Havrda MC
Parkinsons Dis. 2021;2021:5541760. doi: 10.1155/2021/5541760. Epub 2021 Jul 2.
PMID: 34306610

Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos.
Anderson FL, von Herrmann KM, Young AL, Havrda MC
Toxicol Sci. 2021 Sep 28;183(2):378-392. doi: 10.1093/toxsci/kfab090.
PMID: 34289071

The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate.
Hewa Bostanthirige D, Komaragiri SK, Joshi JB, Alzahrani M, Saini I, Jain S, Bowen NJ, Havrda MC, Chaudhary J
Oncoscience. 2021;8:14-30. doi: 10.18632/oncoscience.524. Epub 2021 Mar 24.
PMID: 33884281

Plasma-borne indicators of inflammasome activity in Parkinson's disease patients.
Anderson FL, von Herrmann KM, Andrew AS, Kuras YI, Young AL, Scherzer CR, Hickey WF, Lee SL, Havrda MC
NPJ Parkinsons Dis. 2021 Jan 4;7(1):2. doi: 10.1038/s41531-020-00147-6. Epub 2021 Jan 4.
PMID: 33398042

The effect of botulinum toxin on ureteral inflammation.
Krughoff K, Anderson FL, Palisoul S, Young AL, R Pettus J, L Moodie K, Ogomo C, S Tau S, A Moses R, Havrda MC, R Chavez D
World J Urol. 2021 Jun;39(6):2197-2204. doi: 10.1007/s00345-020-03365-y. Epub 2020 Jul 21.
PMID: 32696129

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice.
von Herrmann KM, Anderson FL, Martinez EM, Young AL, Havrda MC
J Neuroinflammation. 2020 Jul 17;17(1):213. doi: 10.1186/s12974-020-01866-6. Epub 2020 Jul 17.
PMID: 32680528

Characterizing the heterogeneity in 5-aminolevulinic acid-induced fluorescence in glioblastoma.
Almiron Bonnin DA, Havrda MC, Lee MC, Evans L, Ran C, Qian DC, Harrington LX, Valdes PA, Cheng C, Amos CI, Harris BT, Paulsen KD, Roberts DW, Israel MA
J Neurosurg. 2019 May 24;132(6):1706-1714. doi: 10.3171/2019.2.JNS183128. Epub 2019 May 24.
PMID: 31125970

Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target.
Almiron Bonnin DA, Havrda MC, Israel MA
Cancer Res. 2018 Nov 1;78(21):6031-6039. doi: 10.1158/0008-5472.CAN-18-0345. Epub 2018 Oct 17.
PMID: 30333116

Inflammasomes: An Emerging Mechanism Translating Environmental Toxicant Exposure Into Neuroinflammation in Parkinson's Disease.
Anderson FL, Coffey MM, Berwin BL, Havrda MC
Toxicol Sci. 2018 Nov 1;166(1):3-15. doi: 10.1093/toxsci/kfy219.
PMID: 30203060

NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease.
von Herrmann KM, Salas LA, Martinez EM, Young AL, Howard JM, Feldman MS, Christensen BC, Wilkins OM, Lee SL, Hickey WF, Havrda MC
NPJ Parkinsons Dis. 2018;4:24. doi: 10.1038/s41531-018-0061-5. Epub 2018 Aug 15.
PMID: 30131971

View more publications on PubMed