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Joel A. Lefferts, PhD

Title(s)
Associate Professor of Pathology and Laboratory Medicine

Additional Titles/Positions/Affiliations
Assistant Director, Clinical Genomics and Advanced Technology Laboratory

Department(s)
Pathology and Laboratory Medicine

Education
PhD, Rutgers Graduate School of Biomedical Sciences (University of Medicine & Dentistry of New Jersey), Newark, NJ , 2006

Molecular Pathology Fellowship, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH 2006-2010

Contact Information

Department of Pathology
One Medical Center Drive
Lebanon NH 03756

Phone: 603-650-8116
Email: Joel.A.Lefferts@hitchcock.org


Selected Publications

 

A complex case of chronic cutaneous Borrelia burgdorferi sensu stricto infection manifesting as morphea-like sclerosis in the United States.
Diiorio MR, Huang G, Shah PC, Yan S, LeBlanc RE, Lefferts JA, Brown LA, Barton DT
JAAD Case Rep. 2026 Mar;69:176-180. doi: 10.1016/j.jdcr.2026.01.038. Epub 2026 Feb 2.
PMID: 41782738

A novel out-of-frame CREBBP::TRAP1 fusion in malignant intracerebral nerve sheath tumor.
Chakraborty D, Donnelly LL, Lefferts JA, Green DC, Shannon PM, Quezado M, Abdullaev Z, Aldape KD, Lin CC
J Neuropathol Exp Neurol. 2026 Mar 2; pii: nlaf162. doi: 10.1093/jnen/nlaf162. Epub 2026 Mar 2.
PMID: 41769772

Development of a multiplex ddPCR assay for simultaneous absolute quantification of bacterial, fungal, and human DNA.
Huang G, Gallagher TL, Tsongalis GJ, Lefferts JA
PLoS One. 2026;21(2):e0341560. doi: 10.1371/journal.pone.0341560. Epub 2026 Feb 20.
PMID: 41719263

Sclerosing melanocytic tumors with MAP2K1 in frame deletions and 15q gains: A distinctive pathway of nevogenesis with reproducible morphology.
Friedman BJ, Kis O, Shaw B, Cloutier JM, Yan S, Lefferts JA, Alomari AK, Dehner CA, Li A, Moy A, Linos K
Virchows Arch. 2026 Jul;489(1):189-198. doi: 10.1007/s00428-025-04368-z. Epub 2025 Dec 19.
PMID: 41417041

Novel Homozygous Full Gene Deletion of SLC12A5 in a Newborn With Refractory Seizures.
Wainman LM, Wright DL, Shah ND, Khan WA, Tsongalis GJ, Lefferts JA
Am J Med Genet A. 2025 Nov;197(11):e64180. doi: 10.1002/ajmg.a.64180. Epub 2025 Jul 9.
PMID: 40630017

Clinical Implementation of Expanded Solid Tumor Fusion Detection With Whole-Transcriptome Sequencing at an Academic Cancer Center.
Hughes EG, Bergman DT, Green DC, Sukhadia SS, Lefferts JA, Karrs JX, Vyas RS, Cieslak Z, Barbuto JN, Ognjenovic NB, Palisoul BE, Tsongalis GJ, Tafe LJ, Shah PS
JCO Precis Oncol. 2025 May;9:e2400830. doi: 10.1200/PO-24-00830. Epub 2025 May 29.
PMID: 40440583

Simplifying SARS-CoV-2 wastewater-based surveillance using an automated FDA EUA assay.
Sathyanarayana SH, Robins AA, Toledo DM, Gallagher TL, Tsongalis GJ, Hubbard JA, Lefferts JA, Martin IW
Microbiol Spectr. 2025 Apr;13(4):e0249024. doi: 10.1128/spectrum.02490-24. Epub 2025 Feb 25.
PMID: 39998239

Extra-Axial Poorly Differentiated Chordoma Initially Misdiagnosed as Epithelioid Sarcoma.
O'Connor P, Cheung YY, Green DC, Lefferts JA, Jo VY, Kerr DA
Int J Surg Pathol. 2025 May;33(3):646-655. doi: 10.1177/10668969241286086. Epub 2024 Nov 13.
PMID: 39533889

Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.
Jones VM, Thompson LDR, Pettus JR, Green DC, Lefferts JA, Shah PS, Tsongalis GJ, Sajed DP, Guilmette JM, Lewis JS Jr, Fisch AS, Tafe LJ, Kerr DA
Head Neck Pathol. 2024 Oct 14;18(1):93. doi: 10.1007/s12105-024-01700-y. Epub 2024 Oct 14.
PMID: 39400771

Angiomyolipomatous Lesions of the Nasal Cavity (Sinonasal Angioleiomyoma with Adipocytic Differentiation): A Multi-Institutional Immunohistochemical and Molecular Study.
Jones VM, Thompson LDR, Pettus JR, Green DC, Lefferts JA, Shah PS, Tsongalis GJ, Sajed DP, Guilmette JM, Lewis JS, Fisch AS, Tafe LJ, Kerr DA
Res Sq. 2024 Sep 8; pii: rs.3.rs-4843357. doi: 10.21203/rs.3.rs-4843357/v1. Epub 2024 Sep 8.
PMID: 39281855

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