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Scott A. Gerber, PhD

Title(s):
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology

Additional Titles/Positions/Affiliations:
Kenneth E. and Carol L. Weg Distinguished Professor
Director, Cancer Biology & Therapeutics Research Program, NCCC
Associate Director, Quantitative Biomedical Sciences Graduate Program

Department(s):
Molecular and Systems Biology
Biochemistry and Cell Biology

Education:
BA, Chemistry, Willamette University
PhD, Analytical Chemistry, University of Washington
Postdoc, Quantitative Proteomics, Harvard Medical School

Programs:
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences

Websites:
http://proteomics.dartmouth.edu

Contact Information:

One Medical Center Dr.
HB - 7937
Lebanon NH 03756

Office: Rubin 734
Phone: 603.653.3679
Fax: 603.653.9923
Email: scott.a.gerber@dartmouth.edu


Professional Interests:

Signal transduction in cell division
Mass spectrometry-based proteomics
Discovery proteomics for thoracic oncology


Selected Publications:

 

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Gottgens B, Speck NA, Zon LI
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23626-23635. doi: 10.1073/pnas.2003228117. Epub 2020 Sep 3.
PMID: 32883883

WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication.
Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ
J Cell Biol. 2020 Jan 6;219(1) pii: e201904203. doi: 10.1083/jcb.201904203.
PMID: 31874114

The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.
Kim SA, LaCroix IS, Gerber SA, Guerinot ML
Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):24933-24942. doi: 10.1073/pnas.1916892116. Epub 2019 Nov 27.
PMID: 31776249

Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.
Cassidy KB, Bang S, Kurokawa M, Gerber SA
FEBS J. 2020 May;287(10):1985-1999. doi: 10.1111/febs.15132. Epub 2019 Nov 29.
PMID: 31713291

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE
Nat Commun. 2019 Apr 15;10(1):1757. doi: 10.1038/s41467-019-09703-y. Epub 2019 Apr 15.
PMID: 30988284

Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles.
Koeppen K, Barnaby R, Jackson AA, Gerber SA, Hogan DA, Stanton BA
PLoS One. 2019;14(1):e0211290. doi: 10.1371/journal.pone.0211290. Epub 2019 Jan 25.
PMID: 30682135

Phosphatidylinositol-(3,4,5)-Trisphosphate Induces Phagocytosis of Nonmotile Pseudomonas aeruginosa.
Demirdjian S, Hopkins D, Sanchez H, Libre M, Gerber SA, Berwin B
Infect Immun. 2018 Aug;86(8) pii: e00215-18. doi: 10.1128/IAI.00215-18. Epub 2018 Jul 23.
PMID: 29844235

Global assessment of its network dynamics reveals that the kinase Plk1 inhibits the phosphatase PP6 to promote Aurora A activity.
Kettenbach AN, Schlosser KA, Lyons SP, Nasa I, Gui J, Adamo ME, Gerber SA
Sci Signal. 2018 May 15;11(530) pii: eaaq1441. doi: 10.1126/scisignal.aaq1441. Epub 2018 May 15.
PMID: 29764989

Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain.
Zhao Y, Cushing PR, Smithson DC, Pellegrini M, Pletnev AA, Al-Ayyoubi S, Grassetti AV, Gerber SA, Guy RK, Madden DR
Biosci Rep. 2018 Aug 31;38(4) pii: BSR20180231. doi: 10.1042/BSR20180231. Epub 2018 Jul 6.
PMID: 29472314

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa.
Zhou X, Wang B, Emerson JM, Ringelberg CS, Gerber SA, Loros JJ, Dunlap JC
PLoS Genet. 2018 Jan;14(1):e1007192. doi: 10.1371/journal.pgen.1007192. Epub 2018 Jan 19.
PMID: 29351294

View more publications on PubMed