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Scott A. Gerber, PhD

Title(s):
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology

Additional Titles/Positions/Affiliations:
Kenneth E. and Carol L. Weg Distinguished Professor
Director, Cancer Biology & Therapeutics Research Program, NCCC
Associate Director, Quantitative Biomedical Sciences Graduate Program

Department(s):
Molecular and Systems Biology
Biochemistry and Cell Biology

Education:
BA, Chemistry, Willamette University
PhD, Analytical Chemistry, University of Washington
Postdoc, Quantitative Proteomics, Harvard Medical School

Programs:
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences

Websites:
http://proteomics.dartmouth.edu

Contact Information:

One Medical Center Dr.
HB - 7937
Lebanon NH 03756

Office: Rubin 734
Phone: 603.653.3679
Fax: 603.653.9923
Email: scott.a.gerber@dartmouth.edu


Professional Interests:

Signal transduction in cell division
Mass spectrometry-based proteomics
Discovery proteomics for thoracic oncology


Selected Publications:

 

Affinity-based profiling of endogenous phosphoprotein phosphatases by mass spectrometry.
Brauer BL, Wiredu K, Mitchell S, Moorhead GB, Gerber SA, Kettenbach AN
Nat Protoc. 2021 Oct;16(10):4919-4943. doi: 10.1038/s41596-021-00604-3. Epub 2021 Sep 13.
PMID: 34518704

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa.
Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefeld AE, Kolling FW, LaCroix IS, Gerber SA, Hogan DA, Kasetty S, Nadell CD, Stanton BA
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28) pii: e2105370118. doi: 10.1073/pnas.2105370118.
PMID: 34260396

Cellular Calcium Levels Influenced by NCA-2 Impact Circadian Period Determination in Neurospora.
Wang B, Zhou X, Gerber SA, Loros JJ, Dunlap JC
mBio. 2021 Jun 29;12(3):e0149321. doi: 10.1128/mBio.01493-21. Epub 2021 Jun 29.
PMID: 34182778

Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors.
Ognjenovic NB, Bagheri M, Mohamed GA, Xu K, Chen Y, Mohamed Saleem MA, Brown MS, Nagaraj SH, Muller KE, Gerber SA, Christensen BC, Pattabiraman DR
Dev Cell. 2020 Dec 7;55(5):544-557.e6. doi: 10.1016/j.devcel.2020.10.004. Epub 2020 Oct 28.
PMID: 33120014

CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation.
Hsu J, Huang HT, Lee CT, Choudhuri A, Wilson NK, Abraham BJ, Moignard V, Kucinski I, Yu S, Hyde RK, Tober J, Cai X, Li Y, Guo Y, Yang S, Superdock M, Trompouki E, Calero-Nieto FJ, Ghamari A, Jiang J, Gao P, Gao L, Nguyen V, Robertson AL, Durand EM, Kathrein KL, Aifantis I, Gerber SA, Tong W, Tan K, Cantor AB, Zhou Y, Liu PP, Young RA, Gottgens B, Speck NA, Zon LI
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23626-23635. doi: 10.1073/pnas.2003228117. Epub 2020 Sep 3.
PMID: 32883883

WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication.
Park EM, Scott PM, Clutario K, Cassidy KB, Zhan K, Gerber SA, Holland AJ
J Cell Biol. 2020 Jan 6;219(1) pii: e201904203. doi: 10.1083/jcb.201904203.
PMID: 31874114

The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI.
Kim SA, LaCroix IS, Gerber SA, Guerinot ML
Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):24933-24942. doi: 10.1073/pnas.1916892116. Epub 2019 Nov 27.
PMID: 31776249

Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.
Cassidy KB, Bang S, Kurokawa M, Gerber SA
FEBS J. 2020 May;287(10):1985-1999. doi: 10.1111/febs.15132. Epub 2019 Nov 29.
PMID: 31713291

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE
Nat Commun. 2019 Apr 15;10(1):1757. doi: 10.1038/s41467-019-09703-y. Epub 2019 Apr 15.
PMID: 30988284

Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles.
Koeppen K, Barnaby R, Jackson AA, Gerber SA, Hogan DA, Stanton BA
PLoS One. 2019;14(1):e0211290. doi: 10.1371/journal.pone.0211290. Epub 2019 Jan 25.
PMID: 30682135

View more publications on PubMed