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Scott A. Gerber, PhD

Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology

Additional Titles/Positions/Affiliations
Kenneth E. and Carol L. Weg Distinguished Professor
Director, Cancer Biology & Therapeutics Research Program, NCCC
Associate Director, Quantitative Biomedical Sciences Graduate Program

Molecular and Systems Biology
Biochemistry and Cell Biology

BA, Chemistry, Willamette University
PhD, Analytical Chemistry, University of Washington
Postdoc, Quantitative Proteomics, Harvard Medical School

Molecular and Cellular Biology Graduate Programs
Dartmouth Cancer Center
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences


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Contact Information

One Medical Center Dr.
HB - 7937
Lebanon NH 03756

Office: Rubin 734
Phone: 603.653.3679
Fax: 603.653.9923
Email: scott.a.gerber@dartmouth.edu

Professional Interests

Signal transduction in cell division
Mass spectrometry-based proteomics
Discovery proteomics for thoracic oncology

Selected Publications


Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer.
Bagheri M, Mohamed GA, Mohamed Saleem MA, Ognjenovic NB, Lu H, Kolling FW, Wilkins OM, Das S, LaCroix IS, Nagaraj SH, Muller KE, Gerber SA, Miller TW, Pattabiraman DR
Cell Rep Med. 2024 Apr 16;5(4):101504. doi: 10.1016/j.xcrm.2024.101504. Epub 2024 Apr 8.
PMID: 38593809

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in cystic fibrosis.
Li Z, Barnaby R, Nymon A, Roche C, Koeppen K, Ashare A, Hogan DA, Gerber SA, Taatjes DJ, Hampton TH, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2024 May 1;326(5):L574-L588. doi: 10.1152/ajplung.00018.2024. Epub 2024 Mar 5.
PMID: 38440830

The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6.
Spencer ZT, Ng VH, Benchabane H, Siddiqui GS, Duwadi D, Maines B, Bryant JM, Schwarzkopf A, Yuan K, Kassel SN, Mishra A, Pimentel A, Lebensohn AM, Rohatgi R, Gerber SA, Robbins DJ, Lee E, Ahmed Y
Nat Commun. 2023 Oct 5;14(1):6174. doi: 10.1038/s41467-023-41843-0. Epub 2023 Oct 5.
PMID: 37798281

An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa.
Koeppen K, Hampton TH, Barnaby R, Roche C, Gerber SA, Goo YA, Cho BK, Vermilyea DM, Hogan DA, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2023 Jul 1;325(1):L54-L65. doi: 10.1152/ajplung.00150.2022. Epub 2023 May 31.
PMID: 37256658

Pharmacological Induction of mesenchymal-epithelial transition chemosensitizes breast cancer cells and prevents metastatic progression.
Bagheri M, Aisha Mohamed G, Mohamed Saleem MA, Ognjenovic NB, Lu H, Kolling FW, Wilkins OM, Das S, La Croix IS, Nagaraj SH, Muller KE, Gerber SA, Miller TW, Pattabiraman DR
bioRxiv. 2023 Apr 21; pii: 2023.04.19.537586. doi: 10.1101/2023.04.19.537586. Epub 2023 Apr 21.
PMID: 37131809

Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies.
Wiredu K, Aduse-Poku E, Shaefi S, Gerber SA
Anesth Analg. 2023 Mar 1;136(3):422-432. doi: 10.1213/ANE.0000000000006246. Epub 2022 Dec 29.
PMID: 36580411

Intraoperative plasma proteomic changes in cardiac surgery: In search of biomarkers of post-operative delirium.
Wiredu K, O'Connor S, Naseem H, Brauer BL, Kettenbach AN, Frost HR, Shaefi S, Gerber SA
Proteomics Clin Appl. 2023 Jul;17(4):e2200066. doi: 10.1002/prca.202200066. Epub 2023 Jan 4.
PMID: 36567636

Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes.
Wolf BK, Zhao Y, McCray A, Hawk WH, Deary LT, Sugiarto NW, LaCroix IS, Gerber SA, Cheng C, Wang X
Nat Struct Mol Biol. 2023 Jan;30(1):10-21. doi: 10.1038/s41594-022-00880-x. Epub 2022 Dec 15.
PMID: 36522426

Evaluation of Quantification and Normalization Strategies for Phosphoprotein Phosphatase Affinity Proteomics: Application to Breast Cancer Signaling.
Brauer BL, Wiredu K, Gerber SA, Kettenbach AN
J Proteome Res. 2023 Jan 6;22(1):47-61. doi: 10.1021/acs.jproteome.2c00465. Epub 2022 Nov 30.
PMID: 36448918

Metabolic phosphatase moonlights for proteins.
Gerber SA, Kettenbach AN
Nat Cell Biol. 2022 Nov;24(11):1568-1570. doi: 10.1038/s41556-022-00993-x.
PMID: 36266487

View more publications on PubMed