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Allan Gulledge, PhD

Title(s):
Associate Professor of Molecular and Systems Biology

Department(s):
Molecular and Systems Biology

Education:
University of California, Riverside, BS 1991
University of Texas, San Antonio, PhD 2000

Programs:
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine

Websites:
http://www.dartmouth.edu/~gulledge
https://geiselmed.dartmouth.edu/msb/
https://geiselmed.dartmouth.edu/ncd/
https://geiselmed.dartmouth.edu/pemm/

Contact Information:

Geisel School of Medicine
DHMC, Borwell 704E
One Medical Center Drive
Lebanon NH 03756-0001

Office: Borwell 704E
Phone: 603-650-7283
Fax: 603-650-6130
Email: allan@dartmouth.edu

Asst. Phone: 603-650-7731


Professional Interests:

Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in neocortical neurons under a variety of experimental conditions.

Currently, we are investigating signal transduction events that are mediated by a variety of "modulatory" neurotransmitters that are critical for normal cognition and directly involved in many neurological and psychiatric disorders. These modulators (such as acetylcholine, serotonin, and dopamine) activate a variety of receptor subtypes to initiate biochemical signaling cascades within neurons that influence excitability and synaptic transmission. Because there are many different cell types within the cortex, each expressing a unique combination of receptors, neuromodulators can have different, or even opposite, effects on specific neuronal subpopulations. By examining how neuromodulators regulate the activity of many types of cortical neuron, we aim to identify their functional role in facilitating information flow within cortical circuits. This knowledge will provide insight into normal cognition, and may reveal mechanisms contributing to neurological and psychiatric disorders, such as major depression, schizophrenia, and age-dependent dementia.

Rotations and Thesis Projects:

There are are great many mysteries regarding the physiology of the neocortex that remain to be discovered. Among other opportunities, students may wish to consider:

1. Identification of the molecular mechanism(s) by which G-protein-coupled receptors regulate the output of cortical neurons.
2. Characterization of the synaptic release processes that are modified by presynaptic metabotropic and ionotropic receptors.
3. Determination of the role of calcium in regulating the activity of cortical neurons.
4. Revealing plasticity in serotonin receptor expression in cortical neurons driven by selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine.
5. Characterizing the impact of neuronal morphology in synaptic integration.

More information available at http://www.dartmouth.edu/~gulledge

Grant Information:

R01 MH099054: Neuromodulation of cortical circuits in health and disease
Project period: 08/01/13-07/31/18
PI: Allan Gulledge

R01-MH083806: Cholinergic signaling in cortical neurons: a unifying hypothesis
Project period: 07/11/08-06/30/13
PI: Allan Gulledge

NSF 0922631: MRI: Acquisition of a multi-photon imaging and electrophysiology rig
Project period: 08/01/2009 - 07/31/2012
PI: Allan Gulledge

NARSAD Young Investigator Award (2009): CCK-Positive Large Basket Neurons as a Source of Cortical Activation in ADHD
Project Period: 01/01/2010 - 12/31/2012
PI: Allan Gulledge

Neuroscience Center at Dartmouth Collaborative/Translational Funding Award: Cholinergic mechanisms involved in cue discrimination
Project Period: 01/01/2008 - 01/01/2009
PI: Allan Gulledge & David Bucci

Courses Taught:

Scientific Basis of Disease (PEMM 101)
Neurobiology of Disease (PEMM 211)
Neurosciences II (PEMM 212)
Advanced Biomedical Science (PEMM 271)
Medical Neuroscience (MDED 115)
Cardiovascular and Respiratory Physiology (PHSL.110)
Graduate Ethics Course (Ethics in Science) (UNSG.100.04)

Biography:

Dr. Gulledge received his B.S. in Psychobiology from the University of California, Riverside in 1991, and his Ph.D. in Biology from the University of Texas, San Antonio in 2000. He then conducted postdoctoral research at the Australian National University (2000-2005) as an NSF International Research Fellow, and at the National Institute for Physiological Sciences in Okazaki, Japan (2005-2007), as a JSPS Postdoctoral Fellow. Dr. Gulledge joined the faculty of Dartmouth Medical School as an Assistant Professor of Physiology in 2007, and has been an Associate Professor in Physiology and Neurobiology since January, 2015.


Selected Publications:

 

Corrigendum: Mechanisms Underlying Serotonergic Excitation of Callosal Projection Neurons in the Mouse Medial Prefrontal Cortex.
Stephens EK, Baker AL, Gulledge AT
Front Neural Circuits. 2019;13:23. doi: 10.3389/fncir.2019.00023. Epub 2019 Apr 9.
PMID: 31024266

Loss of Neurofascin-186 Disrupts Alignment of AnkyrinG Relative to Its Binding Partners in the Axon Initial Segment.
Alpizar SA, Baker AL, Gulledge AT, Hoppa MB
Front Cell Neurosci. 2019;13:1. doi: 10.3389/fncel.2019.00001. Epub 2019 Jan 22.
PMID: 30723396

Serotonergic Regulation of Corticoamygdalar Neurons in the Mouse Prelimbic Cortex.
Avesar D, Stephens EK, Gulledge AT
Front Neural Circuits. 2018;12:63. doi: 10.3389/fncir.2018.00063. Epub 2018 Aug 7.
PMID: 30131678

Mechanisms Underlying Serotonergic Excitation of Callosal Projection Neurons in the Mouse Medial Prefrontal Cortex.
Stephens EK, Baker AL, Gulledge AT
Front Neural Circuits. 2018;12:2. doi: 10.3389/fncir.2018.00002. Epub 2018 Jan 18.
PMID: 29422840

Preferential cholinergic excitation of corticopontine neurons.
Baker AL, O'Toole RJ, Gulledge AT
J Physiol. 2018 May 1;596(9):1659-1679. doi: 10.1113/JP275194. Epub 2018 Feb 20.
PMID: 29330867

A unifying hypothesis for M1 muscarinic receptor signalling in pyramidal neurons.
Dasari S, Hill C, Gulledge AT
J Physiol. 2017 Mar 1;595(5):1711-1723. doi: 10.1113/JP273627. Epub 2016 Dec 17.
PMID: 27861914

Neuron Morphology Influences Axon Initial Segment Plasticity.
Gulledge AT, Bravo JJ
eNeuro. 2016 Jan-Feb;3(1) pii: ENEURO.0085-15.2016. doi: 10.1523/ENEURO.0085-15.2016. Epub 2016 Feb 13.
PMID: 27022619

Editorial: Neuromodulation of executive circuits.
Puig MV, Gulledge AT, Lambe EK, Gonzalez-Burgos G
Front Neural Circuits. 2015;9:58. doi: 10.3389/fncir.2015.00058. Epub 2015 Oct 8.
PMID: 26500506

Hyperactivity of newborn Pten knock-out neurons results from increased excitatory synaptic drive.
Williams MR, DeSpenza T Jr, Li M, Gulledge AT, Luikart BW
J Neurosci. 2015 Jan 21;35(3):943-59. doi: 10.1523/JNEUROSCI.3144-14.2015.
PMID: 25609613

Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex.
Stephens EK, Avesar D, Gulledge AT
Front Neural Circuits. 2014;8:97. doi: 10.3389/fncir.2014.00097. Epub 2014 Aug 26.
PMID: 25206322

View more publications on PubMed