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Hermes Hsiao-Mei Yeh, PhD

Title(s):
Professor of Molecular and Systems Biology
Professor of Neurology
William W. Brown 1835M Memorial Professor

Additional Titles/Positions/Affiliations:
William W. Brown Professor of Physiology & Neurobiology

Department(s):
Molecular and Systems Biology
Neurology

Education:
1972 - 1976 B.A. DePauw University, Greencastle, IN (Zoology & Physical Chemistry)

1976 - 1981 Ph.D. University of Texas Health, Southwestern Med. Ctr., Dallas, TX (Cell Biology/Neuroscience)

1981 - 1984 Postdoc. Staff Fellow, Laboratory of Vision Research, NEI, NIH, Bethesda, MD (Retinal Neurobiology)

Programs:
Molecular and Cellular Biology Graduate Programs
Program in Experimental and Molecular Medicine

Contact Information:

HB 7400
Department of Molecular and Systems Biology
66 College Street
Hanover NH 03755

Office: 625 RemsenBuilding
Phone: 603-650-1698
Fax: 603-650-1694
Email: hermes.yeh@dartmouth.edu


Professional Interests:

Neurotransmitter Interactions and their Plasticity in the Adult and Developing Brain: Nature and Nurture

Research in my laboratory combines neuroanatomical, electrophysiological, molecular and behavioral approaches to study in the adult and developing brain the plasticity of neurotransmitter receptors, synaptic transmission, neurocircuits, neurobehavior, as well as the cellular and molecular underpinnings of coordinated adaptive changes in neuronal function, morphology, gene and protein expression. A major focus of ongoing research projects employs transgenic mouse models, including a mouse model of Fetal Alcohol Spectrum Disorder (FASD), to investigate: (1) the cellular and molecular signaling mechanisms underlying the regulation of neuronal migration in the embryonic cerebral cortex and striatum by developmental neurotransmitters, such as GABA; (2) how maternal consumption of alcohol and exposure of the fetal brain to alcohol exert adverse influences on the migration of cortical neurons in the short term, as well as long-term influences on the morphological and functional development of inhibitory and excitatory synaptic balance, and neurobehavior, in immature and adult neural circuits; (3) how the short-term and long-term aberrances as the result of prenatal alcohol exposure can be mitigated in our preclinical model of FASD. In addition to shedding light on our understanding of the etiology of FASD, our work has unifying implications insofar as the insights gained from this line of interrogation may be applicable toward understanding the pathoetiology of other neurodevelopmental brain disorders, notably autism and ADHD.
I have taught actively in the medical school and graduate school curricula, and have had leadership roles in directing graduate education and training at the institutional and national levels.

Rotations and Thesis Projects:

Graduate students are encouraged to explore, develop and elaborate on their own research interests and directions. All laboratory rotation and thesis projects reflect the multidisciplinary approach taken in my laboratory. For rotations, the nature of the projects are necessarily of more limited scope - students can expect to conduct focused short-term hypothesis-driven projects.
Some examples of rotation projects:
1. Does maternal binge drinking of ethanol early in pregnancy affect the development of radial glial cells in the developing cerebral cortex of the fetus?
2. What is the expression profile of GABAA receptor subunits in GABAergic cortical interneuronal subpopulations and how are they affected by ethanol exposure?
3. Does prenatal ethanol exposure differentially affect the radial migration of pyramidal neuronal subtypes?
4. Does prenatal ethanol exposure affect differentially the migration of GABAergic interneurons of different embryonic origins?
5. Does ethanol affect cytoskeleton dynamics in migrating cortical neurons?

Interested students are encouraged to meet with Dr. Yeh and discuss rotation projects tailored to their interests.

Grant Information:

RO1 AA023410, Yeh, Hermes H. (PI)
NIH/NIAAA
"Ethanol Exposure In Utero and Interneuronopathy in the Medial Prefrontal Cortex"

3R01AA023410-04S1, Yeh, Hermes H. (PI)
NIH/NIAAA

1R01 AA027754-01, Yeh, Hermes H. (PI)
NIH/NIAAA
Title: The chloride cotransporter NKCC1 in the embryonic etiology and treatment of FASD

F30 AA025534-01, Laurie C. Delatour, PI; Yeh, Hermes H., Sponsor
NIH/NIAAA
"Ethanol exposure in utero: effects on radial migration, form, and function of pyramidal neurons in the somatosensory cortex"

F31 AA027694-01, Stephanie M. Lee, PI; Hermes H., Sponsor
NIH/NIAAA
Ethanol, chloride, calcium and growth cone dynamics in embryonic GABAergic interneurons.

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Courses Taught:

Medical Human Gross Anatomy (U. Rochester Sch. Med.) 1984-1992
Neurobiology for undergraduate neuroscience majors (U. Rochester) 1989-1991
Experimental Neuroscience (U. Rochester Sch. Med.) 1988-1990
Medical Physiology (1st. yr Med. Sch., Bowman Gray Sch. Med.) 1993-1995
Medical Pharmacology (2nd. yr Med. Sch., Bowman Gray Sch. Med.) 1994-1995
Developmental Neuroscience (Bowman Gray Sch. Med.) 1992-1995
Advanced Physiology for graduate students (Bowman Gray) 1992-1995
Neuroscience Special Topics Tutorial (Bowman Gray Sch. Med.) 1992-1995
Integrative Graduate Neuroscience (Bowman Gray Sch. Med.) 1992-1995
Mechanisms of Disease, (2nd yr. Med. Sch., UCHC) 1995-1999
Section Leader: Diseases of the Nervous System 1997-1999
Cellular and Molecular Neuroscience (Grad. Sch., UCHC) 1996-2000
Systems Neuroscience (Grad. Sch., UCHC) 1996-2000
Pharmacology Core Course (Grad. Sch., UCHC) 1996-2000
Cellular Neuroscience (Grad. Sch., U. Rochester SMD), Coordinator, Section on Developmental Neuroscience 2000-2005
Ethics and Professional Integrity (U. Rochester SMD), Co-Director 2000-2005
PBL, Humans Structure and Function (1st. yr. SMD), U. Rochester 2001-2005
PBL, Mechanisms of Drug Action (2nd. Yr. SMD), U. Rochester 2000-2005
Program in Experimental and Molecular Medicine Core Course, DMS 2006-
Program in Experimental and Molecular Medicine PEMM 271, DMS 2008-
Program in Experimental and Molecular Medicine Neuroscience II 2012-


Selected Publications:

 

  • Muñoz G, Urrutia J, Burgos C, Silva V, Aguilar F, Sama M, Yeh HH, Opazo C, Aguayo LG Low concentrations of ethanol protect against synaptotoxicity induced by A in hippocampal neurons. Neurobiology of Aging 36:845-856.

  • DeAngeli NE, Todd TP, Chang SE, Yeh HH, Yeh PW, Bucci DJ. Exposure to Kynurenic Acid during Adolescence Increases Sign-Tracking and Impairs Long-Term Potentiation in Adulthood. Front Behav Neurosci. 2015 Jan 6;8:451. (view details on MedLine)

  • Skorput AG, Yeh HH. Effects of ethanol exposure in utero on Cajal-Retzius cells in the developing cortex. Alcohol Clin Exp Res. 2015 May;39(5):853-62. (view details on MedLine)

  • Skorput AG, Gupta VP, Yeh PW, Yeh HH. Persistent Interneuronopathy in the Prefrontal Cortex of Young Adult Offspring Exposed to Ethanol In Utero. J Neurosci. 2015 Aug 5;35(31):10977-88. (view details on MedLine)

  • Skorput AG, Yeh HH. Chronic Gestational Exposure to Ethanol Leads to Enduring Aberrances in Cortical Form and Function in the Medial Prefrontal Cortex. Alcohol Clin Exp Res. 2016 Jul;40(7):1479-88. (view details on MedLine)

  • Delatour LC, Yeh HH. FASD and Brain Development: Perspectives on Where We are and Where We Need to Go. OBM Neurobiology 2017; 1(1), doi:10.21926/obm.neurobiol.1701002.

  • Delatour LC, Yeh PW, Yeh HH. Ethanol Exposure In Utero Disrupts Radial Migration and Pyramidal Cell Development in the Somatosensory Cortex. Cereb Cortex. 2019 May 1;29(5):2125-2139. (view details on MedLine)

  • Delatour LC, Yeh PW, Yeh HH. ) Prenatal exposure to ethanol alters synaptic activity in layer V/VI pyramidal neurons of the somatosensory cortex. Cerebral Cortex, in press 2019.

  • Skorput AG, Lee S, Yeh PW, Yeh HH. The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero. eLife, in press 2019.