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Stephen L. Lee, MD, PhD

Assistant Professor of Neurology

Additional Titles/Positions/Affiliations
Co-medical Director, The Parkinson Center at DHMC


Washington University School of Medicine, Ph.D. 1997
Washington University School of Medicine, M.D. 1997

Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine


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Contact Information

Department of Neurology
One Medical Center Drive - HB 7500
Lebanon NH 03756

Office: Neurology 3C Clinic
Phone: 603-650-8354
Fax: 603-650-6233
Email: stephen.l.lee@dartmouth.edu

Assistant: Sarah L. Braginetz
Asst. Phone: 603-650-51004
Asst. Email: sarah.l.braginetz@hitchcock.org

Professional Interests

I am interested in understanding how genetic mutations can cause Parkinson's disease and other neurological disorders. I use molecular and cellular techniques to study the effect of genetic mutations causative of disease. In the clinic, I try to identify and characterize inherited neurological disorders and conduct clinical trials that attempt to translate molecular insights into novel therapies.

Grant Information

National Science Foundation IIP-0848523
(PI: Michael Linderman)
SBIR Phase II: Biosensor Device for Recordation of Handwriting

K08 NS044298 (PI)
Genetic Analysis of an Amish Family with Parkinsonism

Translational/Collaborative Grant (PI)
Neuroscience Center at Dartmouth
Targeting Parkinson disease genes by RNA interference: Neurochemical and neurobehavioral analysis.

Clinical Discovery Award (PI: Haines JL)
Michael J. Fox Foundation
Parkinson disease in Ohio Amish

Information and Referral Center (Co-Medical Director: Coffey DJ)
American Parkinson Disease Association

Dartmouth College Strategy 4 (Co-PI: Holmes GL)
Behavioral Core Lab

Courses Taught

Course Co-Director, Neurobiology of Disease (PEMM 211)
Lecturer, Pathophysiological Basis of Brain Diseases
Lecturer, DMS Neuroscience (ND115)
Lecturer, Genetics and Physiology of Behavior (Genetics 142 /Bio 79)
Lecturer, Experimental and Molecular Medicine I (PEMM 101)

Selected Publications


Two weeks of twice-daily prism adaptation treatment does not improve posture or gait in Parkinson's disease: a double-blind randomized controlled trial.
Bultitude JH, Pidgeon DM, LeBlanc PR, Jeffreys CA, Alexandre FP, Lee SL
Trials. 2021 Nov 25;22(1):846. doi: 10.1186/s13063-021-05832-2. Epub 2021 Nov 25.
PMID: 34823572

Lifestyle Factors and Parkinson's Disease Risk in a Rural New England Case-Control Study.
Andrew AS, Anderson FL, Lee SL, Von Herrmann KM, Havrda MC
Parkinsons Dis. 2021;2021:5541760. doi: 10.1155/2021/5541760. Epub 2021 Jul 2.
PMID: 34306610

Plasma-borne indicators of inflammasome activity in Parkinson's disease patients.
Anderson FL, von Herrmann KM, Andrew AS, Kuras YI, Young AL, Scherzer CR, Hickey WF, Lee SL, Havrda MC
NPJ Parkinsons Dis. 2021 Jan 4;7(1):2. doi: 10.1038/s41531-020-00147-6. Epub 2021 Jan 4.
PMID: 33398042

NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease.
von Herrmann KM, Salas LA, Martinez EM, Young AL, Howard JM, Feldman MS, Christensen BC, Wilkins OM, Lee SL, Hickey WF, Havrda MC
NPJ Parkinsons Dis. 2018;4:24. doi: 10.1038/s41531-018-0061-5. Epub 2018 Aug 15.
PMID: 30131971

Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort.
Chou KL, Elm JJ, Wielinski CL, Simon DK, Aminoff MJ, Christine CW, Liang GS, Hauser RA, Sudarsky L, Umeh CC, Voss T, Juncos J, Fang JY, Boyd JT, Bodis-Wollner I, Mari Z, Morgan JC, Wills AM, Lee SL, Parashos SA, NINDS NET-PD Investigators
J Neurol Sci. 2017 Jun 15;377:137-143. doi: 10.1016/j.jns.2017.04.011. Epub 2017 Apr 11.
PMID: 28477684

Therapeutic plasma exchange as a steroid-sparing therapy in a patient with limbic encephalitis due to antibodies to voltage-gated potassium channels.
Martin IW, Martin CL, Dunbar NM, Lee SL, Szczepiorkowski ZM
J Clin Apher. 2016 Feb;31(1):63-5. doi: 10.1002/jca.21395. Epub 2015 Apr 7.
PMID: 25851808

Parkinson disease loci in the mid-western Amish.
Davis MF, Cummings AC, D'Aoust LN, Jiang L, Velez Edwards DR, Laux R, Reinhart-Mercer L, Fuzzell D, Scott WK, Pericak-Vance MA, Lee SL, Haines JL
Hum Genet. 2013 Nov;132(11):1213-21. doi: 10.1007/s00439-013-1316-1. Epub 2013 Jun 21.
PMID: 23793441

Time-dependent statistical and correlation properties of neural signals during handwriting.
Rupasov VI, Lebedev MA, Erlichman JS, Lee SL, Leiter JC, Linderman M
PLoS One. 2012;7(9):e43945. doi: 10.1371/journal.pone.0043945. Epub 2012 Sep 11.
PMID: 22984455

A genome-wide linkage screen in the Amish with Parkinson disease points to chromosome 6.
Cummings AC, Lee SL, McCauley JL, Jiang L, Crunk A, McFarland LL, Gallins PJ, Fuzzell D, Knebusch C, Jackson CE, Scott WK, Pericak-Vance MA, Haines JL
Ann Hum Genet. 2011 May;75(3):351-8. doi: 10.1111/j.1469-1809.2011.00643.x.
PMID: 21488853

Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes.
Sloan CD, Shen L, West JD, Wishart HA, Flashman LA, Rabin LA, Santulli RB, Guerin SJ, Rhodes CH, Tsongalis GJ, McAllister TW, Ahles TA, Lee SL, Moore JH, Saykin AJ
Am J Med Genet B Neuropsychiatr Genet. 2010 Jul;153B(5):1060-9. doi: 10.1002/ajmg.b.31078.
PMID: 20468060

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