Paula R. Sundstrom, PhD
Professor of Microbiology and Immunology
Microbiology and Immunology
University of Washington, Seattle, Washington, Ph.D., 1986
University of Washington, Seattle, Washington, M.S., 1979
B.A. Pomona College, Claremont, California, B.A., 1974
Post-doctoral Fellow, University of California, Irvine, 1989
Dr. Sundstrom joined the Department of Microbiology and Immunology in the Dartmouth Medical School in the Fall of 2003.
Molecular Pathogenesis Program
HB 7550 - Rm. 201
Hanover NH 03755
Molecular mechanisms of fungal pathogenesis and prevention of fungal disease for the most common fungal pathogen of man, Candida albicans. Basic research on adherence mechanisms, signal transduction, virulence gene regulation, and host immune responses using Candida albicans as the model system are employed towards the ultimate goal of generating stratagies for improved prevention and therapy for fungal infections.
National Institute for Craniofacial and Dental Research
National Institute for Allergy and Infectious Diseases
Burroughs Wellcome Fund
Release of transcriptional repression through the HCR promoter region confers uniform expression of HWP1 on surfaces of Candida albicans germ tubes.
The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans.
Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes by Candida albicans.
Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans.
State of differentiation defines buccal epithelial cell affinity for cross-linking to Candida albicans Hwp1.
A 368-base-pair cis-acting HWP1 promoter region, HCR, of Candida albicans confers hypha-specific gene regulation and binds architectural transcription factors Nhp6 and Gcf1p.
Candida albicans HWP1 gene expression and host antibody responses in colonization and disease.