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Paula R. Sundstrom, PhD

Title(s):
Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
University of Washington, Seattle, Washington, Ph.D., 1986
University of Washington, Seattle, Washington, M.S., 1979
B.A. Pomona College, Claremont, California, B.A., 1974
Post-doctoral Fellow, University of California, Irvine, 1989

Dr. Sundstrom joined the Department of Microbiology and Immunology in the Dartmouth Medical School in the Fall of 2003.


Programs:
Molecular Pathogenesis Program

Websites:
http://www.dartmouth.edu/~sundstrom/
http://www.dartmouth.edu/~molpath/
http://www.dartmouth.edu/~mcb/

Contact Information:

Vail Building
HB 7550 - Rm. 201
Hanover NH 03755

Office: 603-650-1613
Phone: 603-650-1629
Fax: 603-650-1318
Email: Paula.R.Sundstrom@Dartmouth.edu

Assistant: Karen L. Thompson
Asst. Phone: 603-650-1613
Asst. Email: Karen.L.Thompson@Dartmouth.edu


Professional Interests:

Molecular mechanisms of fungal pathogenesis and prevention of fungal disease for the most common fungal pathogen of man, Candida albicans. Basic research on adherence mechanisms, signal transduction, virulence gene regulation, and host immune responses using Candida albicans as the model system are employed towards the ultimate goal of generating stratagies for improved prevention and therapy for fungal infections.

Grant Information:

National Institute for Craniofacial and Dental Research

National Institute for Allergy and Infectious Diseases

Burroughs Wellcome Fund

Courses Taught:

Medical Microbiology

Eukaryotic Pathogens


Selected Publications:

 

Release of transcriptional repression through the HCR promoter region confers uniform expression of HWP1 on surfaces of Candida albicans germ tubes.
Kim S, Nguyen QB, Wolyniak MJ, Frechette G, Lehman CR, Fox BK, Sundstrom P
PLoS One. 2018;13(2):e0192260. doi: 10.1371/journal.pone.0192260. Epub 2018 Feb 13.
PMID: 29438403

The Ras/cAMP/PKA signaling pathway and virulence in Candida albicans.
Hogan DA, Sundstrom P
Future Microbiol. 2009 Dec;4(10):1263-70. doi: 10.2217/fmb.09.106.
PMID: 19995187

Stimulation of cell motility and expression of late markers of differentiation in human oral keratinocytes by Candida albicans.
Rollenhagen C, Wollert T, Langford GM, Sundstrom P
Cell Microbiol. 2009 Jun;11(6):946-66. doi: 10.1111/j.1462-5822.2009.01303.x. Epub 2009 Feb 27.
PMID: 19302578

Role of actin cytoskeletal dynamics in activation of the cyclic AMP pathway and HWP1 gene expression in Candida albicans.
Wolyniak MJ, Sundstrom P
Eukaryot Cell. 2007 Oct;6(10):1824-40. Epub 2007 Aug 22.
PMID: 17715368

State of differentiation defines buccal epithelial cell affinity for cross-linking to Candida albicans Hwp1.
Ponniah G, Rollenhagen C, Bahn YS, Staab JF, Sundstrom P
J Oral Pathol Med. 2007 Sep;36(8):456-67.
PMID: 17686003

A 368-base-pair cis-acting HWP1 promoter region, HCR, of Candida albicans confers hypha-specific gene regulation and binds architectural transcription factors Nhp6 and Gcf1p.
Kim S, Wolyniak MJ, Staab JF, Sundstrom P
Eukaryot Cell. 2007 Apr;6(4):693-709. Epub 2007 Jan 12.
PMID: 17220463

View more publications on PubMed