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Deborah A Hogan, PhD

Professor of Microbiology and Immunology

Microbiology and Immunology

Michigan State University, Ph.D., 1999
Harvard University, A.B., 1993

Dr. Hogan received her A.B. degree in Biology from Harvard University in
1993, and her Ph.D. in Microbiology from the Michigan State University in
1999. After postdoctoral work at Harvard Medical School, Dr. Hogan joined
the faculty of the Department of Microbiology and Immunology at Dartmouth Medical School in 2004.


Contact Information:

Vail Building#208
Dewey Field Rd. HB7550
Hanover NH 03755

Phone: 603-650-1252
Fax: 603-650-1318
Email: Deborah.A.Hogan@Dartmouth.edu

Professional Interests:


The interactions between different microbial species govern the activity of microbial communities, whether they be in association with a host or free-living in the environment. Microbial communities have very significant effects on human health. For example, synergistic relationships between the organisms within the human microflora confer protection against pathogens and enable the degradation of complex substrates. At the same time, many illnesses, such as respiratory and genital infections, gastroenteritis, and periodontal diseases, often involve multiple microorganisms. In the Hogan Lab, we are interested in understanding the molecular basis for such interactions by describing the mechanisms by which one microbe affects the physiology, survival, and virulence properties of another microbial species.

Our lab primarily focuses on the interactions between the Gram-negative bacterium Pseudomonas aeruginosa and the dimorphic fungus, Candida albicans. These two organisms co-exist within diverse opportunistic human infections, and clinical observations suggest that P. aeruginosa inhibits C. albicans growth. In our in vitro system, we observe that the bacteria physically attach to the fungal filaments, form biofilms on their surfaces, and kill the fungal cells. Many of the bacterial factors used to kill the fungus also participate in P. aeruginosa virulence towards humans. The fungus responds to the presence of the P. aeruginosa by reverting to a resistant yeast form. We are using genetic screening methods, analysis of defined mutants, biochemical approaches and genomic profiling techniques to better understand the bacterial and fungal factors that are involved in this relationship. By studying the interactions between microbial species, we are learning about important elements relating to the physiology and pathogenesis of the individual microbes. in addition to gaining insight in to how microbial communities function.

For more information, please visit the Hogan Lab Home Page (www.dartmouth.edu/~hoganlab).

Selected Publications:


Profiling of Bacterial and Fungal Microbial Communities in Cystic Fibrosis Sputum Using RNA.
Grahl N, Dolben EL, Filkins LM, Crocker AW, Willger SD, Morrison HG, Sogin ML, Ashare A, Gifford AH, Jacobs NJ, Schwartzman JD, Hogan DA
mSphere. 2018 Aug 8;3(4) pii: e00292-18. doi: 10.1128/mSphere.00292-18. Epub 2018 Aug 8.
PMID: 30089648

PathCORE-T: identifying and visualizing globally co-occurring pathways in large transcriptomic compendia.
Chen KM, Tan J, Way GP, Doing G, Hogan DA, Greene CS
BioData Min. 2018;11:14. doi: 10.1186/s13040-018-0175-7. Epub 2018 Jul 3.
PMID: 29988723

Role of quorum sensing and chemical communication in fungal biotechnology and pathogenesis.
Barriuso J, Hogan DA, Keshavarz T, Martinez MJ
FEMS Microbiol Rev. 2018 May 18; doi: 10.1093/femsre/fuy022. Epub 2018 May 18.
PMID: 29788231

Pearls collections: What we can learn about infectious disease and cancer.
Knoll LJ, Hogan DA, Leong JM, Heitman J, Condit RC
PLoS Pathog. 2018 Mar;14(3):e1006915. doi: 10.1371/journal.ppat.1006915. Epub 2018 Mar 29.
PMID: 29596508

A Multimodal Strategy Used by a Large c-di-GMP Network.
Dahlstrom KM, Collins AJ, Doing G, Taroni JN, Gauvin TJ, Greene CS, Hogan DA, O'Toole GA
J Bacteriol. 2018 Apr 15;200(8) pii: e00703-17. doi: 10.1128/JB.00703-17. Epub 2018 Mar 26.
PMID: 29311282

ADAGE signature analysis: differential expression analysis with data-defined gene sets.
Tan J, Huyck M, Hu D, Zelaya RA, Hogan DA, Greene CS
BMC Bioinformatics. 2017 Nov 22;18(1):512. doi: 10.1186/s12859-017-1905-4. Epub 2017 Nov 22.
PMID: 29166858

An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L150-L156. doi: 10.1152/ajplung.00383.2017. Epub 2017 Oct 5.
PMID: 28982736

<i>Candida</i> and <i>Pseudomonas</i> interact to enhance virulence of mucosal infection in transparent zebrafish.
Bergeron AC, Seman BG, Hammond JH, Archambault LS, Hogan DA, Wheeler RT
Infect Immun. 2017 Aug 28; pii: IAI.00475-17. doi: 10.1128/IAI.00475-17. Epub 2017 Aug 28.
PMID: 28847848

Unsupervised Extraction of Stable Expression Signatures from Public Compendia with an Ensemble of Neural Networks.
Tan J, Doing G, Lewis KA, Price CE, Chen KM, Cady KC, Perchuk B, Laub MT, Hogan DA, Greene CS
Cell Syst. 2017 Jul 26;5(1):63-71.e6. doi: 10.1016/j.cels.2017.06.003. Epub 2017 Jul 12.
PMID: 28711280

Use of RNA-Protein Complexes for Genome Editing in Non-<i>albicans Candida</i> Species.
Grahl N, Demers EG, Crocker AW, Hogan DA
mSphere. 2017 May-Jun;2(3) pii: e00218-17. doi: 10.1128/mSphere.00218-17. Epub 2017 Jun 21.
PMID: 28657070