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Deborah A Hogan, PhD

Title(s)
Professor of Microbiology and Immunology

Department(s)
Microbiology and Immunology

Education
Michigan State University, Ph.D., 1999
Harvard University, A.B., 1993

Dr. Hogan received her A.B. degree in Biology from Harvard University in
1993, and her Ph.D. in Microbiology from the Michigan State University in
1999. After postdoctoral work at Harvard Medical School, Dr. Hogan joined
the faculty of the Department of Microbiology and Immunology at Dartmouth Medical School in 2004.

Websites
http://www.dartmouth.edu/~hoganlab
http://www.dartmouth.edu/~molpath/
http://www.dartmouth.edu/~mcb/

Contact Information

Vail Building#208
Dewey Field Rd. HB7550
Hanover NH 03755

Phone: 603-650-1252
Fax: 603-650-1318
Email: Deborah.A.Hogan@Dartmouth.edu


Professional Interests

MICROBE-MICROBE INTERACTIONS

The interactions between different microbial species govern the activity of microbial communities, whether they be in association with a host or free-living in the environment. Microbial communities have very significant effects on human health. For example, synergistic relationships between the organisms within the human microflora confer protection against pathogens and enable the degradation of complex substrates. At the same time, many illnesses, such as respiratory and genital infections, gastroenteritis, and periodontal diseases, often involve multiple microorganisms. In the Hogan Lab, we are interested in understanding the molecular basis for such interactions by describing the mechanisms by which one microbe affects the physiology, survival, and virulence properties of another microbial species.

Our lab primarily focuses on the interactions between the Gram-negative bacterium Pseudomonas aeruginosa and the dimorphic fungus, Candida albicans. These two organisms co-exist within diverse opportunistic human infections, and clinical observations suggest that P. aeruginosa inhibits C. albicans growth. In our in vitro system, we observe that the bacteria physically attach to the fungal filaments, form biofilms on their surfaces, and kill the fungal cells. Many of the bacterial factors used to kill the fungus also participate in P. aeruginosa virulence towards humans. The fungus responds to the presence of the P. aeruginosa by reverting to a resistant yeast form. We are using genetic screening methods, analysis of defined mutants, biochemical approaches and genomic profiling techniques to better understand the bacterial and fungal factors that are involved in this relationship. By studying the interactions between microbial species, we are learning about important elements relating to the physiology and pathogenesis of the individual microbes. in addition to gaining insight in to how microbial communities function.


For more information, please visit the Hogan Lab Home Page (www.dartmouth.edu/~hoganlab).


Selected Publications

 

Using genome-wide expression compendia to study microorganisms.
Lee AJ, Reiter T, Doing G, Oh J, Hogan DA, Greene CS
Comput Struct Biotechnol J. 2022;20:4315-4324. doi: 10.1016/j.csbj.2022.08.012. Epub 2022 Aug 10.
PMID: 36016717

CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies.
Neff SL, Hampton TH, Puerner C, Cengher L, Doing G, Lee AJ, Koeppen K, Cheung AL, Hogan DA, Cramer RA, Stanton BA
Sci Data. 2022 Jun 16;9(1):343. doi: 10.1038/s41597-022-01431-1. Epub 2022 Jun 16.
PMID: 35710652

Metabolic basis for the evolution of a common pathogenic Pseudomonas aeruginosa variant.
Mould DL, Stevanovic M, Ashare A, Schultz D, Hogan DA
Elife. 2022 May 3;11 pii: e76555. doi: 10.7554/eLife.76555. Epub 2022 May 3.
PMID: 35502894

Transcriptional Response of Candida auris to the Mrr1 Inducers Methylglyoxal and Benomyl.
Biermann AR, Hogan DA
mSphere. 2022 Jun 29;7(3):e0012422. doi: 10.1128/msphere.00124-22. Epub 2022 Apr 27.
PMID: 35473297

Nonmotile Subpopulations of Pseudomonas aeruginosa Repress Flagellar Motility in Motile Cells through a Type IV Pilus- and Pel-Dependent Mechanism.
Lewis KA, Vermilyea DM, Webster SS, Geiger CJ, de Anda J, Wong GCL, O'Toole GA, Hogan DA
J Bacteriol. 2022 May 17;204(5):e0052821. doi: 10.1128/jb.00528-21. Epub 2022 Apr 4.
PMID: 35377166

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway.
Hollomon JM, Liu Z, Rusin SF, Jenkins NP, Smith AK, Koeppen K, Kettenbach AN, Myers LC, Hogan DA
PLoS Genet. 2022 Jan;18(1):e1009622. doi: 10.1371/journal.pgen.1009622. Epub 2022 Jan 4.
PMID: 34982775

Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
O'Toole GA, Crabbe A, Kummerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K
mBio. 2021 Oct 26;12(5):e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21.
PMID: 34544277

Editorial overview of Pearls Microbiome Series: E pluribus unum.
Hogan DA, Heitman J, Jabra-Rizk MA, Knoll LJ, Leong JM, Silverman N
PLoS Pathog. 2021 Aug;17(8):e1009912. doi: 10.1371/journal.ppat.1009912. Epub 2021 Aug 31.
PMID: 34464427

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa.
Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefeld AE, Kolling FW, LaCroix IS, Gerber SA, Hogan DA, Kasetty S, Nadell CD, Stanton BA
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28) pii: e2105370118. doi: 10.1073/pnas.2105370118.
PMID: 34260396

Both Pseudomonas aeruginosa and Candida albicans Accumulate Greater Biomass in Dual-Species Biofilms under Flow.
Kasetty S, Mould DL, Hogan DA, Nadell CD
mSphere. 2021 Jun 30;6(3):e0041621. doi: 10.1128/mSphere.00416-21. Epub 2021 Jun 23.
PMID: 34160236

View more publications on PubMed