COVID-19 Information

Edit Entry | Edit CV

Deborah A Hogan, PhD

Title(s):
Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Michigan State University, Ph.D., 1999
Harvard University, A.B., 1993

Dr. Hogan received her A.B. degree in Biology from Harvard University in
1993, and her Ph.D. in Microbiology from the Michigan State University in
1999. After postdoctoral work at Harvard Medical School, Dr. Hogan joined
the faculty of the Department of Microbiology and Immunology at Dartmouth Medical School in 2004.

Websites:
http://www.dartmouth.edu/~hoganlab
http://www.dartmouth.edu/~molpath/
http://www.dartmouth.edu/~mcb/

Contact Information:

Vail Building#208
Dewey Field Rd. HB7550
Hanover NH 03755

Phone: 603-650-1252
Fax: 603-650-1318
Email: Deborah.A.Hogan@Dartmouth.edu


Professional Interests:

MICROBE-MICROBE INTERACTIONS

The interactions between different microbial species govern the activity of microbial communities, whether they be in association with a host or free-living in the environment. Microbial communities have very significant effects on human health. For example, synergistic relationships between the organisms within the human microflora confer protection against pathogens and enable the degradation of complex substrates. At the same time, many illnesses, such as respiratory and genital infections, gastroenteritis, and periodontal diseases, often involve multiple microorganisms. In the Hogan Lab, we are interested in understanding the molecular basis for such interactions by describing the mechanisms by which one microbe affects the physiology, survival, and virulence properties of another microbial species.

Our lab primarily focuses on the interactions between the Gram-negative bacterium Pseudomonas aeruginosa and the dimorphic fungus, Candida albicans. These two organisms co-exist within diverse opportunistic human infections, and clinical observations suggest that P. aeruginosa inhibits C. albicans growth. In our in vitro system, we observe that the bacteria physically attach to the fungal filaments, form biofilms on their surfaces, and kill the fungal cells. Many of the bacterial factors used to kill the fungus also participate in P. aeruginosa virulence towards humans. The fungus responds to the presence of the P. aeruginosa by reverting to a resistant yeast form. We are using genetic screening methods, analysis of defined mutants, biochemical approaches and genomic profiling techniques to better understand the bacterial and fungal factors that are involved in this relationship. By studying the interactions between microbial species, we are learning about important elements relating to the physiology and pathogenesis of the individual microbes. in addition to gaining insight in to how microbial communities function.


For more information, please visit the Hogan Lab Home Page (www.dartmouth.edu/~hoganlab).


Selected Publications:

 

Both Pseudomonas aeruginosa and Candida albicans Accumulate Greater Biomass in Dual-Species Biofilms under Flow.
Kasetty S, Mould DL, Hogan DA, Nadell CD
mSphere. 2021 Jun 23;:e0041621. doi: 10.1128/mSphere.00416-21. Epub 2021 Jun 23.
PMID: 34160236

Intraspecies heterogeneity in microbial interactions.
Mould DL, Hogan DA
Curr Opin Microbiol. 2021 May 22;62:14-20. doi: 10.1016/j.mib.2021.04.003. Epub 2021 May 22.
PMID: 34034081

Calprotectin-Mediated Zinc Chelation Inhibits Pseudomonas aeruginosa Protease Activity in Cystic Fibrosis Sputum.
Vermilyea DM, Crocker AW, Gifford AH, Hogan DA
J Bacteriol. 2021 Jun 8;203(13):e0010021. doi: 10.1128/JB.00100-21. Epub 2021 Jun 8.
PMID: 33927050

Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1.
Demers EG, Stajich JE, Ashare A, Occhipinti P, Hogan DA
mBio. 2021 Mar 30;12(2) pii: e03328-20. doi: 10.1128/mBio.03328-20. Epub 2021 Mar 30.
PMID: 33785623

Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice.
Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, Deepak P, Ciorba MA, Liu TC, Hogan DA, Debbas P, Braun J, McGovern DPB, Underhill DM, Stappenbeck TS
Science. 2021 Mar 12;371(6534):1154-1159. doi: 10.1126/science.abd0919.
PMID: 33707263

Mrr1 regulation of methylglyoxal catabolism and methylglyoxal-induced fluconazole resistance in Candida lusitaniae.
Biermann AR, Demers EG, Hogan DA
Mol Microbiol. 2021 Jan;115(1):116-130. doi: 10.1111/mmi.14604. Epub 2020 Dec 14.
PMID: 33319423

Correcting for experiment-specific variability in expression compendia can remove underlying signals.
Lee AJ, Park Y, Doing G, Hogan DA, Greene CS
Gigascience. 2020 Nov 3;9(11) pii: giaa117. doi: 10.1093/gigascience/giaa117.
PMID: 33140829

Intraspecies Signaling between Common Variants of Pseudomonas aeruginosa Increases Production of Quorum-Sensing-Controlled Virulence Factors.
Mould DL, Botelho NJ, Hogan DA
mBio. 2020 Aug 25;11(4) pii: e01865-20. doi: 10.1128/mBio.01865-20. Epub 2020 Aug 25.
PMID: 32843558

Conditional antagonism in co-cultures of Pseudomonas aeruginosa and Candida albicans: An intersection of ethanol and phosphate signaling distilled from dual-seq transcriptomics.
Doing G, Koeppen K, Occipinti P, Harty CE, Hogan DA
PLoS Genet. 2020 Aug;16(8):e1008783. doi: 10.1371/journal.pgen.1008783. Epub 2020 Aug 19.
PMID: 32813693

Social Cooperativity of Bacteria during Reversible Surface Attachment in Young Biofilms: a Quantitative Comparison of Pseudomonas aeruginosa PA14 and PAO1.
Lee CK, Vachier J, de Anda J, Zhao K, Baker AE, Bennett RR, Armbruster CR, Lewis KA, Tarnopol RL, Lomba CJ, Hogan DA, Parsek MR, O'Toole GA, Golestanian R, Wong GCL
mBio. 2020 Feb 25;11(1) pii: e02644-19. doi: 10.1128/mBio.02644-19. Epub 2020 Feb 25.
PMID: 32098815

View more publications on PubMed