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Deborah A Hogan, PhD

Professor of Microbiology and Immunology

Microbiology and Immunology

Michigan State University, Ph.D., 1999
Harvard University, A.B., 1993

Dr. Hogan received her A.B. degree in Biology from Harvard University in
1993, and her Ph.D. in Microbiology from the Michigan State University in
1999. After postdoctoral work at Harvard Medical School, Dr. Hogan joined
the faculty of the Department of Microbiology and Immunology at Dartmouth Medical School in 2004.


Contact Information:

Vail Building#208
Dewey Field Rd. HB7550
Hanover NH 03755

Phone: 603-650-1252
Fax: 603-650-1318

Professional Interests:


The interactions between different microbial species govern the activity of microbial communities, whether they be in association with a host or free-living in the environment. Microbial communities have very significant effects on human health. For example, synergistic relationships between the organisms within the human microflora confer protection against pathogens and enable the degradation of complex substrates. At the same time, many illnesses, such as respiratory and genital infections, gastroenteritis, and periodontal diseases, often involve multiple microorganisms. In the Hogan Lab, we are interested in understanding the molecular basis for such interactions by describing the mechanisms by which one microbe affects the physiology, survival, and virulence properties of another microbial species.

Our lab primarily focuses on the interactions between the Gram-negative bacterium Pseudomonas aeruginosa and the dimorphic fungus, Candida albicans. These two organisms co-exist within diverse opportunistic human infections, and clinical observations suggest that P. aeruginosa inhibits C. albicans growth. In our in vitro system, we observe that the bacteria physically attach to the fungal filaments, form biofilms on their surfaces, and kill the fungal cells. Many of the bacterial factors used to kill the fungus also participate in P. aeruginosa virulence towards humans. The fungus responds to the presence of the P. aeruginosa by reverting to a resistant yeast form. We are using genetic screening methods, analysis of defined mutants, biochemical approaches and genomic profiling techniques to better understand the bacterial and fungal factors that are involved in this relationship. By studying the interactions between microbial species, we are learning about important elements relating to the physiology and pathogenesis of the individual microbes. in addition to gaining insight in to how microbial communities function.

For more information, please visit the Hogan Lab Home Page (

Selected Publications:


Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
O'Toole GA, Crabbe A, Kummerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K
mBio. 2021 Oct 26;12(5):e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21.
PMID: 34544277

Editorial overview of Pearls Microbiome Series: E pluribus unum.
Hogan DA, Heitman J, Jabra-Rizk MA, Knoll LJ, Leong JM, Silverman N
PLoS Pathog. 2021 Aug;17(8):e1009912. doi: 10.1371/journal.ppat.1009912. Epub 2021 Aug 31.
PMID: 34464427

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa.
Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefeld AE, Kolling FW, LaCroix IS, Gerber SA, Hogan DA, Kasetty S, Nadell CD, Stanton BA
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28) pii: e2105370118. doi: 10.1073/pnas.2105370118.
PMID: 34260396

Both Pseudomonas aeruginosa and Candida albicans Accumulate Greater Biomass in Dual-Species Biofilms under Flow.
Kasetty S, Mould DL, Hogan DA, Nadell CD
mSphere. 2021 Jun 30;6(3):e0041621. doi: 10.1128/mSphere.00416-21. Epub 2021 Jun 23.
PMID: 34160236

Intraspecies heterogeneity in microbial interactions.
Mould DL, Hogan DA
Curr Opin Microbiol. 2021 Aug;62:14-20. doi: 10.1016/j.mib.2021.04.003. Epub 2021 May 23.
PMID: 34034081

Calprotectin-Mediated Zinc Chelation Inhibits Pseudomonas aeruginosa Protease Activity in Cystic Fibrosis Sputum.
Vermilyea DM, Crocker AW, Gifford AH, Hogan DA
J Bacteriol. 2021 Jun 8;203(13):e0010021. doi: 10.1128/JB.00100-21. Epub 2021 Jun 8.
PMID: 33927050

Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1.
Demers EG, Stajich JE, Ashare A, Occhipinti P, Hogan DA
mBio. 2021 Mar 30;12(2) pii: e03328-20. doi: 10.1128/mBio.03328-20. Epub 2021 Mar 30.
PMID: 33785623

Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice.
Jain U, Ver Heul AM, Xiong S, Gregory MH, Demers EG, Kern JT, Lai CW, Muegge BD, Barisas DAG, Leal-Ekman JS, Deepak P, Ciorba MA, Liu TC, Hogan DA, Debbas P, Braun J, McGovern DPB, Underhill DM, Stappenbeck TS
Science. 2021 Mar 12;371(6534):1154-1159. doi: 10.1126/science.abd0919.
PMID: 33707263

Mrr1 regulation of methylglyoxal catabolism and methylglyoxal-induced fluconazole resistance in Candida lusitaniae.
Biermann AR, Demers EG, Hogan DA
Mol Microbiol. 2021 Jan;115(1):116-130. doi: 10.1111/mmi.14604. Epub 2020 Dec 14.
PMID: 33319423

Correcting for experiment-specific variability in expression compendia can remove underlying signals.
Lee AJ, Park Y, Doing G, Hogan DA, Greene CS
Gigascience. 2020 Nov 3;9(11) pii: giaa117. doi: 10.1093/gigascience/giaa117.
PMID: 33140829

View more publications on PubMed