Angeline S. Andrew, PhD
Associate Professor of Neurology
Dartmouth Medical School, PHD 2001
Tufts University, BS 1996
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
Quantitative Biomedical Sciences
7936 Rubin Building
One Medical Center Drive
Lebanon NH 03756
Office: Rubin 605
Phone: (603) 653-9019
Translating molecular toxicology into human populations; identifying factors that modify prognosis; response to environmental exposures; interactions between multiple stressors.
Rotations and Thesis Projects:
MicroRNA markers of bladder cancer prognosis.
Environmental exposures and neurodegenerative disease risk.
10/1/2018– 9/30/2021 Identify, Analyze, and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS). MPIs: Andrew, Stommel, Bradley, Pioro, CDC / ATSDR, R01TS000288
1/1/2018–12/31/2020 Investigating Aerosolized Cyanobacteria in Amyotrophic Lateral Sclerosis. Stommel (PI), Andrew (Co-I), ALS Association, 18-IIA-437
9/30/2018– 9/29/2019 Describing Treatment Gaps for People with Epilepsy. Jobst (PI), Andrew (Co-I), CDC, U48DP005018
9/30/2016– 9/29/2018 A Population-Based Ohio ALS Repository and a Case-Control Study of ALS Risk Factors. MPIs: Andrew, Stommel, Bradley, Pioro, CDC / ATSDR, R01TS000245
2/1/2014 – 1/31/2018 Dysregulated MicroRNA Markers Of Bladder Cancer. Andrew (PI), NIH / NCI, R21CA182659
Course director: Molecular Biologic Markers in Human Health studies (didactic & computational lab courses).
Lecturer: Cancer Biology. Epidemiology I
Small group leader: Epidemiology and Biostatistics.
SYNERGY Advanced Certificate in Clinical Translational Research. Research Works-in-Progress
Dr. Andrew received her BS from Tufts University double-majoring in Biology and Environmental Science. Her graduate thesis work in Superfund Basic Research Program funded research group elucidated the molecular mechanisms of toxic metals in cell culture, with a PhD from the Pharmacology & Toxicology program at Dartmouth in 2001. Her post-doctoral training in molecular epidemiology included coursework in research design and statistical analysis at the University of Michigan School of Public Health. Her research experience includes wet-bench, population science, and computational skills, such as: assessment of molecular and functional biomarkers, clinical follow-up of a large cohort, SNP analysis and identification of gene x environment interactions, GIS assessment of exposure, and statistical analysis of high-throughput molecular datasets in R.
Andrew AS, Karagas MR, Schroeck FR, Marsit CJ, Schned AR, Pettus J, Armstrong DA, Seigne JD MicroRNA dysregulation and non-muscle invasive bladder cancer prognosis. Cancer Epidemiol Biomarkers Prev. 2019
Andrew AS, Chen CY, Caller TA, Tandan R, Henegan PL, Jackson BP, Hall BP, Bradley WG, Stommel EW. Toenail mercury levels are associated with amyotrophic lateral sclerosis (ALS) risk. Muscle Nerve. 2018. (view details in PubMed)
Andrew AS, Caller TA, Tandan R, Duell EJ, Henegan PL, Field NC, Bradley WG, Stommel EW. Environmental and Occupational Exposures and Amyotrophic Lateral Sclerosis in New England. Neurodegener Dis. 2017;17(2-3):110-6. (view details in PubMed)
Andrew AS, Marsit CJ, Schned AR, Seigne JD, Kelsey KT, Moore JH, Perreard L, Karagas MR, Sempere LF. Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence. Int J Cancer. 2015;137(5):1158-66. (view details in PubMed)
Gui J, Moore JH, Kelsey KT, Marsit CJ, Karagas MR, Andrew AS. A novel survival multifactor dimensionality reduction method for detecting gene-gene interactions with application to bladder cancer prognosis. Hum Genet. 2011;129(1):101-10. (view details in PubMed)
Andrew AS, Gui J, Sanderson AC, Mason RA, Morlock EV, Schned AR, Kelsey KT, Marsit CJ, Moore JH, Karagas MR. Bladder cancer SNP panel predicts susceptibility and survival. Hum Genet. 2009;125(5-6):527-39. (view details in PubMed)
Andrew AS, Nelson HH, Kelsey KT, Moore JH, Meng AC, Casella DP, Tosteson TD, Schned AR, Karagas MR. Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis. 2006;27(5):1030-7. (view details in PubMed)
Andrew AS, Burgess JL, Meza MM, Demidenko E, Waugh MG, Hamilton JW, Karagas MR. Arsenic exposure is associated with decreased DNA repair in vitro and in individuals exposed to drinking water arsenic. Environ Health Perspect. 2006;114(8):1193-8. (view details in PubMed)
Andrew AS, Karagas MR, Hamilton JW. Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer. 2003;104(3):263-8. (view details in PubMed)
Andrew A, Barchowsky A. Nickel-induced plasminogen activator inhibitor-1 expression inhibits the fibrinolytic activity of human airway epithelial cells. Toxicol Appl Pharmacol. 2000;168(1):50-7. (view details in PubMed)