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Yashi F Ahmed, MD, PhD

Professor of Molecular and Systems Biology
Oscar M. Cohn Professor

Molecular and Systems Biology

Massachusetts Institute of Technology, ScB
Duke University Medical School MD, PhD
Brigham and Women's Hospital, Harvard Medical School,
Internship and Residency in Internal Medicine
Princeton University, Postdoctoral Fellowship

Molecular and Cellular Biology Graduate Programs


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Contact Information

Department of Molecular and Systems Biology
HB 7400, Vail 613

Office: Vail 613
Phone: 603.650.1027
Fax: 603.650.1188
Email: yashi.ahmed@dartmouth.edu

Professional Interests

The Wnt signal transduction pathway controls cell proliferation and fate specification in all animals. Deregulation of Wnt signaling causes numerous birth defects and cancers, including nearly all colorectal cancers, the second leading cause of cancer-related death. Therefore, our understanding of Wnt regulatory mechanisms is crucial. Despite the critical role of Wnt signaling in animal development and human diseases, many of the underlying mechanisms remain poorly understood. We work at the interface between developmental biology and cancer biology to uncover these mechanisms, with the long-term goals of better understanding morphogen signaling in animal development and developing new strategies to treat Wnt-driven diseases. To identify and elucidate the roles of previously unknown Wnt pathway activators, we couple state-of-the-art CRISPR-based genetic approaches, super-resolution confocal microscopy, and biochemistry in Drosophila and in mammalian cells. In collaboration, we expand our findings to mouse and human cancer models.

Selected Publications


  • https://www.ncbi.nlm.nih.gov/pubmed/?term=%3A++(ahmed+y%5BAuthor%5D+OR+ahmed+y%5BInvestigator%5D)+AND+(%22catenins%22%5BMeSH+Terms%5D+OR+%22catenins%22%5BAll+Fields%5D+OR+%22catenin%22%5BAll+Fields%5D)