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Michael E. Zegans, MD

Professor of Surgery
Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations
Section Chief Ophthalmology
Francis A. L’Esperance, Jr., MD, Visual Sciences Scholar
Faculty Director, Health Professions Program, Dartmouth College 2016-22

Microbiology and Immunology

F.I. Proctor Foundation, UCSF, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

Molecular Pathogenesis Program


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Contact Information

Section of Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-650-5123

Professional Interests

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

- Ocular microbiology, corneal infection and bacterial biofilm formation
- Effects of microgravity on the eye

Grant Information

1. Medical Student Research Training Fellow 1989-90 12 calendar
Howard Hughes Medical Institute
MHC-Class I Antigen Presentation
2. Continued Support Fellowship (Zegans) 1990-92 NA
Howard Hughes Medical Institute
3. Harmes Scholarship (Zegans) 2000-2003 NA Dartmouth Medical School (Surgery)
4. Hitchcock Foundation Award (Zegans) 2006-07 NA Hitchcock Foundation Inhibitors of Pseudomonas aeruginosa pilin processing
5. 5K08EY13977-4 (Zegans) 8/2002 –8/2007 9 calendar NIH/ NEI Biofilm Formation and P. aeruginosa infection of the eye
6. P20 RR16437 (Green, Director) 9/30/01-6/30/11 1.8 calendar NIHI/NCRR for pilot project Center for Molecular, Cellular, and Translational Immunology (COBRE Award)
7. AI068662-01A1(O’Toole) 9/19/07--8/31/09 3.6 calendar NIH/NIAID Zegans: key personnel
8. U10 EY015114-01A2 (Lietman) 10/2005-10/2010 1.2 calendar NIH/NEI TC for Dartmouth, Steroids for Corneal Ulcers Trial Zegans: Co- PI, Director Dartmouth study site
9. Hitchcock Foundation Pilot Grant (Zegans) 10/2012- 10/2013
Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Zegans: PI.
10. U10EY016214 subaward 7260sc (Zegans) 9/12- 8/13
TANA II- Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Role: PI
11. NCRR 1P20RR030360-01(Taylor) 9/10-04/15 0.6 calendar
NIH-NCRR New Hampshire Idea Network of Biomedical Research Excellence Zegans: Research Mentor

12. 1U10EY018573 - 01A (Lietman) 8/09-8/16 1.2 calendar NIH/NEI
Mycotic Ulcer Treatment Trial Zegans: Co-PI
NIH12ZHA002C 2/13-2/16 0.9 calendar
13. NASA/EPSCoR Integrated Modeling of Microgravity-Induced Visual Changes
Role: Co-PI
14. Norris Cotton Cancer Center (Zegans) 12/12-/6/16 0.6 calendar
Comparative Effectiveness Research
Interferon-Alpha 2b for the Treatment of Ocular Surface Squamous Neoplasia
Role: PI

1. NIH/NEI R21 EY02877-01 (Zegans) 4/18-4/20 0.15 calendar
Fungal virulence factors during corneal infections
Role: PI
2. MedImmune SRA (Zegans) 7/14-current
Anti-Ps1 mAbs / Pseudomonas Aeruginosa Collaboration (investigator initiated collaboration)
Role: PI
3. Zoster Eye Disease Study(ZEDS), NEI
Role: Co-PI, Steering Committee
4. Descemet Endothelial Thickness Comparison Trial (DETECT)
Role: Data Safety Monitoring Committee

Courses Taught

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2020

BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014

BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2016

BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2018

BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2020

BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2022

Selected Publications


Acute effects of postural changes and lower body positive and negative pressure on the eye.
Van Akin MP, Lantz OM, Fellows AM, Toutain-Kidd C, Zegans M, Buckey JC, Anderson AP
Front Physiol. 2022;13:933450. doi: 10.3389/fphys.2022.933450. Epub 2022 Aug 31.
PMID: 36117718

Increased Intraocular Pressure During Hemodialysis: Ocular Dialysis Disequilibrium.
Maja AK, Lewis CY, Steffen E, Zegans ME, Graber ML
Kidney Med. 2022 Sep;4(9):100526. doi: 10.1016/j.xkme.2022.100526. Epub 2022 Aug 1.
PMID: 36043165

Patterns of Antifungal Resistance in Adult Patients With Fungal Keratitis in South India: A Post Hoc Analysis of 3 Randomized Clinical Trials.
Prajna NV, Lalitha P, Krishnan T, Rajaraman R, Radnakrishnan N, Srinivasan M, Devi L, Das M, Liu Z, Zegans ME, Acharya NR, Porco TC, Lietman TM, Rose-Nussbaumer J
JAMA Ophthalmol. 2022 Feb 1;140(2):179-184. doi: 10.1001/jamaophthalmol.2021.5765.
PMID: 35024776

Paradox of complex diversity: Challenges in the diagnosis and management of bacterial keratitis.
Singh RB, Das S, Chodosh J, Sharma N, Zegans ME, Kowalski RP, Jhanji V
Prog Retin Eye Res. 2022 May;88:101028. doi: 10.1016/j.preteyeres.2021.101028. Epub 2021 Nov 20.
PMID: 34813978

Sequential endogenous endophthalmitis, fungal keratitis, bacteremia and vertebral osteomyelitis in a person who injects drugs.
Lewis CY, Zegans ME, Batra NN, Jordan KL
Am J Ophthalmol Case Rep. 2021 Sep;23:101140. doi: 10.1016/j.ajoc.2021.101140. Epub 2021 Jun 17.
PMID: 34195475

PRAME immunohistochemistry is useful in the evaluation of conjunctival melanomas, nevi, and primary acquired melanosis.
LeBlanc RE, Miller DM, Zegans ME
J Cutan Pathol. 2021 Dec;48(12):1442-1448. doi: 10.1111/cup.14078. Epub 2021 Jun 18.
PMID: 34089198

Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice.
Hebert W, DiGiandomenico A, Zegans M
Vaccines (Basel). 2020 Nov 2;8(4) doi: 10.3390/vaccines8040638. Epub 2020 Nov 2.
PMID: 33147726

Oral Miltefosine as Salvage Therapy for Refractory Acanthamoeba Keratitis.
Thulasi P, Saeed HN, Rapuano CJ, Hou JH, Appenheimer AB, Chodosh J, Kang JJ, Morrill AM, Vyas N, Zegans ME, Zuckerman R, Tu EY
Am J Ophthalmol. 2021 Mar;223:75-82. doi: 10.1016/j.ajo.2020.09.048. Epub 2020 Oct 10.
PMID: 33045218

Infectious corneal ulceration: a proposal for neglected tropical disease status.
Ung L, Acharya NR, Agarwal T, Alfonso EC, Bagga B, Bispo PJ, Burton MJ, Dart JK, Doan T, Fleiszig SM, Garg P, Gilmore MS, Gritz DC, Hazlett LD, Iovieno A, Jhanji V, Kempen JH, Lee CS, Lietman TM, Margolis TP, McLeod SD, Mehta JS, Miller D, Pearlman E, Prajna L, Prajna NV, Seitzman GD, Shanbhag SS, Sharma N, Sharma S, Srinivasan M, Stapleton F, Tan DT, Tandon R, Taylor HR, Tu EY, Tuli SS, Vajpayee RB, Van Gelder RN, Watson SL, Zegans ME, Chodosh J
Bull World Health Organ. 2019 Dec 1;97(12):854-856. doi: 10.2471/BLT.19.232660. Epub 2019 Nov 1.
PMID: 31819296

Clinical metagenomics for infectious corneal ulcers: Rags to riches?
Ung L, Bispo PJM, Doan T, Van Gelder RN, Gilmore MS, Lietman T, Margolis TP, Zegans ME, Lee CS, Chodosh J
Ocul Surf. 2020 Jan;18(1):1-12. doi: 10.1016/j.jtos.2019.10.007. Epub 2019 Oct 25.
PMID: 31669750

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