Michael E. Zegans, MD
Title(s)
Professor of Surgery
Professor of Microbiology and Immunology
Additional Titles/Positions/Affiliations
Section Chief Ophthalmology
Francis A. L’Esperance, Jr., MD, Visual Sciences Scholar
Good Neighbor Clinic, Eye Clinic lead, White River Junction, VT
Faculty Director, Health Professions Program, Dartmouth College 2016-22
Department(s)
Surgery
Microbiology and Immunology
Education
University of California - San Francisco, F.I. Proctor Foundation, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985
Programs
Molecular Pathogenesis Program
Websites
http:
https:
Contact Information
Section of Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon NH 03756
Phone: 603-650-5123
Professional Interests
Clinical: Diseases of the cornea, ocular surface and uveitis
Surgical: Corneal transplantation, cataract surgery, conjunctival tumors
Research:
- Ocular microbiology, corneal infection and bacterial biofilm formation
- Effects of microgravity on the eye
Grant Information
RESEARCH FUNDING:
Past:
1. Medical Student Research Training Fellow 1989-90 12 calendar
(Zegans)
Howard Hughes Medical Institute
MHC-Class I Antigen Presentation
2. Continued Support Fellowship (Zegans) 1990-92 NA
Howard Hughes Medical Institute
3. Harmes Scholarship (Zegans) 2000-2003 NA Dartmouth Medical School (Surgery)
4. Hitchcock Foundation Award (Zegans) 2006-07 NA Hitchcock Foundation Inhibitors of Pseudomonas aeruginosa pilin processing
5. 5K08EY13977-4 (Zegans) 8/2002 –8/2007 9 calendar NIH/ NEI Biofilm Formation and P. aeruginosa infection of the eye
6. P20 RR16437 (Green, Director) 9/30/01-6/30/11 1.8 calendar NIHI/NCRR for pilot project Center for Molecular, Cellular, and Translational Immunology (COBRE Award)
7. AI068662-01A1(O’Toole) 9/19/07--8/31/09 3.6 calendar NIH/NIAID Zegans: key personnel
8. U10 EY015114-01A2 (Lietman) 10/2005-10/2010 1.2 calendar NIH/NEI TC for Dartmouth, Steroids for Corneal Ulcers Trial Zegans: Co- PI, Director Dartmouth study site
9. Hitchcock Foundation Pilot Grant (Zegans) 10/2012- 10/2013
Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Zegans: PI.
10. U10EY016214 subaward 7260sc (Zegans) 9/12- 8/13
NIH-NEI
TANA II- Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Role: PI
11. NCRR 1P20RR030360-01(Taylor) 9/10-04/15 0.6 calendar
NIH-NCRR New Hampshire Idea Network of Biomedical Research Excellence Zegans: Research Mentor
12. 1U10EY018573 - 01A (Lietman) 8/09-8/16 1.2 calendar NIH/NEI
Mycotic Ulcer Treatment Trial Zegans: Co-PI
NIH12ZHA002C 2/13-2/16 0.9 calendar
13. NASA/EPSCoR Integrated Modeling of Microgravity-Induced Visual Changes
Role: Co-PI
14. Norris Cotton Cancer Center (Zegans) 12/12-/6/16 0.6 calendar
Comparative Effectiveness Research
Interferon-Alpha 2b for the Treatment of Ocular Surface Squamous Neoplasia
Role: PI
15. NIH/NEI R21 EY02877-01 (Zegans) 4/18-4/20 0.15 calendar
Fungal virulence factors during corneal infections
Role: PI
16. MedImmune SRA (Zegans) 7/14-current
Anti-Ps1 mAbs / Pseudomonas Aeruginosa Collaboration (investigator initiated collaboration)
Role: PI
17. Zoster Eye Disease Study(ZEDS), NEI
Role: Co-PI, Steering Committee
18. Descemet Endothelial Thickness Comparison Trial (DETECT)
Role: Data Safety Monitoring Committee
Present:
1. Fuchs Endothelial Corneal Dystrophy (FECD) Observational Study
Central IRB (Advarra): SSU00242694
DH IRB: STUDY02002087
Sponsor: Design Therapeutics, Inc 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011
Role: Co-PI
2. Extensively drug resistant Pseudomonas aeruginosa keratitis outbreak: virulence mechanisms and mitigation.
NEI: 1R01EY036686-1, AWD0009838 (200148-1)
Role : Co-PI
Courses Taught
Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2020
BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2016
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2018
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2020
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2022
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2023
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2024
Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis. Efficacy of Cefiderocol Against Endophthalmitis Isolates. Routine preoperative assessment for cataract surgery is a source of frustration for primary care providers. Characteristics of Prescreened Patients Who Did Not Participate in the Zoster Eye Disease Study. Cefiderocol Is an Effective Topical Monotherapy for Experimental Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis. Out of sight, but not out of mind: Zoster sine herpete case study and survey of Zoster Eye Disease Study (ZEDS) Group. A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021. Cefiderocol is an effective topical monotherapy for experimental extensively-drug resistant Pseudomonas aeruginosa keratitis. Rise in frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021. Acute effects of postural changes and lower body positive and negative pressure on the eye. |
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