Michael E. Zegans, MD
Title(s)
Professor of Surgery
Professor of Microbiology and Immunology
Additional Titles/Positions/Affiliations
Section Chief Ophthalmology
Francis A. L’Esperance, Jr., MD, Visual Sciences Scholar
Faculty Director, Health Professions Program, Dartmouth College 2016-22
Department(s)
Surgery
Microbiology and Immunology
Education
University of California - San Francisco, F.I. Proctor Foundation, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985
Programs
Molecular Pathogenesis Program
Websites
http:
https:
Contact Information
Section of Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon NH 03756
Phone: 603-650-5123
Professional Interests
Clinical: Diseases of the cornea, ocular surface and uveitis
Surgical: Corneal transplantation, cataract surgery, conjunctival tumors
Research:
- Ocular microbiology, corneal infection and bacterial biofilm formation
- Effects of microgravity on the eye
Grant Information
RESEARCH FUNDING:
Past:
1. Medical Student Research Training Fellow 1989-90 12 calendar
(Zegans)
Howard Hughes Medical Institute
MHC-Class I Antigen Presentation
2. Continued Support Fellowship (Zegans) 1990-92 NA
Howard Hughes Medical Institute
3. Harmes Scholarship (Zegans) 2000-2003 NA Dartmouth Medical School (Surgery)
4. Hitchcock Foundation Award (Zegans) 2006-07 NA Hitchcock Foundation Inhibitors of Pseudomonas aeruginosa pilin processing
5. 5K08EY13977-4 (Zegans) 8/2002 –8/2007 9 calendar NIH/ NEI Biofilm Formation and P. aeruginosa infection of the eye
6. P20 RR16437 (Green, Director) 9/30/01-6/30/11 1.8 calendar NIHI/NCRR for pilot project Center for Molecular, Cellular, and Translational Immunology (COBRE Award)
7. AI068662-01A1(O’Toole) 9/19/07--8/31/09 3.6 calendar NIH/NIAID Zegans: key personnel
8. U10 EY015114-01A2 (Lietman) 10/2005-10/2010 1.2 calendar NIH/NEI TC for Dartmouth, Steroids for Corneal Ulcers Trial Zegans: Co- PI, Director Dartmouth study site
9. Hitchcock Foundation Pilot Grant (Zegans) 10/2012- 10/2013
Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Zegans: PI.
10. U10EY016214 subaward 7260sc (Zegans) 9/12- 8/13
NIH-NEI
TANA II- Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Role: PI
11. NCRR 1P20RR030360-01(Taylor) 9/10-04/15 0.6 calendar
NIH-NCRR New Hampshire Idea Network of Biomedical Research Excellence Zegans: Research Mentor
12. 1U10EY018573 - 01A (Lietman) 8/09-8/16 1.2 calendar NIH/NEI
Mycotic Ulcer Treatment Trial Zegans: Co-PI
NIH12ZHA002C 2/13-2/16 0.9 calendar
13. NASA/EPSCoR Integrated Modeling of Microgravity-Induced Visual Changes
Role: Co-PI
14. Norris Cotton Cancer Center (Zegans) 12/12-/6/16 0.6 calendar
Comparative Effectiveness Research
Interferon-Alpha 2b for the Treatment of Ocular Surface Squamous Neoplasia
Role: PI
15. NIH/NEI R21 EY02877-01 (Zegans) 4/18-4/20 0.15 calendar
Fungal virulence factors during corneal infections
Role: PI
16. MedImmune SRA (Zegans) 7/14-current
Anti-Ps1 mAbs / Pseudomonas Aeruginosa Collaboration (investigator initiated collaboration)
Role: PI
17. Zoster Eye Disease Study(ZEDS), NEI
Role: Co-PI, Steering Committee
18. Descemet Endothelial Thickness Comparison Trial (DETECT)
Role: Data Safety Monitoring Committee
Present:
1. Fuchs Endothelial Corneal Dystrophy (FECD) Observational Study
Central IRB (Advarra): SSU00242694
DH IRB: STUDY02002087
Sponsor: Design Therapeutics, Inc 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011
Role: Co-PI
2. Extensively drug resistant Pseudomonas aeruginosa keratitis outbreak: virulence mechanisms and mitigation.
NEI: 1R01EY036686-1, AWD0009838 (200148-1)
Role : Co-PI
Courses Taught
Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2020
BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2016
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2018
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2020
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2022
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2023
BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2024
Enhanced Efficacy of Cefiderocol With PolyTrim Combination Therapy in a Rabbit Model of Extensively Drug-Resistant Pseudomonas aeruginosa Keratitis. Comparing Surgical Outcomes Before and After Instituting a New Ophthalmology Residency Program at a Veterans Affairs Medical Center. Rethinking Vitamin A Deficiency: Its Causes, Ophthalmologic Presentation, and Management Gaps at a New England Tertiary Hospital. Cefiderocol and Moxifloxacin Have Additive and Synergistic Activity Against Pseudomonas aeruginosa Including an Isolate of the 2023 Keratitis Outbreak. Combination Therapy of Cefiderocol and Polymyxin B Against Pseudomonas aeruginosa Keratitis Isolates In Vitro. Could a Preservative Have Prevented the Extremely-Drug Resistant Pseudomonas aeruginosa Artificial Tears Associated Eye Infection Outbreak of 2023? Surgical management and long-term follow-up of a traumatic intrastromal epithelial cyst. Preflight Myopia and Visual Acuity Changes in Long-Duration Astronauts. Conjunctival Granulomas More Common than Recurrence in an 11-year Series of Pterygium Surgery. Propranolol is efficacious against Aspergillus and Fusarium corneal isolates in vitro and in a murine model of Aspergillus keratitis. |
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