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Michael E. Zegans, MD

Title(s):
Professor of Surgery
Professor of Microbiology and Immunology

Additional Titles/Positions/Affiliations:
Section Chief Ophthalmology
Francis A. L’Esperance, Jr., MD, Visual Sciences Scholar
Faculty Director, Health Professions Program, Dartmouth College

Department(s):
Surgery
Microbiology and Immunology

Education:
F.I. Proctor Foundation, UCSF, Fellow in Cornea and Uveitis 1996-1998
University of Virginia, Resident in Ophthalmology, 1993-1996
University of California - San Francisco, Mt. Zion, Medical Internship 1992-1993
University of California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

Programs:
Molecular Pathogenesis Program

Websites:
http://www.dms.dartmouth.edu/microbio/faculty/

Contact Information:

Section of Ophthalmology
Dartmouth Hitchcock Medical Center
Lebanon NH 03756

Phone: 603-650-5123

Asst. Phone: 603-650-6147


Professional Interests:

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

Research:
- Ocular microbiology/infection and bacterial biofilm formation
- Effects of microgravity on the eye

Grant Information:

RESEARCH FUNDING:
Past:
1. Medical Student Research Training Fellow 1989-90 12 calendar
(Zegans)
Howard Hughes Medical Institute
MHC-Class I Antigen Presentation
2. Continued Support Fellowship (Zegans) 1990-92 NA
Howard Hughes Medical Institute
3. Harmes Scholarship (Zegans) 2000-2003 NA Dartmouth Medical School (Surgery)
4. Hitchcock Foundation Award (Zegans) 2006-07 NA Hitchcock Foundation Inhibitors of Pseudomonas aeruginosa pilin processing
5. 5K08EY13977-4 (Zegans) 8/2002 –8/2007 9 calendar NIH/ NEI Biofilm Formation and P. aeruginosa infection of the eye
6. P20 RR16437 (Green, Director) 9/30/01-6/30/11 1.8 calendar NIHI/NCRR for pilot project Center for Molecular, Cellular, and Translational Immunology (COBRE Award)
7. AI068662-01A1(O’Toole) 9/19/07--8/31/09 3.6 calendar NIH/NIAID Zegans: key personnel
8. U10 EY015114-01A2 (Lietman) 10/2005-10/2010 1.2 calendar NIH/NEI TC for Dartmouth, Steroids for Corneal Ulcers Trial Zegans: Co- PI, Director Dartmouth study site
9. Hitchcock Foundation Pilot Grant (Zegans) 10/2012- 10/2013
Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Zegans: PI.
10. U10EY016214 subaward 7260sc (Zegans) 9/12- 8/13
NIH-NEI
TANA II- Ocular surface microbiome of African children with and without ocular chlamydia infection in a trachoma-endemic area
Role: PI
11. NCRR 1P20RR030360-01(Taylor) 9/10-04/15 0.6 calendar
NIH-NCRR New Hampshire Idea Network of Biomedical Research Excellence Zegans: Research Mentor

12. 1U10EY018573 - 01A (Lietman) 8/09-8/16 1.2 calendar NIH/NEI
Mycotic Ulcer Treatment Trial Zegans: Co-PI
NIH12ZHA002C 2/13-2/16 0.9 calendar
13. NASA/EPSCoR Integrated Modeling of Microgravity-Induced Visual Changes
Role: Co-PI
14. Norris Cotton Cancer Center (Zegans) 12/12-/6/16 0.6 calendar
Comparative Effectiveness Research
Interferon-Alpha 2b for the Treatment of Ocular Surface Squamous Neoplasia
Role: PI

Present:
1. NIH/NEI R21 EY02877-01 (Zegans) 4/18-4/20 0.15 calendar
Fungal virulence factors during corneal infections
Role: PI
2. MedImmune SRA (Zegans) 7/14-current
Anti-Ps1 mAbs / Pseudomonas Aeruginosa Collaboration (investigator initiated collaboration)
Role: PI
3. Zoster Eye Disease Study(ZEDS), NEI
Role: Co-PI, Steering Committee

Courses Taught:

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-present

BIOL 071 - Current Topics in Cell Biology, Department of Biologic Sciences, Dartmouth College 2014

BIOL 070 - Biologic Lessons of the Eye, Department of Biologic Sciences, Dartmouth College 2016


Selected Publications:

 

Microbial Analysis of Donor Corneoscleral Rims and Storage Media.
Tsui E, Luong PM, Fogel J, Fogel ES, Zegans ME
Ocul Immunol Inflamm. 2018 May 3;:1-4. doi: 10.1080/09273948.2018.1459734. Epub 2018 May 3.
PMID: 29723082

The Significance of Repeat Cultures in the Treatment of Severe Fungal Keratitis.
Ray KJ, Prajna NV, Lalitha P, Rajaraman R, Krishnan T, Patel S, Das M, Shah R, Dhakhwa K, McLeod SD, Zegans ME, Acharya NR, Lietman TM, Rose-Nussbaumer J, Mycotic Ulcer Treatment Trial Group.
Am J Ophthalmol. 2018 May;189:41-46. doi: 10.1016/j.ajo.2018.02.003. Epub 2018 Feb 10.
PMID: 29438654

Thrombospondin-1 protects against pathogen-induced lung injury by limiting extracellular matrix proteolysis.
Qu Y, Olonisakin T, Bain W, Zupetic J, Brown R, Hulver M, Xiong Z, Tejero J, Shanks RM, Bomberger JM, Cooper VS, Zegans ME, Ryu H, Han J, Pilewski J, Ray A, Cheng Z, Ray P, Lee JS
JCI Insight. 2018 Feb 8;3(3) pii: 96914. doi: 10.1172/jci.insight.96914. Epub 2018 Feb 8.
PMID: 29415890

Vision Loss Associated With the Opioid Epidemic.
Luong PM, Tsui E, Batra N, Chapman CB, Zegans ME
JAMA Ophthalmol. 2017 Dec 1;135(12):1449-1451. doi: 10.1001/jamaophthalmol.2017.4868.
PMID: 29145566

Predictors of Corneal Perforation or Need for Therapeutic Keratoplasty in Severe Fungal Keratitis: A Secondary Analysis of the Mycotic Ulcer Treatment Trial II.
Prajna NV, Krishnan T, Rajaraman R, Patel S, Shah R, Srinivasan M, Das M, Ray KJ, Oldenburg CE, McLeod SD, Zegans ME, Acharya NR, Lietman TM, Rose-Nussbaumer J, Mycotic Ulcer Treatment Trial Group.
JAMA Ophthalmol. 2017 Sep 1;135(9):987-991. doi: 10.1001/jamaophthalmol.2017.2914.
PMID: 28817744

Ocular changes over 60 min in supine and prone postures.
Anderson AP, Babu G, Swan JG, Phillips SD, Knaus DA, Toutain-Kidd CM, Zegans ME, Fellows AM, Gui J, Buckey JC
J Appl Physiol (1985). 2017 Aug 1;123(2):415-423. doi: 10.1152/japplphysiol.00687.2016. Epub 2017 May 25.
PMID: 28546470

<i>Rhodotorula</i> Endogenous Endophthalmitis: A Novel Harbinger of the Injection Drug Epidemic in the United States.
Luong PM, Kalpakian B, Jaeger LJ, Lahey T, Chapman CB, Zegans ME
Case Rep Infect Dis. 2017;2017:9686353. doi: 10.1155/2017/9686353. Epub 2017 Apr 5.
PMID: 28480087

Adjunctive Oral Voriconazole Treatment of Fusarium Keratitis: A Secondary Analysis From the Mycotic Ulcer Treatment Trial II.
Prajna NV, Krishnan T, Rajaraman R, Patel S, Shah R, Srinivasan M, Devi L, Das M, Ray KJ, O'Brien KS, Oldenburg CE, McLeod SD, Zegans ME, Acharya NR, Lietman TM, Rose-Nussbaumer J, Mycotic Ulcer Treatment Trial Group.
JAMA Ophthalmol. 2017 Jun 1;135(6):520-525. doi: 10.1001/jamaophthalmol.2017.0616.
PMID: 28426856

The cif Virulence Factor Gene Is Present in Isolates From Patients With Pseudomonas aeruginosa Keratitis.
Bahl CD, St Laurent JD, Karthikeyan RS, Priya JL, Prajna L, Zegans ME, Madden DR
Cornea. 2017 Mar;36(3):358-362. doi: 10.1097/ICO.0000000000001132.
PMID: 28079684

Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic Ulcer Treatment Trial II (MUTT II): A Randomized Clinical Trial.
Prajna NV, Krishnan T, Rajaraman R, Patel S, Srinivasan M, Das M, Ray KJ, O'Brien KS, Oldenburg CE, McLeod SD, Zegans ME, Porco TC, Acharya NR, Lietman TM, Rose-Nussbaumer J, Mycotic Ulcer Treatment Trial II Group.
JAMA Ophthalmol. 2016 Dec 1;134(12):1365-1372. doi: 10.1001/jamaophthalmol.2016.4096.
PMID: 27787540