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Bruce A. Stanton, PhD

Title(s)
Professor of Microbiology and Immunology
Andrew C. Vail Memorial Professorship

Additional Titles/Positions/Affiliations
Andrew C. Vail Professor
Director of the Lung Biology Center

Department(s)
Microbiology and Immunology

Education
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs
Molecular and Cellular Biology Graduate Programs

Websites
https://sites.dartmouth.edu/dartcf/

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Contact Information

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 520 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu


Professional Interests

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches, including RNA-seq and sc-RNA-seq, and proteomic approaches.

2. Host-pathogen cross talk. The goal of this project is to elucidate how extracellular vesicles secreted by the host and by pathogens regulate and modify bacterial infections in the lungs.

3. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic suppresses the innate immune response to viral and bacterial infections.

Rotations and Thesis Projects

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

3. Bioinformatics

Grant Information

Cystic Fibrosis Foundation: Research Development Program
Title: Translational Research in Cystic Fibrosis Principal Investigator: B.A. Stanton
Principal Investigator: B.A. Stanton
Project Period: 7/1/19 - 6/30/23

Cystic Fibrosis Foundation: Research Grant
P. aeruginosa siRNA-59370 inhibits the antiviral response of human bronchial epithelial cells
Principal Investigator: B.A. Stanton
Project Period: 12/01/19 - 11/30/21

National Institutes of Health (R01 HL151385-01)
Title: Let-7b in Extracellular Vesicles Secreted by Bronchial Epithelial Cells Increases the Antibiotic Sensitivity of Pseudomonas
Principal Investigator: B.A. Stanton
Project Period: 12/14/20 - 11/31/24

National Institutes of Health (R25 GM1297960)
Title: Data to Action: A secondary school-based citizen science project to address arsenic Contamination of well water.
Principal Investigator: Jane Disney
Role: PI of program in New Hampshire
Project Period: 08/01/18 - 07/31/23

National Institutes of Health (R25 HG011447)
Title: Reproducible and FAIR Bioinformatics Analysis of Omics Data
Principal Investigator: B.A. Stanton
Project Period: 12/14/20 - 11/31/24

National Institutes of Health (P30 DK117469)
Title: DartCF: Dartmouth Cystic Fibrosis Research Center
Principal Investigator: D. Madden
Role: Co-PI of Administrative Core and PI of GI Biology Core and Bioinformatics Core.
Project Period: 07/01/20 - 06/30/25

R25 HG011447 (Stanton/Hampton, Co-PIs)Reproducible and FAIR Bioinformatics Analysis of Omics Data
Co-Principal Investigator: B.A. Stanton
Project period: 12/14/20 - 11/31/25

Courses Taught

Honors 350-Molecular Mechanisms of Human Disease-INBRE-Mt Desert Island Biological Laboratory (MDIBL)
Applied Bioinformatics-MDIBL

Mentoring Information

Dr. Stanton has trained over 100 postdoctoral fellows, graduate students and undergraduates.

Biography

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 6th editionĀ, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.
Dr. Stanton received the Ussing Award from the American Physiological Society in 2016.
In 2019 Dr. Stanton received the Unsung Hero Award from the Cystic Fibrosis Foundation.


Selected Publications

 

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in cystic fibrosis.
Li Z, Barnaby R, Nymon A, Roche C, Koeppen K, Ashare A, Hogan DA, Gerber SA, Taatjes DJ, Hampton TH, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2024 May 1;326(5):L574-L588. doi: 10.1152/ajplung.00018.2024. Epub 2024 Mar 5.
PMID: 38440830

P. aeruginosa tRNA-fMet halves secreted in outer membrane vesicles suppress lung inflammation in Cystic Fibrosis.
Li Z, Barnaby R, Nymon A, Roche C, Koeppen K, Ashare A, Hogan DA, Gerber SA, Taatjes DJ, Hampton TH, Stanton BA
bioRxiv. 2024 Feb 3; pii: 2024.02.03.578737. doi: 10.1101/2024.02.03.578737. Epub 2024 Feb 3.
PMID: 38352468

APPLICATION OF QUANTILE DISCRETIZATION AND BAYESIAN NETWORK ANALYSIS TO PUBLICLY AVAILABLE CYSTIC FIBROSIS DATA SETS.
Fukutani KF, Hampton TH, Bobak CA, MacKenzie TA, Stanton BA
Pac Symp Biocomput. 2024;29:534-548.
PMID: 38160305

Extracellular vesicles secreted by primary human bronchial epithelial cells reduce Pseudomonas aeruginosa burden and inflammation in cystic fibrosis mouse lung.
Sarkar S, Barnaby R, Nymon AB, Taatjes DJ, Kelley TJ, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2024 Feb 1;326(2):L164-L174. doi: 10.1152/ajplung.00253.2023. Epub 2023 Dec 12.
PMID: 38084406

Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk: A Pilot Study.
Howe CG, Armstrong DA, Muse ME, Gilbert-Diamond D, Gui J, Hoen AG, Palys TJ, Barnaby RL, Stanton BA, Jackson BP, Christensen BC, Karagas MR
Expo Health. 2023 Dec;15(4):731-743. doi: 10.1007/s12403-022-00520-1. Epub 2022 Nov 3.
PMID: 38074282

Rocket-miR, a translational launchpad for miRNA-based antimicrobial drug development.
Neff SL, Hampton TH, Koeppen K, Sarkar S, Latario CJ, Ross BD, Stanton BA
mSystems. 2023 Dec 21;8(6):e0065323. doi: 10.1128/msystems.00653-23. Epub 2023 Nov 17.
PMID: 37975659

Bacterial Outer Membrane Vesicles and Immune Modulation of the Host.
Charpentier LA, Dolben EF, Hendricks MR, Hogan DA, Bomberger JM, Stanton BA
Membranes (Basel). 2023 Aug 24;13(9) doi: 10.3390/membranes13090752. Epub 2023 Aug 24.
PMID: 37755174

An rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa.
Koeppen K, Hampton TH, Barnaby R, Roche C, Gerber SA, Goo YA, Cho BK, Vermilyea DM, Hogan DA, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2023 Jul 1;325(1):L54-L65. doi: 10.1152/ajplung.00150.2022. Epub 2023 May 31.
PMID: 37256658

Computationally Efficient Assembly of Pseudomonas aeruginosa Gene Expression Compendia.
Doing G, Lee AJ, Neff SL, Reiter T, Holt JD, Stanton BA, Greene CS, Hogan DA
mSystems. 2023 Feb 23;8(1):e0034122. doi: 10.1128/msystems.00341-22. Epub 2022 Dec 21.
PMID: 36541761

ESKAPE Act Plus: Pathway Activation Analysis for Bacterial Pathogens.
Koeppen K, Hampton TH, Neff SL, Stanton BA
mSystems. 2022 Dec 20;7(6):e0046822. doi: 10.1128/msystems.00468-22. Epub 2022 Oct 19.
PMID: 36259735

View more publications on PubMed