Bruce A. Stanton, PhD
Professor of Microbiology and Immunology
Andrew C. Vail Memorial Professorship
Andrew C. Vail Professor
Director of the Lung Biology Center
Director of the Center for Environmental Health Sciences
Microbiology and Immunology
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980
Molecular and Cellular Biology Graduate Programs
Geisel School of Medicine
Hanover NH 03755
Office: 615 Remsen
1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.
2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa.
Rotations and Thesis Projects:
1. Host-pathogen interactions in Cystic Fibrosis.
2. Arsenic and innate immunity
R01-HL074175 08/15/03 - 06/30/19
Title: Role of Virulence Factors in Pseudomonas-Host Interactions
Specific aims of project: The major goal of this project is to elucidate how outer membrane vesicles secreted by P. aeruginosa inhibit CFTR Cl secretion by airway epithelial cells.
P42-ES007373 4/01/14 - 03/31/19
Title: Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury
PI Project #3: Arsenic and Innate Immunity in Human Lung
Specific aims of project: The major goal of this project is to test the hypothesis that arsenite, MMA and DMA have differential, dose dependent adverse effects on P. aeruginosa infections of the lung by modulating the innate immune response.
P30-GM106394 09/01/13 - 7/31/18
Title: Cellular and Molecular Mechanisms of Lung Disease - COBRE
Specific aims of project: The major goal of this grant is to provide Core support and pilot project funding to members of the Lung Biology Center.
STANTO19R0 7/01/15 - 6/30/19
Title: CF Research Development Program (RDP)
Specific aims of project: The major goal of this grant is to facilitate research to identify novel drugable targets and to develop new therapies for CF patients. This grant supports core facilities and pilot project grants. As PI, Dr. Stanton is not eligible for pilot grant support.
P20-GM103534 09/01/11 - 07/31/16
Title: Quantitative Biology Research Institute
Specific aims of project: The goal of this program is to establish a Quantitative Biology Research Institute that will enhance the ability of scientists to use mathematics and computer science to solve complex biomedical research questions.
Role: Co-I on Administrative Core
Cystic Fibrosis Foundation: Research Grant 04/01/16 - 03/31/18
Title: Effects of VX-809 and VX-770 on Macrophage Function and Inflammation
Specific aims of project: To elucidate the ability of VX-809 and VX-770 to enhance the ability of macrophages to phagocytose and kill P. aeruginosa.
Sanofi: Research Grant 04/01/16 - 03/31/17
Title: Effects of novel iron chelators on Pseudomonas aeruginosa biofilm formation
Specific aims of project: To test the ability of a novel Sanofi drug to kill P. aeruginosa.
Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Introduction to Bioinformatics-INBRE-MDIBL
Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th edition, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.
Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles.
Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress.
Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR Cl<sup>-</sup> secretion.
Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.
Pre-Analytical Handling Conditions and Small RNA Recovery from Urine for miRNA Profiling.
Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa.
ScanGEO: parallel mining of high-throughput gene expression data.
An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
Effectiveness of table top water pitcher filters to remove arsenic from drinking water.
Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells.