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Bruce A. Stanton, PhD

Title(s):
Professor of Microbiology and Immunology
Andrew C. Vail Memorial Professorship

Additional Titles/Positions/Affiliations:
Andrew C. Vail Professor
Director of the Lung Biology Center

Department(s):
Microbiology and Immunology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://www.dartmouth.edu/~lbcobre/
http://www.dartmouth.edu/~toxmetal/about/research-team/faculty/bruce.html

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 520 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches, including RNA-seq and sc-RNA-seq, and proteomic approaches.

2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic suppresses the innate immune response to viral and bacterial infections.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

Grant Information:

National Institutes of Health -
NIGMS (P30-GM103413-15) - COBRE
Title: Cellular and Molecular Mechanisms of Lung Disease
Principal Investigator: B.A. Stanton
Project Period: 10/01/03 - 6/30/20

NIH-NIEHS (P42 ES007373-23)
Title: Toxic Metals in The Northeast
Principal Investigator (2008-2018): B.A. Stanton
Title Project #3: Arsenic and Innate Immunity in the Lung
Principal Investigator: B.A. Stanton (Project 3)
Project Period: 4/01/14 - 3/31/20

Cystic Fibrosis Foundation: Research Development Program
Title: CF Research Development Program (STANTO15R0)
Principal Investigator: B.A. Stanton
Project Period: 7/1/19 - 6/30/23

National Institutes of Health (R01 HL074175-11)
Title: Role of Virulence Factors in Pseudomonas-Host Interactions
Principal Investigator: B.A. Stanton
Project Period: 7/1/15 - 6/30/20

National Institutes of Health (R25 GM1297960)
Title: Data to Action: A secondary school-based citizen science project to address arsenic Contamination of well water.
Principal Investigator: Jane Disney
Role: PI of program in New Hampshire
Project Period: 08/01/18 - 07/31/23

National Institutes of Health (P30 DK117469)
Title: DartCF: Dartmouth Cystic Fibrosis Research Center
Principal Investigator: D. Madden
Role: Co-PI of Administrative Core and PI of Bioinformatics Core.
Project Period: 07/01/18 - 06/30/20

Courses Taught:

Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Applied Bioinformatics-INBRE-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 6th edition, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.
Dr. Stanton received the Ussing Award from the American Physiological Society in 2016.
In 2019 Dr. Stanton received the Unsung Hero Award from the Cystic Fibrosis Foundation.


Selected Publications:

 

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon BP, Santos CD, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S
Am J Physiol Lung Cell Mol Physiol. 2020 Sep 9; doi: 10.1152/ajplung.00218.2020. Epub 2020 Sep 9.
PMID: 32901521

SARS-CoV-2 (COVID-19) and cystic fibrosis.
Stanton BA, Hampton TH, Ashare A
Am J Physiol Lung Cell Mol Physiol. 2020 Sep 1;319(3):L408-L415. doi: 10.1152/ajplung.00225.2020. Epub 2020 Jul 15.
PMID: 32668165

Selection of reference genes for quantitative PCR: identifying reference genes for airway epithelial cells exposed to Pseudomonas aeruginosa.
Hampton TH, Koeppen K, Bashor L, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L256-L265. doi: 10.1152/ajplung.00158.2020. Epub 2020 Jun 10.
PMID: 32521165

Single-cell RNA-seq Analysis Reveals That Prenatal Arsenic Exposure Results in Long-term, Adverse Effects on Immune Gene Expression in Response to Influenza A Infection.
Hsu KS, Goodale BC, Ely KH, Hampton TH, Stanton BA, Enelow RI
Toxicol Sci. 2020 Aug 1;176(2):312-328. doi: 10.1093/toxsci/kfaa080.
PMID: 32514536

Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles.
Koeppen K, Barnaby R, Jackson AA, Gerber SA, Hogan DA, Stanton BA
PLoS One. 2019;14(1):e0211290. doi: 10.1371/journal.pone.0211290. Epub 2019 Jan 25.
PMID: 30682135

Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress.
Goodale BC, Hampton TH, Ford EN, Jackson CE, Shaw JR, Stanton BA, King BL
Aquat Toxicol. 2019 Jan;206:142-153. doi: 10.1016/j.aquatox.2018.11.009. Epub 2018 Nov 12.
PMID: 30476744

Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR Cl- secretion.
Barnaby R, Koeppen K, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L206-L215. doi: 10.1152/ajplung.00316.2018. Epub 2018 Oct 25.
PMID: 30358440

Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.
Hampton TH, Jackson C, Jung D, Chen CY, Glaholt SP, Stanton BA, Colbourne JK, Shaw JR
Environ Sci Technol. 2018 Aug 7;52(15):8811-8821. doi: 10.1021/acs.est.8b01550. Epub 2018 Jul 20.
PMID: 29979584

Pre-Analytical Handling Conditions and Small RNA Recovery from Urine for miRNA Profiling.
Armstrong DA, Dessaint JA, Ringelberg CS, Hazlett HF, Howard L, Abdalla MAK, Barnaby RL, Stanton BA, Cervinski MA, Ashare A
J Mol Diagn. 2018 Sep;20(5):565-571. doi: 10.1016/j.jmoldx.2018.04.003. Epub 2018 Jun 22.
PMID: 29936254

Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa.
Barnaby R, Koeppen K, Nymon A, Hampton TH, Berwin B, Ashare A, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L432-L438. doi: 10.1152/ajplung.00461.2017. Epub 2017 Nov 16.
PMID: 29146575

View more publications on PubMed