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Bruce A. Stanton, PhD

Professor of Microbiology and Immunology
Andrew C. Vail Memorial Professorship

Additional Titles/Positions/Affiliations:
Andrew C. Vail Professor
Director of the Lung Biology Center

Microbiology and Immunology

U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Molecular and Cellular Biology Graduate Programs


Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 520 Remsen
Phone: 603-650-1775

Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches, including RNA-seq and sc-RNA-seq, and proteomic approaches.

2. Host-pathogen cross talk. The goal of this project is to elucidate how extracellular vesicles secreted by the host and by pathogens regulate and modify bacterial infections in the lungs.

3. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic suppresses the innate immune response to viral and bacterial infections.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

3. Bioinformatics

Grant Information:

Cystic Fibrosis Foundation: Research Development Program
Title: Translational Research in Cystic Fibrosis Principal Investigator: B.A. Stanton
Principal Investigator: B.A. Stanton
Project Period: 7/1/19 - 6/30/23

Cystic Fibrosis Foundation: Research Grant
P. aeruginosa siRNA-59370 inhibits the antiviral response of human bronchial epithelial cells
Principal Investigator: B.A. Stanton
Project Period: 12/01/19 - 11/30/21

National Institutes of Health (R01 HL151385-01)
Title: Let-7b in Extracellular Vesicles Secreted by Bronchial Epithelial Cells Increases the Antibiotic Sensitivity of Pseudomonas
Principal Investigator: B.A. Stanton
Project Period: 12/14/20 - 11/31/24

National Institutes of Health (R25 GM1297960)
Title: Data to Action: A secondary school-based citizen science project to address arsenic Contamination of well water.
Principal Investigator: Jane Disney
Role: PI of program in New Hampshire
Project Period: 08/01/18 - 07/31/23

National Institutes of Health (R25 HG011447)
Title: Reproducible and FAIR Bioinformatics Analysis of Omics Data
Principal Investigator: B.A. Stanton
Project Period: 12/14/20 - 11/31/24

National Institutes of Health (P30 DK117469)
Title: DartCF: Dartmouth Cystic Fibrosis Research Center
Principal Investigator: D. Madden
Role: Co-PI of Administrative Core and PI of GI Biology Core and Bioinformatics Core.
Project Period: 07/01/20 - 06/30/25

R25 HG011447 (Stanton/Hampton, Co-PIs)Reproducible and FAIR Bioinformatics Analysis of Omics Data
Co-Principal Investigator: B.A. Stanton
Project period: 12/14/20 - 11/31/25

Courses Taught:

Honors 350-Molecular Mechanisms of Human Disease-INBRE-Mt Desert Island Biological Laboratory (MDIBL)
Applied Bioinformatics-MDIBL


Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 6th edition, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.
Dr. Stanton received the Ussing Award from the American Physiological Society in 2016.
In 2019 Dr. Stanton received the Unsung Hero Award from the Cystic Fibrosis Foundation.

Mentoring Information:

Dr. Stanton has trained over 100 postdoctoral fellows, graduate students and undergraduates.

Selected Publications:


Model Systems to Study the Chronic, Polymicrobial Infections in Cystic Fibrosis: Current Approaches and Exploring Future Directions.
O'Toole GA, Crabbe A, Kummerli R, LiPuma JJ, Bomberger JM, Davies JC, Limoli D, Phelan VV, Bliska JB, DePas WH, Dietrich LE, Hampton TH, Hunter R, Khursigara CM, Price-Whelan A, Ashare A, Cramer RA, Goldberg JB, Harrison F, Hogan DA, Henson MA, Madden DR, Mayers JR, Nadell C, Newman D, Prince A, Rivett DW, Schwartzman JD, Schultz D, Sheppard DC, Smyth AR, Spero MA, Stanton BA, Turner PE, van der Gast C, Whelan FJ, Whitaker R, Whiteson K
mBio. 2021 Sep 21;:e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21.
PMID: 34544277

Let-7b-5p in vesicles secreted by human airway cells reduces biofilm formation and increases antibiotic sensitivity of P. aeruginosa.
Koeppen K, Nymon A, Barnaby R, Bashor L, Li Z, Hampton TH, Liefeld AE, Kolling FW, LaCroix IS, Gerber SA, Hogan DA, Kasetty S, Nadell CD, Stanton BA
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28) pii: e2105370118. doi: 10.1073/pnas.2105370118.
PMID: 34260396

Mild Cystic Fibrosis Lung Disease Is Associated with Bacterial Community Stability.
Hampton TH, Thomas D, van der Gast C, O'Toole GA, Stanton BA
Microbiol Spectr. 2021 Sep 3;9(1):e0002921. doi: 10.1128/Spectrum.00029-21. Epub 2021 Jul 7.
PMID: 34232099

Extracellular Vesicles and Host-Pathogen Interactions: A Review of Inter-Kingdom Signaling by Small Noncoding RNA.
Stanton BA
Genes (Basel). 2021 Jun 30;12(7) pii: 1010. doi: 10.3390/genes12071010. Epub 2021 Jun 30.
PMID: 34208860

Transfer RNA-Derived Fragments, the Underappreciated Regulatory Small RNAs in Microbial Pathogenesis.
Li Z, Stanton BA
Front Microbiol. 2021;12:687632. doi: 10.3389/fmicb.2021.687632. Epub 2021 May 17.
PMID: 34079534

Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells.
Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ
Eur Respir J. 2021 Oct;58(4) pii: 2004149. doi: 10.1183/13993003.04149-2020. Epub 2021 Oct 14.
PMID: 33795318

GAUGE-Annotated Microbial Transcriptomic Data Facilitate Parallel Mining and High-Throughput Reanalysis To Form Data-Driven Hypotheses.
Li Z, Koeppen K, Holden VI, Neff SL, Cengher L, Demers EG, Mould DL, Stanton BA, Hampton TH
mSystems. 2021 Mar 23;6(2) pii: e01305-20. doi: 10.1128/mSystems.01305-20. Epub 2021 Mar 23.
PMID: 33758032

CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells.
Koeppen K, Nymon A, Barnaby R, Li Z, Hampton TH, Ashare A, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2021 Apr 1;320(4):L530-L544. doi: 10.1152/ajplung.00621.2020. Epub 2021 Jan 20.
PMID: 33471607

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S
Am J Physiol Lung Cell Mol Physiol. 2020 Dec 1;319(6):L908-L925. doi: 10.1152/ajplung.00218.2020. Epub 2020 Sep 9.
PMID: 32901521

SARS-CoV-2 (COVID-19) and cystic fibrosis.
Stanton BA, Hampton TH, Ashare A
Am J Physiol Lung Cell Mol Physiol. 2020 Sep 1;319(3):L408-L415. doi: 10.1152/ajplung.00225.2020. Epub 2020 Jul 15.
PMID: 32668165

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