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Bruce A. Stanton, PhD

Title(s):
Professor of Microbiology and Immunology
Andrew C. Vail Memorial Professorship

Additional Titles/Positions/Affiliations:
Andrew C. Vail Professor
Director of the Lung Biology Center
Director of the Center for Environmental Health Sciences

Department(s):
Microbiology and Immunology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://www.dartmouth.edu/~lbcobre/
http://www.dartmouth.edu/~toxmetal/about/research-team/faculty/bruce.html

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 615 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches.

2. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic affects the innate immune response to Pseudomonas aeruginosa.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

Grant Information:

R01-HL074175 08/15/03 - 06/30/19
NIH/NHLBI
Title: Role of Virulence Factors in Pseudomonas-Host Interactions
Specific aims of project: The major goal of this project is to elucidate how outer membrane vesicles secreted by P. aeruginosa inhibit CFTR Cl secretion by airway epithelial cells.
Role: PI


P42-ES007373 4/01/14 - 03/31/19
NIH/NIEHS
Title: Sources and Protracted Effects of Early Life Exposure to Arsenic and Mercury
PI Project #3: Arsenic and Innate Immunity in Human Lung
Specific aims of project: The major goal of this project is to test the hypothesis that arsenite, MMA and DMA have differential, dose dependent adverse effects on P. aeruginosa infections of the lung by modulating the innate immune response.
Role: PI


P30-GM106394 09/01/13 - 7/31/18
NIH/NIGMS
Title: Cellular and Molecular Mechanisms of Lung Disease - COBRE
Specific aims of project: The major goal of this grant is to provide Core support and pilot project funding to members of the Lung Biology Center.
Role: PI


STANTO19R0 7/01/15 - 6/30/19
CF Foundation
Title: CF Research Development Program (RDP)
Specific aims of project: The major goal of this grant is to facilitate research to identify novel drugable targets and to develop new therapies for CF patients. This grant supports core facilities and pilot project grants. As PI, Dr. Stanton is not eligible for pilot grant support.
Role: PI

P20-GM103534 09/01/11 - 07/31/16
NIH/NIGMS
Title: Quantitative Biology Research Institute
Specific aims of project: The goal of this program is to establish a Quantitative Biology Research Institute that will enhance the ability of scientists to use mathematics and computer science to solve complex biomedical research questions.
Role: Co-I on Administrative Core

Cystic Fibrosis Foundation: Research Grant 04/01/16 - 03/31/18
Title: Effects of VX-809 and VX-770 on Macrophage Function and Inflammation
Specific aims of project: To elucidate the ability of VX-809 and VX-770 to enhance the ability of macrophages to phagocytose and kill P. aeruginosa.
Role: PI

Sanofi: Research Grant 04/01/16 - 03/31/17
Title: Effects of novel iron chelators on Pseudomonas aeruginosa biofilm formation
Specific aims of project: To test the ability of a novel Sanofi drug to kill P. aeruginosa.
Role: PI

Courses Taught:

Honors 350-Molecular Mechanisms of Human Disease-INBRE-MDIBL
Introduction to Bioinformatics-INBRE-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 5th edition, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.


Selected Publications:

 

Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles.
Koeppen K, Barnaby R, Jackson AA, Gerber SA, Hogan DA, Stanton BA
PLoS One. 2019;14(1):e0211290. doi: 10.1371/journal.pone.0211290. Epub 2019 Jan 25.
PMID: 30682135

Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress.
Goodale BC, Hampton TH, Ford EN, Jackson CE, Shaw JR, Stanton BA, King BL
Aquat Toxicol. 2019 Jan;206:142-153. doi: 10.1016/j.aquatox.2018.11.009. Epub 2018 Nov 12.
PMID: 30476744

Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR Cl<sup>-</sup> secretion.
Barnaby R, Koeppen K, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L206-L215. doi: 10.1152/ajplung.00316.2018. Epub 2018 Oct 25.
PMID: 30358440

Arsenic Reduces Gene Expression Response to Changing Salinity in Killifish.
Hampton TH, Jackson C, Jung D, Chen CY, Glaholt SP, Stanton BA, Colbourne JK, Shaw JR
Environ Sci Technol. 2018 Aug 7;52(15):8811-8821. doi: 10.1021/acs.est.8b01550. Epub 2018 Jul 20.
PMID: 29979584

Pre-Analytical Handling Conditions and Small RNA Recovery from Urine for miRNA Profiling.
Armstrong DA, Dessaint JA, Ringelberg CS, Hazlett HF, Howard L, Abdalla MAK, Barnaby RL, Stanton BA, Cervinski MA, Ashare A
J Mol Diagn. 2018 Sep;20(5):565-571. doi: 10.1016/j.jmoldx.2018.04.003. Epub 2018 Jun 22.
PMID: 29936254

Lumacaftor (VX-809) restores the ability of CF macrophages to phagocytose and kill Pseudomonas aeruginosa.
Barnaby R, Koeppen K, Nymon A, Hampton TH, Berwin B, Ashare A, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L432-L438. doi: 10.1152/ajplung.00461.2017. Epub 2017 Nov 16.
PMID: 29146575

ScanGEO: parallel mining of high-throughput gene expression data.
Koeppen K, Stanton BA, Hampton TH
Bioinformatics. 2017 Nov 1;33(21):3500-3501. doi: 10.1093/bioinformatics/btx452.
PMID: 29036513

An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.
Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR
Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L150-L156. doi: 10.1152/ajplung.00383.2017. Epub 2017 Oct 5.
PMID: 28982736

Effectiveness of table top water pitcher filters to remove arsenic from drinking water.
Barnaby R, Liefeld A, Jackson BP, Hampton TH, Stanton BA
Environ Res. 2017 Oct;158:610-615. doi: 10.1016/j.envres.2017.07.018. Epub 2017 Jul 15.
PMID: 28719869

Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells.
Goodale BC, Rayack EJ, Stanton BA
Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163. doi: 10.1016/j.taap.2017.06.010. Epub 2017 Jun 15.
PMID: 28625800

View more publications on PubMed