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Bruce A. Stanton, PhD

Title(s):
Professor of Microbiology and Immunology
Andrew C. Vail Memorial Professorship

Additional Titles/Positions/Affiliations:
Andrew C. Vail Professor
Director of the Lung Biology Center

Department(s):
Microbiology and Immunology

Education:
U. Maine, BS 1974
Yale University, MS 1976
Yale University, PHD 1980

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
https://sites.dartmouth.edu/dartcf/

Contact Information:

Geisel School of Medicine
HB 7701
Hanover NH 03755

Office: 520 Remsen
Phone: 603-650-1775
Email: bas@dartmouth.edu


Professional Interests:

1. Host-pathogen interactions in Cystic Fibrosis. The goal of this project is to elucidate how Pseudomonas aeruginosa infects airway epithelial cells and forms drug resistant biofilms in patients with CF, and to understand how airway epithelial cells facilitate drug resistant by Pseudomonas aeruginosa using genomic approaches, including RNA-seq and sc-RNA-seq, and proteomic approaches.

2. Host-pathogen cross talk. The goal of this project is to elucidate how extracellular vesicles secreted by the host and by pathogens regulate and modify bacterial infections in the lungs.

3. Arsenic and innate immunity. The goal of this project is to elucidate how arsenic suppresses the innate immune response to viral and bacterial infections.

Rotations and Thesis Projects:

1. Host-pathogen interactions in Cystic Fibrosis.

2. Arsenic and innate immunity

3. Bioinformatics

Grant Information:

Cystic Fibrosis Foundation: Research Development Program
Title: Translational Research in Cystic Fibrosis Principal Investigator: B.A. Stanton
Principal Investigator: B.A. Stanton
Project Period: 7/1/19 - 6/30/23

Cystic Fibrosis Foundation: Research Grant
P. aeruginosa siRNA-59370 inhibits the antiviral response of human bronchial epithelial cells
Principal Investigator: B.A. Stanton
Project Period: 12/01/19 - 11/30/21

National Institutes of Health (R01 HL151385-01)
Title: Let-7b in Extracellular Vesicles Secreted by Bronchial Epithelial Cells Increases the Antibiotic Sensitivity of Pseudomonas
Principal Investigator: B.A. Stanton
Project Period: 12/14/20 - 11/31/24

National Institutes of Health (R25 GM1297960)
Title: Data to Action: A secondary school-based citizen science project to address arsenic Contamination of well water.
Principal Investigator: Jane Disney
Role: PI of program in New Hampshire
Project Period: 08/01/18 - 07/31/23

National Institutes of Health (R25 HG011447)
Title: Reproducible and FAIR Bioinformatics Analysis of Omics Data
Principal Investigator: B.A. Stanton
Project Period: 12/14/20 - 11/31/24

National Institutes of Health (P30 DK117469)
Title: DartCF: Dartmouth Cystic Fibrosis Research Center
Principal Investigator: D. Madden
Role: Co-PI of Administrative Core and PI of GI Biology Core and Bioinformatics Core.
Project Period: 07/01/20 - 06/30/25

R25 HG011447 (Stanton/Hampton, Co-PIs)Reproducible and FAIR Bioinformatics Analysis of Omics Data
Co-Principal Investigator: B.A. Stanton
Project period: 12/14/20 - 11/31/25

Courses Taught:

Honors 350-Molecular Mechanisms of Human Disease-INBRE-Mt Desert Island Biological Laboratory (MDIBL)
Applied Bioinformatics-MDIBL

Biography:

Biography. Dr. Stanton received his B.S. from the University of Maine 1974 and his Ph.D. from Yale University in 1980. He came to Dartmouth in 1984 as an Assistant Professor, was promoted to Associate Professor in 1988, and to Professor in 1993. Dr. Stanton has co-written and co-edited several textbooks including Renal Physiology, now in its 6th edition, and Physiology, now in its 7th edition. He was named Andrew C. Vail Professor in 2010.
Dr. Stanton received the Ussing Award from the American Physiological Society in 2016.
In 2019 Dr. Stanton received the Unsung Hero Award from the Cystic Fibrosis Foundation.

Mentoring Information:

Dr. Stanton has trained over 100 postdoctoral fellows, graduate students and undergraduates.


Selected Publications:

 

Healthy versus inflamed lung environments differentially effect MSCs.
Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ
Eur Respir J. 2021 Apr 1; pii: 2004149. doi: 10.1183/13993003.04149-2020. Epub 2021 Apr 1.
PMID: 33795318

GAUGE-Annotated Microbial Transcriptomic Data Facilitate Parallel Mining and High-Throughput Reanalysis To Form Data-Driven Hypotheses.
Li Z, Koeppen K, Holden VI, Neff SL, Cengher L, Demers EG, Mould DL, Stanton BA, Hampton TH
mSystems. 2021 Mar 23;6(2) pii: e01305-20. doi: 10.1128/mSystems.01305-20. Epub 2021 Mar 23.
PMID: 33758032

CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells.
Koeppen K, Nymon A, Barnaby R, Li Z, Hampton TH, Ashare A, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2021 Apr 1;320(4):L530-L544. doi: 10.1152/ajplung.00621.2020. Epub 2021 Jan 20.
PMID: 33471607

Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells.
Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon B, Dos Santos C, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S
Am J Physiol Lung Cell Mol Physiol. 2020 Dec 1;319(6):L908-L925. doi: 10.1152/ajplung.00218.2020. Epub 2020 Sep 9.
PMID: 32901521

SARS-CoV-2 (COVID-19) and cystic fibrosis.
Stanton BA, Hampton TH, Ashare A
Am J Physiol Lung Cell Mol Physiol. 2020 Sep 1;319(3):L408-L415. doi: 10.1152/ajplung.00225.2020. Epub 2020 Jul 15.
PMID: 32668165

Selection of reference genes for quantitative PCR: identifying reference genes for airway epithelial cells exposed to Pseudomonas aeruginosa.
Hampton TH, Koeppen K, Bashor L, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L256-L265. doi: 10.1152/ajplung.00158.2020. Epub 2020 Jun 10.
PMID: 32521165

Single-cell RNA-seq Analysis Reveals That Prenatal Arsenic Exposure Results in Long-term, Adverse Effects on Immune Gene Expression in Response to Influenza A Infection.
Hsu KS, Goodale BC, Ely KH, Hampton TH, Stanton BA, Enelow RI
Toxicol Sci. 2020 Aug 1;176(2):312-328. doi: 10.1093/toxsci/kfaa080.
PMID: 32514536

Tobramycin reduces key virulence determinants in the proteome of Pseudomonas aeruginosa outer membrane vesicles.
Koeppen K, Barnaby R, Jackson AA, Gerber SA, Hogan DA, Stanton BA
PLoS One. 2019;14(1):e0211290. doi: 10.1371/journal.pone.0211290. Epub 2019 Jan 25.
PMID: 30682135

Profiling microRNA expression in Atlantic killifish (Fundulus heteroclitus) gill and responses to arsenic and hyperosmotic stress.
Goodale BC, Hampton TH, Ford EN, Jackson CE, Shaw JR, Stanton BA, King BL
Aquat Toxicol. 2019 Jan;206:142-153. doi: 10.1016/j.aquatox.2018.11.009. Epub 2018 Nov 12.
PMID: 30476744

Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR Cl- secretion.
Barnaby R, Koeppen K, Stanton BA
Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L206-L215. doi: 10.1152/ajplung.00316.2018. Epub 2018 Oct 25.
PMID: 30358440

View more publications on PubMed