James C. Leiter III, MD
Title(s)
Emeritus Professor of Molecular and Systems Biology
Emeritus Professor of Medicine
Department(s)
Molecular and Systems Biology
Medicine
Education
Dartmouth College, AB 1975
Dartmouth Medical School, MD 1979
Programs
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
NIH Biosketch
Leiter_J_BIO_2025-04-03.pdf
Websites
http:
Contact Information
Research, White River Junction VAHC Building 22
163 Veterans Drive
White River Junction VT 05001
Office: 2-118 Freedom Building
Phone: 802-952-9454
Email: James.C.Leiter@Dartmouth.EDU
Professional Interests
Dr. Leiter is interested in the neurophysiology of respiratory control, central chemosensitivity and Sudden Infant Death Syndrome. Additional interests include the neurobiology of deep brain stimulation in Parkinson's Disease and neuropsychiatric disorders.
Rotations and Thesis Projects
There are current opportunities to work studying interactions among central chemosensitivity and the laryngeal chemoreflex as it pertains to SIDS. They are examining the role of serotonin and adenosine in the modulation of these reflex responses. We are using lentiviral vectors to alter astrocytic functions and thereby alter cardiorespiratory reflex control of autonomic function.
In respect to deep brain stimulation, we are studying the role of DBS in movement disorders and substance abuse. A strong background in engineering and mathematics is helpful in these studies.
Grant Information
Grant Information (updated 2025):
HD100823-01: Does neurotransmitter plasticity of para-serotonergic neurons augment autoresuscitation following perinatal stress and buffer SIDS risk?
NICHD 107060-01A1: Inflammatory stressors in serotonergic brainstem dysfunction and SIDS.
NHLB1 79313-01: SIDS, failed autoresuscitation, and a novel serotonergic brainstem-cerebellar circuit.
DA047637-01A1: Characterization of novel neural respiratory circuit to counter opioid-induced respiratory depression.
UH3 NS119772-011: Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with spinal cord injury.
NSF 2042543: Collaborative research: a multiplexed microbiosensing platform for understanding real time neurotransmitter dynamics in the brain.
Renal Research Institute: Validation of a model of dynamic regulation of intravascular volume during hemodialysis.
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