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Seddon R. Savage, MD

Adjunct Associate Professor of Anesthesiology


Barnard College, BA 1972
Columbia University
College of Physicians and Surgeons, MS 1976
Dartmouth Medical School, MD 1980

Contact Information:

Phone: 603-491-6104
Email: seddon.savage@dartmouth.edu

Professional Interests:

Strategies to reduce opioid related harm
Multidimensional management of chronic pain.
Strategies for effective and safe opioid therapy of pain.
Interfaces of pain and addiction.
Pain education, policy and practice systems.
Clinician health and practice issues.
Healthcare reform

Courses Taught:

Bi-annual Symposium on Substance Use 2004-present
University Seminar on Substance Use and Addiction for Faculty and Selected Students, 2006-present.
Pain Medicine Interfaces with Addiction, Addiction Psychiatry fellowship 2007- present
Pain Management lectures in Health Psychology, Dartmouth College, 2007 and 2008.
On Doctoring facilitator, DMS 1st and 2nd year students, 1997-2004.
Continuing education sessions for residents and faculty on aspects of pain management, various, 1986-present.

Selected Publications:


Cannabis in Pain Treatment: Clinical and Research Considerations.
Savage SR, Romero-Sandoval A, Schatman M, Wallace M, Fanciullo G, McCarberg B, Ware M
J Pain. 2016 Jun;17(6):654-68. doi: 10.1016/j.jpain.2016.02.007. Epub 2016 Mar 4.
PMID: 26961090

NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.
Bretz CA, Savage SR, Capozzi ME, Suarez S, Penn JS
Sci Rep. 2015 Nov 3;5:14963. doi: 10.1038/srep14963. Epub 2015 Nov 3.
PMID: 26527057

RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cells.
Savage SR, McCollum GW, Yang R, Penn JS
Mol Vis. 2015;21:568-76. Epub 2015 May 20.
PMID: 26015769

RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα.
Savage SR, Bretz CA, Penn JS
PLoS One. 2015;10(1):e0116941. doi: 10.1371/journal.pone.0116941. Epub 2015 Jan 24.
PMID: 25617622

A pain research agenda for the 21st century.
Gereau RW 4th, Sluka KA, Maixner W, Savage SR, Price TJ, Murinson BB, Sullivan MD, Fillingim RB
J Pain. 2014 Dec;15(12):1203-14. doi: 10.1016/j.jpain.2014.09.004. Epub 2014 Oct 29.
PMID: 25419990

Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types.
Watkins WM, McCollum GW, Savage SR, Capozzi ME, Penn JS, Morrison DG
Exp Eye Res. 2013 Nov;116:240-6. doi: 10.1016/j.exer.2013.09.014. Epub 2013 Sep 26.
PMID: 24076411

What to do when pain and addiction coexist.
Savage SR
J Fam Pract. 2013 Jun;62(6 Suppl):S10-6.
PMID: 23828808

Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Capozzi ME, McCollum GW, Savage SR, Penn JS
Invest Ophthalmol Vis Sci. 2013 Jun 19;54(6):4197-207. doi: 10.1167/iovs.13-11608. Epub 2013 Jun 19.
PMID: 23716627

Sublingual buprenorphine/naloxone for chronic pain in at-risk patients: development and pilot test of a clinical protocol.
Rosenblum A, Cruciani RA, Strain EC, Cleland CM, Joseph H, Magura S, Marsch LA, McNicholas LF, Savage SR, Sundaram A, Portenoy RK
J Opioid Manag. 2012 Nov-Dec;8(6):369-82. doi: 10.5055/jom.2012.0137.
PMID: 23264315

Informed consent in opioid therapy: a potential obligation and opportunity.
Cheatle MD, Savage SR
J Pain Symptom Manage. 2012 Jul;44(1):105-16. doi: 10.1016/j.jpainsymman.2011.06.015. Epub 2012 Mar 21.
PMID: 22445273