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Seddon R. Savage, MD

Title(s)
Clinical Associate Professor of Anesthesiology

Department(s)
Anesthesiology

Education
Barnard College, BA 1972
Columbia University
College of Physicians and Surgeons, MS 1976
Dartmouth Medical School, MD 1980

Contact Information

Phone: 603-491-6104
Email: seddon.savage@dartmouth.edu


Professional Interests

Strategies to reduce opioid related harm
Multidimensional management of chronic pain.
Strategies for effective and safe opioid therapy of pain.
Interfaces of pain and addiction.
Pain education, policy and practice systems.
Clinician health and practice issues.
Healthcare reform

Courses Taught

Bi-annual Symposium on Substance Use 2004-present
University Seminar on Substance Use and Addiction for Faculty and Selected Students, 2006-present.
Pain Medicine Interfaces with Addiction, Addiction Psychiatry fellowship 2007- present
Pain Management lectures in Health Psychology, Dartmouth College, 2007 and 2008.
On Doctoring facilitator, DMS 1st and 2nd year students, 1997-2004.
Continuing education sessions for residents and faculty on aspects of pain management, various, 1986-present.




Selected Publications

 

Comprehensive evaluation of phosphoproteomic-based kinase activity inference.
Muller-Dott S, Jaehnig EJ, Munchic KP, Jiang W, Yaron-Barir TM, Savage SR, Garrido-Rodriguez M, Johnson JL, Lussana A, Petsalaki E, Lei JT, Dugourd A, Krug K, Cantley LC, Mani DR, Zhang B, Saez-Rodriguez J
Nat Commun. 2025 May 22;16(1):4771. doi: 10.1038/s41467-025-59779-y. Epub 2025 May 22.
PMID: 40404650

Proteomic-based stemness score measures oncogenic dedifferentiation and enables the identification of druggable targets.
Kołodziejczak-Guglas I, Simões RLS, de Souza Santos E, Demicco EG, Lazcano Segura RN, Ma W, Wang P, Geffen Y, Storrs E, Petralia F, Colaprico A, da Veiga Leprevost F, Pugliese P, Ceccarelli M, Noushmehr H, Nesvizhskii AI, Kamińska B, Priebe W, Lubiński J, Zhang B, Lazar AJ, Kurzawa P, Mesri M, Robles AI, Clinical Proteomic Tumor Analysis Consortium, Ding L, Malta TM, Wiznerowicz M
Cell Genom. 2025 Jun 11;5(6):100851. doi: 10.1016/j.xgen.2025.100851. Epub 2025 Apr 17.
PMID: 40250426

Precision proteogenomics reveals pan-cancer impact of germline variants.
Martins Rodrigues F, Terekhanova NV, Imbach KJ, Clauser KR, Esai Selvan M, Mendizabal I, Geffen Y, Akiyama Y, Maynard M, Yaron TM, Li Y, Cao S, Storrs EP, Gonda OS, Gaite-Reguero A, Govindan A, Kawaler EA, Wyczalkowski MA, Klein RJ, Turhan B, Krug K, Mani DR, Leprevost FDV, Nesvizhskii AI, Carr SA, Fenyo D, Gillette MA, Colaprico A, Iavarone A, Robles AI, Huang KL, Kumar-Sinha C, Aguet F, Lazar AJ, Cantley LC, Marigorta UM, Gumuş ZH, Bailey MH, Getz G, Porta-Pardo E, Ding L, Clinical Proteomic Tumor Analysis Consortium
Cell. 2025 May 1;188(9):2312-2335.e26. doi: 10.1016/j.cell.2025.03.026. Epub 2025 Apr 14.
PMID: 40233739

Multi-scale signaling and tumor evolution in high-grade gliomas.
Liu J, Cao S, Imbach KJ, Gritsenko MA, Lih TM, Kyle JE, Yaron-Barir TM, Binder ZA, Li Y, Strunilin I, Wang YT, Tsai CF, Ma W, Chen L, Clark NM, Shinkle A, Naser Al Deen N, Caravan W, Houston A, Simin FA, Wyczalkowski MA, Wang LB, Storrs E, Chen S, Illindala R, Li YD, Jayasinghe RG, Rykunov D, Cottingham SL, Chu RK, Weitz KK, Moore RJ, Sagendorf T, Petyuk VA, Nestor M, Bramer LM, Stratton KG, Schepmoes AA, Couvillion SP, Eder J, Kim YM, Gao Y, Fillmore TL, Zhao R, Monroe ME, Southard-Smith AN, Li YE, Jui-Hsien Lu R, Johnson JL, Wiznerowicz M, Hostetter G, Newton CJ, Ketchum KA, Thangudu RR, Barnholtz-Sloan JS, Wang P, Fenyo D, An E, Thiagarajan M, Robles AI, Mani DR, Smith RD, Porta-Pardo E, Cantley LC, Iavarone A, Chen F, Mesri M, Nasrallah MP, Zhang H, Resnick AC, Chheda MG, Rodland KD, Liu T, Ding L, Philadelphia Coalition for a Cure, Clinical Proteomic Tumor Analysis Consortium
Cancer Cell. 2024 Jul 8;42(7):1217-1238.e19. doi: 10.1016/j.ccell.2024.06.004.
PMID: 38981438

Pan-cancer proteogenomics expands the landscape of therapeutic targets.
Savage SR, Yi X, Lei JT, Wen B, Zhao H, Liao Y, Jaehnig EJ, Somes LK, Shafer PW, Lee TD, Fu Z, Dou Y, Shi Z, Gao D, Hoyos V, Gao Q, Zhang B
Cell. 2024 Aug 8;187(16):4389-4407.e15. doi: 10.1016/j.cell.2024.05.039. Epub 2024 Jun 24.
PMID: 38917788

Advancing action on the political determinants of health in the United States.
Savage SR, Kraft SA, Tanner C, Houde M
J Public Health Policy. 2024 Sep;45(3):484-494. doi: 10.1057/s41271-024-00497-y. Epub 2024 Jun 20.
PMID: 38902356

Correction to: Using phosphoproteomics data to understand cellular signaling: a comprehensive guide to bioinformatics resources.
Savage SR, Zhang B
Clin Proteomics. 2024 Mar 7;21(1):20. doi: 10.1186/s12014-024-09473-w. Epub 2024 Mar 7.
PMID: 38454337

Proteogenomic analysis of chemo-refractory high-grade serous ovarian cancer.
Chowdhury S, Kennedy JJ, Ivey RG, Murillo OD, Hosseini N, Song X, Petralia F, Calinawan A, Savage SR, Berry AB, Reva B, Ozbek U, Krek A, Ma W, da Veiga Leprevost F, Ji J, Yoo S, Lin C, Voytovich UJ, Huang Y, Lee SH, Bergan L, Lorentzen TD, Mesri M, Rodriguez H, Hoofnagle AN, Herbert ZT, Nesvizhskii AI, Zhang B, Whiteaker JR, Fenyo D, McKerrow W, Wang J, Schurer SC, Stathias V, Chen XS, Barcellos-Hoff MH, Starr TK, Winterhoff BJ, Nelson AC, Mok SC, Kaufmann SH, Drescher C, Cieslik M, Wang P, Birrer MJ, Paulovich AG
Cell. 2024 Feb 15;187(4):1016. doi: 10.1016/j.cell.2024.01.016.
PMID: 38364782

Pan-cancer proteogenomics characterization of tumor immunity.
Petralia F, Ma W, Yaron TM, Caruso FP, Tignor N, Wang JM, Charytonowicz D, Johnson JL, Huntsman EM, Marino GB, Calinawan A, Evangelista JE, Selvan ME, Chowdhury S, Rykunov D, Krek A, Song X, Turhan B, Christianson KE, Lewis DA, Deng EZ, Clarke DJB, Whiteaker JR, Kennedy JJ, Zhao L, Segura RL, Batra H, Raso MG, Parra ER, Soundararajan R, Tang X, Li Y, Yi X, Satpathy S, Wang Y, Wiznerowicz M, Gonzalez-Robles TJ, Iavarone A, Gosline SJC, Reva B, Robles AI, Nesvizhskii AI, Mani DR, Gillette MA, Klein RJ, Cieslik M, Zhang B, Paulovich AG, Sebra R, Gumuş ZH, Hostetter G, Fenyo D, Omenn GS, Cantley LC, Ma'ayan A, Lazar AJ, Ceccarelli M, Wang P, Clinical Proteomic Tumor Analysis Consortium
Cell. 2024 Feb 29;187(5):1255-1277.e27. doi: 10.1016/j.cell.2024.01.027. Epub 2024 Feb 14.
PMID: 38359819

Frozen tissue coring and layered histological analysis improves cell type-specific proteogenomic characterization of pancreatic adenocarcinoma.
Savage SR, Wang Y, Chen L, Jewell S, Newton C, Dou Y, Li QK, Bathe OF, Robles AI, Omenn GS, Thiagarajan M, Zhang H, Hostetter G, Zhang B
Clin Proteomics. 2024 Jan 30;21(1):7. doi: 10.1186/s12014-024-09450-3. Epub 2024 Jan 30.
PMID: 38291365

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