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Edward J. Usherwood, PhD

Title(s)
Professor of Microbiology and Immunology

Department(s)
Microbiology and Immunology

Education
University of Cambridge, U.K., Ph.D., 1997
University of Cambridge, U.K., BA 1994

Dr. Usherwood received his B.A. in 1990 in Natural Sciences from the University of Cambridge, U.K. He continued his studies at the University of Cambridge and was awarded his Ph.D. from the Department of Pathology in 1994. From 1994 to 1997 Dr. Usherwood undertook postdoctoral research at the University of Edinburgh, U.K. then he moved to Memphis, TN for further postdoctoral work in the Department of Immunology at St. Jude's Children's Research Hospital. From 1999 to 2001 he held a position as a Research Assistant Member at The Trudeau Institute, NY. He came to Dartmouth in 2001 as an Assistant Professor, then was promoted to Associate Professor in 2007 and Full Professor in 2013.

Programs
Immunology Program
Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Norris Cotton Cancer Center

Websites
Usherwood lab website:
http://geiselmed.dartmouth.edu/usherwood/

http://geiselmed.dartmouth.edu/microbio/
http://geiselmed.dartmouth.edu/immuno/

Contact Information

Dartmouth Medical School
Borwell Research Building - HB7556
1 Medical Center Drive
Lebanon NH 03756

Phone: 603-650-7730
Fax: 603-650-6223
Email: Edward.J.Usherwood@Dartmouth.Edu


Professional Interests

Determining factors necessary for memory T cell responses to optimize immunotherapy.

Our work determines the factors necessary for long-term survival of T cells to maintain their protective activity against both tumors and virus infections. While there is typically a large expansion of T cells early during an immune response, only a minority of these cells have the ability to survive long-term in the host. This prolonged survival is necessary for providing sustained protection against re-infection or recurrence of tumors. In fact, a major positive prognostic indicator for adoptive T cell therapies targeting cancer is the length of time that these T cells are sustained in the patient.

Our laboratory uses a variety of cutting-edge molecular techniques coupled with in vivo and in vitro models to understand the fundamental programming of memory T cell responses. These range from manipulation of transcriptional regulation, cell-extrinsic signaling and gene editing to metabolic reprogramming of T cells. We then devise methods to exploit this knowledge to design T cells that can better survive in the hostile environment of a tumor and enhance anti-tumor activity.

Grant Information

NCI R01 "Immune surveillance in murine gammaherpesvirus infection"
NIAID R01 "T cell function in murine gammaherpesvirus infection"

Courses Taught

Immune Therapy Advanced Course (MCB graduate program)
MCB graduate program core course


Selected Publications

 

Mitochondrial dysfunction triggers actin polymerization necessary for rapid glycolytic activation.
Chakrabarti R, Fung TS, Kang T, Elonkirjo PW, Suomalainen A, Usherwood EJ, Higgs HN
J Cell Biol. 2022 Nov 7;221(11) pii: e202201160. doi: 10.1083/jcb.202201160. Epub 2022 Sep 14.
PMID: 36102863

Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma.
Molodtsov AK, Khatwani N, Vella JL, Lewis KA, Zhao Y, Han J, Sullivan DE, Searles TG, Preiss NK, Shabaneh TB, Zhang P, Hawkes AR, Malik BT, Kolling FW 4th, Usherwood EJ, Wong SL, Phillips JD, Shirai K, Angeles CV, Yan S, Curiel TJ, Huang YH, Cheng C, Turk MJ
Immunity. 2021 Sep 14;54(9):2117-2132.e7. doi: 10.1016/j.immuni.2021.08.019.
PMID: 34525340

Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women.
Patel MV, Shen Z, Rodriguez-Garcia M, Usherwood EJ, Tafe LJ, Wira CR
Front Immunol. 2021;12:657326. doi: 10.3389/fimmu.2021.657326. Epub 2021 Apr 23.
PMID: 33968059

Control of B Cell Lymphoma by Gammaherpesvirus-Induced Memory CD8 T Cells.
Preiss NK, Kang T, Usherwood YK, Huang YH, Branchini BR, Usherwood EJ
J Immunol. 2020 Dec 15;205(12):3372-3382. doi: 10.4049/jimmunol.2000734. Epub 2020 Nov 13.
PMID: 33188072

Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity.
Sun Y, Preiss NK, Valenteros KB, Kamal Y, Usherwood YK, Frost HR, Usherwood EJ
J Immunol. 2020 Nov 15;205(10):2649-2666. doi: 10.4049/jimmunol.2000459. Epub 2020 Sep 30.
PMID: 32998985

CD8+ T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine.
Cho HS, Ha S, Shin HM, Reboldi A, Hall JA, Huh JR, Usherwood EJ, Berg LJ
Immunohorizons. 2020 Feb 7;4(2):57-71. doi: 10.4049/immunohorizons.1900093. Epub 2020 Feb 7.
PMID: 32034085

Dissociating STAT4 and STAT5 Signaling Inhibitory Functions of SOCS3: Effects on CD8 T Cell Responses.
Hwang JY, Holland JE, Valenteros KB, Sun Y, Usherwood YK, Verissimo AF, McLellan JS, Grigoryan G, Usherwood EJ
Immunohorizons. 2019 Nov 20;3(11):547-558. doi: 10.4049/immunohorizons.1800075. Epub 2019 Nov 20.
PMID: 31748225

Neuropilin-1 Regulates the Secondary CD8 T Cell Response to Virus Infection.
Hwang JY, Sun Y, Carroll CR, Usherwood EJ
mSphere. 2019 May 22;4(3) pii: e00221-19. doi: 10.1128/mSphere.00221-19. Epub 2019 May 22.
PMID: 31118303

Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.
Huang LH, Melton EM, Li H, Sohn P, Jung D, Tsai CY, Ma T, Sano H, Ha H, Friedline RH, Kim JK, Usherwood E, Chang CCY, Chang TY
Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E340-E356. doi: 10.1152/ajpendo.00174.2017. Epub 2018 Mar 13.
PMID: 29533741

Cross-species conservation of episome maintenance provides a basis for in vivo investigation of Kaposi's sarcoma herpesvirus LANA.
Habison AC, de Miranda MP, Beauchemin C, Tan M, Cerqueira SA, Correia B, Ponnusamy R, Usherwood EJ, McVey CE, Simas JP, Kaye KM
PLoS Pathog. 2017 Sep;13(9):e1006555. doi: 10.1371/journal.ppat.1006555. Epub 2017 Sep 14.
PMID: 28910389

View more publications on PubMed