Michael W. Fanger, PhD
Emeritus Professor of Microbiology and Immunology
Microbiology and Immunology
Yale University, Ph.D., 1967
Wabash College, B.A., 1962
Professor Fanger received the B.A. degree from Wabash College in 1962 and the Ph.D. in Biochemistry from Yale University in 1967. After postdoctoral training at the National Institute for Medical Research in London, England and the University of Illinois Medical School in Chicago, he was appointed to the faculty of the Microbiology Department at Case Western Reserve University in Cleveland in 1970. In 1981, Professor Fanger moved to the Dartmouth Medical School. He served as Chair of the Department of Microbiology and Immunology from 1992 to 2002, and is currently Professor of Microbiology and Immunology, and Professor of Medicine.
Dartmouth Medical School
Borwell Research Building-HB 7556
1 Medical Center Drive
Lebanon NH 03756
Office: Borwell 600W
Research in Dr. Fanger's laboratory has focused on studies of the role that innate immunity plays in inducing adaptive immunity in the human female reproductive tract and on the mechanisms by which antigen presentation is mediated by human Dendritic Cells (DCs). As DCs play a major role in the initiation of immunity through processing and presentation of antigen, fusion proteins that target antigens to molecules expressed primarily on antigen presenting cells are being investigated as vaccines for immunotherapy of cancer.
Manufacturing development and clinical production of NKG2D chimeric antigen receptor-expressing T cells for autologous adoptive cell therapy.
Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell-Treated Mice.
Effects of menstrual cycle status and gender on human neutrophil phenotype.
Human fallopian tube neutrophils--a distinct phenotype from blood neutrophils.
Differential regulation of neutrophil chemotaxis to IL-8 and fMLP by GM-CSF: lack of direct effect of oestradiol.
Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus-type I.
Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxis.
Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblasts.
Inhibition of human polymorphonuclear cell oxidative burst by 17-beta-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivity.