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Ambrose Cheung, MD

Title(s):
Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Northwestern University Medical School, MD 1980
Colby College, BA 1976

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://dms.dartmouth.edu/microbio/
http://www.dartmouth.edu/~mcb/

Contact Information:

Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755

Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU


Professional Interests:

Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.


Selected Publications:

 

YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus.
Mikheyeva IV, Thomas JM, Kolar SL, Corvaglia AR, Gaϊa N, Leo S, Francois P, Liu GY, Rawat M, Cheung AL
Mol Microbiol. 2019 Jan 12; doi: 10.1111/mmi.14207. Epub 2019 Jan 12.
PMID: 30636083

Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection.
Li L, Abdelhady W, Donegan NP, Seidl K, Cheung A, Zhou YF, Yeaman MR, Bayer AS, Xiong YQ
J Infect Dis. 2018 Sep 22;218(9):1367-1377. doi: 10.1093/infdis/jiy340.
PMID: 29868791

Small RNA teg49 Is Derived from a <i>sarA</i> Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus.
Manna AC, Kim S, Cengher L, Corvaglia A, Leo S, Francois P, Cheung AL
Infect Immun. 2018 Feb;86(2) pii: e00635-17. doi: 10.1128/IAI.00635-17. Epub 2018 Jan 22.
PMID: 29133345

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in <i>Staphylococcus aureus-</i>Infected Wounds.
Falahee PC, Anderson LS, Reynolds MB, Pirir M, McLaughlin BE, Dillen CA, Cheung AL, Miller LS, Simon SI
J Immunol. 2017 Sep 1;199(5):1772-1782. doi: 10.4049/jimmunol.1700649. Epub 2017 Jul 21.
PMID: 28733486

A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.
Nair DR, Chen J, Monteiro JM, Josten M, Pinho MG, Sahl HG, Wu J, Cheung A
J Antibiot (Tokyo). 2017 Oct;70(10):1009-1019. doi: 10.1038/ja.2017.79. Epub 2017 Jul 12.
PMID: 28698673

Bypassing the restriction system to improve transformation of <i>Staphylococcus epidermidis</i>.
Costa SK, Donegan NP, Corvaglia AR, Francois P, Cheung AL
J Bacteriol. 2017 May 30; pii: JB.00271-17. doi: 10.1128/JB.00271-17. Epub 2017 May 30.
PMID: 28559294

Persister formation in Staphylococcus aureus is associated with ATP depletion.
Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K
Nat Microbiol. 2016 Apr 18;1:16051. doi: 10.1038/nmicrobiol.2016.51. Epub 2016 Apr 18.
PMID: 27572649

The Global Regulon sarA Regulates β-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections.
Li L, Cheung A, Bayer AS, Chen L, Abdelhady W, Kreiswirth BN, Yeaman MR, Xiong YQ
J Infect Dis. 2016 Nov 1;214(9):1421-1429. Epub 2016 Aug 19.
PMID: 27543672

Persister formation in <i>Staphylococcus aureus</i> is associated with ATP depletion.
Conlon BP, Rowe SE, Gandt AB, Nuxoll AS, Donegan NP, Zalis EA, Clair G, Adkins JN, Cheung AL, Lewis K
Nat Microbiol. 2016;1 pii: 16051. Epub 2016 Apr 18.
PMID: 27398229

Staphylococcal enterotoxin A-activated regulatory T cells promote allergen-specific T<sub>H</sub>2 response to intratracheal allergen inoculation.
Zeng WP, McFarland MM, Zhou B, Holtfreter S, Flesher S, Cheung A, Mallick A
J Allergy Clin Immunol. 2017 Feb;139(2):508-518.e4. doi: 10.1016/j.jaci.2016.04.033. Epub 2016 Jun 8.
PMID: 27394914