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Ambrose Cheung, MD

Title(s)
Emeritus Professor of Microbiology and Immunology

Department(s)
Microbiology and Immunology

Education
Northwestern University Medical School, MD 1980
Colby College, BA 1976

Programs
Molecular and Cellular Biology Graduate Programs

Websites
http://dms.dartmouth.edu/microbio/
http://www.dartmouth.edu/~mcb/

Academic Analytics
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Contact Information

Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755

Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU


Professional Interests

Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.


Selected Publications

 

Role of the NaHCO(3) Transporter MpsABC in the NaHCO(3)-β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus.
Fan SH, Proctor RA, Ersoy SC, Manna AC, Cheung AL, Gotz F, Chambers HF, Bayer AS
Microbiol Spectr. 2023 Apr 27;:e0014123. doi: 10.1128/spectrum.00141-23. Epub 2023 Apr 27.
PMID: 37102972

Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO(3)-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus.
Ersoy SC, Goncalves B, Cavaco G, Manna AC, Sobral RG, Nast CC, Proctor RA, Chambers HF, Cheung A, Bayer AS
Microbiol Spectr. 2022 Dec 21;10(6):e0342222. doi: 10.1128/spectrum.03422-22. Epub 2022 Nov 15.
PMID: 36377886

Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria.
Schultz JR, Costa SK, Jachak GR, Hegde P, Zimmerman M, Pan Y, Josten M, Ejeh C, Hammerstad T, Sahl HG, Pereira PM, Pinho MG, Dartois V, Cheung A, Aldrich CC
J Med Chem. 2022 Oct 27;65(20):13910-13934. doi: 10.1021/acs.jmedchem.2c01151. Epub 2022 Oct 11.
PMID: 36219779

Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus.
Manna AC, Leo S, Girel S, Gonzalez-Ruiz V, Rudaz S, Francois P, Cheung AL
Sci Rep. 2022 Sep 2;12(1):14963. doi: 10.1038/s41598-022-18815-3. Epub 2022 Sep 2.
PMID: 36056144

The thematic role of extracellular loop of VraG in activation of the membrane sensor GraS in a cystic fibrosis MRSA strain differs in nuance from the CA-MRSA strain JE2.
Cho J, Rigby WFC, Cheung AL
PLoS One. 2022;17(6):e0270393. doi: 10.1371/journal.pone.0270393. Epub 2022 Jun 23.
PMID: 35737676

CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies.
Neff SL, Hampton TH, Puerner C, Cengher L, Doing G, Lee AJ, Koeppen K, Cheung AL, Hogan DA, Cramer RA, Stanton BA
Sci Data. 2022 Jun 16;9(1):343. doi: 10.1038/s41597-022-01431-1. Epub 2022 Jun 16.
PMID: 35710652

Regulation of neutrophil myeloperoxidase inhibitor SPIN by the small RNA Teg49 in Staphylococcus aureus.
Cengher L, Manna AC, Cho J, Theprungsirikul J, Sessions K, Rigby W, Cheung AL
Mol Microbiol. 2022 Jun;117(6):1447-1463. doi: 10.1111/mmi.14919. Epub 2022 May 31.
PMID: 35578788

The NaHCO(3)-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus (MRSA) Is Influenced by mecA Genotype.
Ersoy SC, Manna AC, Proctor RA, Chambers HF, Harrison EM, Bayer AS, Cheung A
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0025222. doi: 10.1128/aac.00252-22. Epub 2022 May 16.
PMID: 35575577

Impacts of NaHCO(3) on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO(3)-Responsive versus NaHCO(3)-Non-Responsive Phenotypes.
Ersoy SC, Chan LC, Yeaman MR, Chambers HF, Proctor RA, Ludwig KC, Schneider T, Manna AC, Cheung A, Bayer AS
Antibiotics (Basel). 2022 Mar 30;11(4) doi: 10.3390/antibiotics11040462. Epub 2022 Mar 30.
PMID: 35453214

New Mechanistic Insights into Purine Biosynthesis with Second Messenger c-di-AMP in Relation to Biofilm-Related Persistent Methicillin-Resistant Staphylococcus aureus Infections.
Li L, Li Y, Zhu F, Cheung AL, Wang G, Bai G, Proctor RA, Yeaman MR, Bayer AS, Xiong YQ
mBio. 2021 Dec 21;12(6):e0208121. doi: 10.1128/mBio.02081-21. Epub 2021 Nov 2.
PMID: 34724823

View more publications on PubMed