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Ambrose Cheung, MD

Professor of Microbiology and Immunology

Microbiology and Immunology

Northwestern University Medical School, MD 1980
Colby College, BA 1976

Molecular and Cellular Biology Graduate Programs


Contact Information:

Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755

Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU

Professional Interests:

Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.

Selected Publications:


Expanding the Staphylococcus aureus SarA Regulon to Small RNAs.
Oriol C, Cengher L, Manna AC, Mauro T, Pinel-Marie ML, Felden B, Cheung A, Rouillon A
mSystems. 2021 Oct 12;:e0071321. doi: 10.1128/mSystems.00713-21. Epub 2021 Oct 12.
PMID: 34636666

The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections.
Modi G, Marqus GM, Vippila MR, Gollapalli DR, Kim Y, Manna AC, Chacko S, Maltseva N, Wang X, Cullinane RT, Zhang Y, Kotler JLM, Kuzmic P, Zhang M, Lawson AP, Joachimiak A, Cheung A, Snider BB, Rothstein DM, Cuny GD, Hedstrom L
ACS Infect Dis. 2021 Sep 30; doi: 10.1021/acsinfecdis.1c00342. Epub 2021 Sep 30.
PMID: 34590817

The Staphylococcus aureus toxin-antitoxin system YefM-YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation.
Qi X, Brothers KM, Ma D, Mandell JB, Donegan NP, Cheung AL, Richardson AR, Urish KL
J Bone Jt Infect. 2021;6(7):241-253. doi: 10.5194/jbji-6-241-2021. Epub 2021 Jul 2.
PMID: 34262845

Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections.
Cheung AL, Cho J, Bayer AS, Yeaman MR, Xiong YQ, Donegan NP, Mikheyeva IV, Lee GY, Yang SJ
Infect Immun. 2021 Sep 16;89(10):e0034721. doi: 10.1128/IAI.00347-21. Epub 2021 Jul 6.
PMID: 34227840

GraS Sensory Activity in Staphylococcus epidermidis Is Modulated by the "Guard Loop" of VraG and the ATPase Activity of VraF.
Costa SK, Cho J, Cheung AL
J Bacteriol. 2021 Aug 9;203(17):e0017821. doi: 10.1128/JB.00178-21. Epub 2021 Aug 9.
PMID: 34096781

The extracellular loop of the membrane permease VraG interacts with GraS to sense cationic antimicrobial peptides in Staphylococcus aureus.
Cho J, Costa SK, Wierzbicki RM, Rigby WFC, Cheung AL
PLoS Pathog. 2021 Mar;17(3):e1009338. doi: 10.1371/journal.ppat.1009338. Epub 2021 Mar 1.
PMID: 33647048

Impact of the Novel Prophage ϕSA169 on Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection.
Li L, Wang G, Li Y, Francois P, Bayer AS, Chen L, Seidl K, Cheung A, Xiong YQ
mSystems. 2020 Jun 30;5(3) pii: e00178-20. doi: 10.1128/mSystems.00178-20. Epub 2020 Jun 30.
PMID: 32606024

The Stringent Response Contributes to Persistent Methicillin-Resistant Staphylococcus aureus Endovascular Infection Through the Purine Biosynthetic Pathway.
Li L, Bayer AS, Cheung A, Lu L, Abdelhady W, Donegan NP, Hong JI, Yeaman MR, Xiong YQ
J Infect Dis. 2020 Sep 1;222(7):1188-1198. doi: 10.1093/infdis/jiaa202.
PMID: 32333768

The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection.
Ma D, Mandell JB, Donegan NP, Cheung AL, Ma W, Rothenberger S, Shanks RMQ, Richardson AR, Urish KL
mBio. 2019 Nov 26;10(6) pii: e01658-19. doi: 10.1128/mBio.01658-19. Epub 2019 Nov 26.
PMID: 31772059

Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa.
Limoli DH, Warren EA, Yarrington KD, Donegan NP, Cheung AL, O'Toole GA
Elife. 2019 Nov 12;8 pii: e47365. doi: 10.7554/eLife.47365. Epub 2019 Nov 12.
PMID: 31713513

View more publications on PubMed