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Ambrose Cheung, MD

Title(s)
Professor of Microbiology and Immunology

Department(s)
Microbiology and Immunology

Education
Northwestern University Medical School, MD 1980
Colby College, BA 1976

Programs
Molecular and Cellular Biology Graduate Programs

Websites
http://dms.dartmouth.edu/microbio/
http://www.dartmouth.edu/~mcb/

Contact Information

Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755

Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU


Professional Interests

Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.


Selected Publications

 

The thematic role of extracellular loop of VraG in activation of the membrane sensor GraS in a cystic fibrosis MRSA strain differs in nuance from the CA-MRSA strain JE2.
Cho J, Rigby WFC, Cheung AL
PLoS One. 2022;17(6):e0270393. doi: 10.1371/journal.pone.0270393. Epub 2022 Jun 23.
PMID: 35737676

CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies.
Neff SL, Hampton TH, Puerner C, Cengher L, Doing G, Lee AJ, Koeppen K, Cheung AL, Hogan DA, Cramer RA, Stanton BA
Sci Data. 2022 Jun 16;9(1):343. doi: 10.1038/s41597-022-01431-1. Epub 2022 Jun 16.
PMID: 35710652

Regulation of neutrophil myeloperoxidase inhibitor SPIN by the small RNA Teg49 in Staphylococcus aureus.
Cengher L, Manna AC, Cho J, Theprungsirikul J, Sessions K, Rigby W, Cheung AL
Mol Microbiol. 2022 Jun;117(6):1447-1463. doi: 10.1111/mmi.14919. Epub 2022 May 31.
PMID: 35578788

The NaHCO3-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus (MRSA) Is Influenced by mecA Genotype.
Ersoy SC, Manna AC, Proctor RA, Chambers HF, Harrison EM, Bayer AS, Cheung A
Antimicrob Agents Chemother. 2022 Jun 21;66(6):e0025222. doi: 10.1128/aac.00252-22. Epub 2022 May 16.
PMID: 35575577

Impacts of NaHCO3 on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO3-Responsive versus NaHCO3-Non-Responsive Phenotypes.
Ersoy SC, Chan LC, Yeaman MR, Chambers HF, Proctor RA, Ludwig KC, Schneider T, Manna AC, Cheung A, Bayer AS
Antibiotics (Basel). 2022 Mar 30;11(4) pii: 462. doi: 10.3390/antibiotics11040462. Epub 2022 Mar 30.
PMID: 35453214

New Mechanistic Insights into Purine Biosynthesis with Second Messenger c-di-AMP in Relation to Biofilm-Related Persistent Methicillin-Resistant Staphylococcus aureus Infections.
Li L, Li Y, Zhu F, Cheung AL, Wang G, Bai G, Proctor RA, Yeaman MR, Bayer AS, Xiong YQ
mBio. 2021 Dec 21;12(6):e0208121. doi: 10.1128/mBio.02081-21. Epub 2021 Nov 2.
PMID: 34724823

Expanding the Staphylococcus aureus SarA Regulon to Small RNAs.
Oriol C, Cengher L, Manna AC, Mauro T, Pinel-Marie ML, Felden B, Cheung A, Rouillon A
mSystems. 2021 Oct 26;6(5):e0071321. doi: 10.1128/mSystems.00713-21. Epub 2021 Oct 12.
PMID: 34636666

The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections.
Modi G, Marqus GM, Vippila MR, Gollapalli DR, Kim Y, Manna AC, Chacko S, Maltseva N, Wang X, Cullinane RT, Zhang Y, Kotler JLM, Kuzmic P, Zhang M, Lawson AP, Joachimiak A, Cheung A, Snider BB, Rothstein DM, Cuny GD, Hedstrom L
ACS Infect Dis. 2021 Nov 12;7(11):3062-3076. doi: 10.1021/acsinfecdis.1c00342. Epub 2021 Sep 30.
PMID: 34590817

The Staphylococcus aureus toxin-antitoxin system YefM-YoeB is associated with antibiotic tolerance and extracellular dependent biofilm formation.
Qi X, Brothers KM, Ma D, Mandell JB, Donegan NP, Cheung AL, Richardson AR, Urish KL
J Bone Jt Infect. 2021;6(7):241-253. doi: 10.5194/jbji-6-241-2021. Epub 2021 Jul 2.
PMID: 34262845

Role of the Staphylococcus aureus Extracellular Loop of GraS in Resistance to Distinct Human Defense Peptides in PMN and Invasive Cardiovascular infections.
Cheung AL, Cho J, Bayer AS, Yeaman MR, Xiong YQ, Donegan NP, Mikheyeva IV, Lee GY, Yang SJ
Infect Immun. 2021 Sep 16;89(10):e0034721. doi: 10.1128/IAI.00347-21. Epub 2021 Jul 6.
PMID: 34227840

View more publications on PubMed