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Ambrose Cheung, MD

Title(s):
Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Northwestern University Medical School, MD 1980
Colby College, BA 1976

Programs:
Molecular and Cellular Biology Graduate Programs

Websites:
http://dms.dartmouth.edu/microbio/
http://www.dartmouth.edu/~mcb/

Contact Information:

Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755

Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU


Professional Interests:

Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.


Selected Publications:

 

The stringent response contributes to persistent methicillin-resistant Staphylococcus aureus endovascular infection through the purine biosynthetic pathway.
Li L, Bayer AS, Cheung A, Lu L, Abdelhady W, Donegan NP, Hong JI, Yeaman MR, Xiong YQ
J Infect Dis. 2020 Apr 25; pii: jiaa202. doi: 10.1093/infdis/jiaa202. Epub 2020 Apr 25.
PMID: 32333768

The Toxin-Antitoxin MazEF Drives Staphylococcus aureus Biofilm Formation, Antibiotic Tolerance, and Chronic Infection.
Ma D, Mandell JB, Donegan NP, Cheung AL, Ma W, Rothenberger S, Shanks RMQ, Richardson AR, Urish KL
mBio. 2019 Nov 26;10(6) pii: e01658-19. doi: 10.1128/mBio.01658-19. Epub 2019 Nov 26.
PMID: 31772059

Interspecies interactions induce exploratory motility in Pseudomonas aeruginosa.
Limoli DH, Warren EA, Yarrington KD, Donegan NP, Cheung AL, O'Toole GA
Elife. 2019 Nov 12;8 pii: e47365. doi: 10.7554/eLife.47365. Epub 2019 Nov 12.
PMID: 31713513

MgrA Governs Adherence, Host Cell Interaction, and Virulence in a Murine Model of Bacteremia Due to Staphylococcus aureus.
Li L, Wang G, Cheung A, Abdelhady W, Seidl K, Xiong YQ
J Infect Dis. 2019 Aug 9;220(6):1019-1028. doi: 10.1093/infdis/jiz219.
PMID: 31177268

CspA regulation of Staphylococcus aureus carotenoid levels and σB activity is controlled by YjbH and Spx.
Donegan NP, Manna AC, Tseng CW, Liu GY, Cheung AL
Mol Microbiol. 2019 Aug;112(2):532-551. doi: 10.1111/mmi.14273. Epub 2019 May 22.
PMID: 31074903

Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis.
Williams MR, Costa SK, Zaramela LS, Khalil S, Todd DA, Winter HL, Sanford JA, O'Neill AM, Liggins MC, Nakatsuji T, Cech NB, Cheung AL, Zengler K, Horswill AR, Gallo RL
Sci Transl Med. 2019 May 1;11(490) pii: eaat8329. doi: 10.1126/scitranslmed.aat8329.
PMID: 31043573

YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus.
Mikheyeva IV, Thomas JM, Kolar SL, Corvaglia AR, Gaϊa N, Leo S, Francois P, Liu GY, Rawat M, Cheung AL
Mol Microbiol. 2019 Apr;111(4):1039-1056. doi: 10.1111/mmi.14207. Epub 2019 Feb 17.
PMID: 30636083

Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection.
Li L, Abdelhady W, Donegan NP, Seidl K, Cheung A, Zhou YF, Yeaman MR, Bayer AS, Xiong YQ
J Infect Dis. 2018 Sep 22;218(9):1367-1377. doi: 10.1093/infdis/jiy340.
PMID: 29868791

Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus.
Manna AC, Kim S, Cengher L, Corvaglia A, Leo S, Francois P, Cheung AL
Infect Immun. 2018 Feb;86(2) pii: e00635-17. doi: 10.1128/IAI.00635-17. Epub 2018 Jan 22.
PMID: 29133345

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.
Falahee PC, Anderson LS, Reynolds MB, Pirir M, McLaughlin BE, Dillen CA, Cheung AL, Miller LS, Simon SI
J Immunol. 2017 Sep 1;199(5):1772-1782. doi: 10.4049/jimmunol.1700649. Epub 2017 Jul 21.
PMID: 28733486

View more publications on PubMed