Ambrose Cheung, MD
Title(s):
Professor of Microbiology and Immunology
Department(s):
Microbiology and Immunology
Education:
Northwestern University Medical School, MD 1980
Colby College, BA 1976
Programs:
Molecular and Cellular Biology Graduate Programs
Websites:
http:
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Contact Information:
Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755
Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU
Professional Interests:
Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.
Selected Publications: |
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YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus. Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection. Small RNA teg49 Is Derived from a <i>sarA</i> Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus. α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in <i>Staphylococcus aureus-</i>Infected Wounds. A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism. Bypassing the restriction system to improve transformation of <i>Staphylococcus epidermidis</i>. Persister formation in Staphylococcus aureus is associated with ATP depletion. The Global Regulon sarA Regulates β-Lactam Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus In Vitro and in Endovascular Infections. Persister formation in <i>Staphylococcus aureus</i> is associated with ATP depletion. Staphylococcal enterotoxin A-activated regulatory T cells promote allergen-specific T<sub>H</sub>2 response to intratracheal allergen inoculation. |
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