Ambrose Cheung, MD
Title(s)
Emeritus Professor of Microbiology and Immunology
Department(s)
Microbiology and Immunology
Education
Northwestern University Medical School, MD 1980
Colby College, BA 1976
Programs
Molecular and Cellular Biology Graduate Programs
Websites
http:
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Contact Information
Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755
Phone: 603-650-1740
Fax: 603-650-1762
Email: Ambrose.Cheung@Dartmouth.EDU
Professional Interests
Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.
Role of the NaHCO(3) Transporter MpsABC in the NaHCO(3)-β-Lactam-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus. Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO(3)-Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus. Identification of 5-(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant Gram-Positive Bacteria. Teg58, a small regulatory RNA, is involved in regulating arginine biosynthesis and biofilm formation in Staphylococcus aureus. The thematic role of extracellular loop of VraG in activation of the membrane sensor GraS in a cystic fibrosis MRSA strain differs in nuance from the CA-MRSA strain JE2. CF-Seq, an accessible web application for rapid re-analysis of cystic fibrosis pathogen RNA sequencing studies. Regulation of neutrophil myeloperoxidase inhibitor SPIN by the small RNA Teg49 in Staphylococcus aureus. The NaHCO(3)-Responsive Phenotype in Methicillin-Resistant Staphylococcus aureus (MRSA) Is Influenced by mecA Genotype. Impacts of NaHCO(3) on β-Lactam Binding to PBP2a Protein Variants Associated with the NaHCO(3)-Responsive versus NaHCO(3)-Non-Responsive Phenotypes. New Mechanistic Insights into Purine Biosynthesis with Second Messenger c-di-AMP in Relation to Biofilm-Related Persistent Methicillin-Resistant Staphylococcus aureus Infections. |
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