Ambrose Cheung, MD
Professor of Microbiology and Immunology
Microbiology and Immunology
Northwestern University Medical School, MD 1980
Colby College, BA 1976
Molecular and Cellular Biology Graduate Programs
Dartmouth Medical School
Vail 210 - HB 7550
Hanover NH 03755
Dr. Cheung's major research interests are regulation of virulence gene in Staphylococcus aureus, a major human pathogen both in the community and in hospital settings. My lab has four separate but related directions: 1) regulation of virulence determinants by global regulatory in S. aureus; 2) expression of virulence genes in vivo; 3) development of novel targets for antimicrobial therapy; 4) role of sRNA in virulence in S. aureus.
MgrA Governs Adherence, Host Cell Interaction, and Virulence in a Murine Model of Bacteremia Due to Staphylococcus aureus.
CspA regulation of Staphylococcus aureus carotenoid levels and σB activity is controlled by YjbH and Spx.
Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis.
YpdA, a putative bacillithiol disulfide reductase, contributes to cellular redox homeostasis and virulence in Staphylococcus aureus.
Role of Purine Biosynthesis in Persistent Methicillin-Resistant Staphylococcus aureus Infection.
Small RNA teg49 Is Derived from a sarA Transcript and Regulates Virulence Genes Independent of SarA in Staphylococcus aureus.
α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus-Infected Wounds.
A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.
Bypassing the Restriction System To Improve Transformation of Staphylococcus epidermidis.
Persister formation in Staphylococcus aureus is associated with ATP depletion.