Jay C. Dunlap, PhD
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor
Molecular and Systems Biology
Biochemistry and Cell Biology
Harvard University, Ph.D. 1979
Molecular and Cellular Biology Graduate Programs
Dartmouth Medical School
Hanover NH 03755
Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.
Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.
The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora.
Circadian Proteomic Analysis Uncovers Mechanisms of Post-Transcriptional Regulation in Metabolic Pathways.
Learning and Imputation for Mass-spec Bias Reduction (LIMBR).
Light-regulated promoters for tunable, temporal, and affordable control of fungal gene expression.
A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa.
Circadian Clearance of a Fungal Pathogen from the Lung Is Not Based on Cell-intrinsic Macrophage Rhythms.
Just-So Stories and Origin Myths: Phosphorylation and Structural Disorder in Circadian Clock Proteins.
Light sensing by opsins and fungal ecology: NOP-1 modulates entry into sexual reproduction in response to environmental cues.
Guidelines for Genome-Scale Analysis of Biological Rhythms.
Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity.