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Jay C. Dunlap, PhD

Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor

Molecular and Systems Biology
Biochemistry and Cell Biology

Harvard University, Ph.D. 1979

Molecular and Cellular Biology Graduate Programs


Contact Information

Dartmouth Medical School
HB 7400
Hanover NH 03755

Office: 603-650-1907
Phone: 603-650-1108
Fax: 603-650-1233
Email: jay.dunlap@Dartmouth.edu

Assistant: Cheryl Bush
Asst. Phone: 603-650-1907
Asst. Email: genetics@dartmouth.edu

Professional Interests

Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.

Grant Information

Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.

Selected Publications


Domains Required for FRQ-WCC Interaction within the Core Circadian Clock of Neurospora.
Wang B, Dunlap JC
bioRxiv. 2023 Feb 26; pii: 2023.02.25.530043. doi: 10.1101/2023.02.25.530043. Epub 2023 Feb 26.
PMID: 36865291

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.
Kelliher CM, Stevenson EL, Loros JJ, Dunlap JC
PLoS Biol. 2023 Jan;21(1):e3001961. doi: 10.1371/journal.pbio.3001961. Epub 2023 Jan 5.
PMID: 36603054

Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation.
Wang B, Stevenson EL, Dunlap JC
G3 (Bethesda). 2023 Feb 9;13(2) doi: 10.1093/g3journal/jkac334.
PMID: 36537198

Optimized fluorescent proteins for 4-color and photoconvertible live-cell imaging in Neurospora crassa.
Wang Z, Bartholomai BM, Loros JJ, Dunlap JC
Fungal Genet Biol. 2023 Jan;164:103763. doi: 10.1016/j.fgb.2022.103763. Epub 2022 Dec 5.
PMID: 36481248

PRD-2 mediates clock-regulated perinuclear localization of clock gene RNAs within the circadian cycle of Neurospora.
Bartholomai BM, Gladfelter AS, Loros JJ, Dunlap JC
Proc Natl Acad Sci U S A. 2022 Aug 2;119(31):e2203078119. doi: 10.1073/pnas.2203078119. Epub 2022 Jul 26.
PMID: 35881801

Evolution of the repression mechanisms in circadian clocks.
Tyler J, Lu Y, Dunlap J, Forger DB
Genome Biol. 2022 Jan 10;23(1):17. doi: 10.1186/s13059-021-02571-0. Epub 2022 Jan 10.
PMID: 35012616

Quantitative single molecule RNA-FISH and RNase-free cell wall digestion in Neurospora crassa.
Bartholomai BM, Gladfelter AS, Loros JJ, Dunlap JC
Fungal Genet Biol. 2021 Nov;156:103615. doi: 10.1016/j.fgb.2021.103615. Epub 2021 Aug 20.
PMID: 34425213

Cellular Calcium Levels Influenced by NCA-2 Impact Circadian Period Determination in Neurospora.
Wang B, Zhou X, Gerber SA, Loros JJ, Dunlap JC
mBio. 2021 Jun 29;12(3):e0149321. doi: 10.1128/mBio.01493-21. Epub 2021 Jun 29.
PMID: 34182778

PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock.
Kelliher CM, Lambreghts R, Xiang Q, Baker CL, Loros JJ, Dunlap JC
Elife. 2020 Dec 9;9 doi: 10.7554/eLife.64007. Epub 2020 Dec 9.
PMID: 33295874

Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit.
Pelham JF, Dunlap JC, Hurley JM
Cell Commun Signal. 2020 Nov 11;18(1):181. doi: 10.1186/s12964-020-00658-y. Epub 2020 Nov 11.
PMID: 33176800

View more publications on PubMed