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Jay C. Dunlap, PhD

Title(s)
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor

Department(s)
Molecular and Systems Biology
Biochemistry and Cell Biology

Education
Harvard University, Ph.D. 1979

Programs
Molecular and Cellular Biology Graduate Programs

Websites
http://geiselmed.dartmouth.edu/dunlaploros/

Academic Analytics
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Contact Information

Dartmouth Medical School
HB 7400
Hanover NH 03755

Office: 603-650-1907
Phone: 603-650-1108
Fax: 603-650-1233
Email: jay.dunlap@Dartmouth.edu

Assistant: Cheryl Bush
Asst. Phone: 603-650-1907
Asst. Email: genetics@dartmouth.edu


Professional Interests

Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.

Grant Information

Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.


Selected Publications

 

Transcriptional rewiring of an evolutionarily conserved circadian clock.
Goity A, Dovzhenok A, Lim S, Hong C, Loros J, Dunlap JC, Larrondo LF
EMBO J. 2024 May;43(10):2015-2034. doi: 10.1038/s44318-024-00088-3. Epub 2024 Apr 16.
PMID: 38627599

Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock.
Tariq D, Maurici N, Bartholomai BM, Chandrasekaran S, Dunlap JC, Bah A, Crane BR
Elife. 2024 Mar 25;12 doi: 10.7554/eLife.90259. Epub 2024 Mar 25.
PMID: 38526948

Acetylation of WCC is dispensable for the core circadian clock but differentially regulates acute light responses in Neurospora.
Wang B, Edamo ME, Zhou X, Wang Z, Gerber SA, Kettenbach AN, Dunlap JC
bioRxiv. 2023 Nov 30; pii: 2023.11.29.569266. doi: 10.1101/2023.11.29.569266. Epub 2023 Nov 30.
PMID: 38076981

A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.
Wang B, Zhou X, Kettenbach AN, Mitchell HD, Markillie LM, Loros JJ, Dunlap JC
Nat Commun. 2023 Jun 8;14(1):3371. doi: 10.1038/s41467-023-38817-7. Epub 2023 Jun 8.
PMID: 37291101

Domains required for the interaction of the central negative element FRQ with its transcriptional activator WCC within the core circadian clock of Neurospora.
Wang B, Dunlap JC
J Biol Chem. 2023 Jul;299(7):104850. doi: 10.1016/j.jbc.2023.104850. Epub 2023 May 21.
PMID: 37220856

A crucial role for dynamic expression of components encoding the negative arm of the circadian clock.
Wang B, Zhou X, Kettenbach AN, Mitchell HD, Markillie LM, Loros JJ, Dunlap JC
bioRxiv. 2023 Apr 24; pii: 2023.04.24.538162. doi: 10.1101/2023.04.24.538162. Epub 2023 Apr 24.
PMID: 37162945

Domains Required for FRQ-WCC Interaction within the Core Circadian Clock of Neurospora.
Wang B, Dunlap JC
bioRxiv. 2023 Feb 26; pii: 2023.02.25.530043. doi: 10.1101/2023.02.25.530043. Epub 2023 Feb 26.
PMID: 36865291

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.
Kelliher CM, Stevenson EL, Loros JJ, Dunlap JC
PLoS Biol. 2023 Jan;21(1):e3001961. doi: 10.1371/journal.pbio.3001961. Epub 2023 Jan 5.
PMID: 36603054

Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation.
Wang B, Stevenson EL, Dunlap JC
G3 (Bethesda). 2023 Feb 9;13(2) doi: 10.1093/g3journal/jkac334.
PMID: 36537198

Optimized fluorescent proteins for 4-color and photoconvertible live-cell imaging in Neurospora crassa.
Wang Z, Bartholomai BM, Loros JJ, Dunlap JC
Fungal Genet Biol. 2023 Jan;164:103763. doi: 10.1016/j.fgb.2022.103763. Epub 2022 Dec 5.
PMID: 36481248

View more publications on PubMed