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Jay C. Dunlap, PhD

Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor

Molecular and Systems Biology
Biochemistry and Cell Biology

Harvard University, Ph.D. 1979

Molecular and Cellular Biology Graduate Programs


Contact Information:

Dartmouth Medical School
HB 7400
Hanover NH 03755

Office: 603-650-1907
Phone: 603-650-1108
Fax: 603-650-1233

Assistant: Cheryl Bush
Asst. Phone: 603-650-1907
Asst. Email:

Professional Interests:

Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.

Grant Information:

Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.

Selected Publications:


A Pro- and Anti-inflammatory Axis Modulates the Macrophage Circadian Clock.
Chen S, Fuller KK, Dunlap JC, Loros JJ
Front Immunol. 2020;11:867. doi: 10.3389/fimmu.2020.00867. Epub 2020 May 14.
PMID: 32477351

Evaluating the circadian rhythm and response to glucose addition in dispersed growth cultures of Neurospora crassa.
Kelliher CM, Loros JJ, Dunlap JC
Fungal Biol. 2020 May;124(5):398-406. doi: 10.1016/j.funbio.2019.11.004. Epub 2019 Nov 20.
PMID: 32389302

The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora.
Wang B, Kettenbach AN, Zhou X, Loros JJ, Dunlap JC
Mol Cell. 2019 May 16;74(4):771-784.e3. doi: 10.1016/j.molcel.2019.03.003. Epub 2019 Apr 3.
PMID: 30954403

Circadian Proteomic Analysis Uncovers Mechanisms of Post-Transcriptional Regulation in Metabolic Pathways.
Hurley JM, Jankowski MS, De Los Santos H, Crowell AM, Fordyce SB, Zucker JD, Kumar N, Purvine SO, Robinson EW, Shukla A, Zink E, Cannon WR, Baker SE, Loros JJ, Dunlap JC
Cell Syst. 2018 Dec 26;7(6):613-626.e5. doi: 10.1016/j.cels.2018.10.014. Epub 2018 Dec 12.
PMID: 30553726

Learning and Imputation for Mass-spec Bias Reduction (LIMBR).
Crowell AM, Greene CS, Loros JJ, Dunlap JC
Bioinformatics. 2019 May 1;35(9):1518-1526. doi: 10.1093/bioinformatics/bty828.
PMID: 30247517

Light-regulated promoters for tunable, temporal, and affordable control of fungal gene expression.
Fuller KK, Dunlap JC, Loros JJ
Appl Microbiol Biotechnol. 2018 May;102(9):3849-3863. doi: 10.1007/s00253-018-8887-7. Epub 2018 Mar 22.
PMID: 29569180

A HAD family phosphatase CSP-6 regulates the circadian output pathway in Neurospora crassa.
Zhou X, Wang B, Emerson JM, Ringelberg CS, Gerber SA, Loros JJ, Dunlap JC
PLoS Genet. 2018 Jan;14(1):e1007192. doi: 10.1371/journal.pgen.1007192. Epub 2018 Jan 19.
PMID: 29351294

Circadian Clearance of a Fungal Pathogen from the Lung Is Not Based on Cell-intrinsic Macrophage Rhythms.
Chen S, Fuller KK, Dunlap JC, Loros JJ
J Biol Rhythms. 2018 Feb;33(1):99-105. doi: 10.1177/0748730417745178. Epub 2017 Dec 27.
PMID: 29281921

Just-So Stories and Origin Myths: Phosphorylation and Structural Disorder in Circadian Clock Proteins.
Dunlap JC, Loros JJ
Mol Cell. 2018 Jan 18;69(2):165-168. doi: 10.1016/j.molcel.2017.11.028. Epub 2017 Dec 21.
PMID: 29276084

Light sensing by opsins and fungal ecology: NOP-1 modulates entry into sexual reproduction in response to environmental cues.
Wang Z, Wang J, Li N, Li J, Trail F, Dunlap JC, Townsend JP
Mol Ecol. 2018 Jan;27(1):216-232. doi: 10.1111/mec.14425. Epub 2017 Dec 12.
PMID: 29134709

View more publications on PubMed