Jay C. Dunlap, PhD
Title(s)
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor
Department(s)
Molecular and Systems Biology
Biochemistry and Cell Biology
Education
Harvard University, Ph.D. 1979
Programs
Molecular and Cellular Biology Graduate Programs
Contact Information
Dartmouth Medical School
HB 7400
Hanover NH 03755
Office: 603-650-1907
Phone: 603-650-1108
Fax: 603-650-1233
Email: jay.dunlap@Dartmouth.edu
Assistant: Cheryl Bush
Asst. Phone: 603-650-1907
Asst. Email: genetics@dartmouth.edu
Professional Interests
Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.
Grant Information
Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.
Selected Publications |
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Domains Required for FRQ-WCC Interaction within the Core Circadian Clock of Neurospora. Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability. Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation. Optimized fluorescent proteins for 4-color and photoconvertible live-cell imaging in Neurospora crassa. PRD-2 mediates clock-regulated perinuclear localization of clock gene RNAs within the circadian cycle of Neurospora. Evolution of the repression mechanisms in circadian clocks. Quantitative single molecule RNA-FISH and RNase-free cell wall digestion in Neurospora crassa. Cellular Calcium Levels Influenced by NCA-2 Impact Circadian Period Determination in Neurospora. PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock. Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit. |
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