Jay C. Dunlap, PhD
Professor of Molecular and Systems Biology
Professor of Biochemistry and Cell Biology
Nathan Smith Professor
Molecular and Systems Biology
Biochemistry and Cell Biology
Harvard University, Ph.D. 1979
Molecular and Cellular Biology Graduate Programs
Dartmouth Medical School
Hanover NH 03755
Dr. Dunlap's laboratory is interested in understanding the mechanism by which eukaryotic organisms, including humans, keep time on a daily basis, and how this capacity to keep time is used to regulate metabolism and development. They have cloned "clock genes" as a first step towards identifying gears in the circadian oscillator , have isolated genes whose activities are controlled on a daily basis by the clock, and are studying the means by which the clock controls gene expression.
Dr. Dunlap is supported by an R35 MIRA grant from NIGMS and a U01 consortium grant from NIBIB.
Quantitative single molecule RNA-FISH and RNase-free cell wall digestion in Neurospora crassa.
Cellular Calcium Levels Influenced by NCA-2 Impact Circadian Period Determination in Neurospora.
PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock.
Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit.
A Pro- and Anti-inflammatory Axis Modulates the Macrophage Circadian Clock.
Evaluating the circadian rhythm and response to glucose addition in dispersed growth cultures of Neurospora crassa.
The Phospho-Code Determining Circadian Feedback Loop Closure and Output in Neurospora.
Circadian Proteomic Analysis Uncovers Mechanisms of Post-Transcriptional Regulation in Metabolic Pathways.
Learning and Imputation for Mass-spec Bias Reduction (LIMBR).
Prediction of Metabolite Concentrations, Rate Constants and Post-Translational Regulation Using Maximum Entropy-Based Simulations with Application to Central Metabolism of Neurospora crassa.