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Surachai Supattapone, MD, PhD

Professor of Biochemistry and Cell Biology
Professor of Medicine

Biochemistry and Cell Biology

Johns Hopkins University School of Medicine, Ph.D. 1992
Johns Hopkins University School of Medicine, M.D. 1992, Oxford University D.Phil. 1991

Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Neuroscience Center at Dartmouth


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Contact Information

Dartmouth Medical School
74 College Street
Vail Building Room 311
Hanover NH 03755

Office: 603-646-5212
Phone: 603-646-5213
Email: supattapone@dartmouth.edu

Professional Interests

Prion Diseases
Protein Misfolding
Genome-wide CRISPR screens


Surachai joined the Dartmouth faculty in 2001, and has enjoyed teaching in the Year One Metabolism and Scientific Basis of Medicine courses for medical students, as well as the Core Course for Molecular and Cellular Biology graduate students. He has also greatly enjoyed having the opportunity to mentor students conducting laboratory research projects on the pathogenesis of prion disease. Surachai has also served as the Chair for the Molecular and Cellular Biology (MCB) Graduate Program, the director for the Clinical Translational Science Masters Program, a director for the Cellular and Molecular Basis of Disease course, and member of the Medical Education Committee and the Committee for Student Performance and Conduct. He has also served as a standing member of two NIH study sections. He has won teaching awards at Geisel and at the University of California at San Francisco, and been elected as a Fellow to both the American Society for Microbiology (ASM) and the American Association for the Advancement of Science (AAAS).

Selected Publications


Conformational diversity in purified prions produced in vitro.
Walsh DJ, Schwind AM, Noble GP, Supattapone S
PLoS Pathog. 2023 Jan;19(1):e1011083. doi: 10.1371/journal.ppat.1011083. Epub 2023 Jan 10.
PMID: 36626391

A single protective polymorphism in the prion protein blocks cross-species prion replication in cultured cells.
Arshad H, Patel Z, Amano G, Li LY, Al-Azzawi ZAM, Supattapone S, Schmitt-Ulms G, Watts JC
J Neurochem. 2023 Apr;165(2):230-245. doi: 10.1111/jnc.15739. Epub 2022 Dec 24.
PMID: 36511154

Hydrogen Peroxide-induced Cell Death in Mammalian Cells.
Chidawanyika T, Supattapone S
J Cell Signal. 2021;2(3):206-211. doi: 10.33696/signaling.2.052.
PMID: 35079745

Alternating anti-prion regimens reduce combination drug resistance but do not further extend survival in scrapie-infected mice.
Beauchemin KS, Rees JR, Supattapone S
J Gen Virol. 2021 Dec;102(12) doi: 10.1099/jgv.0.001705.
PMID: 34904943

SEC24A facilitates colocalization and Ca(2)(+) flux between the endoplasmic reticulum and mitochondria.
Chidawanyika T, Chakrabarti R, Beauchemin KS, Higgs HN, Supattapone S
J Cell Sci. 2021 Mar 26;134(6) doi: 10.1242/jcs.249276. Epub 2021 Mar 26.
PMID: 33622772

Cofactor molecules: Essential partners for infectious prions.
Supattapone S
Prog Mol Biol Transl Sci. 2020;175:53-75. doi: 10.1016/bs.pmbts.2020.07.009. Epub 2020 Aug 24.
PMID: 32958241

Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion.
Burke CM, Mark KMK, Walsh DJ, Noble GP, Steele AD, Diack AB, Manson JC, Watts JC, Supattapone S
PLoS Pathog. 2020 Sep;16(9):e1008875. doi: 10.1371/journal.ppat.1008875. Epub 2020 Sep 8.
PMID: 32898162

A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells.
Chidawanyika T, Mark KMK, Supattapone S
mBio. 2020 Aug 11;11(4) doi: 10.1128/mBio.01704-20. Epub 2020 Aug 11.
PMID: 32788383

Emergence of prions selectively resistant to combination drug therapy.
Burke CM, Mark KMK, Kun J, Beauchemin KS, Supattapone S
PLoS Pathog. 2020 May;16(5):e1008581. doi: 10.1371/journal.ppat.1008581. Epub 2020 May 18.
PMID: 32421750

Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation.
Burke CM, Walsh DJ, Mark KMK, Deleault NR, Nishina KA, Agrimi U, Di Bari MA, Supattapone S
PLoS Pathog. 2020 Apr;16(4):e1008495. doi: 10.1371/journal.ppat.1008495. Epub 2020 Apr 15.
PMID: 32294141

View more publications on PubMed