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Surachai Supattapone, MD, PhD

Title(s):
Professor of Biochemistry and Cell Biology
Professor of Medicine

Department(s):
Biochemistry and Cell Biology
Medicine

Education:
Johns Hopkins University School of Medicine, Ph.D. 1992
Johns Hopkins University School of Medicine, M.D. 1992, Oxford University Ph.D. 1991

Programs:
Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Neuroscience Center at Dartmouth

Websites:
http://dms.dartmouth.edu/supattapone/
http://dms.dartmouth.edu/ncd/
http://dms.dartmouth.edu/mcb/faculty/supattapone.php
http://www.dartmouth.edu/~m2p2/colleagues/faculty.html#supattapone

Contact Information:

Dartmouth Medical School
HB 7200
Hanover NH 03755

Office: 311 Vail Building
Phone: 603-650-1192
Fax: 603-650-1193
Email: supattapone@dartmouth.edu


Professional Interests:

Prion Diseases
Neurodegeneration
Protein Misfolding
Genome-wide CRISPR screens

Biography:

Surachai joined the Dartmouth faculty in 2001, and has enjoyed teaching in the Year One Metabolism and Scientific Basis of Medicine courses for medical students, as well as the Core Course for Molecular and Cellular Biology graduate students. He has also greatly enjoyed having the opportunity to mentor students conducting laboratory research projects on the pathogenesis of prion disease. Surachai has also served as director for the Clinical Translational Science Masters Program, a co-director for the Cellular and Molecular Basis of Disease course, and member of the Medical Education Committee and the Committee for Student Performance and Conduct. He has won teaching awards at Geisel and at the University of California at San Francisco, and been elected as a Fellow to both the American Society for Microbiology (ASM) and the American Academy of Arts and Sciences (AAAS).


Selected Publications:

 

Cofactor molecules: Essential partners for infectious prions.
Supattapone S
Prog Mol Biol Transl Sci. 2020;175:53-75. doi: 10.1016/bs.pmbts.2020.07.009. Epub 2020 Aug 24.
PMID: 32958241

Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion.
Burke CM, Mark KMK, Walsh DJ, Noble GP, Steele AD, Diack AB, Manson JC, Watts JC, Supattapone S
PLoS Pathog. 2020 Sep;16(9):e1008875. doi: 10.1371/journal.ppat.1008875. Epub 2020 Sep 8.
PMID: 32898162

A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells.
Chidawanyika T, Mark KMK, Supattapone S
mBio. 2020 Aug 11;11(4) pii: e01704-20. doi: 10.1128/mBio.01704-20. Epub 2020 Aug 11.
PMID: 32788383

Emergence of prions selectively resistant to combination drug therapy.
Burke CM, Mark KMK, Kun J, Beauchemin KS, Supattapone S
PLoS Pathog. 2020 May;16(5):e1008581. doi: 10.1371/journal.ppat.1008581. Epub 2020 May 18.
PMID: 32421750

Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation.
Burke CM, Walsh DJ, Mark KMK, Deleault NR, Nishina KA, Agrimi U, Di Bari MA, Supattapone S
PLoS Pathog. 2020 Apr;16(4):e1008495. doi: 10.1371/journal.ppat.1008495. Epub 2020 Apr 15.
PMID: 32294141

Full restoration of specific infectivity and strain properties from pure mammalian prion protein.
Burke CM, Walsh DJ, Steele AD, Agrimi U, Di Bari MA, Watts JC, Supattapone S
PLoS Pathog. 2019 Mar;15(3):e1007662. doi: 10.1371/journal.ppat.1007662. Epub 2019 Mar 25.
PMID: 30908557

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM
Cell Rep. 2019 Jan 29;26(5):1368. doi: 10.1016/j.celrep.2019.01.064.
PMID: 30699361

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM
Cell Rep. 2019 Jan 2;26(1):145-158.e8. doi: 10.1016/j.celrep.2018.12.021.
PMID: 30605671

SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen.
Chidawanyika T, Sergison E, Cole M, Mark K, Supattapone S
Cell Death Discov. 2018;4:115. doi: 10.1038/s41420-018-0135-5. Epub 2018 Dec 18.
PMID: 30588337

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S
Sci Rep. 2018 Jun 22;8(1):9554. doi: 10.1038/s41598-018-27900-5. Epub 2018 Jun 22.
PMID: 29934597

View more publications on PubMed