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Surachai Supattapone, MD, PhD

Title(s):
Professor of Biochemistry & Cell Biology
Professor of Medicine

Department(s):
Biochemistry & Cell Biology
Medicine

Education:
Johns Hopkins University School of Medicine, Ph.D. 1992
Johns Hopkins University School of Medicine, M.D. 1992, Oxford University Ph.D. 1991

Programs:
Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Neuroscience Center at Dartmouth

Websites:
http://dms.dartmouth.edu/supattapone/
http://dms.dartmouth.edu/ncd/
http://dms.dartmouth.edu/mcb/faculty/supattapone.php
http://www.dartmouth.edu/~m2p2/colleagues/faculty.html#supattapone

Contact Information:

Dartmouth Medical School
HB 7200
Hanover NH 03755

Office: 311 Vail Building
Phone: 603-650-1192
Fax: 603-650-1193
Email: supattapone@dartmouth.edu


Professional Interests:

Prion Diseases
Alzheimer's disease
Protein Misfolding

Biography:

Surachai joined the Dartmouth faculty in 2001, and has enjoyed teaching in the Year One Metabolism and Scientific Basis of Medicine courses for medical students, as well as the Core Course for Molecular and Cellular Biology graduate students. He has also greatly enjoyed having the opportunity to mentor students conducting laboratory research projects on the pathogenesis of prion disease. Surachai has also served as director for the Clinical Translational Science Masters Program, a co-director for the Cellular and Molecular Basis of Disease course, and member of the Medical Education Committee and the Committee for Student Performance and Conduct. He has won teaching awards at Geisel and at the University of California at San Francisco.

Mentoring Information:

Surachai would be happy to mentor faculty on integrating basic science in medical education.


Selected Publications:

 

Full restoration of specific infectivity and strain properties from pure mammalian prion protein.
Burke CM, Walsh DJ, Steele AD, Agrimi U, Di Bari MA, Watts JC, Supattapone S
PLoS Pathog. 2019 Mar;15(3):e1007662. doi: 10.1371/journal.ppat.1007662. Epub 2019 Mar 25.
PMID: 30908557

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM
Cell Rep. 2019 Jan 29;26(5):1368. doi: 10.1016/j.celrep.2019.01.064.
PMID: 30699361

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM
Cell Rep. 2019 Jan 2;26(1):145-158.e8. doi: 10.1016/j.celrep.2018.12.021.
PMID: 30605671

SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen.
Chidawanyika T, Sergison E, Cole M, Mark K, Supattapone S
Cell Death Discov. 2018;4:115. doi: 10.1038/s41420-018-0135-5. Epub 2018 Dec 18.
PMID: 30588337

Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S
Sci Rep. 2018 Jun 22;8(1):9554. doi: 10.1038/s41598-018-27900-5. Epub 2018 Jun 22.
PMID: 29934597

CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins.
Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S
MBio. 2016 Sep 27;7(5) pii: e01367-16. doi: 10.1128/mBio.01367-16. Epub 2016 Sep 27.
PMID: 27677791

Interallelic Transcriptional Enhancement as an in Vivo Measure of Transvection in Drosophila melanogaster.
Noble GP, Dolph PJ, Supattapone S
G3 (Bethesda). 2016 Oct 13;6(10):3139-3148. doi: 10.1534/g3.116.032300. Epub 2016 Oct 13.
PMID: 27489208

The effect of reducing agents on challenge of rainbow trout with AeromonasĀ salmonicida.
Supattapone SY, Supattapone S, Cramer RA
J Fish Dis. 2017 Mar;40(3):437-441. doi: 10.1111/jfd.12511. Epub 2016 Jun 13.
PMID: 27291986

Dissociation of recombinant prion autocatalysis from infectivity.
Noble GP, Supattapone S
Prion. 2015;9(6):405-11. doi: 10.1080/19336896.2015.1123843.
PMID: 26645356

Expanding the prion disease repertoire.
Supattapone S
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11748-9. doi: 10.1073/pnas.1515143112. Epub 2015 Sep 1.
PMID: 26330608

View more publications on PubMed