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Surachai Supattapone, MD, PhD

Professor of Biochemistry and Cell Biology
Professor of Medicine

Biochemistry and Cell Biology

Johns Hopkins University School of Medicine, Ph.D. 1992
Johns Hopkins University School of Medicine, M.D. 1992, Oxford University Ph.D. 1991

Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Neuroscience Center at Dartmouth


Contact Information:

Dartmouth Medical School
HB 7200
Hanover NH 03755

Office: 311 Vail Building
Phone: 603-650-1192
Fax: 603-650-1193
Email: supattapone@dartmouth.edu

Professional Interests:

Prion Diseases
Alzheimer's disease
Protein Misfolding


Surachai joined the Dartmouth faculty in 2001, and has enjoyed teaching in the Year One Metabolism and Scientific Basis of Medicine courses for medical students, as well as the Core Course for Molecular and Cellular Biology graduate students. He has also greatly enjoyed having the opportunity to mentor students conducting laboratory research projects on the pathogenesis of prion disease. Surachai has also served as director for the Clinical Translational Science Masters Program, a co-director for the Cellular and Molecular Basis of Disease course, and member of the Medical Education Committee and the Committee for Student Performance and Conduct. He has won teaching awards at Geisel and at the University of California at San Francisco.

Mentoring Information:

Surachai would be happy to mentor faculty on integrating basic science in medical education.

Selected Publications:


Comparative Analysis of Mutant Huntingtin Binding Partners in Yeast Species.
Zhao Y, Zurawel AA, Jenkins NP, Duennwald ML, Cheng C, Kettenbach AN, Supattapone S
Sci Rep. 2018 Jun 22;8(1):9554. doi: 10.1038/s41598-018-27900-5. Epub 2018 Jun 22.
PMID: 29934597

CAG Expansions Are Genetically Stable and Form Nontoxic Aggregates in Cells Lacking Endogenous Polyglutamine Proteins.
Zurawel AA, Kabeche R, DiGregorio SE, Deng L, Menon KM, Opalko H, Duennwald ML, Moseley JB, Supattapone S
MBio. 2016 Sep 27;7(5) pii: e01367-16. doi: 10.1128/mBio.01367-16. Epub 2016 Sep 27.
PMID: 27677791

Interallelic Transcriptional Enhancement as an in Vivo Measure of Transvection in Drosophila melanogaster.
Noble GP, Dolph PJ, Supattapone S
G3 (Bethesda). 2016 Oct 13;6(10):3139-3148. doi: 10.1534/g3.116.032300. Epub 2016 Oct 13.
PMID: 27489208

The effect of reducing agents on challenge of rainbow trout with Aeromonas salmonicida.
Supattapone SY, Supattapone S, Cramer RA
J Fish Dis. 2017 Mar;40(3):437-441. doi: 10.1111/jfd.12511. Epub 2016 Jun 13.
PMID: 27291986

Dissociation of recombinant prion autocatalysis from infectivity.
Noble GP, Supattapone S
Prion. 2015;9(6):405-11. doi: 10.1080/19336896.2015.1123843.
PMID: 26645356

Expanding the prion disease repertoire.
Supattapone S
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11748-9. doi: 10.1073/pnas.1515143112. Epub 2015 Sep 1.
PMID: 26330608

A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers.
Noble GP, Wang DW, Walsh DJ, Barone JR, Miller MB, Nishina KA, Li S, Supattapone S
PLoS Pathog. 2015 Jun;11(6):e1005017. doi: 10.1371/journal.ppat.1005017. Epub 2015 Jun 30.
PMID: 26125623

Requirements for mutant and wild-type prion protein misfolding in vitro.
Noble GP, Walsh DJ, Miller MB, Jackson WS, Supattapone S
Biochemistry. 2015 Feb 10;54(5):1180-7. doi: 10.1021/bi501495j. Epub 2015 Jan 22.
PMID: 25584902

Synthesis of high titer infectious prions with cofactor molecules.
Supattapone S
J Biol Chem. 2014 Jul 18;289(29):19850-4. doi: 10.1074/jbc.R113.511329. Epub 2014 May 23.
PMID: 24860097

Elucidating the role of cofactors in mammalian prion propagation.
Supattapone S
Prion. 2014 Jan-Feb;8(1):100-5.
PMID: 24365977