Surachai Supattapone, MD, PhD
Professor of Biochemistry and Cell Biology
Professor of Medicine
Biochemistry and Cell Biology
Johns Hopkins University School of Medicine, Ph.D. 1992
Johns Hopkins University School of Medicine, M.D. 1992, Oxford University D.Phil. 1991
Molecular and Cellular Biology Graduate Programs
Molecular Pathogenesis Program
Neuroscience Center at Dartmouth
Dartmouth Medical School
74 College Street
Vail Building Room 311
Hanover NH 03755
Genome-wide CRISPR screens
Surachai joined the Dartmouth faculty in 2001, and has enjoyed teaching in the Year One Metabolism and Scientific Basis of Medicine courses for medical students, as well as the Core Course for Molecular and Cellular Biology graduate students. He has also greatly enjoyed having the opportunity to mentor students conducting laboratory research projects on the pathogenesis of prion disease. Surachai has also served as the Chair for the Molecular and Cellular Biology (MCB) Graduate Program, the director for the Clinical Translational Science Masters Program, a director for the Cellular and Molecular Basis of Disease course, and member of the Medical Education Committee and the Committee for Student Performance and Conduct. He has also served as a standing member of two NIH study sections. He has won teaching awards at Geisel and at the University of California at San Francisco, and been elected as a Fellow to both the American Society for Microbiology (ASM) and the American Association for the Advancement of Science (AAAS).
Conformational diversity in purified prions produced in vitro.
A single protective polymorphism in the prion protein blocks cross-species prion replication in cultured cells.
Hydrogen Peroxide-induced Cell Death in Mammalian Cells.
Alternating anti-prion regimens reduce combination drug resistance but do not further extend survival in scrapie-infected mice.
SEC24A facilitates colocalization and Ca(2)(+) flux between the endoplasmic reticulum and mitochondria.
Cofactor molecules: Essential partners for infectious prions.
Identification of a homology-independent linchpin domain controlling mouse and bank vole prion protein conversion.
A Genome-Wide CRISPR/Cas9 Screen Reveals that Riboflavin Regulates Hydrogen Peroxide Entry into HAP1 Cells.
Emergence of prions selectively resistant to combination drug therapy.
Cofactor and glycosylation preferences for in vitro prion conversion are predominantly determined by strain conformation.