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Barbara C. Jobst, MD, PhD

Title(s):
Professor of Neurology

Additional Titles/Positions/Affiliations:
Professor of Neurology,
Louis and Ruth Frank Professor of Neurosciences-
Geisel School of Medicine at Dartmouth
Section Chief, Department of Neurology-DHMC
Director, Dartmouth-Hitchcock Epilepsy Center
Director, Epilepsy and Cognition (ECog) Lab-DHMC

Department(s):
Neurology

Education:
B.S. 1986
M.D. 1993
Ph.D. (Germany Dr. Med 1995)

Programs:
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine

Websites:
http://www.dartmouth.edu/~epilab
http://dms.dartmouth.edu/ncd/
http://patients.dartmouth-hitchcock.org/epilepsy.html
http://managingepilepsywell.org

Contact Information:

Department of Neurology
One Medical Center Drive
Lebanon NH 03756

Fax: 603-650-7617
Email: Barbara.C.Jobst@hitchcock.org

Assistant: Nancy Solis
Asst. Phone: 603-650-6265
Asst. Email: Nancy.S.Solis@hitchcock.org


Professional Interests:

Clinical epileptology and central neurophysiology
Epilepsy Surgery
Brain Stimulation
Human Cortical Electrophysiology and single unit recordings
Electrophysiological Correlate of Cognition
Treatment of cognitive disability in epilepsy patients
Imaging in Epilepsy

Rotations and Thesis Projects:

Human Cortical Intracranial Electrophysiology

Grant Information:

2012-2014 Home-based Self Management and Cognitive Training Changes Lives for Patients with Epilepsy CDC 3U48DP001935-04S3 PI Center for Disease Control

2008 to present RNS System Long-term Treatment Clinical Investigation PI Neuropace Inc.

2011-2015 Mechanisms of cognitive impairment in temporal lobe epilepsy NIH R01NS074450-02 Co-PI National Institutes of Health

2014 to present DARPA Grant – Memory Enhancement with Modeling, Electrophysiology, and Stimulation

Biography:

Barbara C. Jobst, MD, PhD is Professor of Neurology at the Geisel School of Medicine at Dartmouth, the Louis and Ruth Frank Endowed Professor of Neurology at the Geisel School of Medicine at Dartmouth, Vice Chair and Section Chief in the Adult Neurology Department at Dartmouth-Hitchcock Medical Center and Director of the Dartmouth-Hitchcock Epilepsy Center. She has extensive leadership experience and is a graduate of ELAM (Executive Leadership in Academic Medicine). She has served on the Board of Trustees of Dartmouth-Hitchcock.
She received her medical degree in Germany and trained in epilepsy surgery. She was an exchange student at Dartmouth Medical School in 1992. Barbara came to DHMC in 1996 for her residency and is on faculty since 2001. She established the Intraoperative Neurophysiologic Monitoring Program where she gained experience in the operative environment. She also established the Women’s Seizure Clinic at DHMC and in 2007 assumed leadership of the Dartmouth-Hitchcock Epilepsy Center. Under her leadership, the Center became the only nationally recognized level 4 epilepsy center in Northern New England.
She established multiple interdisciplinary clinical and research initiatives, many of them representing truly translational projects from bench to bedside. She is well recognized nationally and internationally for her expertise in epilepsy surgery including responsive brain stimulation and cognition in epilepsy. She is well published in the field of epilepsy and frequently invited as a speaker to national and international conferences.
She has participated in multiple multi-center clinical trials. Dr. Jobst has worked on public health concerns of epilepsy in conjunction with the CDC. She currently is the principle investigator of the Managing Epilepsy Well Network, one of the thematic research networks of the Center of Disease Control. In addition she has developed a cognitive-behavioral program for memory problems (HOBSCOTCH= home-based self-management and cognitive training changes lives) that is currently distributed and tested in the North East. She has been an active member of professional organizations such as the American Epilepsy Society and the American Academy of Neurology (AAN). She currently serves as Chair of the American Epilepsy Society meeting. She is on the editorial board of Neurology and Epilepsy.

Mentoring Information:

Stephen Meisenhelter, Ashlee Robbins, Robert Quon


Selected Publications:

 

  • Weidemann CT, Kragel JE, Lega BC, Worrell GA, Sperling MR, Sharan AD, Jobst BC, Khadjevand F, Davis KA, Wanda PA, Kadel A, Rizzuto DS, Kahana MJ Neural activity reveals interactions between episodic and semantic memory systems during retrieval. J Exp Psychol Gen. 2019 Jan;148(1):1-12. doi: 10.1037/xge0000480 (view details on MedLine)

  • Solomon EA, Kragel JE, Gross R, Lega B, Sperling MR, Worrell G, Sheth SA, Zaghloul KA, Jobst BC, Stein JM, Das S, Gorniak R, Inman CS, Seger S, Rizzuto DS, Kahana MJ Medial temporal lobe functional connectivity predicts stimulation-induced theta power. Nat Commun. 2018;9(1):4437. doi: 10.1038/s41467-018-06876-w (view details on MedLine)

  • Meisenhelter S, Testorf ME, Gorenstein MA, Hasulak NR, Tcheng TK, Aronson JP, Jobst BC Cognitive tasks and human ambulatory electrocorticography using the RNS System. J Neurosci Methods. 2018. doi: 10.1016/j.jneumeth.2018.09.026 (view details on MedLine)

  • Waldman ZJ, Camarillo-Rodriguez L, Chervenova I, Berry B, Shimamoto S, Elahian B, Kucewicz M, Ganne C, He XS, Davis LA, Stein J, Das S, Gorniak R, Sharan AD, Gross R, Inman CS, Lega BC, Zaghloul K, Jobst BC, Davis KA, Wanda P, Khadjevand M, Tracy J, Ri Ripple oscillations in the left temporal neocortex are associated with impaired verbal episodic memory encoding. Epilepsy & Behavior : E&B. 2018;88:33-40. doi: 10.1016/j.yebeh.2018.08.018 (view details on MedLine)

  • Friedman D, Spruill TM, Liu H, Tatsuoka C, Stoll S, Jobst BC, Fraser RT, Johnson EK, Chaytor N, Sajatovic M Deprssive symptoms and suicidality among individual with epilepsy enrolled in self-management studies: Results from the US Centers for Disease Control and Prevention Managing Epilepsy Well (MEW) Network. Epilepsy & Behavior: E&B. 2018. doi: 10.1016/j.yebeh.2018. 06.024 (view details on MedLine)

  • Goyal A, Miller J, Watrous AJ, Lee SA, Coffey T, Sperling MR, Sharan A, Worrell G, Berry B, Lega B, Jobst BC, Davis KA, Inman C, Sheth SA, Wanda PA, Ezzyat Y, Das SR, Stein J, Gorniak R, Jacobs J Electrical stimulation in hippocampus and entorhinal cortex impairs spatial and temporal memory. J Neurosci. 2018 May 9;38(19):4471-4481. doi: 10.1523/JNEUROSCI.3049-17.2018 (view details on MedLine)

  • Chen E, Sajatovic M, Liu H, Bukach A, Tatsuoka C, Welter E, Schmidt SS, Bamps YA, Stoll SC, Spruill TM, Friedman D, Begley CE, Shegog R, Fraser RT, Johnson EK, Jobst BC Demographic and clinical correlates of seizure frequency: findings from the Managing Epilepsy Well Network database. J Clin Neurol. 2018 Apr;14(2):206-211. doi: 10.3988/jcn.2018.14.2.206 (view details on MedLine)

  • Meisenhelter S, Jobst BC Neurostimulation for Memory Enhancement in Epilepsy. Curr Neurol Neurosci Rep. 2018 Apr 19;18(6):30. doi: 10.1007/s11910-018-0837-3 (view details on MedLine)

  • Hartshorn A, Jobst BC Responsive brain stimulation in epilepsy. Therapeutic Advances in Chronic Disease. 2018 April;1-8. doi: 10.1177/2040622318774173

  • Ezzyat Y, Wanda PA, Levy DF, Kadel A, Aka A, Pedisich I, Sperling MR, Sharan AD, Lega BC, Burks A, Gross RE, Inman CS, Jobst BC, Gorenstein MA, Davis KA, Worrell GA, Kucewicz MT, Stein JM, Gorniak R, Das SR, Rizzuto DS, Kahana MJ Closed-loop stimulation of temporal cortex rescues functional networks and improves memory. Nat Commun. 2018 Feb 6;9(1):365. doi: 10.1038/s41467-017-02753-0 (view details on MedLine)