{"id":4060,"date":"2026-06-01T07:05:48","date_gmt":"2026-06-01T11:05:48","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/?p=4060"},"modified":"2026-06-01T07:06:20","modified_gmt":"2026-06-01T11:06:20","slug":"publication-alert-continuous-dna-methylation-deconvolution-based-surrogate-for-b-cell-differentiation-state-in-chronic-lymphocytic-leukemia","status":"publish","type":"post","link":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/2026\/06\/01\/publication-alert-continuous-dna-methylation-deconvolution-based-surrogate-for-b-cell-differentiation-state-in-chronic-lymphocytic-leukemia\/","title":{"rendered":"Publication Alert | Continuous DNA methylation deconvolution-based surrogate for B-cell differentiation state in chronic lymphocytic leukemia"},"content":{"rendered":"<p class=\"isSelectedEnd\">Researchers from four Dartmouth departments\u2014the Department of Epidemiology, Dartmouth Cancer Center, the Department of Pathology and Laboratory Medicine, and the Department of Molecular and Systems Biology\u2014have published a new study titled, <em>\"Continuous DNA methylation deconvolution-based surrogate for B-cell differentiation state in chronic lymphocytic leukemia.\"<\/em><\/p>\n<p class=\"isSelectedEnd\">The research team developed a novel metric, the B-Index, to capture chronic lymphocytic leukemia (CLL) along a continuous spectrum of B-cell differentiation, reflecting the many developmental stages from which CLL may arise. The study found that the B-Index accurately classifies CLL clinical subtypes with 98.8% accuracy, exhibits a stronger epigenetic signal than IGHV gene percent identity, and reveals additional biological variation within established clinical subgroups.<\/p>\n<p class=\"isSelectedEnd\">These findings provide a more nuanced understanding of CLL biology and may help advance future research into disease classification and progression.<\/p>\n<p>To read the full study, <a href=\"https:\/\/www.nature.com\/articles\/s43856-026-01666-8\">click here<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from four Dartmouth departments\u2014the Department of Epidemiology, Dartmouth Cancer Center, the Department of Pathology and Laboratory Medicine, and the Department of Molecular and Systems Biology\u2014have published a new study titled, &#8220;Continuous DNA methylation deconvolution-based surrogate for B-cell differentiation state in chronic lymphocytic leukemia.&#8221; The research team developed a novel [\u2026] <\/p>\n<div class=\"clear\"><\/div>\n<p><a class=\"more_link clearfix\" href=\"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/2026\/06\/01\/publication-alert-continuous-dna-methylation-deconvolution-based-surrogate-for-b-cell-differentiation-state-in-chronic-lymphocytic-leukemia\/\" rel=\"nofollow\">Read More<\/a><\/p>\n","protected":false},"author":369,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[2],"tags":[],"class_list":["post-4060","post","type-post","status-publish","format-standard","hentry","category-news","author-369"],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/paQAoO-13u","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/posts\/4060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/users\/369"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/comments?post=4060"}],"version-history":[{"count":2,"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/posts\/4060\/revisions"}],"predecessor-version":[{"id":4062,"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/posts\/4060\/revisions\/4062"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/media?parent=4060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/categories?post=4060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/epidemiology\/wp-json\/wp\/v2\/tags?post=4060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}