{"id":423,"date":"2017-05-02T16:04:42","date_gmt":"2017-05-02T16:04:42","guid":{"rendered":"https:\/\/geiselmed2.dartmouth.edu\/dartlab\/dartlab-presentations\/"},"modified":"2025-01-29T16:19:33","modified_gmt":"2025-01-29T21:19:33","slug":"dartlab-presentations","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/dartlab\/about-us\/dartlab-presentations\/","title":{"rendered":"DartLab Publications and Presentations"},"content":{"rendered":"

Peer-reviewed Publications with DartLab Co-Authors:<\/strong><\/h2>\n

Connor RI, Sakharkar M, Rappazzo CG, Kaku CI, Curtis NC, Shin S, Wieland-Alter WF, Wentworth J<\/strong>, Mielcarz DW<\/strong>, Weiner JA, Ackerman ME, Walker LM, Lee J, Wright PF. Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2. Pathog Immun. 2024 Jun 18;9(2):1-24. doi: 10.20411\/pai.v9i2.679. PMID: 38933606; PMCID: PMC11197847.<\/p>\n

Phillips JD, Fay KA, Bergeron AJ<\/strong>, Zhang P<\/strong>, Mielcarz DW<\/strong>, Calkins AM<\/strong>, Searles TG, Christensen BC, Finley DJ, Turk MJ, Channon JY<\/strong>. The Effect of Lung Resection for NSCLC on Circulating Immune Cells: A Pilot Study. Curr Oncol. 2023 May 17;30(5):5116-5134. doi: 10.3390\/curroncol30050387. PMID: 37232845; PMCID: PMC10217048.<\/p>\n

Kaku CI, Starr TN, Zhou P, Dugan HL, Khalif\u00e9 P, Song G, Champney ER, Mielcarz DW<\/strong>, Geoghegan JC, Burton DR, Andrabi R, Bloom JD, Walker LM. Evolution of antibody immunity following Omicron BA.1 breakthrough infection. Nat Commun. 2023 May 12;14(1):2751. doi: 10.1038\/s41467-023-38345-4. PMID: 37173311; PMCID: PMC10180619.<\/p>\n

Fadul CE, Mao-Draayer Y, Ryan KA, Noelle RJ, Wishart HA, Channon JY<\/strong>, Kasper IR, Oliver B, Mielcarz DW<\/strong>, Kasper LH. Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Oct 15;8(6):e1096. doi: 10.1212\/NXI.0000000000001096. PMID: 34654708; PMCID: PMC8527364.<\/p>\n

Kaku CI, Bergeron AJ<\/strong>, Ahlm C, Normark J, Sakharkar M, Forsell MNE, Walker LM. Recall of preexisting cross-reactive B cell memory after Omicron BA.1 breakthrough infection. Sci Immunol. 2022 Jul 29;7(73):eabq3511. doi: 10.1126\/sciimmunol.abq3511. Epub 2022 Jul 29. PMID: 35549299; PMCID: PMC9097882.<\/p>\n

Box A, Holmes L, DeLay M, Adams D, Bergeron A<\/strong>, Clise-Dwyer K, Cochran M, Guerra RDR, Meyer EM, Brundage KM. Cell Sorter Cleaning Practices and Their Impact on Instrument Sterility. J Biomol Tech. 2022 Feb 2;33(1):3fc1f5fe.e2675d74. doi: 10.7171\/3fc1f5fe.e2675d74. PMID: 35837003; PMCID: PMC9258916.<\/p>\n

Mielcarz DW<\/strong>, Bergeron AJ,<\/strong> DeLong JK<\/strong>, Dias A<\/strong>, Smith KM<\/strong>, Mack KL<\/strong>, Kasper LH, Channon JY<\/strong>
\nIFN\u00df-1b treatment leads to changes in the B cell subset and cytokine secretion profile in patients with
\nrelapsing-remitting multiple sclerosis. medRxiv 22270266 [Preprint] 2022.02.25. Available from:
\ndoi:https:\/\/doi.org\/10.1101\/2022.02.25.22270266<\/p>\n

Mielcarz DW<\/strong>, Bergeron AJ<\/strong>, DeLong JK<\/strong>, Dias A<\/strong>, Smith KM<\/strong>, Mack KL<\/strong>, Kasper LK, Channon JY<\/strong>
\nCirculating B Cells in Relapsing-Remitting Multiple Sclerosis Show Markedly Different Patterns of Regulatory
\nMarker Expression Compared with Healthy Controls. medRxiv 22279393 [Preprint] 2022.08.30.
\nAvailable from: doi:https:\/\/doi.org\/10.1101\/2022.08.30.22279393<\/p>\n

Farzan SF, Howe CG, Zens MS, Palys T, Channon JY<\/strong>, Li Z, Chen Y, Karagas MR. Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study. Environ Health Perspect. 2017; 125:127002. PMID: 29373859.<\/span><\/p>\n

Howe CG, Li Z, Zens MS, Palys T, Chen Y, Channon JY<\/strong>, Karagas MR, Farzan SF. Dietary B Vitamin Intake Is Associated with Lower Urinary Monomethyl Arsenic and Oxidative Stress Marker 15-F(2t)-Isoprostane among New Hampshire Adults. J Nutr. 2017; 147:2289-2296. PMID: 29070711.<\/span><\/p>\n

Pant AB, Wang Y, Mielcarz DW<\/strong>, Kasper EJ, Telesford KM, Mishra M, Haque A, Channon JY<\/strong>, Kasper LH, Begum-Haque S. Alteration of CD39+Foxp3+ CD4 T cell and cytokine levels in EAE\/MS following anti-CD52 treatment. J Neuroimmunol. 2017; 303:22-30. PMID: 28087077.<\/span><\/p>\n

Koeppen K, Hampton TH, Jarek M, Scharfe M, Gerber SA, <\/span>Mielcarz DW<\/b>, Demers EG, Dolben EL, Hammond JH, Hogan DA, Stanton BA. A Novel Mechanism of Host-Pathogen PLoS Pathog. 2016; e1005672.<\/span><\/p>\n

Talebian L, Fischer DA, Wu J, Channon JY<\/strong>, Sentman CL, Ernstoff MS, Meehan KR. The natural killer-activating receptor, NKG2D, on CD3+CD8+ T cells plays a critical role in identifying and killing autologous myeloma cells. Transfusion. 2014; 54:1515-21. PMID: 24446786.<\/span><\/p>\n

Barth RJ Jr, Fisher DA, Wallace PK, Channon JY<\/strong>, Noelle RJ, Gui J, Ernstoff MS. A randomized trial of ex vivo CD40L activation of a dendritic cell vaccine in colorectal cancer patients: tumor-specific immune responses are associated with improved survival. Clin Cancer Res. 2010; 16:5548-56. PMID: 20884622.<\/span><\/p>\n

Talebian L, Coutermarsh B, Channon JY<\/strong>, Stanton BA. Corr4A and VRT325 do not reduce the inflammatory response to P. aeruginosa in human cystic fibrosis airway epithelial cells. Cell Physiol Biochem. 2009; 23:199-204. PMID: 19255514<\/span><\/p>\n

Fahey JV, Schaefer TM, Channon JY<\/strong>, Wira CR. Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract. Hum Reprod. 2005; 20:1439-46. PMID: 15734755. <\/span><\/p>\n

Oral Presentations:<\/strong><\/h2>\n

New England Immunology Conference (2018)<\/strong><\/p>\n

Panelist: J. Channon (Flow Cytometry)<\/p>\n

CYTO 2017 (International Flow Cytometry\u00a0<\/b><\/span>Conference)<\/b><\/p>\n

Characterization and Utilization of the ZE5 for Human Immune Monitoring<\/span><\/p>\n

D. Mielcarz, A. Bergeron, G. Ward, R. Andreozzi and J. Channon.<\/p>\n

(Presentation sponsored by Bio-Rad, Inc.)<\/span><\/p>\n

ZE5\/YETI Early Access User Meeting (2016)<\/strong><\/p>\n

Characterization of the YETI flow cytometer for use in an immune monitoring laboratory.<\/span><\/p>\n

Mielcarz, A. Bergeron, G. Ward, R. Andreozzi, J. Channon.<\/p>\n

(Sponsored by Propel Labs, Inc.)<\/span><\/p>\n

New England Immunology Conference (2015)<\/strong><\/p>\n

Panelist: J. Channon (Flow Cytometry)<\/p>\n

Alemtuzumab Treatment Dramatically Alters T and B Cell Frequency and Phenotype in Relapsing-Remitting MS Patients<\/p>\n

D. Mielcarz, J. DeLong, A. Bergeron, G. Ward, L. Janney, L. Kasper and J. Channon.<\/p>\n

XXVIII Congress of the International Society for Advancement of Cytometry (2013) <\/strong><\/p>\n

Relapsing-Remitting MS Patients Have Significant Differences in Circulating B
\nCells Subset and Phenotype Compared with Healthy Controls, and IFN\u03b2-1b Treatment Can Alter the Composition and Phenotype of These Subsets<\/p>\n

D. Mielcarz, J. DeLong, A. Bergeron, K. Smith, A. Heyn, L. Kasper and J. Channon.<\/p>\n

Immunology 2012 (99th Annual Meeting of the American Association of Immunologists)<\/strong><\/p>\n

IFNbeta-1b alters the composition of circulating B cell subsets, and leads to changes in the B cell cytokine secretion profile in patients with relapsing-remitting multiple sclerosis.<\/p>\n

D. Mielcarz, A. Bergeron, J. DeLong, K. Smith, A. Heyn, K. Mack, M.A. Conrad, B. Oliver, L. Kasper, and J. Channon<\/p>\n

Posters:<\/strong><\/h2>\n

FOCIS (2018)<\/b><\/span><\/p>\n

Development of 12+ Color Modular Staining Panels with a Common Backbone to Interrogate CD40L-based Activation of Human B Cells, PBMC, Neutrophils and Monocyte-derived Dendritic Cells<\/span><\/p>\n

Daniel Mielcarz, Alan Bergeron, Mikayla Kravetz, Ryan Andreozzi, Andrew Calkins, Randolph Noelle, Jay Rothstein, Xinming Cai, Catherine Jones, Sambasiva Rao, Frank Nestle and Jacqueline Channon<\/span><\/p>\n

Annual Meeting of the American Academy of Neurology (2016)<\/strong><\/p>\n

The Retinoid Receptor (RXR) Selective Agonist IRX4204 Promotes Differentiation of Human aTreg Cells and Inhibits Differentiation of Human Th17 Cells<\/span><\/p>\n

Mielcarz, A. Bergeron, J. DeLong, R. Andreozzi, E. Nowak, R. Chandraratna, M. Sanders, R. Noelle, J. Channon.<\/p>\n

Northeast Regional Life Sciences Core Directors (2016)<\/strong><\/p>\n

DartLab: Immune monitoring and Flow Cytometry Shared Resource<\/span><\/p>\n

Mielcarz, A. Bergeron, G. Ward, R. Andreozzi, J. Channon.<\/p>\n

Northeast Regional Life Sciences Core Directors (2015)<\/strong><\/p>\n

IRX4204, a novel RXR agonist, alters cytokine secretion of T cells and monocytes, and increases in vitro <\/em>adaptive T regulatory cell proliferation<\/p>\n

D. Mielcarz, J. DeLong, R. Andreozzi, A. Bergeron, G. Ward, L. Kasper and J. Channon.<\/p>\n

XXIX Congress of the International Society for Advancement of Cytometry (2014) <\/strong><\/p>\n

Alemtuzumab Treatment Dramatically Alters T and B Cell Frequency and Phenotype in Relapsing- Remitting MS Patients<\/p>\n

D. Mielcarz, J. DeLong, A.J. Bergeron, N. Martin, L. Kasper and J. Channon.<\/p>\n

XXIX Congress of the International Society for Advancement of Cytometry (2014)<\/strong><\/p>\n

Development of an 8-Color Human Regulatory T-Cell Extracellular Staining Panel Using Commercially Available Fluorophore-Conjugated Antibodies<\/p>\n

J. DeLong, D. Mielcarz, A.J. Bergeron, G. Ward, N. Martin and J. Channon.<\/p>\n

XXIX Congress of the International Society for Advancement of Cytometry (2014)<\/strong><\/p>\n

Flow Cytometer Assurance in a Multi-Instrument Shared Resource<\/p>\n

G. Ward, N. Martin, A. Bergeron, D. Mielcarz, J. Delong and J. Channon.<\/p>\n

29th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (2013) <\/strong><\/p>\n

Anti-CD52 therapy induces significant changes in T and B cell subset frequency and cytokine expression by B cells in multiple sclerosis patients<\/p>\n

D. Mielcarz, A. Bergeron, J. DeLong, C. Sears, R. Grady, J. Channon, L. Kasper<\/p>\n

64th Annual Meeting of the American Academy of Neurology (2012)<\/strong><\/p>\n

IFN\u03b2-1b Treatment Alters the Composition of Circulating B Cell Subsets, In Particular Reducing the Number of Autoantibody Secreting B1 Cells in Patients with Relapsing-Remitting Multiple Sclerosis<\/p>\n

D. Mielcarz, A. Bergeron, J. DeLong, K. Smith, A. Heyn, K. Mack, M.A. Conrad, B. Oliver, L. Kasper, and J. Channon<\/p>\n","protected":false},"excerpt":{"rendered":"

Peer-reviewed Publications with DartLab Co-Authors: Connor RI, Sakharkar M, Rappazzo CG, Kaku CI, Curtis NC, Shin S, Wieland-Alter WF, Wentworth J, Mielcarz DW, Weiner JA, Ackerman ME, Walker LM, Lee J, Wright PF. Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2. Pathog Immun. 2024 Jun 18;9(2):1-24. [\u2026] <\/p>\n

<\/div>\n

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