Sourabh Dhingra, PhD
Sourabh joined Cramer lab in June after finishing his PhD at Northern Illinois University. During his PhD, he gained extensive knowledge about molecular biology of Aspergillus spp. Specifically, I studied regulation of secondary metabolism in Aspergillus spp.
Currently, he is investigating the virulence attributes of A. fumigatus. He is interested in the effects of the infection site microenvironment, particularly to changes in oxygen availability, on fungal and host metabolism and how these effects determine the outcome of infection. As hypoxia adaptation has been shown to contribute to the virulence of A. fumigatus, he is interested in testing the hypothesis whether remediation of hypoxia at the infection site can reduce fungal virulence and improve the efficacy of existing antifungal drugs. Along these lines, he is pursuing the identification of transcriptional networks that mediate A. fumigatus adaptation to hypoxia.
Selected representative publications
Lin H-C, Tsunematsu Y, Dhingra S, Xu W, Fukutomi M, et al. (2014) Generation of Complexity in Fungal Terpene Biosynthesis: Discovery of a Multifunctional Cytochrome P450 in the Fumagillin Pathway. Journal of the American Chemical Society.
Dhingra S, Lind AL, Lin H-C, Tang Y, Rokas A, et al. (2013) The Fumagillin Gene Cluster, an Example of Hundreds of Genes under veA Control in Aspergillus fumigatus. PLoS ONE 8: e77147.
Lin HC, Chooi YH, Dhingra S, Xu W, Calvo AM, et al. (2013) The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene. J Am Chem Soc 135: 4616-4619.
Ramamoorthy V, Dhingra S, Kincaid A, Shantappa S, Feng X, et al. (2013) The Putative C2H2 Transcription Factor MtfA Is a Novel Regulator of Secondary Metabolism and Morphogenesis in Aspergillus nidulans. Plos One 8.
Dhingra S, Andes D, Calvo AM (2012) VeA regulates conidiation, gliotoxin production, and protease activity in the opportunistic human pathogen Aspergillus fumigatus. Eukaryot Cell 11: 1531-1543.