{"id":636,"date":"2017-12-12T18:21:23","date_gmt":"2017-12-12T18:21:23","guid":{"rendered":"https:\/\/geiselmed2.dartmouth.edu\/compton\/?page_id=636"},"modified":"2017-12-14T18:39:01","modified_gmt":"2017-12-14T18:39:01","slug":"samuel","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/compton\/members\/former\/samuel\/","title":{"rendered":"Samuel Bakhoum"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-content\/uploads\/sites\/30\/2017\/12\/samuel.jpg\" alt=\"\" width=\"325\" height=\"271\" class=\"alignleft size-full wp-image-607\" srcset=\"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-content\/uploads\/sites\/30\/2017\/12\/samuel.jpg 325w, https:\/\/geiselmed.dartmouth.edu\/compton\/wp-content\/uploads\/sites\/30\/2017\/12\/samuel-300x250.jpg 300w\" sizes=\"auto, (max-width: 325px) 100vw, 325px\" \/>My project focuses on mechanisms underlying chromosome segregation fidelity in human cells. During division, missegregation occurs due to kinetochore-microtubule mal-attachments, whose correction is necessary for faithful segregation. We have uncovered that the Kinesin-13, Kif2b, increases microtubule dynamics at the kinetochores, hence allowing for the release of erronous attachments and the general destabilization of kinetochore fibers in early mitosis necessary for proper chromosome alignment.<\/p>\n<p>These pictures represent a monopolar spindle, a bipolar spindle with monooriented unaligned chromosomes, and an anaphase spindle with lagging chromatids.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-content\/uploads\/sites\/30\/2017\/12\/3_spindles.jpg\" alt=\"\" width=\"700\" height=\"231\" class=\"alignleft size-full wp-image-637\" srcset=\"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-content\/uploads\/sites\/30\/2017\/12\/3_spindles.jpg 700w, https:\/\/geiselmed.dartmouth.edu\/compton\/wp-content\/uploads\/sites\/30\/2017\/12\/3_spindles-300x99.jpg 300w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>My project focuses on mechanisms underlying chromosome segregation fidelity in human cells. During division, missegregation occurs due to kinetochore-microtubule mal-attachments, whose correction is necessary for faithful segregation. We have uncovered that the Kinesin-13, Kif2b, increases microtubule dynamics at the kinetochores, hence allowing for the release of erronous attachments and the [\u2026] <\/p>\n<div class=\"clear\"><\/div>\n<p><a class=\"more_link clearfix\" href=\"https:\/\/geiselmed.dartmouth.edu\/compton\/members\/former\/samuel\/\" rel=\"nofollow\">Read More<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"parent":32,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-636","page","type-page","status-publish","hentry","author-2"],"_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/pages\/636","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/comments?post=636"}],"version-history":[{"count":1,"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/pages\/636\/revisions"}],"predecessor-version":[{"id":894,"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/pages\/636\/revisions\/894"}],"up":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/pages\/32"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/compton\/wp-json\/wp\/v2\/media?parent=636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}