Small changes in phospho-occupancy at the kinetochore\u2013microtubule interface drive mitotic fidelity.
\nKucharski TJ, Hards R, Vandal SE, Abad MA, Jeyaprakash AA, Kaye E, al-Rawi A, Ly T, Godek KM, Gerber SA, Compton DA
\nJ. Cell Biol. 2022; 2022.07.25<\/p>\n
A pluripotent developmental state confers a low fidelity of chromosome segregation.
\nDeng C, Ya A, Compton DA, and Godek KM
\nbioRxiv. 2022; 2022.03.01.482524.<\/p>\n
Chromosome segregation fidelity is controlled by small changes in phospho-occupancy at the kinetochore-microtubule interface.
\nKucharski TJ, Hards R, Godek KM, Gerber SA, and Compton DA
\nbioRxiv. 2021;2021.02.16.431549.<\/p>\n
Kinetochores respond to subtle changes in the stability of microtubule attachments.
\nWarren JD, Valles SY, and Compton DA
\nbioRxiv. 2021:2021.02.19.432040<\/p>\n
Identifying cyclinA\/cdk1 substrates in mitosis in human cells.
\nDumitru A and Compton DA
\nMethods Mol. Biol.2022;2415:175-182. doi: 10.1007\/978-1-0716-1904-9_13<\/p>\n
A comparative analysis of methods to measure kinetochore-microtubule attachment stability in mitosis.
\nWarren JD, Orr B, and Compton DA
\nMethods Mol. Biol.2020;158:91-116. doi: 10.1016\/bs.mcb.2020.01.004.<\/p>\n
<\/p>\n
Godek, K.M., Compton, D.A.:\u00a0 Quantitative methods to measure aneuploidy and chromosomal instability.\u00a0 Methods Cell Biol<\/a> 144:15-32 (2018).<\/p>\n Zhao, Y., Carter, R., Natarajan, S., Varn, F.S., Compton, D.A., Gaward, C., Cheng, C., and Godek, K.M.:\u00a0 Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells.\u00a0 BMC Med Genomics<\/a> 12(1):79 doi: 10.1186\/s1290-019-0532-5 (2019).<\/p>\n Laucius, C.D., Orr, B., and Compton, D.A.:\u00a0 Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.\u00a0 Cell Cycle<\/a> 18:1702-1713 (2019).<\/p>\n Dumitru, AMG, Rusin, SF, Clark, AEM, Kettenbach, AN, and Compton DA: Cyclin A\/Cdk1 modulates Plk1 activity in pro metaphase to regulate kinetochore-microtubule attachment stability.\u00a0eLIFE<\/b><\/a>. eLife 2017;6:e29303 DOI: 10.7554\/eLife.29303.<\/p>\n Orr, B, Talje, L, Liu, Z, Kwok, BH, and Compton, DA: Adaptive resistance to an inhibitor of chromosomal instability in human cancer cells.\u00a0Cell Reports<\/b><\/a>. 17:1755-1763 (2016).<\/p>\n Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E.: Specific CP110 phosphorylation sites mediate anaphase catastrophe after CDK2 inhibition: Evidence for cooperation with USP33 knockdown.\u00a0Mol Cancer Ther<\/a><\/b>. 14:2576-2585 (2015).<\/p>\n Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, Compton DA, Waldman T.: Intact cohesion, anaphase, and chromosome segregation in human cells harboring tumor-derived mutations in STAG2.\u00a0PLoS Genet<\/a><\/b>. 12(2):e1005865. doi: 10.1371\/journal.pgen.1005865. (2016).<\/p>\n Godek KM, Venere M, Wu Q, Mills KD, Hickey WF, Rich JN, Compton DA.: Chromosomal instability affects the tumorigenicity of glioblastoma tumor-initiating cells.\u00a0Cancer Discov<\/a><\/b>. 6:532-545. (2016).<\/p>\n Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ, Dmitrovsky E.: Dinaciclib induces anaphase catastrophe in lung cancer cells via inhibition of cyclin-dependent kinases 1 and 2.\u00a0Mol Cancer Ther<\/a><\/b>. 15:2758-2766. (2016).<\/p>\n Meppelink, A, Kabeche, L, Vromans, MJ, Compton, DA, and Lens, SM: Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.\u00a0Cell Reports<\/a><\/b>\u00a011:508-151 (2015).<\/p>\n Hu, S, Danilov, AV, Godek, K, Orr, B, Tafe, TJ, Rodriquez-Canales, J, Behrens, C, Mino, B, Moran, CA, Memoli, VA, Mustachio, LM, Galimberti, F, Ravi, S, DeCastro, A, Lu, Y, Sekula, D, Andrew, AS, Wistuba, II, Freemantle, S, Compton, DA, and Dmitrovsky, E: CDK2 inhibition causes anaphase catastrophe in lung cancer through the centrosomal protein CP110.\u00a0Cancer Res<\/a><\/b>\u00a075:2029-2038 (2015).<\/p>\n Bakhoum, SF, Kabeche, L, Wood, MD, Laucius, CD, Qu, D, Laughney, AM, Reynolds, GE, Louie, RJ, Phillips, J, Chan, DA, Zaki, MI, Murnane, JP, Petritsch, C, and Compton, DA: Numerical chromosomal instability mediates susceptibility to radiation treatment.\u00a0Nature Comm.<\/a><\/b>\u00a0doi: 10.1038\/ncomms6990. (2015).<\/p>\n Godek, KM, Kabeche, L, and Compton, DA: Regulation of kinetochore-microtubule attachments through homeostatic control during mitosis.\u00a0Nat Rev Mol Cell Biol<\/a><\/b>\u00a016:57-64. (2015)<\/p>\n Bakhoum, SF, Kabeche, L, Wood, MD, Qu, D, Laughney, AM, Reynolds, GE, Louie RJ, Phillips, J, Chan, DA, Zaki, BI, Murnane, JP, Petritsch, C, and Compton, DA: Numerical chromosomal instability mediates susceptibility to radiation treatment.\u00a0Nature Comm.<\/a><\/b>\u00a06:5990 DOI 10.1038\/ncomms6990 (2015).<\/p>\n Bakhoum, SF, Slikworth, WT, Nardi, IK, Nicholson, JM, Compton, DA and Cimini, D.: The mitotic origin of chromosomal instability\u00a0Curr. Biol.<\/a><\/b>\u00a024:R148-R149 (2014).<\/p>\n Kleyman, M, Kabeche, L, and Compton DA.: STAG2 promotes error correction in mitosis by regulating kinetochore-microtubule attachments.\u00a0J. Cell Sci.<\/a><\/b>\u00a0(2014).<\/p>\n Bakhoum, SF, Kabeche, L, Murnane, JP, Zaki, BI, and Compton, DA: DNA damage response during mitosis induces whole chromosome mis-segregation.\u00a0Cancer Discov.<\/a><\/b>\u00a0(2014).<\/p>\n Kabeche, L and Compton, DA: Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation.\u00a0Nature<\/a><\/b>\u00a0502:110-113 (2013).<\/p>\n Orr, B and Compton DA: A double-edged sword: how oncogenes and tumor suppressor genes can contribute to chromosomal instability.\u00a0Front. Oncol.<\/a><\/b>\u00a03:164 (2013)<\/p>\n Maia, AR, Garcia, Z, Kabeche, L, Barisic M, Maffini, S, Macedo-Ribeiro, S, Cheeseman, IM, Compton, DA, Kaverina, I and Maiato, H: Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore-microtubule attachments.\u00a0J. Cell Biol.<\/a><\/b>\u00a0199:285-301 (2012)<\/p>\n Kabeche, L and Compton, DA: Checkpoint-independent stabilization of kinetochore-microtubule attachments by Mad2 in human cells.\u00a0Curr Biol<\/a><\/b>\u00a022:638-644 (2012)<\/p>\n Hood, EA, Kettenbach, A, Gerber, S, and Compton, DA: Polo kinase (Plk1) regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.\u00a0Mol. Biol. Cell<\/a><\/b>\u00a023:2264-2274 (2012).<\/p>\n Bakhoum, SF, Danilova, OV, Kaur, P, Levy, NB, and Compton, DA: Chromosomal instability substantiates poor patient prognosis in patients with Diffuse B-Cell Lymphoma.\u00a0Clin. Cancer Res.<\/a><\/b>\u00a017:7704-7711 (2011).<\/p>\n Thompson, SL and Compton, DA: Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors.\u00a0Proc. Natl. Acad. Sci. USA<\/a><\/b>\u00a0108:17974-17978 (2011).<\/p>\n Thompson, SL and Compton, DA: Chromosomes and cancer cells.\u00a0Chromosome Research<\/a><\/b>\u00a019:433-444 (2011).<\/p>\n Galimberti, F, Thompson, SL, Ravi, S, Compton, DA, and Dmitrovsky, E: Anaphase catastrophe is a target for cancer therapy.\u00a0Clin Cancer Res<\/a>.<\/b>\u00a017:1218-1222 (2011).<\/p>\n Charlebois, BD, Kollu, S, Schek, HT, Compton, DA, and Hunt, AJ: Spindle pole mechanics studied in mitotic asters: dynamic distribution of spindle forces through compliant linkages.\u00a0Biophys. J.<\/a><\/b>\u00a0100:1756-1764 (2011).<\/p>\n Amity L Manning, Samuel F Bakhoum, Stefano Maffini, Clara Correia-Melo, Helder Maiato and Duane A Compton.: CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore-microtubule dynamics to promote mitotic progression and fidelity.\u00a0EMBO Journal<\/a><\/b>\u00a029:3531-3543 (2010)<\/p>\n Thompson, SL, Bakhoum, SF, and Compton, DA: Mechanisms of chromosomal instability.\u00a0Curr Biol.<\/a><\/b>\u00a020:R285-R295 (2010)<\/p>\n Thompson, SL, and Compton, DA: Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.\u00a0J. Cell Biol.<\/a><\/b>\u00a0188:369-381 (2010).<\/p>\n Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, Direnzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E.: Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe.\u00a0Clin Cancer Res<\/a><\/b>. 16:109-120 (2010)<\/p>\n Kollu S, Bakhoum SF, Compton DA.: Interplay of Microtubule Dynamics and Sliding during Bipolar Spindle Formation in Mammalian Cells.\u00a0Curr Biol<\/a><\/b>. 19:2108-2113<\/p>\n Bakhoum SF, Genovese G, Compton DA.: Deviant kinetochore microtubule dynamics underlie chromosomal instability.\u00a0Curr Biol<\/a><\/b>. 2009 Dec 1;19(22):1937-42.<\/p>\n Bakhoum SF, Compton DA.: Cancer: CINful centrosomes.\u00a0Curr Biol<\/a><\/b>. 2009 Aug 11;19(15):R642-5.<\/p>\n Maffini, S., Maia, A.R.R., Manning, A.L., Maliga, Z., Pereira, A.L., Junqueira, M., Shevchenko, A., Hyman, A., Yates, J.R., Galjart, N., Compton, D.A., and Maiato, H.: Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.\u00a0Curr. Biol.<\/a><\/b>\u00a019:1566-1572 (2009)<\/p>\n Bakhoum, S.F., Thompson, S.L., Manning, A.L., and Compton, D.A.: Genome stability is ensured by temporal control of kinetochore-microtubule dynamics\u00a0Nature Cell Biol.<\/a><\/b>\u00a011:27-35 (2009).<\/p>\n Manning, A.L. and Compton, D.A.:\u00a0Snapshot: Nonmotor proteins in spindle assembly<\/a>\u00a0Cell<\/b>\u00a0134: 694-694e1<\/p>\n Thompson, S.L., and Compton, D.A.: Examining the link between chromosomal instability and aneuploidy in human cells.J. Cell Biol.<\/a><\/b>\u00a0180:665-672 (2008).<\/p>\n Manning, A.L. and Compton, D.A.: Structural and regulatory roles of nonmotor spindle proteins.\u00a0Curr. Op. Cell Biol<\/a><\/b>. 20:101-106 (2008).<\/p>\n Compton, D.A.: Standing Tall.\u00a0Dartmouth Medicine<\/a><\/b>\u00a032:70 (2007).<\/p>\n Compton, D.A.: Chromosome orientation.\u00a0J. Cell Biol.<\/a><\/b>\u00a0179:179-181 (2007).<\/p>\n Myers, L.C. and Compton, D.A.: Mitosis: Springtime for chromatin.\u00a0Curr. Biol.<\/a><\/b>\u00a017:R460-R462 (2007).<\/p>\n Manning, A.L., Ganem, N.J., Bakhoum, S., Wagenbach, M., Wordeman, L., and Compton, D.A.: The kinesin-13 proteins Kif2a, Kif2b and Kif2c\/MCAK have distinct roles during mitosis in human cells.\u00a0Mol. Biol. Cell<\/a><\/b>\u00a0(2007)<\/p>\n Manning, A.L., and Compton, D.A.: Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells.\u00a0Curr. Biol.<\/a><\/b>\u00a017: 260-265 (2007).<\/p>\n Compton, D.A.: Mitosis: Disorderly conduct at kinetochores.\u00a0Curr. Biol.<\/a><\/b>\u00a016:R494-R496. (2006).<\/p>\n Hall, V.J. Compton, D.A., Stojkovic, P., Nesbitt, M., Herbert, M., Murdoch, A., and Stjkovic, M.: Developmental competience of human in vitro aged oocytes as host cells for nuclear transfer.\u00a0Hum. Reprod.<\/a><\/b>\u00a0(2006).<\/p>\n Ganem, N.J, and Compton, D.A.: Functional roles of poleward microtubule flux during mitosis.\u00a0Cell Cycle<\/a><\/b>\u00a05:481-485. (2006)<\/p>\n Compton, D.A.: Chromosomes walk the line.\u00a0Nature Cell Biol.<\/a><\/b>\u00a08:308-310. (2006)<\/p>\n Ganem, N.J., Upton, K., and Compton, D.A.: Efficient mitosis in human cells lacking polewards microtubule flux.\u00a0Curr. Biol.<\/a><\/b>\u00a015:1827-1832 (2005)<\/p>\n Compton, D.A.: Regulation of mitosis by poly(ADP-ribosyl)ation.\u00a0Biochem. J.<\/b>\u00a0391:e5-e6 (2005)<\/p>\n Compton, D.A.: Mitosis: PARty time in the spindle.\u00a0Current Biol.<\/b><\/a>\u00a015:R178-179 (2005)<\/p>\n Simerly, C., Navara, C., Hyun, S.H., Lee, B.C., Kang, S.K., Capuano, S., Gosman, G., Dominko, T., Chong, K.-Y., Compton, D., Hwang, W.S., and Schatten, G.: Embryogenesis and blastocyst development after somatic cell nuclear transfer in non-human primates (NHP-SCNT): overcoming defects caused by meiotic spindle extraction.\u00a0Dev. Biol.<\/b><\/a>276:237-252 (2004)<\/p>\n Kisurina-Evgenieva, O., Mack, G., Du, Q., Macara, I., Khodjakov, A., and Compton, D.A.: Multiple mechanisms regulate NuMA dynamics at spindle poles.\u00a0J. Cell Sci.<\/b><\/a>\u00a0117:6391-6400 (2004)<\/p>\n Ganem, N., and Compton, D.A.: The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK.\u00a0J. Cell Biol.<\/b><\/a>\u00a0166:473-478 (2004)<\/p>\n Einarson, M.B., Cukierman, E., Compton, D.A., and Glemis, E.A.: Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis.\u00a0Mol. Cell Biol.<\/b><\/a>\u00a024:3957-3971 (2004)<\/p>\n Chakravarty, A., Howard, L., and Compton, D.A.: A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract.\u00a0Mol. Biol. Cell<\/b><\/a>\u00a015:2116-2132. (2004)<\/p>\n Ota, J., Yamashita, Y., Okawa, K., Kisanuki, H., Fijiwara, S., Ishikawa, M., Choi, Y.L., Ueno, S., Ohki, R., Koinuma, K., Wada, T., Compton, D., Kadoya, T., and Mano, H.: Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders.\u00a0Oncogene<\/b><\/a>\u00a022:5720-5728. (2003)<\/p>\n Levesque, A.A., Howard, L., and Compton, D.A.: A functional relationship between NuMA and Kid is involved in both spindle organization and chromosome alignment in vertebrate cells.\u00a0Mol. Biol. Cell<\/b><\/a>\u00a014:3541-3552. (2003)<\/p>\n Simerly, C., Dominko, T., Navara, C., Payne, C., Capuano, S., Gosman, G., Chong, K.-Y., Takahashi, D., Chace, C., Compton, D., Hewitson, L., and Schatten, G.: Molecular correlates of primate nuclear transfer failures.\u00a0Science<\/b><\/a>\u00a0300: 297 (2003).<\/p>\n Khodjakov, A., Copenagle, L., Gordon, M.B., Compton, D.A., and Kapoor, T.M.: Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis\u00a0J. Cell Biol.<\/b><\/a>\u00a0160:671-683 (2003).<\/p>\n Garrett, S., Auer, K., Compton, D.A., and Kapoor, T.M.: hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division.Curr. Biol.<\/b><\/a>\u00a012:2055-2059 (2002).<\/p>\n Du, Q., Taylor, L., Compton, D.A., and Macara I.G.: LGN blocks the ability of NuMA to bind and stabilize microtubules: a mechanism for mitotic spindle assembly regulation.Curr. Biol.<\/b><\/a>\u00a012:1928-1933 (2002).<\/p>\n Compton, D.A.: Chromosome Segregation: Pulling from the Poles.\u00a0Curr. Biol.<\/b><\/a>\u00a012:R651-R653 (2002).<\/p>\n Kapoor,T.M. and Compton, D.A.: Searching for the middle ground: mechanisms of chromosome alignment during mitosis.\u00a0J. Cell Biol.<\/b><\/a>\u00a0157:551-556. (2002).<\/p>\n Mack, G. and Compton, D.A.: Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a novel spindle-associated protein.\u00a0Proc. Natl. Acad. Sci.,\u00a0<\/b><\/a>USA. 98:14434-14439.(2001).<\/p>\n Levesque, A. and Compton, D.A.: The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles.\u00a0J. Cell Biol.<\/b><\/a>\u00a0154:1135-1146. (2001).<\/p>\n Gordon, M., Howard, L., and Compton, D.A.: Chromosome movement in mitosis requires microtubule anchorage at spindle poles.\u00a0J. Cell Biol.<\/a><\/b>\u00a0152:425-434. (2001).<\/p>\n Dionne, M.A., Sanchez, A., and Compton, D.A.: ch-TOGp is required for microtubule aster formation in a mammalian mitotic extract.\u00a0J. Biol. Chem.<\/a><\/b>\u00a0275:12346-12352. (2000).<\/p>\n Ye, K., Compton, D.A., Lai, M.M., Walensky, L.D., and Snyder, S.H.: Protein 4.1N binding to nuclear NuMA in PC12 cells mediates the anti-proliferative actions of nerve growth factor.\u00a0J. Neuroscience<\/b>\u00a019:10747-10756 (1999).<\/p>\n Mountain, V., Simerly, C., Howard, L., Ando, A., Schatten, G., and Compton, D.A.: The kinesin-related protein HSET opposes the activity of Eg5 and cross links microtubules in the mammalian mitotic spindle.\u00a0J. Cell Biol.\u00a0<\/a><\/b>147:351-365. (1999).<\/p>\n Quintyne, N.J., Gill, S.R., Eckley, D.M., Crego, C.L., Compton, D.A., and Schroer, T.A.: Dynactin is required for microtubule anchoring at centrosomes.\u00a0J. Cell Biol.<\/b><\/a>\u00a0147:321-334 (1999).<\/p>\n Dionne, M.A., Howard, L., and Compton, D.A.: NuMA is a component of an insoluble matrix at mitotic spindle poles.\u00a0Cell Motil. Cytoskel.<\/a><\/b>\u00a042:189-203. (1999).<\/p>\n Compton, D.A.: Focusing on spindle poles.\u00a0J. Cell Sci.<\/a><\/b>\u00a0111:1477-1481 (1998).<\/p>\n Gaglio, T., Dionne, M.A., and Compton, D.A.: Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes.\u00a0J. Cell Biol.<\/a><\/b>\u00a0138:1055-1066 (1997).<\/p>\n Saredi, A., Howard, L., and Compton, D.A.: Phosphorylation regulates the assembly of NuMA in a mammalian mitotic extract.\u00a0J. Cell Sci.<\/a><\/b>\u00a0110:1287-1297 (1997).<\/p>\n Gaglio, T., Saredi, A., Bingham, J.B., Hasbani, M.J., Gill, S.R., Schroer, T.A., and Compton, D.A.: Opposing motor activities are required for the organization of the polar ends of the mammalian mitotic spindle.\u00a0J. Cell Biol.<\/a><\/b>\u00a0135:399-414 (1996).<\/p>\n Saredi, A., Howard, L., and Compton, D.A.: NuMA assembles into an extensive filamentous structure when expressed in the cell cytoplasm.\u00a0J. Cell Sci.<\/a><\/b>\u00a0109:619-630 (1996).<\/p>\n Gaglio, T., Saredi, A., and Compton, D.A.: NuMA is required for the organization of microtubules into aster-like mitotic arrays.\u00a0J. Cell Biol.<\/a><\/b>\u00a0131:693-708 (1995).<\/p>\n Compton, D.A., and Luo, C.: Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis.\u00a0J. Cell Sci.<\/a><\/b>\u00a0108:621-633 (1995).<\/p>\n Compton, D.A.: In vitro approaches for the study of molecular motors in aster formation.\u00a0Methods in Cell Biol.<\/b>\u00a067:225-239. (2001).<\/p>\n Compton, D.A.: Spindle assembly in animal cells.\u00a0Ann. Rev. Biochem..<\/b>\u00a069:95-114 (2000).<\/p>\n Mountain, V., and Compton, D.A.: Dissecting the role of molecular motors in the mitotic spindle.\u00a0Anat. Rec. (New Anat),<\/b>261:14-24 (2000).<\/p>\n Compton, D.A.: New tools for the anti-mitotic toolbox.\u00a0Science\u00a0<\/b>286:913-914 (1999).<\/p>\n Gueth-Hallonet, C., Osborn, M., and Compton, D.A.: NuMA. in Guidebook to the Cytoskeletal and Motor Proteins; ed. Ron Vale and Thomas Kreis; Oxford University Press, Oxford, UK (1997).<\/p>\n Compton, D.A.: Production of M-phase and I-phase extracts from mammalian cells. in Molecular Motors and the Cytoskeleton: Part B (a volume of Methods in Enzymology); ed. Richard B. Vallee; Academic Press, San Diego, CA. (1997).<\/p>\n","protected":false},"excerpt":{"rendered":" Journal Articles: Small changes in phospho-occupancy at the kinetochore\u2013microtubule interface drive mitotic fidelity. Kucharski TJ, Hards R, Vandal SE, Abad MA, Jeyaprakash AA, Kaye E, al-Rawi A, Ly T, Godek KM, Gerber SA, Compton DA J. Cell Biol. 2022; 2022.07.25 A pluripotent developmental state confers a low fidelity of chromosome [\u2026] <\/p>\nInvited Book Chapters:<\/h2>\n