{"id":64,"date":"2021-09-09T16:51:50","date_gmt":"2021-09-09T16:51:50","guid":{"rendered":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/?page_id=64"},"modified":"2026-05-18T16:51:03","modified_gmt":"2026-05-18T16:51:03","slug":"news","status":"publish","type":"page","link":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/news\/","title":{"rendered":"News"},"content":{"rendered":"<p><strong><span style=\"font-size: 14pt\">May 2026<\/span><\/strong><\/p>\n<p>Published in npj Systems Biology and Applications and authored by research assistant Jeffrey Hage: A new statistical method for recovering count information from proportional data by applying trained priors, named Mahalanobis Count Inference (MCI). The method is generally applicable to multiple kinds of biological measurements (e.g. single-cell transcriptomics).<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41540-026-00737-9\"><span style=\"font-size: 10pt\">Inferring absolute counts from proportions by constraining multivariate normal distributions<\/span><\/a><\/p>\n<hr \/>\n<p><strong><span style=\"font-size: 14pt\">November 2024<\/span><\/strong><\/p>\n<p>QBS Ph.D. student Ze Zhang, published an application of detailed DNA-based immune profiling in head and neck cancer immunotherapy response in npj Precision Oncology.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41698-024-00759-8\"><span style=\"font-size: 10pt\">Methylation cytometric pretreatment blood immune profiles with tumor mutation burden as prognostic indicators for survival outcomes in head and neck cancer patients on anti-PD-1 therapy<\/span><\/a><\/p>\n<hr \/>\n<h4><span style=\"font-size: 14pt\"><strong>June 2024<\/strong><\/span><\/h4>\n<p>Congratulations to graduating Dartmouth senior Samuel Reynolds who contributed two lead-author manuscripts related to his independent study and senior honors thesis work in the lab on DNA based cell typing with methylation cytometry.<\/p>\n<p><span style=\"font-size: 10pt\"><a href=\"https:\/\/link.springer.com\/article\/10.1186\/s13148-023-01609-3\">Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer<\/a><\/span><\/p>\n<p><span style=\"font-size: 10pt\"><a href=\"https:\/\/www.tandfonline.com\/doi\/10.1080\/15592294.2023.2289786?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub%20%200pubmed\">Detailed immune profiling in pediatric Crohn's disease using methylation cytometry<\/a><\/span><\/p>\n<h4><span style=\"font-size: 14pt\"><strong>April 2024<\/strong><\/span><\/h4>\n<hr \/>\n<p>Ph.D. student Sarah Lee published back-to-back articles in Nature Communications on single-cell gene expression and epigenetic modifications in pediatric central nervous system tumors.<\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-47712-8\"><span style=\"font-size: 10pt\">Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors<\/span><\/a><\/p>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-024-47943-9\"><span style=\"font-size: 10pt\">Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors<\/span><\/a><\/p>\n<h4><span style=\"font-size: 14pt\"><strong>February 2022<\/strong><\/span><\/h4>\n<hr \/>\n<p>Dr. Lucas Salas M.D., MPH, Ph.D., and QBS Ph.D. student Ze Zhang, published their novel immune-profiling method using DNA from blood in Nature Communications. Their work is picked up by the online news services <a href=\"https:\/\/www.genomeweb.com\/cancer\/new-dna-based-immune-cell-profiling-method-could-boost-biomarker-discovery#.YvUR6ezMKfV\">GenomeWeb<\/a> and <a href=\"https:\/\/medicalxpress.com\/news\/2022-02-immune-profiling-method-dna-blood.html\">Medical Xpress<\/a>.<\/p>\n<p class=\"c-article-title\" data-test=\"article-title\"><a href=\"https:\/\/www.nature.com\/articles\/s41467-021-27864-7\"><span style=\"font-size: 10pt\">Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>May 2026 Published in npj Systems Biology and Applications and authored by research assistant Jeffrey Hage: A new statistical method for recovering count information from proportional data by applying trained priors, named Mahalanobis Count Inference (MCI). The method is generally applicable to multiple kinds of biological measurements (e.g. single-cell transcriptomics). [\u2026] <\/p>\n<div class=\"clear\"><\/div>\n<p><a class=\"more_link clearfix\" href=\"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/news\/\" rel=\"nofollow\">Read More<\/a><\/p>\n","protected":false},"author":224,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-64","page","type-page","status-publish","hentry","author-224"],"_links":{"self":[{"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/pages\/64","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/users\/224"}],"replies":[{"embeddable":true,"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/comments?post=64"}],"version-history":[{"count":16,"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/pages\/64\/revisions"}],"predecessor-version":[{"id":286,"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/pages\/64\/revisions\/286"}],"wp:attachment":[{"href":"https:\/\/geiselmed.dartmouth.edu\/christensenlab\/wp-json\/wp\/v2\/media?parent=64"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}