Publications
Hinchcliff M, Huang CC, Wood TA, Matthew Mahoney J, Martyanov V, Bhattacharyya S, Tamaki Z, Lee J, Carns M, Podlusky S, Sirajuddin A, Shah SJ, Chang RW, Lafyatis R, Varga J, Whitfield ML
Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis.
J Invest Dermatol 2013 Mar 14;
PMID: 23677167
Lenna S, Farina AG, Martyanov V, Christmann RB, Wood TA, Farber HW, Scorza R, Whitfield ML, Lafyatis R, Trojanowska M
Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension.
Arthritis Rheum 2013 May; 65(5):1357-66
PMID: 23400395
Grant GD, Gamsby J, Martyanov V, Brooks L 3rd, George LK, Mahoney JM, Loros JJ, Dunlap JC, Whitfield ML
Live-cell monitoring of periodic gene expression in synchronous human cells identifies Forkhead genes involved in cell cycle control.
Mol Biol Cell 2012 Aug; 23(16):3079-93
PMID: 22740631
Lakota K, Wei J, Carns M, Hinchcliff M, Lee J, Whitfield ML, Sodin-Semrl S, Varga J
Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?
Arthritis Res Ther 2012 May 1; 14(3):R102
PMID: 22548780
Wei J, Fang F, Lam AP, Sargent JL, Hamburg E, Hinchcliff ME, Gottardi CJ, Atit R, Whitfield ML, Varga J
Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells.
Arthritis Rheum 2012 Aug; 64(8):2734-45
PMID: 22328118
Pendergrass SA, Lemaire R, Francis IP, Mahoney JM, Lafyatis R, Whitfield ML
Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies.
J Invest Dermatol 2012 May; 132(5):1363-73
PMID: 22318389
Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO
Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets.
Am J Pathol 2012 Mar; 180(3):1080-94
PMID: 22245215
Bhattacharyya S, Sargent JL, Du P, Lin S, Tourtellotte WG, Takehara K, Whitfield ML, Varga J
Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis.
PLoS One 2011; 6(9):e23082
PMID: 21931594
Sargent JL, Whitfield ML
Capturing the heterogeneity in systemic sclerosis with genome-wide expression profiling.
Expert Rev Clin Immunol 2011 Jul; 7(4):463-73
PMID: 21790289
Allen JA, Peterson A, Sufit R, Hinchcliff ME, Mahoney JM, Wood TA, Miller FW, Whitfield ML, Varga J
Post-epidemic eosinophilia-myalgia syndrome associated with L-tryptophan.
Arthritis Rheum 2011 Nov; 63(11):3633-9
PMID: 21702023
Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerod A, Borresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters.
Nat Genet 2011 Jun 5; 43(7):621-9
PMID: 21642992
Christmann RB, Hayes E, Pendergrass S, Padilla C, Farina G, Affandi AJ, Whitfield ML, Farber HW, Lafyatis R
Interferon and alternative activation of monocyte/macrophages in systemic sclerosis-associated pulmonary arterial hypertension.
Arthritis Rheum 2011 Jun; 63(6):1718-28
PMID: 21425123
Katsumoto TR, Whitfield ML, Connolly MK
The pathogenesis of systemic sclerosis.
Annu Rev Pathol 2011; 6:509-37
PMID: 21090968
Wei J, Ghosh AK, Sargent JL, Komura K, Wu M, Huang QQ, Jain M, Whitfield ML, Feghali-Bostwick C, Varga J
PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis.
PLoS One 2010 Nov 2; 5(11):e13778
PMID: 21072170
Pendergrass SA, Hayes E, Farina G, Lemaire R, Farber HW, Whitfield ML, Lafyatis R
Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury.
PLoS One 2010 Aug 17; 5(8):e12106
PMID: 20808962
Lemaire R, Farina G, Bayle J, Dimarzio M, Pendergrass SA, Milano A, Perbal B, Whitfield ML, Lafyatis R
Antagonistic effect of the matricellular signaling protein CCN3 on TGF-beta- and Wnt-mediated fibrillinogenesis in systemic sclerosis and Marfan syndrome.
J Invest Dermatol 2010 Jun; 130(6):1514-23
PMID: 20182440
Sargent JL, Milano A, Bhattacharyya S, Varga J, Connolly MK, Chang HY, Whitfield ML
A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity.
J Invest Dermatol 2010 Mar; 130(3):694-705
PMID: 19812599
Chandriani S, Frengen E, Cowling VH, Pendergrass SA, Perou CM, Whitfield ML, Cole MD
A core MYC gene expression signature is prominent in basal-like breast cancer but only partially overlaps the core serum response.
PLoS One 2009 Aug 19; 4(8):e6693
PMID: 19690609
Milks MW, Cripps JG, Lin H, Wang J, Robinson RT, Sargent JL, Whitfield ML, Gorham JD
The role of Ifng in alterations in liver gene expression in a mouse model of fulminant autoimmune hepatitis.
Liver Int 2009 Oct; 29(9):1307-15
PMID: 19490417
Varga J, Whitfield ML
Transforming growth factor-beta in systemic sclerosis (scleroderma).
Front Biosci (Schol Ed) 2009 Jun 1; 1:226-35
PMID: 19482698
Chung L, Fiorentino DF, Benbarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL, Whitfield ML, Chang HY, Robinson WH
Molecular framework for response to imatinib mesylate in systemic sclerosis.
Arthritis Rheum 2009 Feb; 60(2):584-91
PMID: 19180499
Beyrouthy MJ, Alexander KE, Baldwin A, Whitfield ML, Bass HW, McGee D, Hurt MM
Identification of G1-regulated genes in normally cycling human cells.
PLoS One 2008; 3(12):e3943
PMID: 19079774
Milano A, Pendergrass SA, Sargent JL, George LK, McCalmont TH, Connolly MK, Whitfield ML
Molecular subsets in the gene expression signatures of scleroderma skin.
PLoS One 2008 Jul 16; 3(7):e2696
PMID: 18648520
Sargent JL, Milano A, Connolly MK, Whitfield ML
Scleroderma gene expression and pathway signatures.
Curr Rheumatol Rep 2008 Jul; 10(3):205-11
PMID: 18638428
Andrew AS, Jewell DA, Mason RA, Whitfield ML, Moore JH, Karagas MR
Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population.
Environ Health Perspect 2008 Apr; 116(4):524-31
PMID: 18414638