Selected Publications
Michael Sporn, M.D.
Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening.
Wakamori S, Taguchi K, Nakayama Y, Ohkoshi A, Sporn MB, Ogawa T, Katori Y, Yamamoto M
Free Radic Biol Med. 2022 Aug 1;188:206-220. doi: 10.1016/j.freeradbiomed.2022.06.239. Epub 2022 Jun 24.
PMID: 35753588
Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction.
Zhang A, Suzuki T, Adachi S, Naganuma E, Suzuki N, Hosoya T, Itoh K, Sporn MB, Yamamoto M
Mol Cell Biol. 2021 Oct 26;41(11):e0023621. doi: 10.1128/MCB.00236-21. Epub 2021 Aug 16.
PMID: 34398680
CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.
Meng X, Waddington JC, Tailor A, Lister A, Hamlett J, Berry N, Park BK, Sporn MB
J Med Chem. 2020 Sep 10;63(17):9965-9976. doi: 10.1021/acs.jmedchem.0c01088. Epub 2020 Aug 19.
PMID: 32787104
Retraction notice to "Synthetic triterpenoids, CDDO-Imidazolide and CDDO-Ethyl amide, induce chondrogenesis" [Osteoarthr Cartil 20 (2012) 446-450].
Suh N, Paul S, Lee HJ, Yoon T, Shah N, Son AI, Reddi AH, Medici D, Sporn MB
Osteoarthritis Cartilage. 2020 Jun;28(6):865. doi: 10.1016/j.joca.2020.05.005.
PMID: 32471658
Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models.
Leal AS, Zydeck K, Carapellucci S, Reich LA, Zhang D, Moerland JA, Sporn MB, Liby KT
NPJ Breast Cancer. 2019;5:39. doi: 10.1038/s41523-019-0135-5. Epub 2019 Nov 1.
PMID: 31700995
Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention.
Zhang D, Leal AS, Carapellucci S, Shahani PH, Bhogal JS, Ibrahim S, Raban S, Jurutka PW, Marshall PA, Sporn MB, Wagner CE, Liby KT
Cancer Prev Res (Phila). 2019 Apr;12(4):211-224. doi: 10.1158/1940-6207.CAPR-18-0317. Epub 2019 Feb 13.
PMID: 30760500
Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762.
Zhang D, Leal AS, Carapellucci S, Zydeck K, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2018 Mar;11(3):143-156. doi: 10.1158/1940-6207.CAPR-17-0264. Epub 2017 Dec 15.
PMID: 29246957
Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids.
Fu L, Lin QX, Onyango EO, Liby KT, Sporn MB, Gribble GW
Org Biomol Chem. 2017 Jul 19;15(28):6001-6005. doi: 10.1039/c7ob01420a.
PMID: 28678272
Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT
Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.
PMID: 28254412
The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Leal AS, Sporn MB, Pioli PA, Liby KT
Carcinogenesis. 2016 Dec;37(12):1170-1179. Epub 2016 Sep 22.
PMID: 27659181
Commentary on Eagle and Foley: "Cytotoxicity in Human Cell Cultures".
Sporn MB
Cancer Res. 2016 Mar 1;76(5):989-90. doi: 10.1158/0008-5472.CAN-16-0152.
PMID: 26933164
The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. Epub 2015 Nov 10.
PMID: 26554632
Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT
Pharmacol Res. 2015 Oct;100:135-47. doi: 10.1016/j.phrs.2015.07.024. Epub 2015 Jul 31.
PMID: 26238177
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.
To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT
Carcinogenesis. 2015 Jul;36(7):769-81. doi: 10.1093/carcin/bgv061. Epub 2015 May 4.
PMID: 25939751
PARP inhibitors for chemoprevention--reply.
To C, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2014 Nov;7(11):1172. doi: 10.1158/1940-6207.CAPR-14-0264.
PMID: 25368012
Karen T. Liby, Ph.D.
T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages.
Torres GM, Yang H, Park C, Spezza PA, Khatwani N, Bhandari R, Liby KT, Pioli PA
Front Immunol. 2022;13:768753. doi: 10.3389/fimmu.2022.768753. Epub 2022 Feb 21.
PMID: 35265066
CDDO-Me Alters the Tumor Microenvironment in Estrogen Receptor Negative Breast Cancer.
Ball MS, Bhandari R, Torres GM, Martyanov V, ElTanbouly MA, Archambault K, Whitfield ML, Liby KT, Pioli PA
Sci Rep. 2020 Apr 16;10(1):6560. doi: 10.1038/s41598-020-63482-x. Epub 2020 Apr 16.
PMID: 32300202
Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models.
Leal AS, Zydeck K, Carapellucci S, Reich LA, Zhang D, Moerland JA, Sporn MB, Liby KT
NPJ Breast Cancer. 2019;5:39. doi: 10.1038/s41523-019-0135-5. Epub 2019 Nov 1.
PMID: 31700995
Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention.
Zhang D, Leal AS, Carapellucci S, Shahani PH, Bhogal JS, Ibrahim S, Raban S, Jurutka PW, Marshall PA, Sporn MB, Wagner CE, Liby KT
Cancer Prev Res (Phila). 2019 Apr;12(4):211-224. doi: 10.1158/1940-6207.CAPR-18-0317. Epub 2019 Feb 13.
PMID: 30760500
Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762.
Zhang D, Leal AS, Carapellucci S, Zydeck K, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2018 Mar;11(3):143-156. doi: 10.1158/1940-6207.CAPR-17-0264. Epub 2017 Dec 15.
PMID: 29246957
Sustained Release Talazoparib Implants for Localized Treatment of BRCA1-deficient Breast Cancer.
Belz JE, Kumar R, Baldwin P, Ojo NC, Leal AS, Royce DB, Zhang D, van de Ven AL, Liby KT, Sridhar S
Theranostics. 2017;7(17):4340-4349. doi: 10.7150/thno.18563. Epub 2017 Sep 26.
PMID: 29158830
Synthetic oleanane triterpenoids enhance blood brain barrier integrity and improve survival in experimental cerebral malaria.
Crowley VM, Ayi K, Lu Z, Liby KT, Sporn M, Kain KC
Malar J. 2017 Nov 14;16(1):463. doi: 10.1186/s12936-017-2109-0. Epub 2017 Nov 14.
PMID: 29137631
Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids.
Fu L, Lin QX, Onyango EO, Liby KT, Sporn MB, Gribble GW
Org Biomol Chem. 2017 Jul 19;15(28):6001-6005. doi: 10.1039/c7ob01420a.
PMID: 28678272
Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT
Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.
PMID: 28254412
The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Leal AS, Sporn MB, Pioli PA, Liby KT
Carcinogenesis. 2016 Dec;37(12):1170-1179. Epub 2016 Sep 22.
PMID: 27659181
Charlotte Williams, B.S.
Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Leal AS, Williams CR, Royce DB, Pioli PA, Sporn MB, Liby KT
Cancer Lett. 2017 May 28;394:76-87. doi: 10.1016/j.canlet.2017.02.021. Epub 2017 Feb 27.
PMID: 28254412
The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. Epub 2015 Nov 10.
PMID: 26554632
Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
Cao M, Onyango EO, Williams CR, Royce DB, Gribble GW, Sporn MB, Liby KT
Pharmacol Res. 2015 Oct;100:135-47. doi: 10.1016/j.phrs.2015.07.024. Epub 2015 Jul 31.
PMID: 26238177
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.
To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT
Carcinogenesis. 2015 Jul;36(7):769-81. doi: 10.1093/carcin/bgv061. Epub 2015 May 4.
PMID: 25939751
The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice.
To C, Kim EH, Royce DB, Williams CR, Collins RM, Risingsong R, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2014 Jul;7(7):698-707. doi: 10.1158/1940-6207.CAPR-14-0047. Epub 2014 May 9.
PMID: 24817481
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT
Carcinogenesis. 2013 Jan;34(1):199-210. doi: 10.1093/carcin/bgs319. Epub 2012 Oct 6.
PMID: 23042302
The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
Tran K, Risingsong R, Royce D, Williams CR, Sporn MB, Liby K
Cancer Prev Res (Phila). 2012 May;5(5):726-34. doi: 10.1158/1940-6207.CAPR-11-0404. Epub 2012 Mar 8.
PMID: 22401982
CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT
Cancer Prev Res (Phila). 2012 Jan;5(1):89-97. doi: 10.1158/1940-6207.CAPR-11-0359. Epub 2011 Sep 20.
PMID: 21933912
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Liby KT, Royce DB, Risingsong R, Williams CR, Maitra A, Hruban RH, Sporn MB
Cancer Prev Res (Phila). 2010 Nov;3(11):1427-34. doi: 10.1158/1940-6207.CAPR-10-0197. Epub 2010 Oct 19.
PMID: 20959520
Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM, Sporn MB
Cancer Prev Res (Phila). 2009 Dec;2(12):1050-8. doi: 10.1158/1940-6207.CAPR-09-0085. Epub 2009 Dec 1.
PMID: 19952361
Renee Risingsong, B.S.
The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Cao M, Royce DB, Risingsong R, Williams CR, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2016 Jan;9(1):105-14. doi: 10.1158/1940-6207.CAPR-15-0325. Epub 2015 Nov 10.
PMID: 26554632
Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.
To C, Ringelberg CS, Royce DB, Williams CR, Risingsong R, Sporn MB, Liby KT
Carcinogenesis. 2015 Jul;36(7):769-81. doi: 10.1093/carcin/bgv061. Epub 2015 May 4.
PMID: 25939751
The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice.
To C, Kim EH, Royce DB, Williams CR, Collins RM, Risingsong R, Sporn MB, Liby KT
Cancer Prev Res (Phila). 2014 Jul;7(7):698-707. doi: 10.1158/1940-6207.CAPR-14-0047. Epub 2014 May 9.
PMID: 24817481
The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer.
Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT
Carcinogenesis. 2013 Jan;34(1):199-210. doi: 10.1093/carcin/bgs319. Epub 2012 Oct 6.
PMID: 23042302
The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice.
Tran K, Risingsong R, Royce D, Williams CR, Sporn MB, Liby K
Cancer Prev Res (Phila). 2012 May;5(5):726-34. doi: 10.1158/1940-6207.CAPR-11-0404. Epub 2012 Mar 8.
PMID: 22401982
CDDO-methyl ester delays breast cancer development in BRCA1-mutated mice.
Kim EH, Deng C, Sporn MB, Royce DB, Risingsong R, Williams CR, Liby KT
Cancer Prev Res (Phila). 2012 Jan;5(1):89-97. doi: 10.1158/1940-6207.CAPR-11-0359. Epub 2011 Sep 20.
PMID: 21933912
Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Liby KT, Royce DB, Risingsong R, Williams CR, Maitra A, Hruban RH, Sporn MB
Cancer Prev Res (Phila). 2010 Nov;3(11):1427-34. doi: 10.1158/1940-6207.CAPR-10-0197. Epub 2010 Oct 19.
PMID: 20959520
Triterpenoids CDDO-methyl ester or CDDO-ethyl amide and rexinoids LG100268 or NRX194204 for prevention and treatment of lung cancer in mice.
Liby K, Risingsong R, Royce DB, Williams CR, Ma T, Yore MM, Sporn MB
Cancer Prev Res (Phila). 2009 Dec;2(12):1050-8. doi: 10.1158/1940-6207.CAPR-09-0085. Epub 2009 Dec 1.
PMID: 19952361
A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin.
Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, Groopman JD, Kensler TW, Sporn MB
Cancer Res. 2008 Aug 15;68(16):6727-33. doi: 10.1158/0008-5472.CAN-08-1123.
PMID: 18701497
Prevention and treatment of experimental estrogen receptor-negative mammary carcinogenesis by the synthetic triterpenoid CDDO-methyl Ester and the rexinoid LG100268.
Liby K, Risingsong R, Royce DB, Williams CR, Yore MM, Honda T, Gribble GW, Lamph WW, Vannini N, Sogno I, Albini A, Sporn MB
Clin Cancer Res. 2008 Jul 15;14(14):4556-63. doi: 10.1158/1078-0432.CCR-08-0040.
PMID: 18628471