Publications
Cao C, Rioult-Pedotti MS, Migani P, Yu CJ, Tiwari R, Parang K, Spaller MR, Goebel DJ, Marshall J
Impairment of TrkB-PSD-95 signaling in Angelman syndrome.
PLoS Biol 2013 Feb; 11(2):e1001478
PMID: 23424281 [PubMed - in process]
Kaur M, Rupasinghe CN, Klosi E, Spaller MR, Chow CS
Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA.
Bioorg Med Chem 2013 Mar 1; 21(5):1240-7
PMID: 23375098 [PubMed - in process]
Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D
Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer.
ACS Chem Biol 2012 Apr 20; 7(4):770-9
PMID: 22292614 [PubMed - indexed for MEDLINE]
Wang L, Lau JS, Patra CR, Cao Y, Bhattacharya S, Dutta S, Nandy D, Wang E, Rupasinghe CN, Vohra P, Spaller MR, Mukhopadhyay D
RGS-GAIP-interacting protein controls breast cancer progression.
Mol Cancer Res 2010 Dec; 8(12):1591-600
PMID: 21047775 [PubMed - indexed for MEDLINE]
LeBlanc BW, Iwata M, Mallon AP, Rupasinghe CN, Goebel DJ, Marshall J, Spaller MR, Saab CY
A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia.
Neuroscience 2010 May 5; 167(2):490-500
PMID: 20167266 [PubMed - indexed for MEDLINE]
Rubini C, Ruzza P, Spaller MR, Siligardi G, Hussain R, Udugamasooriya DG, Bellanda M, Mammi S, Borgogno A, Calderan A, Cesaro L, Brunati AM, Donella-Deana A
Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.
Biopolymers 2010; 94(3):298-306
PMID: 19921743 [PubMed - indexed for MEDLINE]
Li M, Duc AC, Klosi E, Pattabiraman S, Spaller MR, Chow CS
Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.
Biochemistry 2009 Sep 8; 48(35):8299-311
PMID: 19645415 [PubMed - indexed for MEDLINE]
Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupasinghe CN, Baretton GB, Aust DE, Langer S, Datta K, Simons M, Spaller MR, Mukhopadhyay D
Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.
Clin Cancer Res 2009 Jun 15; 15(12):4095-103
PMID: 19509165 [PubMed - indexed for MEDLINE]
Sharma SC, Memic A, Rupasinghe CN, Duc AC, Spaller MR
T7 phage display as a method of peptide ligand discovery for PDZ domain proteins.
Biopolymers 2009; 92(3):183-93
PMID: 19235856 [PubMed - indexed for MEDLINE]
Memic A, Spaller MR
How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides.
Chembiochem 2008 Nov 24; 9(17):2793-5
PMID: 18985647 [PubMed - indexed for MEDLINE]
Udugamasooriya DG, Sharma SC, Spaller MR
A chemical library approach to organic-modified peptide ligands for PDZ domain proteins: a synthetic, thermodynamic and structural investigation.
Chembiochem 2008 Jul 2; 9(10):1587-9
PMID: 18506876 [PubMed - indexed for MEDLINE]
Udugamasooriya DG, Spaller MR
Conformational constraint in protein ligand design and the inconsistency of binding entropy.
Biopolymers 2008 Aug; 89(8):653-67
PMID: 18335423 [PubMed - indexed for MEDLINE]
Muders MH, Baretton GB, Aust DE, Dutta SK, Wang E, Ikeda Y, Spaller MR, Datta K, Mukhopadhyay D
[GIPC: a new target for therapy in pancreatic adenocarcinoma?].
Verh Dtsch Ges Pathol 2007; 91():286-93
PMID: 18314626 [PubMed - indexed for MEDLINE]
Sharma SC, Rupasinghe CN, Parisien RB, Spaller MR
Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1.
Biochemistry 2007 Nov 6; 46(44):12709-20
PMID: 17939682 [PubMed - indexed for MEDLINE]
Klosi E, Saro D, Spaller MR
Bivalent peptides as PDZ domain ligands.
Bioorg Med Chem Lett 2007 Nov 15; 17(22):6147-50
PMID: 17890086 [PubMed - indexed for MEDLINE]
Saro D, Li T, Rupasinghe C, Paredes A, Caspers N, Spaller MR
A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.
Biochemistry 2007 May 29; 46(21):6340-52
PMID: 17474715 [PubMed - indexed for MEDLINE]
Spaller MR
Act globally, think locally: systems biology addresses the PDZ domain.
ACS Chem Biol 2006 May 23; 1(4):207-10
PMID: 17163673 [PubMed - indexed for MEDLINE]
Muhuhi J, Spaller MR
Expanding the synthetic method and structural diversity potential for the intramolecular Aza Diels-Alder cyclization.
J Org Chem 2006 Jul 21; 71(15):5515-26
PMID: 16839130 [PubMed - indexed for MEDLINE]
Piserchio A, Spaller M, Mierke DF
Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels.
AAPS J 2006 Jun 2; 8(2):E396-401
PMID: 16796391 [PubMed - indexed for MEDLINE]
Cook JD, Bencze KZ, Jankovic AD, Crater AK, Busch CN, Bradley PB, Stemmler AJ, Spaller MR, Stemmler TL
Monomeric yeast frataxin is an iron-binding protein.
Biochemistry 2006 Jun 27; 45(25):7767-77
PMID: 16784228 [PubMed - indexed for MEDLINE]
Rupasinghe CN, Spaller MR
The interplay between structure-based design and combinatorial chemistry.
Curr Opin Chem Biol 2006 Jun; 10(3):188-93
PMID: 16616591 [PubMed - indexed for MEDLINE]
Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, Esteban JA
Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.
EMBO J 2006 Apr 19; 25(8):1623-34
PMID: 16601687 [PubMed - indexed for MEDLINE]
Udugamasooriya G, Saro D, Spaller MR
Bridged peptide macrocycles as ligands for PDZ domain proteins.
Org Lett 2005 Mar 31; 7(7):1203-6
PMID: 15787467 [PubMed - indexed for MEDLINE]
Ukpabi N, Sharma S, Spaller MR, Tsang P
(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.
J Biomol NMR 2004 Sep; 30(1):111-2
PMID: 15452444 [PubMed - indexed for MEDLINE]
Saro D, Klosi E, Paredes A, Spaller MR
Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands.
Org Lett 2004 Sep 30; 6(20):3429-32
PMID: 15387515 [PubMed - indexed for MEDLINE]
Piserchio A, Salinas GD, Li T, Marshall J, Spaller MR, Mierke DF
Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.
Chem Biol 2004 Apr; 11(4):469-73
PMID: 15123241 [PubMed - indexed for MEDLINE]
Li T, Saro D, Spaller MR
Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain.
Bioorg Med Chem Lett 2004 Mar 22; 14(6):1385-8
PMID: 15006367 [PubMed - indexed for MEDLINE]
Spaller MR, Thielemann WT, Brennan PE, Bartlett PA
Combinatorial synthetic design. Solution and polymer-supported synthesis of heterocycles via intramolecular aza Diels-Alder and imino alcohol cyclizations.
J Comb Chem 2002 Sep-Oct; 4(5):516-22
PMID: 12217025 [PubMed - indexed for MEDLINE]
Spaller MR, Burger MT, Fardis M, Bartlett PA
Synthetic strategies in combinatorial chemistry.
Curr Opin Chem Biol 1997 Jun; 1(1):47-53
PMID: 9667834 [PubMed - indexed for MEDLINE]
Martin SF, Spaller MR, Hergenrother PJ
Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.
Biochemistry 1996 Oct 1; 35(39):12970-7
PMID: 8841144 [PubMed - indexed for MEDLINE]
Hergenrother PJ, Spaller MR, Haas MK, Martin SF
Chromogenic assay for phospholipase C from Bacillus cereus.
Anal Biochem 1995 Aug 10; 229(2):313-6
PMID: 7485988 [PubMed - indexed for MEDLINE]