The discipline of Pharmacology from Greek, pharmakon is an applied science combining medicine, physiology, biochemistry, genetics, biology and immunology. Specifically, it is the study of interactions that occur between living cells, systems and organisms and natural or synthetic chemicals that affect normal or abnormal functions. This field encompasses drug target discovery, drug composition, interactions, therapeutics and toxicology. Recently, scientists have made enormous progress in the identification of many novel drug targets for the treatment of many diseases, including cancer and cardiovascular disease. The goal of our Department of Pharmacology and Toxicology is to continue this progress by providing the intellectual and physical environment to foster discovery and translation.

Our Department has 17 primary appointee faculty and 7 additional faculty members with joint appointments in Medicine, Psychiatry, and Community and Family Medicine. We currently have 55 graduate students in our umbrella graduate Program of Experimental and Molecular Medicine.

Cell cycle arrest in human tumors before administration of gemcitabine. (Stained cells reflect those in S and G2 phase of the cell cycle) Figure courtesy of Alan Eastman, Ph.D.

Our research laboratories span the Geisel School of Medicine in Hanover and the Dartmouth-Hitchcock Medical Center in Lebanon. Our department has strong ties with the Norris Cotton Cancer Center, a National Cancer Institute Comprehensive Cancer Center. The research strengths of our department include biochemical pharmacology, cancer and carcinogenesis, cell and molecular pharmacology, experimental therapeutics, clinical pharmacology, genetic and molecular toxicology as well as neuropharmacology and molecular cardiology. This research is supported by external grant funding of over $3,500,000 annually in direct costs. An NIH funded training program exists in cancer biology and there is an NIH designated Super Fund Program. Our graduate program offers a fostering academic environment while rigorously preparing students for exciting biomedical careers in academia, industry, and government. There is a strong funding track-record for each faculty member as well as internal and external funding sources for graduate students.