Bill D. Roebuck, Ph.D.
Professor of Pharmacology and Toxicology
Adjunct Professor of Environmental Studies
Hanover, NH 03755
Phone: (603) 650-1676
Modulation of toxic processes by dietary factors or nutritional status; evaluation of the effects of dietary dithiolethiones on prevention of liver cancer; chemoprevention of cancer.
Work in Dr. Roebuck's laboratory is in the area of chemical carcinogenesis and cancer chemoprevention. He conducts experiments in two different models of cancer, namely, the rat/aflatoxin model for liver cancer. The common theme of his studies is the modulation of cancer development by nutritional factors or chemicals that would or could be added to the diet of animals including humans. Experimental effects are quantified by mitotic activity, number and size of putative preneoplastic lesions, and incidence and multiplicity of cancers.
With respect to the study of liver carcinogenicity, experimental focus is on the inhibition of aflatoxin-induced hepatic cancer in rats and the mechanisms of carcinogenesis. Aflatoxin is the most potent of the naturally occurring carcinogens and is associated with liver cancer in many populations worldwide. It is widely believed that the total elimination of this carcinogen from the human environment is not possible. The prevention of liver cancer by the inclusion of various antioxidants and enzyme inducers into the diet is under investigation. In collaboration with Dr. Thomas J. Curphey at Dartmouth Medical School, we are chemically synthesizing and evaluating the structure-activity relationship of a class of chemoprotective chemicals, the dithiolethiones, in an effort to understand the molecular features that result in cancer chemoprotection against aflatoxin-induced liver cancer. This work involves extensive collaboration with Drs. T.W. Kensler and J.D. Groopman of Johns Hopkins University.
For a complete listing of publications on PubMed, click here.