David W. Nierenberg, M.D.
Edward Tulloh Krumm Professor of Medicine
and of Pharmacology and Toxicology
Senior Associate Dean for Medical Education
Section of Clinical Pharmacology
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon, NH 03756
Phone: (603) 650-7679
At Dartmouth, much of Dr. Nierenberg's initial work focussed on drug interactions between methotrexate and other drugs which share the same renal secretory pathway. Through a combination of in vitro and clinical studies, Dr. Nierenberg demonstrated that drugs which interact with methotrexate to increase toxicity can often be identified with an in vitro laboratory model of tubular secretion.
A second area of research has involved studies of the cancer chemopreventive effects of fat-soluble vitamins. In collaboration with Drs. Greenberg, Baron, and Colacchio, Dr. Nierenberg has been active in studying the clinical pharmacology of retinol, beta-carotene, and alpha-tocopherol, and also studying their abilities to prevent cancer in high-risk patients. Most recently, his work has extended to the study of the clinical pharmacology of these fat-soluble vitamins in patients with a variety of malignant and benign diseases; as well as the clinical pharmacology of various anticancer drugs.
For a complete listing of publications on PubMed, click here.