Joyce A. DeLeo, Ph.D.
Professor of Pharmacology and Toxicology
Professor of Anesthesiology and of Neurology
Director of Academic-Industry Partnerships, SYNERGY (Dartmouth Center for Clinical and Translational Science)
Hanover, NH 03755
The mission of Dr. DeLeo's laboratory is to create a better understanding of central nervous system mechanisms that lead to chronic pain including neuropathic and low back pain. This knowledge will translate into development of new, effective approaches for treatment and even prevention of these chronic pain syndromes. The pain that follows peripheral nerve or root injury is chronic and consistently refractory to available treatments and analgesics. These neuropathic and low back pain syndromes include deafferentation pain, HIV, diabetic, cancer and ischemic neuropathies, phantom limb pain, trigeminal neuralgia, postherpetic neuralgias, nerve injury caused by surgery or trauma and low back pain due to herniated discs (radicular pain). Neuropathic and radicular pain are not only chronic and intractable, but also debilitating and cause extreme physical, psychological and social distress.
Newer research directions now include mechanisms and treatment of brain tumors with particular emphasis on glial/immune/tumor interactions and the role of the microenvironment in tumor growth.
For a complete listing of publications on PubMed, click here.