Alumni Publications and Awards

Robert Allaway, PhD '16

Publications
Allaway RJ, Fischer DA, de Abreu FB, Gardner TB, Gordon SR, Barth RJ, Colacchio TA, Wood M, Kacsoh BZ, Bouley SJ, Cui J, Hamilton J, Choi JA, Lange JT, Peterson JD, Padmanabhan V, Tomlinson CR, Tsongalis GJ, Suriawinata AA, Greene CS, Sanchez Y, Smith KD. Fine-needle biopsy patient-derived xenografts from early stage pancreatic cancer and patient-matched metastatic-PDX models for testing targeted agents. Oncotarget. 2016 Feb 25.

Awards
Albert J. Ryan Predoctoral Fellowship, 2016
Dartmouth Graduate Student Travel Award, 2015
AAAS/Science Program for Excellence in Science, 2015
Children's Tumor Foundation Young Investigator Award


Daniel Avesar, PhD '13

Publications
Brown TT, Erhart M, Avesar D, Dale AM, Halgren E, Evans JL. Atypical right hemisphere specialization for object representations in an adolescent with specific language impairment. Front Hum Neurosci. 2014; 8:82.

Avesar D, Gulledge AT. Selective serotonergic excitation of callosal projection neurons. Frontiers in Neural Circuits 2012; 6:12.

Gulledge AT, Dasari S, Onoue K, Stephens EK, Hasse JM, Avesar D. A sodium-pump-mediated afterhyperpolarization in pyramidal neurons. J Neurosci. 2013 Aug 7;33(32):13025-41.

Awards
Albert J. Ryan Predoctoral Fellowship, 2012
Dartmouth Graduate Student Travel Award, 2012


Emmanuel Balandya, MD, PhD '12

Publications
Balandya E, Wieland-Alter W, Sanders K, Lahey T. Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression. Am J Reprod Immunol. 2012; 68(4):322-30.

Balandya E, Sheth S, Sanders K, Wieland-Alter W, Lahey T. Semen protects CD4+ target cells from HIV infection but promotes the preferential transmission of R5 tropic HIV. J Immunol. 2010; 185(12):7596-604.

Lyimo MA, Howell AL, Balandya E, Eszterhas SK, Connor RI. Innate factors in human breast milk inhibit cell-free HIV-1 but not cell-associated HIV-1 infection of CD4+ cells. J Acquir Immune Defic Syndr. 2009; 51(2):117-24.


Amanda Balboni, PhD '14

Publications
Dunphy KA, Seo JH, Kim DJ, Roberts AL, Tao L, DiRenzo J, Balboni AL, Crisi GM, Hagen MJ, Chandrasekaran T, Gauger KJ, Schneider SS, Jerry DJ. Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation. Cancer Cell Int. 2013; 13:74.

DeCastro AJ, Dunphy KA, Hutchinson J, Balboni AL, Cherukuri P, Jerry DJ, DiRenzo J. MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of ΔNP63α and promotes mesenchymal-to-epithelial transition. Cell Death Dis. 2013; 4:e514.

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J. ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res. 2013; 73(2):1020-30.

Kent S, Hutchinson J, Balboni A, Decastro A, Cherukuri P, DiRenzo J. Cell Cycle. ΔNp63α promotes cellular quiescence via induction and activation of Notch3. Cell Cycle 2011; 10:3111-8.

Norris AM, Gore A, Balboni A, Young A, Longnecker DS, Korc M. AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia. Oncogene 2012; 1-10. Epub ahead of print.

Cherukuri P, DeCastro A, Balboni A, Downey S, Liu J, Hutchinson J, DiRenzo J. Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ and the cellular stress response. PLoS One 2012; 7:e50066.

Awards
Albert J. Ryan Predoctoral Fellowship, 2012


Michael Ball

Publications
Ball MS, Shipman EP, Kim H, Liby KT, Pioli PA. CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages. PLoS ONE. 2016; 11.

Awards
Albert J. Ryan Predoctoral Fellowship, 2014
Top Poster, Celebration of Biomedical Research at Dartmouth Poster Session, 2015
Dartmouth Graduate Student Travel Award, 2016


Alex Bender, PhD '14

Publications
Bender AC, Natola H, Ndong C, Holmes GL, Scott RC, Lenck-Santini PP. Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiol Dis. 2013; 54:297-307.

Bender AC, Morse RP, Scott RC, Holmes GL, Lenck-Santini PP. SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy Behav 2012; 23:177-86. Review.

Holmes GL, Bender AC, Wu EX, Scott RC, Lenck-Santini PP, Morse RP. Maturation of EEG oscillations in children with sodium channel mutations. Brain Dev 2012; 34:469-77.

Awards
Best Poster (co-awarded), Graduate Students category, Neuroscience Day at Dartmouth, 2013
Ruth L. Kirschstein National Research Service Award, National Institutes of Health, NINDS, 2011-2014


Mark Bilodeau

Awards
Founder's Affiliate Fellowship, American Heart Association
Albert J. Ryan Predoctoral Fellowship, 2013


Alexander Busch, PhD '13

Publications
Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther. 2014; 15(4):463-72.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol 2012; 41:1751-61.

Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E. Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models. Cancer Prev Res (Phila) 2011; 4:818-28.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol 2012; 41:1751-61.

Awards
Albert J. Ryan Predoctoral Fellowship, 2012


Li-Ju Chang, PhD '11

Publications
Chang LJ, Eastman A. Differential regulation of p21 (waf1) protein half-life by DNA damage and Nutlin-3 in p53 wild-type tumors and its therapeutic implications. Cancer Biol Ther. 2012; 13(11):1047-57.

Chang LJ, Eastman A. Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle. 2012; 11(9):1818-26.


Fadzai Chinyengetere, PhD '13

Publications
Ma T, Galimberti F, Erkmen CP, Memoli V, Chinyengetere F, Sempere L, Beumer JH, Anyang BN, Nugent W, Johnstone D, Tsongalis GJ, Kurie JM, Li H, Direnzo J, Guo Y, Freemantle SJ, Dragnev KH, Dmitrovsky E. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013; 12(8):1545-55.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol 2012; 41:1751-61.

Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E. Evidence for the ubiquitin protease UBP43 as an antineoplastic target. Mol Cancer Ther 2012; 11:1968-77.

Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E. Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia. Cancer Res 2010; 70:9875-85.


Jennifer Davey, PhD '13

Publications
Ding M, Rzucidlo EM, Davey JC, Xie Y, Liu R, Jin Y, Stavola L, Martin KA. Adiponectin in the heart and vascular system. Vitam Horm 2012; 90:289-319.


Andrew DeCastro, PhD '14

Publications
DeCastro AJ, Dunphy KA, Hutchinson J, Balboni AL, Cherukuri P, Jerry DJ, DiRenzo J. MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of ΔNP63α and promotes mesenchymal-to-epithelial transition. Cell Death Dis. 2013; 4:e514.

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J. ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res. 2013; 73(2):1020-30.

Cherukuri P, Decastro AJ, Balboni AL, Downey SL, Liu JY, Hutchinson JA, Direnzo J. Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. PLoS One 2012; 7:e50066.

Kent S, Hutchinson J, Balboni A, Decastro A, Cherukuri P, Direnzo J. ΔNp63α promotes cellular quiescence via induction and activation of Notch3. Cell Cycle 2011; 10:3111-8.

Awards
Predoctoral Traineeship Award-Department of Defense (DOD) Breast Cancer Research Program (BCRP) of the Office of the Congressionally Directed Medical Research Programs (CDMRP), 2011-2014


Sondra Downey

Publications
Downey SL, Florea BI, Overkleeft HS, Kisselev AF. Use of Proteasome Inhibitors. Curr. Protoc. Immunol. 2015; 109, 9.10.1-9.10.9.

Wilkins OM, Downey SL, Weyburne ES, Williams DA, Mirabella AC, Overkleeft HS, Kisselev AF. Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity. Anal Biochem. 2014; 451:1-3.

Shabaneh TB, Downey SL, Goddard AL, Screen M, Lucas MM, Eastman A, Kisselev AF. Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib. PLoS One. 2013; 8(2):e56132.

Cherukuri P, Decastro AJ, Balboni AL, Downey SL, Liu JY, Hutchinson JA, Direnzo J. Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. PLoS One 2012; 7:e50066.

Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol. 2011; 18(5):608-18.

Awards
Best Poster award, Molecular Therapeutics of Cancer Conference, Princeton NJ, 2012
Dartmouth Graduate Student Travel Award, 2015


Adina Fischer, PhD '13

Publications
Roth RM, Lance CE, Isquith PK, Fischer AS, Giancola PR. Confirmatory factor analysis of the behavior rating inventory of executive function-adult version in healthy adults and application to attention-deficit/hyperactivity disorder. Arch Clin Neuropsychol. 2013; 28(5):425-34.


Catherine Fricano

Publications
Fricano CJ, Despenza T Jr, Frazel PW, Li M, O'Malley AJ, Westbrook GL, Luikart BW. Fatty acids increase neuronal hypertrophy of Pten knockdown neurons. Front Mol Neurosci. 2014; 7:30.

Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, Pettus JR, Froehlich HM, Memoli VA, Morganelli PM, Swinnen JV, Timmerman LA, Chaychi L, Fricano CJ, Eisenberg BL, Coleman WB, Kinlaw WB. Lipoprotein lipase links dietary fat to solid tumor cell proliferation. Mol Cancer Ther 2011; 10:427-36.

Awards
Albert J. Ryan Predoctoral Fellowship, 2014
Top Poster, Dartmouth Integrative Biology Symposium, 2014


Fabrizio Galimberti, PhD '11

Publications
Busch AM, Galimberti F, Nehls KE, Roengvoraphoj M, Sekula D, Li B, Guo Y, Direnzo J, Fiering SN, Spinella MJ, Robbins DJ, Memoli VA, Freemantle SJ, Dmitrovsky E. All-trans-retinoic acid antagonizes the Hedgehog pathway by inducing patched. Cancer Biol Ther. 2014; 15(4):463-72.

Ma T, Galimberti F, Erkmen CP, Memoli V, Chinyengetere F, Sempere L, Beumer JH, Anyang BN, Nugent W, Johnstone D, Tsongalis GJ, Kurie JM, Li H, Direnzo J, Guo Y, Freemantle SJ, Dragnev KH, Dmitrovsky E. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013; 12(8):1545-55.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol. 2012; 41(5):1751-61.

Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E. Evidence for the ubiquitin protease UBP43 as an antineoplastic target. Mol Cancer Ther. 2012; 11(9):1968-77.

Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E. Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models. Cancer Prev Res (Phila). 2011; 4(6):818-28.

Galimberti F, Thompson SL, Ravi S, Compton DA, Dmitrovsky E. Anaphase catastrophe is a target for cancer therapy. Clin Cancer Res. 2011; 17(6):1218-22.

Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E. Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia. Cancer Res. 2010; 70(23):9875-85.

Galimberti F, Thompson SL, Liu X, Li H, Memoli V, Green SR, DiRenzo J, Greninger P, Sharma SV, Settleman J, Compton DA, Dmitrovsky E. Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe. Clin Cancer Res. 2010; 16(1):109-20.

Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E. Uncovering growth-suppressive MicroRNAs in lung cancer. Clin Cancer Res. 2009; 15(4):1177-83.

Feng Q, Sekula D, Guo Y, Liu X, Black CC, Galimberti F, Shah SJ, Sempere LF, Memoli V, Andersen JB, Hassel BA, Dragnev K, Dmitrovsky E. UBE1L causes lung cancer growth suppression by targeting cyclin D1. Mol Cancer Ther. 2008; 7(12):3780-8.

Freemantle SJ, Liu X, Feng Q, Galimberti F, Blumen S, Sekula D, Kitareewan S, Dragnev KH, Dmitrovsky E.Cyclin degradation for cancer therapy and chemoprevention. J Cell Biochem. 2007; 102(4):869-77. Review.


Lan Guo, PhD '14

Publications
Guo L, Yeh ML, Cuzon Carlson VC, Johnson-Venkatesh EM, Yeh HH. Nerve growth factor in the hippocamposeptal system: evidence for activity-dependent anterograde delivery and modulation of synaptic activity. J Neuroscience 2012; 32:7701-10.

Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG. Synthesis and ex vivo autoradiographic evaluation of ethyl-β-D-galactopyranosyl-(1,4')-2'-deoxy-2'-[18F]fluoro-β-D-glucopyranoside--a novel radioligand for lactose-binding protein: implications for early detection of pancreatic carcinomas with PET. Mol Imaging Biol. 2011; 13(3):536-46.

Awards
Albert J. Ryan Predoctoral Fellowship, 2012


Cynthia Hahn, PhD '14

Publications
Hahn CK, Lowrey CH. Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism. Blood. 2013; 122(4):477-85.

Awards
American Society of Hematology Trainee Research Award, 2010
Ruth L. Kirschstein National Research Service Award for Individual Predoctoral MD/PhD (NIH F30)
American Society of Hematology Abstract Achievement Award, 2012


Mike Hasse

Publications
Gulledge AT, Dasari S, Onoue K, Stephens EK, Hasse JM, Avesar D. A sodium-pump-mediated afterhyperpolarization in pyramidal neurons. J Neurosci. 2013 Aug 7;33(32):13025-41.


Amanda Hernan, PhD '13

Publications
Hernan AE, Alexander A, Lenck-Santini PP, Scott RC, Holmes GL. Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH. PLoS One. 2014; 9(2):e89812.

Hernan AE, Alexander A, Jenks KR, Barry J, Lenck-Santini PP, Isaeva E, Holmes GL, Scott RC. Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. Neurobiol Dis. 2014; 63:25-34.

Iseava E, Hernan A, Iseav D, Holmes GL. Thrombin facilitates seizures through activation of persistent sodium current. Ann Neurol 2012; 72:192-8.

Hernan A, Holmes GL, Isaev D, Scott R, Isaeva E. Altered short-term plasticity in the prefrontal cortex after early life seizures. Neurobiol Dis. 2012; 50C:120-126.

Kleen JK, Sesque A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott R. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav 2011; 22:214-9.

Awards
Questcor Pharmaceuticals Investigator Initiated Grant, September 2011 - June 2012
Dartmouth Graduate Student Travel Award, 2011


Courtney (Kozul) Horvath, PhD '10

Publications
Fei DL, Li H, Kozul CD, Black KE, Singh S, Gosse JA, DiRenzo J, Martin KA, Wang B, Hamilton JW, Karagas MR, Robbins DJ. Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res. 2010; 70(5):1981-8.

Kozul CD, Ely KH, Enelow RI, Hamilton JW. Low-dose arsenic compromises the immune response to influenza A infection in vivo. Environ Health Perspect. 2009; 117(9):1441-7.

Kozul CD, Hampton TH, Davey JC, Gosse JA, Nomikos AP, Eisenhauer PL, Weiss DJ, Thorpe JE, Ihnat MA, Hamilton JW. Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung. Environ Health Perspect. 2009; 117(7):1108-15.

Kozul CD, Nomikos AP, Hampton TH, Warnke LA, Gosse JA, Davey JC, Thorpe JE, Jackson BP, Ihnat MA, Hamilton JW. Laboratory diet profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem Biol Interact. 2008; 173(2):129-40.

Mabaera R, Greene MR, Richardson CA, Conine SJ, Kozul CD, Lowrey CH. Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood. 2008; 111(1):411-20.

Martin KA, Merenick BL, Ding M, Fetalvero KM, Rzucidlo EM, Kozul CD, Brown DJ, Chiu HY, Shyu M, Drapeau BL, Wagner RJ, Powell RJ. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. J Biol Chem. 2007; 282(49):36112-20.


Ryan Horvath, MD '12, PhD '10

Publications
Horvath RJ, Romero-Sandoval EA, De Leo JA. Glial modulation in pain states: translation into humans. In: Kruger L, Light AR, editors. Translational Pain Research: From Mouse to Man. Boca Raton, FL: CRC Press; 2010. Chapter 9.

Horvath RJ, Romero-Sandoval EA, De Leo JA. Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and mu opioid receptor protein expression while enhancing perivascular microglial ED2. Pain. 2010; 150(3):401-13.

Romero-Sandoval EA, Horvath R, Landry RP, DeLeo JA. Cannabinoid receptor type 2 activation induces a microglial anti-inflammatory phenotype and reduces migration via MKP induction and ERK dephosphorylation. Mol Pain. 2009; 5:25.

Horvath RJ, DeLeo JA. Morphine enhances microglial migration through modulation of P2X4 receptor signaling. J Neurosci. 2009; 29(4):998-1005.

Horvath RJ, Nutile-McMenemy N, Alkaitis MS, Deleo JA. Differential migration, LPS-induced cytokine, chemokine, and NO expression in immortalized BV-2 and HAPI cell lines and primary microglial cultures. J Neurochem. 2008; 107(2):557-69.

Romero-Sandoval EA, Horvath RJ, DeLeo JA. Neuroimmune interactions and pain: focus on glial-modulating targets. Curr Opin Investig Drugs. 2008; 9(7):726-34. Review.

Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Sierra K, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J. Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study. Pharmacogenet Genomics. 2008; 18(7):611-20.


Shanhu Hu

Awards
Dartmouth Graduate Student Travel Award, 2014
Top Poster, Dartmouth Integrative Biology Symposium, 2014


Jeremy Huckins

Publications
Lord LD, Expert P, Huckins JF, Turkheimer FE. Cerebral energy metabolism and the brain's functional network architecture: an integrative review. J Cereb Blood Flow Metab. 2013; 33(9):1347-54.

Awards
Top Poster, Dartmouth Integrative Biology Symposium, April 2010
Neukom Graduate Fellow, 2012
Top Poster, Dartmouth Integrative Biology Symposium, April 2013


Valerie Jacobs, PhD '12

Publications
Valdes PA, Jacobs VL, Wilson BC, Leblond F, Roberts DW, Paulsen KD. System and methods for wide-field quantitative fluorescence imaging during neurosurgery. Opt Lett. 2013; 38(15):2786-8.

Jacobs VL, De Leo JA. Increased glutamate uptake in astrocytes via propentofylline results in increased tumor cell apoptosis using the CNS-1 glioma model. J Neurooncol. 2013; 114(1):33-42.

Valdés PA, Leblond F, Jacobs VL, Wilson BC, Paulsen KD, Roberts DW. Quantitative, spectrally-resolved intraoperative fluorescence imaging. Sci Rep. 2012; 2:798.

Jacobs VL, Liu Y, De Leo JA. Propentofylline targets TROY, a novel microglial signaling pathway. PLoS One. 2012; 7(5):e37955.

Landry RP, Jacobs VL, Romero-Sandoval EA, DeLeo JA. Propentofylline, a CNS glial modulator does not decrease pain in post-herpetic neuralgia patients: in vitro evidence for differential responses in human and rodent microglia and macrophages. Exp Neurol. 2012; 234(2):340-50.

Jacobs VL, Landry RP, Liu Y, Romero-Sandoval EA, De Leo JA. Propentofylline decreases tumor growth in a rodent model of glioblastoma multiforme by a direct mechanism on microglia. Neuro Oncol. 2012; 14(2):119-31.

Jacobs VL, Valdes PA, Hickey WF, De Leo JA. Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model. ASN Neuro. 2011; 3(3):e00063.

Côté AL, Zhang P, O'Sullivan JA, Jacobs VL, Clemis CR, Sakaguchi S, Guevara-Patiño JA, Turk MJ. Stimulation of the glucocorticoid-induced TNF receptor family-related receptor on CD8 T cells induces protective and high-avidity T cell responses to tumor-specific antigens. J Immunol. 2011; 186(1):275-83.


Kevin Johnson

Publications
O'Sullivan DE*, Johnson KC*, Skinner L, Koestler DC, Christensen BC. Epigenetic and genetic burden measures are associated with tumor characteristics in invasive breast carcinoma. Epigenetics. 2016. *Co-first author

Kresoja-Rakic J, Kapaklikaya E, Ziltener G, Dalcher D, Santoro R, Christensen BC, Johnson KC, Schwaller B, Weder W, Stahel RA, Felley-Bosco E. Identification of cis- and trans-acting elements regulating calretinin expression in mesothelioma cells. Oncotarget. 2016.

Johnson KC, Koestler DC, Fleischer T, Chen P, Jenson EG, Marotti JD, Onega T, Kristensen VN, Christensen BC. DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer. Clin Epigenetics. 2015;7:75.

Fleischer T, Frigessi A, Johnson KC, Edvardsen H, Touleimat N, Klajic J, Riis ML, Haakensen VD, Wärnberg F, Naume B, Helland A, Børresen-Dale AL, Tost J, Christensen BC, Kristensen VN. Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis. Genome Biol. 2014;15:435.

Ung M, Ma X, Johnson KC, Christensen BC, Cheng C. Effect of estrogen receptor α binding on functional DNA methylation in breast cancer. Epigenetics. 2014; 9(4):523-32.

Johnson KC, Koestler DC, Cheng C, Christensen BC. Age-related DNA methylation in normal breast tissue and its relationship with invasive breast tumor methylation. Epigenetics. 2014; 9(2):268-75.

Busch AM, Johnson KC, Stan RV, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle SJ. Evidence for tankyrases as antineoplastic targets in lung cancer. BMC Cancer. 2013; 13:211.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol 2012; 41:1751-61.

Awards
Dartmouth Cancer Epidemiology Program Travel Award, 2016
Albert J. Ryan Pre-doctoral Fellow, 2014-15
Dartmouth Integrative Biology Symposium Poster Winner, 2015
Neukom Institute at Dartmouth Travel Grant, 2015
Neukom Institute at Dartmouth Travel Grant, 2014
Albert J. Ryan Predoctoral Fellowship, 2014
Best Journal Club Presentation, MPTT/CBMT seminar series, 2013


Mandeep Kaur, PhD '13

Publications
Kaur M
, Cole M. MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase. Cancer Res 2012. Epub ahead of print.

Doe MR, Ascano JM, Kaur M, Cole MD. Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells. Cancer Res 2012; 72:949-57.

Awards
Albert J. Ryan Predoctoral Fellowship, since 2011-13


Sierra Kent, PhD '11

Publications
Kent S, Hutchinson J, Balboni A, Decastro A, Cherukuri P, Direnzo J. ΔNp63α promotes cellular quiescence via induction and activation of Notch3. Cell Cycle. 2011; 10(18):3111-8.

Patrignani P, Di Febbo C, Tacconelli S, Douville K, Guglielmi MD, Horvath RJ, Ding M, Kent S, Stitham J, Gleim S, Baccante G, Moretta V, Di Francesco L, Capone ML, Porreca E, Hwa J. Differential association between human prostacyclin receptor polymorphisms and the development of venous thrombosis and intimal hyperplasia: a clinical biomarker study. Pharmacogenet Genomics. 2008; 18(7):611-20.

Takacs CM, Baird JR, Hughes EG, Kent SS, Benchabane H, Paik R, Ahmed Y. Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli. Science. 2008; 319(5861):333-6.


Jonathan Kleen, MD'13, PhD '11

Publications
Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 2013; 81(1):18-24.

Kleen JK, Scott RC, Lenck-Santini PP, Holmes GL. Cognitive and Behavioral Co-Morbidities of Epilepsy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012.

Kleen JK, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. J Neurosci. 2011; 31(43):15397-406.

Kleen JK, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy Behav. 2011; 22(2):214-9.

Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 2011; 52(3):e12-5.

Kleen JK, Holmes GL. Taming TLR4 may ease seizures. Nat Med. 2010; 16(4):369-70.

Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Ann Neurol. 2010; 67(2):250-7.

Kleen JK, Holmes GL. Brain inflammation initiates seizures. Nat Med. 2008; 14(12):1309-10.


Stella Lee

Awards
Dartmouth Graduate Student Travel Award, 2014
Society for Experimental Biology Travel Grant Award, 2014


Corina Lesseur, MD, PhD '14

Publications
Lesseur C, Armstrong DA, Paquette AG, Li Z, Padbury JF, Marsit CJ. Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation. Am J Obstet Gynecol. 2014. pii: S0002-9378(14)00610-3.

Lesseur C, Armstrong DA, Murphy MA, Appleton AA, Koestler DC, Paquette AG, Lester BM, Marsit CJ. Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior. Psychoneuroendocrinology. 2014; 40:1-9.

Armstrong DA, Lesseur C, Conradt E, Lester BM, Marsit CJ. Global and gene-specific DNA methylation across multiple tissues in early infancy: implications for children's health research. FASEB J. 2014; 28(5):2088-97.

Appleton AA, Armstrong DA, Lesseur C, Lee J, Padbury JF, Lester BM, Marsit CJ. Patterning in placental 11-B hydroxysteroid dehydrogenase methylation according to prenatal socioeconomic adversity. PLoS One. 2013; 8(9):e74691.

Lesseur C, Armstrong DA, Paquette AG, Koestler DC, Padbury JF, Marsit CJ. Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors. Mol Cell Endocrinol. 2013; 381(1-2):160-7.

Paquette AG, Lesseur C, Armstrong DA, Koestler DC, Appleton AA, Lester BM, Marsit CJ. Placental HTR2A methylation is associated with infant neurobehavioral outcomes. Epigenetics. 2013; 8(8):796-801.

Koestler DC, Li J, Baron JA, Tsongalis GJ, Butterly LF, Goodrich M, Lesseur C, Karagas MR, Marsit CJ, Moore JH, Andrew AS, Srivastava A. Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon. Mod Pathol. 2014; 27(1):145-55.

Lesseur C, Gilbert-Diamond D, Andrew AS, Ekstrom RM, Li Z, Kelsey KT, Marsit CJ, Karagas MR. A case-control study of polymorphisms in xenobiotic and arsenic metabolism genes and arsenic-related bladder cancer in New Hampshire. Toxicol Lett 2012; 210:100-6.

Kerley-Hamilton JS, Trask HW, Ridley CJA, DuFour E, Lesseur C, Ringelberg CS, Moodie KL, Shipman SL, Korc M, Gui J, Shworak NW, Tomlinson CR. Inherent and benzo [a] pyrene-induced differential aryl hydrocarbon receptor signaling greatly affects life span, atherosclerosis, cardiac gene expression, and body and heart growth in mice. Toxicol Sci 2012; 126: 391-404.


Ningjing Li, MD, PhD '13

Publications
Li N, Li A, Nattie E. Focal microdialysis of CO2 in the perifornical-hypothalamic area increases ventilation during wakefulness but not NREM sleep. Respir Physiol Neurobiol. 2012; pii: S1569-9048(12)00262-5. Epub ahead of print.

Awards
Research Recognition Award from Respiration Section of American Physiological Society
Dartmouth Graduate Student Travel Fund, 2011
Albert J. Ryan Predoctoral Fellowship, 2013


Fang Liu, PhD '13

Publications
Liu F, Gore AJ, Wilson JL, Korc M. DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine PLoS One. 2014; 9(1):e84982.

Liu F, Korc M. Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther 2012; 11:2138-48.


Marcella Lucas, PhD '13

Publications
Jenks KR, Lucas MM, Duffy BA, Robbins AA, Gimi B, Barry JM, Scott RC. Enrichment and training improve cognition in rats with cortical malformations. PLoS One. 2013; 8(12):e84492.

Shabaneh TB, Downey SL, Goddard AL, Screen M, Lucas MM, Eastman A, Kisselev AF. Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib. PLoS One. 2013; 8(2):e56132.

Lucas MM, Lenck-Santini PP, Holmes GL, Scott RC. Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures. Brain 2011; 134:1684-93.

Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chem Biol 2009; 16:1278-89.

Awards
Epilepsy Foundation Health Science Student Fellowship
Dartmouth Grad Studies Travel Award
Dartmouth Grad Studies Alumni Research Award
Dartmouth Grad Studies Community Service Award


Tian Ma, PhD '13

Publications
Ma T, Lopez-Aguiar AG, Li A, Lu Y, Sekula D, Nattie EE, Freemantle S, Dmitrovsky E. Mice lacking G0S2 are lean and cold-tolerant. Cancer Biol Ther. 2014; 15(5):643-50.

Ma T, Galimberti F, Erkmen CP, Memoli V, Chinyengetere F, Sempere L, Beumer JH, Anyang BN, Nugent W, Johnstone D, Tsongalis GJ, Kurie JM, Li H, Direnzo J, Guo Y, Freemantle SJ, Dragnev KH, Dmitrovsky E. Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer. Mol Cancer Ther. 2013; 12(8):1545-55.

Ma T, Dong JP, Sekula DJ, Fei DL, Lamph WW, Henderson M, Lu Y, Blumen S, Freemantle SJ, Dmitrovsky E. Repression of exogenous gene expression by the retinoic acid target gene G0S2. Int J Oncol. 2013; 42(5):1743-53.

Ma T, Fuld AD, Rigas JR, Hagey AE, Gordon GB, Dmitrovsky E, Dragnev KH. A phase I trial and in vitro studies combining ABT-751 with Carboplatin in previously treated non-small cell lung cancer patients. Chemotherapy 2012; 58:321-9.

Galimberti F, Busch AM, Chinyengetere F, Ma T, Sekula D, Memoli VA, Dragnev KH, Liu F, Johnson KC, Guo Y, Freemantle SJ, Andrew AS, Greninger P, Robbins DJ, Settleman J, Benes C, Dmitrovsky E. Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations. Int J Oncol 2012; 41:1751-61.

Guo Y, Chinyengetere F, Dolinko AV, Lopez-Aguiar A, Lu Y, Galimberti F, Ma T, Feng Q, Sekula D, Freemantle SJ, Andrew AS, Memoli V, Dmitrovsky E. Evidence for the ubiquitin protease UBP43 as an antineoplastic target. Mol Cancer Ther 2012; 11:1968-77.

Dragnev KH, Ma T, Cyrus J, Galimberti F, Memoli V, Busch AM, Tsongalis GJ, Seltzer M, Johnstone D, Erkmen CP, Nugent W, Rigas JR, Liu X, Freemantle SJ, Kurie JM, Waxman S, Dmitrovsky E. Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models. Cancer Prev Res (Phila) 2011; 4:818-28.

Guo Y, Dolinko AV, Chinyengetere F, Stanton B, Bomberger JM, Demidenko E, Zhou DC, Gallagher R, Ma T, Galimberti F, Liu X, Sekula D, Freemantle S, Dmitrovsky E. Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia. Cancer Res. 2010; 70:9875-85.


Elizabeth Macari, PhD '12

Publications
Macari ER, Schaeffer EK, West RJ, Lowrey CH. Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells. Blood. 2013; 121(5):830-9.

Macari ER, Lowrey CH. Induction of human fetal hemoglobin via the NRF2 antioxidant response signaling pathway.Blood. 2011; 117(22):5987-97.

Mabaera R, West RJ, Conine SJ, Macari ER, Boyd CD, Engman CA, Lowrey CH. A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger. Exp Hematol. 2008; 36(9):1057-72.


Pingping Mao

Publications
Yim CY, Mao P, Spinella MJ. Headway and hurdles in the clinical development of dietary phytochemicals for cancer therapy and prevention: lessons learned from vitamin A derivatives. AAPS J. 2014; 16(2):281-8.

Mao P, Hever-Jardine MP, Rahme GJ, Yang E, Tam J, Kodali A, Biswal B, Fadul CE, Gaur A, Israel MA, Spinella MJ. Serine/threonine kinase 17A is a novel candidate for therapeutic targeting in glioblastoma. PLoS One. 2013; 8(11):e81803.

Mao P, Hever MP, Niemaszyk LM, Haghkerdar JM, Yanco EG, Desai D, Beyrouthy MJ, Kerley-Hamilton JS, Freemantle SJ, Spinella MJ. Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. J Biol Chem 2011; 286:19381-91.

Awards
Rosaline Borison Memorial Predoctoral Fellow, 2012


Vanessa Mock

Awards
Albert J. Ryan Predoctoral Fellowship, 2015


Lucy Mukura, PhD '13

Publications
Lahey T, Ghosh M, Fahey JV, Shen Z, Mukura LR, Song Y, Cu-Uvin S, Mayer KH, Wright PF, Kappes JC, Ochsenbauer C, Wira CR. Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract. PLoS One 2012; 7:e38100.

Mukura LR, Ghosh M, Fahey JV, Cu-Uvin S, Wira CR. Genital tract viral load in HIV type 1-positive women correlates with specific cytokine levels in cervical-vaginal secretions but is not a determinant of infectious virus or anti-HIV activity. AIDS Res Hum Retroviruses 2012; 28:1533-9.

Wira CR, Patel MV, Ghosh M, Mukura L, Fahey JV. Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections. Am J Reprod Immunol 2011; 65:196-211.

Awards
Albert J. Ryan Predoctoral Fellowship, 2012


Lisa Mustachio

Publications
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E. Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown. Mol Cancer Ther. 2015;14:2576-85.

Hu S, Danilov AV, Godek K, Orr B, Tafe LJ, Rodriguez-Canales J, Behrens C, Mino B, Moran CA, Memoli VA, Mustachio LM, Galimberti F, Ravi S, DeCastro A, Lu Y, Sekula D, Andrew AS, Wistuba II, Freemantle S, Compton DA, Dmitrovsky E. CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110. Cancer Res. 2015;75:2029-38.

Gui JG, Mustachio LM, Su DM, Craig RW. Thymus size and age-related thymic involution: early programming, sexual dimorphism, and stroma. Aging and Disease 2012; 3:280-90.

Awards
Dartmouth Graduate Student Travel Award, 2014


Marie Onakomaiya, PhD '14

Publications
Onakomaiya MM, Porter DM, Oberlander JG, Henderson LP. Sex and exercise interact to alter the expression of anabolic androgenic steroid-induced anxiety-like behaviors in the mouse. Horm Behav. 2014; 66(2):283-297.

Oberlander JG, DM Porter DM, Onakomaiya MM, Penatti CAA, Moss SJ, Vithlani M, Clark AS, Henderson LP. Estrous cycle variations in GABAA receptor phosphorylation enable rapid modulation by anabolic androgenic steroids in the medial preoptic area. Neuroscience 2012; 226:397-410.

Awards
NIDA Early Career Investigators Travel Award, 2011
Albert J. Ryan Predoctoral Fellowship, 2012
Dartmouth College Arts and Sciences Travel Award, 2012
Dartmouth College Alumni Research Awards
Graduate Student Community Award


Daniel Osipovitch

Publications
Osipovitch DC, Parker AS, Makokha CD, Desrosiers J, Kett WC, Moise L, Bailey-Kellogg C, Griswold KE. Design and analysis of immune-evading enzymes for ADEPT therapy. Protein Eng Des Sel 2012; 25:613-23.

Gill A, Scanlon TC, Osipovitch DC, Madden DR, Griswold KE. Crystal structure of a charge engineered human lysozyme having enhanced bactericidal activity. PLoS One 2011; 6:e16788.


Haoxu Ouyang, PhD '13

Publications
Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia JR, Kauppinen S, Wells W, Korc M. Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors. Clin Cancer Res 2010; 16:4246-55.

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E. MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors. J Clin Invest 2010; 120:1298-309.


Alison Paquette

Publications
Lesseur C, Armstrong DA, Paquette AG, Li Z, Padbury JF, Marsit CJ. Maternal obesity and gestational diabetes are associated with placental leptin DNA methylation. Am J Obstet Gynecol. 2014. pii: S0002-9378(14)00610-3.

Lesseur C, Armstrong DA, Murphy MA, Appleton AA, Koestler DC, Paquette AG, Lester BM, Marsit CJ. Sex-specific associations between placental leptin promoter DNA methylation and infant neurobehavior. Psychoneuroendocrinology. 2014; 40:1-9.

Lesseur C, Armstrong DA, Paquette AG, Koestler DC, Padbury JF, Marsit CJ. Tissue-specific Leptin promoter DNA methylation is associated with maternal and infant perinatal factors. Mol Cell Endocrinol. 2013; 381(1-2):160-7.

Paquette AG, Lesseur C, Armstrong DA, Koestler DC, Appleton AA, Lester BM, Marsit CJ. Placental HTR2A methylation is associated with infant neurobehavioral outcomes. Epigenetics. 2013; 8(8):796-801.

Awards
Dartmouth Graduate Student Travel Award, 2013
Dartmouth Graduate Student Counsel Travel Grant, 2014


Nadia Penrod, PhD '13

Publications
Penrod NM, Cowper-Sal-lari R, Moore JH. Systems genetics for drug target discovery. Trends Pharmacol Sci 2011; 32:623-30.

Penrod NM, Poku KA, Vaughan DE, Asselbergs FW, Brown NJ, Moore JH, Williams SM. Epistatic interactions in genetic regulation of t-PA and PAI-1 levels in a Ghanaian population. PLoS One 2011; 6:e16639.

Penrod NM, Greene CS, Granizo-Mackenzie D, Moore JH. Artificial immune systems for epistasis analysis in human genetics. Lecture Notes Compu Sc 2010 6023:194-204.

Dervieux T, Wessels JA, van der Straaten T, Penrod N, Moore JH, Guchelaar HJ, Kremer JM. Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis. Pharmacogenet Genomics 2009; 19:935-44.

Greene CS, Penrod NM, Kiralis J, Moore JH. Spatially uniform relieff (SURF) for computationally-efficient filtering of gene-gene interactions. BioData Min 2009; 2:5.

Greene CS, Penrod NM, Williams SM, Moore JH. Failure to replicate a genetic association may provide important clues about genetic architecture. PLoS One 2009; 4:e5639.

Awards
Dartmouth College Arts and Sciences Travel Award, 2010


Valeriya Posternak

Publications
Posternak V, Cole MD. Strategically targeting MYC in cancer. F1000 Reviews. 2016 Mar.

Awards
Albert J. Ryan Predoctoral Fellowship, 2014
Dartmouth Graduate Student Travel Award, 2015
Albert J. Ryan Predoctoral Fellowship, 2015
Top poster, 8th Annual Integrative Biology Symposium, 2015


Ashlee Robbins

Publications
Jenks KR, Lucas MM, Duffy BA, Robbins AA, Gimi B, Barry JM, Scott RC. Enrichment and training improve cognition in rats with cortical malformations. PLoS One. 2013; 8(12):e84492.

Robbins AA, Fox SE, Holmes GL, Scott RC, Barry JM. Short duration waveforms recorded extracellularly from freely moving rats are representative of axonal activity. Front Neural Circuits. 2013; 7:181.


Melissa Rundle

Publications
Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 2013; 81(1):18-24.


Emily Schaeffer, PhD '14

Publications
Schaeffer EK, West RJ, Conine SJ, Lowrey CH. Multiple physical stresses induce γ-globin gene expression and fetal hemoglobin production in erythroid cells. Blood Cells Mol Dis. 2014; 52(4):214-24.

Macari ER, Schaeffer EK, West RJ, Lowrey CH. Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells. Blood. 2013; 121(5):830-9.


Neal Schilling, PhD '12

Publications
Xiao C, Ogle SA, Schumacher MA, Schilling N, Tokhunts RA, Orr-Asman MA, Miller ML, Robbins DJ, Hollande F, Zavros Y. Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol. 2010; 299(6):G1252-65.

Singh S, Tokhunts R, Baubet V, Goetz JA, Huang ZJ, Schilling NS, Black KE, MacKenzie TA, Dahmane N, Robbins DJ. Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner. Hum Genet. 2009; 125(1):95-103.

Ogden SK, Fei DL, Schilling NS, Ahmed YF, Hwa J, Robbins DJ. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature. 2008; 456(7224):967-70.

Farzan SF, Singh S, Schilling NS, Robbins DJ. The adventures of sonic hedgehog in development and repair. III. Hedgehog processing and biological activity. Am J Physiol Gastrointest Liver Physiol. 2008; 294(4):G844-9.


Sladjana Skopelja

Publications
Jones JD, Hamilton BJ, Skopelja S, Rigby WF. Induction of interleukin-6 production by rituximab in human B cells. Arthritis Rheumatol. 2014;66:2938-46.

Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA. Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain. J Neurosci. 2013; 33(43):17182-7.


Alex Skorput

Awards
Albert J. Ryan Predoctoral Fellowship, 2014


Ryan Soderquist, PhD '14

Publications
Soderquist RS, Danilov AV, Eastman A. Gossypol Increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress. J Biol Chem. 2014; 289(23):16190-16199.

Soderquist R, Pletnev AA, Danilov AV, Eastman A. The putative BH3 mimetic S1 sensitizes leukemia to ABT-737 by increasing reactive oxygen species, inducing endoplasmic reticulum stress, and upregulating the BH3-only protein NOXA. Apoptosis. 2014; 19(1):201-9.

Danilov AV, Soderquist RS, Bates DJ, Eastman A. Toward a cure for chronic lymphocytic leukemia: an attack on multiple fronts. Expert Rev Anticancer Ther. 2013; 13(9):1009-12.

Soderquist R, Bates DJ, Danilov AV, Eastman A. Gossypol overcomes stroma-mediated resistance to the BCL2 inhibitor ABT-737 in chronic lymphocytic leukemia cells ex vivo. Leukemia. 2013; 27(11):2262-4.

Wood M, Rawe M, Johansson G, Pang S, Soderquist RS, Patel AV, Nelson S, Seibel W, Ratner N, Sanchez Y. Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. Mol Cancer Ther 2011; 10:1740-50.

Albershardt TC, Salerni BL, Soderquist RS, Bates DJ, Pletnev AA, Kisselev AF, Eastman A. Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. J Biol Chem 2011; 286:24882-95.

Awards
Dartmouth Graduate Student Travel Award, 2014
Best poster award, Molecular Therapeutics of Cancer conference, 2013


Emily Stephens

Publications
Gulledge AT, Dasari S, Onoue K, Stephens EK, Hasse JM, Avesar D. A sodium-pump-mediated afterhyperpolarization in pyramidal neurons. J Neurosci. 2013 Aug 7;33(32):13025-41.


Jaclyn (Sullivan) Weier, PhD '16

Publications
Sullivan JM, Havrda MC, Paolella BR, Kettenbach A, Gerber S, Israel, MA. 2016. N-terminal phosphorylation of Id2 is a key regulator of cell cycle transit in neural precursor cells. Stem Cells. 2016.

Havrda MC, Paolella BR, Ran C, Jering KS, Wray CM, Sullivan JM, Nailor A, Hitoshi Y, Israel MA. Id2 mediates oligodendrocyte precursor cell maturation arrest and is tumorigenic in a PDGF-rich microenvironment. Cancer Res. 2014; 74(6):1822-32.

Awards
Fall 2014 Graduate Student Award, 2014
Graduate Student Council Travel Award, 2014
Albert J. Ryan Predoctoral Fellowship, 2013-2016


Sabrina Taylor, PhD '13

Publications
Taylor SR, Smith C, Harris BT, Costine BA, Duhaime AC. Maturation-dependent response of neurogenesis after traumatic brain injury in children. J Neurosurg Pediatr. 2013; 12(6):545-54.


Ali Titiz, PhD '14

Publications
Richard GR, Titiz A, Tyler A, Holmes GL, Scott RC, Lenck-Santini PP. Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus. 2013; 23(12):1269-79.


Anne Marie Thompson, PhD '14

Publications
Thompson AM, Martin KA2, Rzucidlo EM. Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK. PLoS One. 2014; 9(1):e85495.


Kim Tran, PhD '11

Publications
Tran K, Risingsong R, Royce DB, Williams CR, Sporn MB, Pioli PA, Gediya LK, Njar VC, Liby KT. The combination of the histone deacetylase inhibitor vorinostat and synthetic triterpenoids reduces tumorigenesis in mouse models of cancer. Carcinogenesis. 2013;34(1):199-210.

Tran K, Risingsong R, Royce D, Williams CR, Sporn MB, Liby K. The synthetic triterpenoid CDDO-methyl ester delays estrogen receptor-negative mammary carcinogenesis in polyoma middle T mice. Cancer Prev Res (Phila). 2012; 5(5):726-34.


Emily Weyburne '16

Publications
Kraus M, Bader J, Geurink PP, Weyburne ES, Mirabella AC, Silzle T, Shabaneh TB, van der Linden WA, de Bruin G, Haile SR, van Rooden E, Appenzeller C, Li N, Kisselev AF, Overkleeft H, Driessen C. The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells. Haematologica. 2015;100:1350-60.

Wilkins OM, Downey SL, Weyburne ES, Williams DA, Mirabella AC, Overkleeft HS, Kisselev AF. Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity. Anal Biochem. 2014; 451:1-3.

Awards
Best Poster award at 2015 Molecular Therapeutics of Cancer Research Conference meeting
Best Poster award at 2015 New England Shared Resources Conference meeting
Excellence for Journal Club Award April 2015


Asaf Wyszynski PhD '14

Publications
Andrew AS, Gui J, Hu T, Wyszynski A, Marsit CJ, Kelsey KT, Schned AR, Tanyos SA, Pendleton EM, Ekstrom RM, Li Z, Zens MS, Borsuk M, Moore JH, Karagas MR. Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study. BJU Int. 2014. [Epub ahead of print].

Wyszynski A, Tanyos SA, Rees JR, Marsit CJ, Kelsey KT, Schned AR, Pendleton EM, Celaya MO, Zens MS, Karagas MR, Andrew AS. Body mass and smoking are modifiable risk factors for recurrent bladder cancer. Cancer. 2014; 120(3):408-14.


Wei Yang

Publications
Yang W, Hosford SR, Dillon LM, Shee K, Liu SC, Bean JR, Salphati L, Pang J, Zhang X, Nannini MA, Demidenko E, Bates DJ, Lewis LD,Marotti JD, Eastman A, Miller TW. Strategically timing inhibition of phosphatidylinositol 3-kinase to maximize therapeutic index in estrogen receptor alpha-positive, PIK3CA-mutant breast cancer. Clin Cancer Res. 2016.

Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH, Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW. P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. Oncogene. 2015;34:3968-76.

Bean JR, Hosford SR, Symonds LK, Owens P, Dillon LM, Yang W, Shee K, Schwartz GN, Marotti JD, Muller KE, Rosenkranz KM, Barth RJ, Chen VS, Agarwal VR, Miller TW. The PI3K/mTOR dual inhibitor P7170 demonstrates potent activity against endocrine-sensitive and endocrine-resistant ER+ breast cancer. Breast Cancer Res Treat. 2015;149:69-79.

Yang W, Chamberlin MD, Miller TW. Treatment strategies for hormone receptor-positive, HER2-negative advanced breast cancer. J OncoPathology, Volume 2, Number 2, 2014, pp. 33-42(10).

Awards
Dartmouth Graduate Student Travel Award, 2014


Christina Yim

Publications
Yim CY, Sekula DJ, Hever-Jardine MP, Liu X, Warzecha JM, Tam J, Freemantle SJ, Dmitrovsky E, Spinella MJ. G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program. Cancer Res. 2016;76:1204-13.

Yim CY, Mao P, Spinella MJ. Headway and hurdles in the clinical development of dietary phytochemicals for cancer therapy and prevention: lessons learned from vitamin A derivatives. AAPS J. 2014; 16(2):281-8.

Awards
Dartmouth Graduate Student Travel Award, 2015