Primary Biomedical Physiology & Immunotherapy Faculty

Alix Ashare, M.D.

Associate Professor of Medicine and of Anesthesiology
Research Description: Currently my laboratory is investigating the potential mechanisms of increased lung inflammation in patients with inflammatory lung diseases, with an emphasis on the investigation of impaired alveolar macrophage function in these patient populations. Currently, my laboratory is particularly interested in how hypoxia impacts macrophage phenotype and function and how these changes in the immune cell may contribute to the chronic inflammation seen in patients with asthma and cystic fibrosis.

Richard Chou, M.D., Ph.D.

Assistant Professor of Medicine
Research Description: The research focus of our laboratory is to investigate the cellular and molecular mechanisms of autoimmune and neurological diseases using animal models, translational research, and clinical studies.

Richard I. Enelow, M.D.

Professor of Medicine and Microbiology/Immunology
Vice-Chair for Research
Chief, Pulmonary/Critical Care

Research Description: T cell responses to influenza and other virus infection, and the mechanisms of immunopathology in respiratory virus infection.

Francesca Gilli, PhD

Assistant Professor of Neurology
Research Description: We are interested in understanding the neuroimmunology of Multiple Sclerosis (MS) and its rodent models. Particularly, we are investigating the cellular and molecular pathways that contribute to neuroinflammation and central nervous system (CNS)-related tissue damage, aiming at understanding how inflammation contributes to neurodegeneration and disability progression in MS. The overall intention of this work is to identify new therapeutic targets or strategies that will improve our ability to manage progressive MS as well as other neurodegenerative diseases.

William R. Green, Ph.D.

Professor and Chair, Department of Microbiology and Immunology
Research Description: T cell immune responses to viral diseases; cell-mediated immunity to mouse retroviruses that cause either leukemia or immunodeficiency; immunity to the mouse acquired immunodeficiency syndrome (MAIDS) retroviral isolate and the mechanism of retroviral pathogenesis; studies on novel vaccine approaches.

Allan T. Gulledge, Ph.D.

Associate Professor of Molecular and Systems Biology
Research Description: Our focus is the cellular neurophysiology of the cerebral cortex, with emphasis on understanding signal integration and transmission within individual neurons.

Matthew C. Havrda Ph.D.

Assistant Professor of Molecular and Systems Biology
Research Description: Molecular events contributing to the initiation and progression of Parkinson's disease. Investigating the neuroinflammatory activities of disease associated environmental toxins using molecular, cellular and organismal approaches.

Alexandra L. Howell, Ph.D.

Professor of Medicine and of Microbiology and Immunology
Research Description: My laboratory studies the use of genome engineering using CRISPR/Cas to cleave both viral and cellular genes important for HIV infection and replication. We deliver these genes with lentiviral vectors and have shown we can both eliminate the HIV provirus from an infected cell as well as protect an uninfected cell from infection.

Aihua Li, M.D.

Associate Professor of Molecular and Systems Biology
Research Description: The general theme of the research is the control of breathing, blood pressure and sympathetic nerve activity by hypothalamus and brainstem, with specific emphasis on the roles of central chemoreceptors in cardiorespiratory functions and in health and diseases e.g. neurogenic hypertension, sleep disorders and sudden infant death syndrome.

Bryan W. Luikart, Ph.D.

Assistant Professor of Molecular and Systems Biology
Research Description: We study the molecular mechanisms that direct the formation of synapses onto new neurons as they integrate into the synaptic circuitry of the central nervous system.

Andrew R. Pachner, M.D.

Professor of Neurology
Research Description: Our laboratory is focused on translational research in Multiple Sclerosis (MS), a chronic inflammatory, disabling disease of the CNS. We are working on both patients with MS and experimental models of MS in rodents to develop improved biomarkers and therapies.

Patricia A. Pioli, Ph.D.

Assistant Professor of Obstetrics and Gynecology, and of Microbiology and Immunology
Research Description: Reproductive immunology; sex hormone regulation of macrophage immune function and signal transduction

William F.C. Rigby, M.D.

Professor of Medicine, Microbiology and Immunology
Research Description: Posttranscriptional regulation of cytokine and CD40 ligand gene expression, RNA-protein infections, Von Hippel-Lindau regulation of mRNA stability.

R. Brooks Robey, M.D., F.A.S.N.

Associate Professor of Medicine; Associate Chief of Staff for Research and Development (VA)
Research Description: Regulation and function of mammalian hexokinases with specific emphasis on the interface between metabolism and cell survival in both adaptive (ischemic preconditioning) and maladaptive (cancer) contexts.

Radu V. Stan, MD, PhD

Associate Professor of Biochemistry, and of Pathology
Director, Optical Cell Imaging Facility; Co-Director, Irradiation, Pre-clinical Imaging and Microscopy Shared Resource, Norris Cotton Cancer Center

Research Description: Role of blood vessels in the pathogenesis of inflammatory disease and cancer. Using a broad variety of experimental approaches (e.g. genetically modified mouse models, cell biological approaches in cell culture and fluorescence and electron microscopy), our lab studies the biology of specific vascular endothelial gene products (i.e. PLVAP and interacting partners) and endothelial specific structures (e.g. fenestrae, caveolae, and vesiculo-vacuolar organelles) in normal cardiovascular function and the adaptive responses that occur in disease. A significant part of our work is devoted to developing novel therapeutic and diagnostic strategies for inflammation and cancer.

Harold M. Swartz, M.D., Ph.D.

Professor of Radiology, The Dartmouth Institute, and of Community and Family Medicine
Research Description: The development and application of Electron Paramagnetic Resonance (EPR) to viable systems, including human subjects and animal models, especially 1. oximetry for cancer and peripheral vascular disease. 2. techniques for after-the-fact dosimetry to meet the need for rapid and accurate triage in a population that has potentially been exposed to doses that could cause the acute radiation syndrome (ARS).

Hermes H. Yeh, Ph.D.

William W. Brown Professor of Physiology and Neurobiology
Department of Molecular and Systems Biology
Director, Program in Experimental and Molecular Medicine

Research Description: Cellular and molecular mechanisms of neuroreceptor interactions and plasticity in the adult and developing CNS.

Enrichment Faculty

Robert A. Darnall, M.D.

Professor of Molecular and Systems Biology, and of Pediatrics
Research Description: The role of medullary serotonergic neurons in the Sudden Infant Death Syndrome. Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases REM.

Valerie Anne Galton, Ph.D.

Professor of Molecular and Systems Biology
Research Description: The roles of the iodothyronine deiodinases in the regulation of intracellular thyroid hormone levels and thyroid hormone action during development and in adult mammals. Studies use mice made deficient in the either or both the types 1 and 2 iodothyronine deiodinase.

Paul M. Guyre, Ph.D.

Professor of Microbiology & Immunology
Research Description: Mechanisms of hormone/cytokine interactions in control of immunity, Inflammation, sepsis, and autoimmunity.

James C. Leiter, M.D.

Professor of Molecular and Systems Biology and of Medicine
Research Description: Respiratory neurobiology especially in the areas of pH regulation in neurons and astrocytes, central chemosensitivity and comparative aspects of rhythm generation.

Robert A. Maue, Ph.D.

Professor of Medical Education and of Biochemistry
Research Description: Cellular and molecular mechanisms underlying neuronal development in the CNS, particularly as related to neurodegenerative diseases; neurotrophin and growth factor actions; regulation of neuronal ion channels and genes; molecular biology; electrophysiology.

Eugene E. Nattie, M.D.

Professor of Molecular and Systems Biology
Research Description: Central chemoreceptors that sense changes in brain pH and stimulate breathing. The role of central chemoreception in the medullary raphe in the sudden infant death syndrome.

William G. North, Ph.D.

Professor of Molecular and Systems Biology
Research Description: Neuropeptides in breast cancer, in small-cell carcinoma, and in Alzheimer's disease.

Charles R. Wira, Ph.D.

Professor of Microbiology and Immunology
Research Description: Physiology of reproduction; cellular and molecular actions of sex hormones regulation of the mucosal immune system in the rodent and human female reproductive tract as it relates to protection against sexually transmitted diseases including HIV-1.