Primary Faculty M-Z
Assistant Professor of Molecular and Systems Biology; Scientific Director, Comprehensive Breast Program, Norris Cotton Cancer Center; Co-Director, Molecular Tumor Board, Norris Cotton Cancer Center
Research Description: Research in the Miller Laboratory focuses on the translational application of knowledge of cell signaling pathways to therapeutics for breast cancer. Our work spans the spectrum of basic cancer biology, through translational studies in mouse models and human tissues, and interfaces with clinical trials. We use an array of methods and technologies both in our lab and through interaction with core facilities, including mammalian tissue culture, molecular analyses of gene and protein expression, gene expression microarrays, chromatin immunoprecipitation, next-generation DNA sequencing, bioinformatics, protein microarrays, mass spectrometry, mouse models, and live animal imaging.
Professor of Neurology
Research Description: Our laboratory is focused on translational research in Multiple Sclerosis (MS), a chronic inflammatory, disabling disease of the CNS. We are working on both patients with MS and experimental models of MS in rodents to develop improved biomarkers and therapies.
Assistant Professor of Epidemiology
Research Description: Metabolism of steroids including sex hormones, cholesterol, and bile acids in relation to the development and recurrence of colorectal polyps and cancers.
Assistant Professor of Obstetrics and Gynecology, and of Microbiology and Immunology
Research Description: Reproductive immunology; sex hormone regulation of macrophage immune function and signal transduction
Professor of Medicine, Microbiology and Immunology
Research Description: Posttranscriptional regulation of cytokine and CD40 ligand gene expression, RNA-protein infections, Von Hippel-Lindau regulation of mRNA stability.
Associate Professor of Medicine; Associate Chief of Staff for Research and Development (VA)
Research Description: Regulation and function of mammalian hexokinases with specific emphasis on the interface between metabolism and cell survival in both adaptive (ischemic preconditioning) and maladaptive (cancer) contexts.
Associate Professor of Molecular and Systems Biology
Associate Director for Basic Sciences, Norris Cotton Cancer Center
Research Description: Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death. The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.
Associate Professor of Biochemistry, and of Pathology
Director, Optical Cell Imaging Facility; Co-Director, Irradiation, Pre-clinical Imaging and Microscopy Shared Resource, Norris Cotton Cancer Center
Research Description: Role of blood vessels in the pathogenesis of inflammatory disease and cancer. Using a broad variety of experimental approaches (e.g. genetically modified mouse models, cell biological approaches in cell culture and fluorescence and electron microscopy), our lab studies the biology of specific vascular endothelial gene products (i.e. PLVAP and interacting partners) and endothelial specific structures (e.g. fenestrae, caveolae, and vesiculo-vacuolar organelles) in normal cardiovascular function and the adaptive responses that occur in disease. A significant part of our work is devoted to developing novel therapeutic and diagnostic strategies for inflammation and cancer.
Professor of Radiology, The Dartmouth Institute, and of Community and Family Medicine
Research Description: The development and application of Electron Paramagnetic Resonance (EPR) to viable systems, including human subjects and animal models, especially 1. oximetry for cancer and peripheral vascular disease. 2. techniques for after-the-fact dosimetry to meet the need for rapid and accurate triage in a population that has potentially been exposed to doses that could cause the acute radiation syndrome (ARS).
Professor of Psychological and Brain Sciences
Research Description: Neurobiology of spatial orientation and navigation, learning and memory. Understanding 1) the neurobiological basis of spatial cognition and navigation, and 2) the neurobiological mechanisms underlying learning and memory. We use single cell chronic unit recording techniques in rodents to correlate the activity of neurons with the animal's behavior.
Assistant Professor of Medicine, and of Molecular and Systems Biology
Research Description: Our laboratory studies the role of aryl hydrocarbon receptor in adult-onset diseases from in utero exposures to environmental toxicants, pancreatic cancer, and the development of high throughput genomics as a tool to predict the outcome of gene/environment interactions.
Professor of Pathology
Research Description: Greg Tsongalis is the Director of the Laboratory for Clinical Genomics and Advanced Technologies (CGAT) at the Geisel School of Medicine. His area of expertise is in clinical molecular diagnostic applications. His research interests are in the pathogenesis of solid tumors, disease association of SNP genotyping and personalized medicine.
Professor of Psychological & Brain Sciences
Research Description: Uses functional magnetic resonance imaging to assess the role of prefrontal and limbic circuits in the evaluation of events that predict biologically relevant outcomes. This work has implications for the understanding of the emotion fear as well as disorders of fear management (e.g., anxiety disorders).
William W. Brown Professor of Physiology and Neurobiology
Department of Molecular and Systems Biology
Director, Program in Experimental and Molecular Medicine
Research Description: Cellular and molecular mechanisms of neuroreceptor interactions and plasticity in the adult and developing CNS.