Graduate Program Committee

Ethan Dmitrovsky, M.D.

Andrew G. Wallace Professor and Chair of Pharmacology and Toxicology
Research Description: Translational research (bench to bedside) and studies of vitamin A derivatives known as retinoids and their roles in tumor cell differentiation therapy and chemoprevention.
Contact Information:
Dartmouth Medical School, HB 7650
Hanover, NH 03755
Office: (603) 650-1667, Remsen 522
Lab: (603) 650-1921, Remsen 621A & 624
Fax: (603) 650-1129
E-mail: Ethan.Dmitrovsky@Dartmouth.edu

Joyce A. DeLeo, Ph.D.

Professor of Anesthesiology and Irene Heinz Given Professor and Chair of Pharmacology and Toxicology, Director of the Neuroscience Center at Dartmouth
Research Description: Neuropharmacology; Neuroimmunology: Mechanisms that lead to chronic pain with a focus on spinal neuroimmune responses. Central neuroimmune activation and neuroinflammation play a key role in generating chronic pain. Utilization of molecular, cellular, and in vivo behavioral pharmacological approaches with the ultimate goal to develop novel, non-addictive therapeutics for the prevention and treatment of chronic neuropathic and low back pain.
Contact Information:
Dartmouth Medical School, HB 7650
Hanover, NH 03755
Office: (603) 650-1667, Remsen 522
Fax: (603) 650-1129
E-mail: Joyce.A.DeLeo@Dartmouth.edu

Michael J. Spinella, Ph.D.

Associate Professor of Pharmacology and Toxicology
Research Description: Identifying downstream genes and pathways signaling induced differentiation and growth suppression of human solid tumor cells, especially in response to retinoids; relationship between differentiation and cell-cycle control, and the role deregulation of differentiation plays in tumorigenesis and acquired resistance to chemotherapeutic agents.
Contact Information:
Dartmouth Medical School, HB 7650
Hanover, NH 03755
Office: (603) 650-1920, Remsen 620
Lab: (603) 650-1620
Fax: (603) 650-1129
E-mail: Michael.J.Spinella@Dartmouth.edu


Scott Gleim

Student Representative

David J. Robbins, Ph.D.

Associate Professor of Pharmacology and Toxicology
Research Description: The Hedgehog (Hh) signal transduction pathway plays a critical role in both embryonic development and in cancer, through mechanisms that are poorly understood. My research program is focused on elucidating the role Hh plays in human disease. This goal is approached in two ways: 1) elucidating the production and presentation of the secreted ligand Hh and 2) dissecting the signaling pathway downstream of the Hh receptor. We study this signaling pathway in both developmental and pathological settings, making our research highly complementary and mutually supporting. Such an approach will more rapidly decipher the mechanism by which the Hh pathway contributes to human disease.
Contact Information:
Dartmouth Medical School, HB 7650
Hanover, NH 03755
Office: (603) 650-1716, Remsen 614
Lab: (603) 650-1964, Remsen 607
Fax: (603) 650-1129
E-mail: David.J.Robbins@Dartmouth.edu

John Hwa, M.D., Ph.D.

Associate Professor of Pharmacology, Toxicology and of Medicine (Cardiology)
Research Description: The structure and function of G-protein coupled receptors (molecular pharmacology): Analysis of the ligand binding pocket, receptor activation, constitutive activity and naturally occurring mutations (pharmacogenetics).
Contact Information:
520 Remsen, HB 7650
Hanover, NH 03755
Office: (603) 650-1813, Remsen 520
Lab: (603) 650-1814
Fax: (603) 650-1129
E-mail: John.Hwa@Dartmouth.edu
http://geiselmed.dartmouth.edu/hwa/

James DiRenzo, Ph.D.

Associate Professor of Pharmacology and Toxicology
Research Description: Regulation of proliferation, self-renewal and cellular differentiation in mammary epithelial stem cells. Mammary gland carcinogenesis, tumor stem cell theory, genetic control over stem cell renewal.
Contact Information:
Dartmouth Medical School, HB 7650
Hanover, NH 03755
Office: (603) 650-1794, Remsen 611
Lab: (603) 650-1795, Remsen 601 & 612
Fax: (603) 650-1129
E-mail: James.DiRenzo@Dartmouth.edu

Hillary Davis

Theme Administrator