Publications
Thiaville MM, Stoeck A, Chen L, Wu RC, Magnani L, Oidtman J, Shih IeM, Lupien M, Wang TL
Identification of PBX1 Target Genes in Cancer Cells by Global Mapping of PBX1 Binding Sites.
PLoS One 2012; 7(5):e36054
PMID: 22567123
Akhtar-Zaidi B, Cowper-Sal-lari R, Corradin O, Saiakhova A, Bartels CF, Balasubramanian D, Myeroff L, Lutterbaugh J, Jarrar A, Kalady MF, Willis J, Moore JH, Tesar PJ, Laframboise T, Markowitz S, Lupien M, Scacheri PC
Epigenomic enhancer profiling defines a signature of colon cancer.
Science 2012 May 11; 336(6082):736-9
PMID: 22499810
Magnani L, Ballantyne EB, Zhang X, Lupien M
PBX1 genomic pioneer function drives ERĪ± signaling underlying progression in breast cancer.
PLoS Genet 2011 Nov; 7(11):e1002368
PMID: 22125492
Tang Q, Chen Y, Meyer C, Geistlinger T, Lupien M, Wang Q, Liu T, Zhang Y, Brown M, Liu XS
A comprehensive view of nuclear receptor cancer cistromes.
Cancer Res 2011 Nov 15; 71(22):6940-7
PMID: 21940749
Magnani L, Eeckhoute J, Lupien M
Pioneer factors: directing transcriptional regulators within the chromatin environment.
Trends Genet 2011 Nov; 27(11):465-74
PMID: 21885149
Serandour AA, Avner S, Percevault F, Demay F, Bizot M, Lucchetti-Miganeh C, Barloy-Hubler F, Brown M, Lupien M, Metivier R, Salbert G, Eeckhoute J
Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.
Genome Res 2011 Apr; 21(4):555-65
PMID: 21233399
Cowper-Sal lari R, Cole MD, Karagas MR, Lupien M, Moore JH
Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies.
Wiley Interdiscip Rev Syst Biol Med 2011 Sep-Oct; 3(5):513-26
PMID: 21197657
Madak-Erdogan Z, Lupien M, Stossi F, Brown M, Katzenellenbogen BS
Genomic collaboration of estrogen receptor alpha and extracellular signal-regulated kinase 2 in regulating gene and proliferation programs.
Mol Cell Biol 2011 Jan; 31(1):226-36
PMID: 20956553
Lupien M, Meyer CA, Bailey ST, Eeckhoute J, Cook J, Westerling T, Zhang X, Carroll JS, Rhodes DR, Liu XS, Brown M
Growth factor stimulation induces a distinct ER(alpha) cistrome underlying breast cancer endocrine resistance.
Genes Dev 2010 Oct 1; 24(19):2219-27
PMID: 20889718
He HH, Meyer CA, Shin H, Bailey ST, Wei G, Wang Q, Zhang Y, Xu K, Ni M, Lupien M, Mieczkowski P, Lieb JD, Zhao K, Brown M, Liu XS
Nucleosome dynamics define transcriptional enhancers.
Nat Genet 2010 Apr; 42(4):343-7
PMID: 20208536
Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S
MYC regulation of a "poor-prognosis" metastatic cancer cell state.
Proc Natl Acad Sci U S A 2010 Feb 23; 107(8):3698-703
PMID: 20133671
Wade HE, Kobayashi S, Eaton ML, Jansen MS, Lobenhofer EK, Lupien M, Geistlinger TR, Zhu W, Nevins JR, Brown M, Otteson DC, McDonnell DP
Multimodal regulation of E2F1 gene expression by progestins.
Mol Cell Biol 2010 Apr; 30(8):1866-77
PMID: 20123965
Boros J, Donaldson IJ, O'Donnell A, Odrowaz ZA, Zeef L, Lupien M, Meyer CA, Liu XS, Brown M, Sharrocks AD
Elucidation of the ELK1 target gene network reveals a role in the coordinate regulation of core components of the gene regulation machinery.
Genome Res 2009 Nov; 19(11):1963-73
PMID: 19687146
Wang Q, Li W, Zhang Y, Yuan X, Xu K, Yu J, Chen Z, Beroukhim R, Wang H, Lupien M, Wu T, Regan MM, Meyer CA, Carroll JS, Manrai AK, Janne OA, Balk SP, Mehra R, Han B, Chinnaiyan AM, Rubin MA, True L, Fiorentino M, Fiore C, Loda M, Kantoff PW, Liu XS, Brown M
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
Cell 2009 Jul 23; 138(2):245-56
PMID: 19632176
Eeckhoute J, Lupien M, Brown M
Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies.
Methods Mol Biol 2009; 556:155-64
PMID: 19488877
Lupien M, Brown M
Cistromics of hormone-dependent cancer.
Endocr Relat Cancer 2009 Jun; 16(2):381-9
PMID: 19369485
Lupien M, Eeckhoute J, Meyer CA, Krum SA, Rhodes DR, Liu XS, Brown M
Coactivator function defines the active estrogen receptor alpha cistrome.
Mol Cell Biol 2009 Jun; 29(12):3413-23
PMID: 19364822
Eeckhoute J, Lupien M, Meyer CA, Verzi MP, Shivdasani RA, Liu XS, Brown M
Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.
Genome Res 2009 Mar; 19(3):372-80
PMID: 19129543
Krum SA, Miranda-Carboni GA, Lupien M, Eeckhoute J, Carroll JS, Brown M
Unique ERalpha cistromes control cell type-specific gene regulation.
Mol Endocrinol 2008 Nov; 22(11):2393-406
PMID: 18818283
Setlur SR, Mertz KD, Hoshida Y, Demichelis F, Lupien M, Perner S, Sboner A, Pawitan Y, Andren O, Johnson LA, Tang J, Adami HO, Calza S, Chinnaiyan AM, Rhodes D, Tomlins S, Fall K, Mucci LA, Kantoff PW, Stampfer MJ, Andersson SO, Varenhorst E, Johansson JE, Brown M, Golub TR, Rubin MA
Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer.
J Natl Cancer Inst 2008 Jun 4; 100(11):815-25
PMID: 18505969
Lupien M, Eeckhoute J, Meyer CA, Wang Q, Zhang Y, Li W, Carroll JS, Liu XS, Brown M
FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.
Cell 2008 Mar 21; 132(6):958-70
PMID: 18358809
Frietze S, Lupien M, Silver PA, Brown M
CARM1 regulates estrogen-stimulated breast cancer growth through up-regulation of E2F1.
Cancer Res 2008 Jan 1; 68(1):301-6
PMID: 18172323
Eeckhoute J, Keeton EK, Lupien M, Krum SA, Carroll JS, Brown M
Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer.
Cancer Res 2007 Jul 1; 67(13):6477-83
PMID: 17616709
Lupien M, Jeyakumar M, Hebert E, Hilmi K, Cotnoir-White D, Loch C, Auger A, Dayan G, Pinard GA, Wurtz JM, Moras D, Katzenellenbogen J, Mader S
Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.
Mol Endocrinol 2007 Apr; 21(4):797-816
PMID: 17299137
Lupien M, Dievart A, Morales CR, Hermo L, Calvo E, Kay DG, Hu C, Jolicoeur P
Expression of constitutively active Notch1 in male genital tracts results in ectopic growth and blockage of efferent ducts, epididymal hyperplasia and sterility.
Dev Biol 2006 Dec 15; 300(2):497-511
PMID: 17046738
Dayan G, Lupien M, Auger A, Anghel SI, Rocha W, Croisetiere S, Katzenellenbogen JA, Mader S
Tamoxifen and raloxifene differ in their functional interactions with aspartate 351 of estrogen receptor alpha.
Mol Pharmacol 2006 Aug; 70(2):579-88
PMID: 16679488
Hu C, Dievart A, Lupien M, Calvo E, Tremblay G, Jolicoeur P
Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors.
Am J Pathol 2006 Mar; 168(3):973-90
PMID: 16507912
Lupien M, Marshall S, Leser W, Pollack GS, Honegger HW
Antibodies against the PER protein of Drosophila label neurons in the optic lobe, central brain, and thoracic ganglia of the crickets Teleogryllus commodus and Teleogryllus oceanicus.
Cell Tissue Res 2003 Jun; 312(3):377-91
PMID: 12764606